SG10201609301QA - Drug containing carrier into cell for forming immune complex - Google Patents

Drug containing carrier into cell for forming immune complex

Info

Publication number
SG10201609301QA
SG10201609301QA SG10201609301QA SG10201609301QA SG10201609301QA SG 10201609301Q A SG10201609301Q A SG 10201609301QA SG 10201609301Q A SG10201609301Q A SG 10201609301QA SG 10201609301Q A SG10201609301Q A SG 10201609301QA SG 10201609301Q A SG10201609301Q A SG 10201609301QA
Authority
SG
Singapore
Prior art keywords
cell
immune complex
drug containing
containing carrier
forming immune
Prior art date
Application number
SG10201609301QA
Inventor
Tomoyuki Igawa
Naoka Hironiwa
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2011/077619 external-priority patent/WO2012073992A1/en
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG10201609301QA publication Critical patent/SG10201609301QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
SG10201609301QA 2011-11-30 2012-11-30 Drug containing carrier into cell for forming immune complex SG10201609301QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/JP2011/077619 WO2012073992A1 (en) 2010-11-30 2011-11-30 Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
JP2012123773 2012-05-30

Publications (1)

Publication Number Publication Date
SG10201609301QA true SG10201609301QA (en) 2016-12-29

Family

ID=48535590

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201402750SA SG11201402750SA (en) 2011-11-30 2012-11-30 Drug containing carrier into cell for forming immune complex
SG10201609301QA SG10201609301QA (en) 2011-11-30 2012-11-30 Drug containing carrier into cell for forming immune complex

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201402750SA SG11201402750SA (en) 2011-11-30 2012-11-30 Drug containing carrier into cell for forming immune complex

Country Status (12)

Country Link
US (2) US20150056182A1 (en)
EP (2) EP3517550A1 (en)
JP (4) JP6124800B2 (en)
KR (3) KR20140100532A (en)
CN (3) CN113416256A (en)
BR (1) BR112014013081A2 (en)
CA (2) CA3233142A1 (en)
HK (1) HK1198771A1 (en)
MX (2) MX358220B (en)
RU (1) RU2739792C1 (en)
SG (2) SG11201402750SA (en)
WO (1) WO2013081143A1 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3056568T3 (en) 2006-03-31 2021-11-01 Chugai Pharmaceutical Co Ltd PROCEDURES FOR CONTROL OF THE BLOOD PHARMACOKINETICS OF ANTIBODIES
CN106519025B (en) 2007-09-26 2021-04-23 中外制药株式会社 Method for changing isoelectric point of antibody by using amino acid substitution of CDR
KR102469853B1 (en) 2008-04-11 2022-11-22 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
TWI440469B (en) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
AU2011337704B2 (en) 2010-11-30 2017-06-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
MX352889B (en) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Fcî“riib-specific fc antibody.
WO2013047748A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
KR102239138B1 (en) 2011-09-30 2021-04-12 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule inducing immune response to target antigen
TW201817745A (en) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
WO2013081143A1 (en) 2011-11-30 2013-06-06 中外製薬株式会社 Drug containing carrier into cell for forming immune complex
DK2857420T3 (en) 2012-05-30 2020-11-23 Chugai Pharmaceutical Co Ltd TARGET TISSUE SPECIFIC ANTIGIN BINDING MOLECULE
US20150353630A1 (en) * 2012-05-30 2015-12-10 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for eliminating aggregated antigens
EP3597747B1 (en) 2012-08-24 2023-03-15 Chugai Seiyaku Kabushiki Kaisha Mouse fcgammarii-specific fc antibody
SG10201709559PA (en) 2012-08-24 2017-12-28 Chugai Pharmaceutical Co Ltd Fcγriib-specific fc region variant
US11267868B2 (en) 2013-04-02 2022-03-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
BR112016006502A2 (en) 2013-09-30 2017-09-19 Chugai Pharmaceutical Co Ltd METHOD FOR THE PRODUCTION OF ANTIGEN-BINDING MOLECULE USING MODIFIED HELPER PHAGUE
CA2943681A1 (en) 2014-04-18 2015-10-22 The Research Foundation For The State University Of New York Humanized anti-tf-antigen antibodies
RU2746356C2 (en) 2014-12-19 2021-04-12 Чугаи Сейяку Кабусики Кайся C5 antibodies and their application methods
PE20221834A1 (en) 2014-12-19 2022-11-29 Chugai Pharmaceutical Co Ltd ANTIMYOSTATIN ANTIBODIES
WO2016117346A1 (en) 2015-01-22 2016-07-28 Chugai Seiyaku Kabushiki Kaisha A combination of two or more anti-c5 antibodies and methods of use
KR20170110129A (en) 2015-02-05 2017-10-10 추가이 세이야쿠 가부시키가이샤 Antibodies comprising ionic concentration dependent antigen binding domains, Fc region variants, antibodies that bind to IL-8, and their use
TWI805046B (en) 2015-02-27 2023-06-11 日商中外製藥股份有限公司 Use of IL-6 receptor antibody for preparing pharmaceutical composition
CR20180217A (en) 2015-09-18 2018-05-03 Chugai Pharmaceutical Co Ltd ANTIBODIES THAT JOIN INTERLEUCINE 8 (IL-8) AND ITS USES
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
KR20190039937A (en) 2016-07-08 2019-04-16 스태튼 바이오테크놀로지 비.브이. Anti-ApoC3 antibodies and methods of use thereof
US11858980B2 (en) 2016-08-02 2024-01-02 Visterra, Inc. Engineered polypeptides and uses thereof
CN116251182A (en) 2016-08-05 2023-06-13 中外制药株式会社 Compositions for preventing or treating IL-8 related diseases
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN110944672A (en) * 2017-01-17 2020-03-31 得克萨斯A&M大学系统 Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells
JP7191833B2 (en) 2017-01-30 2022-12-19 中外製薬株式会社 Anti-sclerostin antibodies and uses thereof
CN110506056A (en) 2017-04-21 2019-11-26 斯塔滕生物技术有限公司 Anti- APOC3 antibody and its application method
JP7185884B2 (en) 2017-05-02 2022-12-08 国立研究開発法人国立精神・神経医療研究センター METHOD FOR PREDICTING AND DETERMINING THERAPEUTIC EFFECT OF IL-6 AND NEUTROPHIL-RELATED DISEASE
WO2018224951A2 (en) * 2017-06-05 2018-12-13 Janssen Biotech, Inc. Engineered multispecific antibodies and other multimeric proteins with asymmetrical ch2-ch3 region mutations
WO2019036869A1 (en) * 2017-08-21 2019-02-28 深圳市博奥康生物科技有限公司 Shrna of human tl6 gene and applications thereof
JP7232190B2 (en) 2017-10-20 2023-03-02 中外製薬株式会社 Methods for Measuring Uptake of Molecules into Cells
CA3080103A1 (en) 2017-10-31 2019-05-09 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
CA3093729A1 (en) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
CN112585165A (en) 2018-04-25 2021-03-30 普罗米修斯生物科学公司 Optimized anti-TL 1A antibodies
CN113227134A (en) * 2018-12-05 2021-08-06 株式会社梅花治疗 Fc region variants of antibodies
US20220259278A1 (en) * 2019-07-08 2022-08-18 Progen Co., Ltd. Novel fusion protein and use of same
CN114901311A (en) 2019-10-24 2022-08-12 普罗米修斯生物科学公司 Humanized antibodies to TNF-like ligand 1A (TL1A) and uses thereof
CA3164818A1 (en) 2019-12-18 2021-06-24 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
JP2023520216A (en) 2020-04-01 2023-05-16 アヴァロ セラピューティクス， インコーポレイテッド Methods and treatments involving excess free LIGHT
KR102151501B1 (en) * 2020-05-26 2020-09-03 박성은 Composition for improving hair and head skin
WO2022025184A1 (en) 2020-07-29 2022-02-03 中外製薬株式会社 Method for measuring pharmacokinetics of drug labeled with non-radioactive substance
KR20240007196A (en) * 2021-05-14 2024-01-16 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 antigen-binding molecule
WO2022244838A1 (en) 2021-05-19 2022-11-24 中外製薬株式会社 Method for predicting in vivo pharmacokinetics of molecule
CA3221735A1 (en) 2021-06-18 2022-12-22 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies

Family Cites Families (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091539B2 (en) 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells
ES521371A0 (en) 1982-04-12 1984-05-16 Hybritech Inc A PROCEDURE FOR THE PURIFICATION OF AN ANTIBODY.
US4689299A (en) 1982-09-30 1987-08-25 University Of Rochester Human monoclonal antibodies against bacterial toxins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4801687A (en) 1986-10-27 1989-01-31 Bioprobe International, Inc. Monoclonal antibody purification process using protein A
US4851341A (en) 1986-12-19 1989-07-25 Immunex Corporation Immunoaffinity purification system
JPH01144991A (en) 1987-12-02 1989-06-07 Kagaku Oyobi Ketsusei Riyouhou Kenkyusho Purification of blood coagulation factor viii
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JPH0636741B2 (en) * 1989-11-08 1994-05-18 帝人株式会社 Method for separating human protein C
WO1991012023A2 (en) 1990-02-16 1991-08-22 Boston Biomedical Research Institute Hybrid reagents capable of selectively releasing molecules into cells
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (en) 1990-07-10 2000-04-17 Cambridge Antibody Tech Process for producing specific binding pair elements
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2246502T3 (en) 1990-08-29 2006-02-16 Genpharm International, Inc. TRANSGENIC NON-HUMAN ANIMALS ABLE TO PRODUCE HETEROLOGICAL ANTIBODIES.
DK0605522T3 (en) 1991-09-23 2000-01-17 Medical Res Council Process for producing humanized antibodies
DK1024191T3 (en) 1991-12-02 2008-12-08 Medical Res Council Preparation of autoantibodies displayed on phage surfaces from antibody segment libraries
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
ATE381614T1 (en) 1992-07-24 2008-01-15 Amgen Fremont Inc FORMATION OF XENOGENE ANTIBODIES
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
WO1994029471A1 (en) 1993-06-10 1994-12-22 Genetic Therapy, Inc. Adenoviral vectors for treatment of hemophilia
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
FR2707189B1 (en) 1993-07-09 1995-10-13 Gradient Ass Method for treating combustion residues and installation for implementing said method.
GB9314271D0 (en) 1993-07-09 1993-08-18 Inst Of Cancer The Research Cell growth factor receptors
IL107742A0 (en) 1993-11-24 1994-02-27 Yeda Res & Dev Chemically-modified binding proteins
CA2177367A1 (en) 1993-12-03 1995-06-08 Andrew David Griffiths Recombinant binding proteins and peptides
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
AU701342B2 (en) 1994-07-13 1999-01-28 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin-8
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
EP0739981A1 (en) 1995-04-25 1996-10-30 Vrije Universiteit Brussel Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
ES2304786T3 (en) 1995-04-27 2008-10-16 Amgen Fremont Inc. ANTI-IL-8 HUMAN ANTIBODIES, DERIVED FROM IMMUNIZED XENORATONES.
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc Human antibodies derived from immunized xenomice
DE69731289D1 (en) 1996-03-18 2004-11-25 Univ Texas IMMUNGLOBULIN-LIKE DOMAIN WITH INCREASED HALF-VALUE TIMES
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
US6670453B2 (en) 1997-10-27 2003-12-30 Unilever Patent Holdings B.V. Multivalent antigen-binding proteins
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) * 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US7572619B2 (en) 2000-03-22 2009-08-11 Octagene Gmbh Recombinant blood clotting factors
FR2807767B1 (en) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement MONOCLONAL ANTIBODIES ANTI-D
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
EP2141243A3 (en) 2000-10-16 2010-01-27 Brystol-Myers Squibb Company Protein scaffolds for antibody mimics and other binding proteins
EP2341060B1 (en) 2000-12-12 2019-02-20 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
US20040002450A1 (en) 2000-12-29 2004-01-01 Janette Lazarovits Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040001822A1 (en) 2000-12-29 2004-01-01 Avigdor Levanon Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US20040001839A1 (en) 2000-12-29 2004-01-01 Avigdor Levanon Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
US7667004B2 (en) 2001-04-17 2010-02-23 Abmaxis, Inc. Humanized antibodies against vascular endothelial growth factor
US20030157561A1 (en) 2001-11-19 2003-08-21 Kolkman Joost A. Combinatorial libraries of monomer domains
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
CN100374457C (en) 2001-11-14 2008-03-12 森托科尔公司 Anti-IL-6 antibodies, compositions, methods and uses
WO2003057881A1 (en) 2001-12-28 2003-07-17 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein
AR038568A1 (en) * 2002-02-20 2005-01-19 Hoffmann La Roche ANTI-A BETA ANTIBODIES AND ITS USE
US20080199471A1 (en) 2002-03-01 2008-08-21 Bernett Matthew J Optimized cd40 antibodies and methods of using the same
US7317091B2 (en) * 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
WO2003074679A2 (en) 2002-03-01 2003-09-12 Xencor Antibody optimization
DK1512015T3 (en) 2002-06-12 2009-07-06 Genencor Int Methods for improving the binding properties of a molecule
AU2003256266A1 (en) 2002-06-12 2003-12-31 Genencor International, Inc. Methods and compositions for milieu-dependent binding of a targeted agent to a target
ITMI20021527A1 (en) 2002-07-11 2004-01-12 Consiglio Nazionale Ricerche C5 COMPONENT ANTIBODIES OF COMPLEMENT AND THEIR USE
US8193318B2 (en) 2002-08-14 2012-06-05 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
BRPI0314814C1 (en) 2002-09-27 2021-07-27 Xencor Inc antibody comprising an fc variant
RU2325186C2 (en) 2002-09-27 2008-05-27 Ксенкор, Инк. ANTIBODY CONTAINING Fc-VARIANT PART (VERSIONS), PHARMACEUTICAL FORMULATION, CONTAINING ANTIBODY AND METHOD OF MAMMAL MEDICAL TREATMENT
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
PT1562972E (en) 2002-10-15 2010-11-10 Facet Biotech Corp Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
CA2766627C (en) 2003-05-02 2019-12-03 Xencor, Inc. Optimized fc variants and methods for their generation
AU2004273791A1 (en) 2003-09-05 2005-03-31 Genentech, Inc. Antibodies with altered effector functions
US8101720B2 (en) 2004-10-21 2012-01-24 Xencor, Inc. Immunoglobulin insertions, deletions and substitutions
CA2545539A1 (en) 2003-10-15 2005-04-28 Pdl Biopharma, Inc. Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
CA2543360A1 (en) 2003-10-24 2005-05-06 Joost A. Kolkman Ldl receptor class a and egf domain monomers and multimers
US7820800B2 (en) 2003-11-05 2010-10-26 Ares Trading S.A. Process for the purification of IL-18 binding protein
CA2545603A1 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto
CA2546054C (en) 2003-12-10 2014-05-13 Medarex, Inc. Interferon alpha antibodies and their uses
WO2005077981A2 (en) 2003-12-22 2005-08-25 Xencor, Inc. Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
DE602005015542D1 (en) 2004-01-12 2009-09-03 Applied Molecular Evolution VARIANTS OF FC REGION
DE602005020743D1 (en) 2004-02-11 2010-06-02 Warner Lambert Co PROCESS FOR TREATING OSTEOARTHRITIS WITH ANTI-IL-6 ANTIBODIES
US20050260711A1 (en) 2004-03-30 2005-11-24 Deepshikha Datta Modulating pH-sensitive binding using non-natural amino acids
WO2005123780A2 (en) 2004-04-09 2005-12-29 Protein Design Labs, Inc. Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
MXPA06011796A (en) 2004-04-16 2007-05-07 Macrogenics Inc FCgammaRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF.
CA2568952C (en) 2004-06-18 2019-05-21 Ambrx, Inc. Novel antigen-binding polypeptides and their uses
ES2372503T3 (en) 2004-07-06 2012-01-20 Bioren, Inc. REVISED MUTAGENESIS TO DEVELOP ALTERED POLYPEPTIDES WITH POTENTIATED PROPERTIES.
EP1919950A1 (en) * 2004-07-15 2008-05-14 Xencor, Inc. Optimized fc variants
EA012464B1 (en) 2004-08-04 2009-10-30 Эпплайд Молекьюлар Эволюшн, Инк. Antibody against cd20 and use thereof
AU2005277567A1 (en) 2004-08-16 2006-03-02 Medimmune, Llc Integrin antagonists with enhanced antibody dependent cell-mediated cytotoxicity activity
CA2577133A1 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
EP1812068A4 (en) 2004-10-29 2010-06-09 Medimmune Inc Methods of preventing and treating rsv infections and related conditions
US7632497B2 (en) 2004-11-10 2009-12-15 Macrogenics, Inc. Engineering Fc Antibody regions to confer effector function
RU2412200C2 (en) 2004-11-12 2011-02-20 Ксенкор, Инк. Fc-VERSIONS WITH CHANGED BINDING WITH FcRn
CN102746404B (en) 2004-11-12 2016-01-20 赞科股份有限公司 To FcRn in conjunction with reformed Fc variant
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
EP1871808A2 (en) 2005-03-31 2008-01-02 Xencor, Inc. Fc VARIANTS WITH OPTIMIZED PROPERTIES
US10011858B2 (en) 2005-03-31 2018-07-03 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
CA2606102C (en) 2005-04-26 2014-09-30 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
US8163881B2 (en) 2005-05-31 2012-04-24 The Board Of Regents Of The University Of Texas System Immunoglobulin molecules with improved characteristics
FR2888850B1 (en) 2005-07-22 2013-01-11 Pf Medicament NOVEL ANTI-IGF-IR ANTIBODIES AND THEIR APPLICATIONS
SI2573114T1 (en) 2005-08-10 2016-08-31 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP1931709B1 (en) 2005-10-03 2016-12-07 Xencor, Inc. Fc variants with optimized fc receptor binding properties
ES2577292T3 (en) 2005-11-07 2016-07-14 Genentech, Inc. Binding polypeptides with diversified VH / VL hypervariable sequences and consensus
CA2631212A1 (en) 2005-11-28 2007-07-05 Medimmune, Llc Antagonists of hmgb1 and/or rage and methods of use thereof
ES2654040T3 (en) * 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Antibody modification method for the purification of bispecific antibodies
TWI395754B (en) 2006-04-24 2013-05-11 Amgen Inc Humanized c-kit antibody
WO2008105886A2 (en) 2006-05-26 2008-09-04 Macrogenics, Inc. HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
EP2032159B1 (en) 2006-06-26 2015-01-07 MacroGenics, Inc. Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
JP2009545322A (en) 2006-08-02 2009-12-24 ザ ユーエービー リサーチ ファウンデーション Methods and compositions relating to a defined antigen-specific soluble monoclonal variable lymphocyte receptor
DK2383297T5 (en) 2006-08-14 2022-07-04 Xencor Inc Optimized antibodies directed against CD19
CA3163418A1 (en) 2006-10-06 2008-05-22 Jeffrey S. Isenberg Prevention of tissue ischemia, related methods and compositions
US20100034194A1 (en) 2006-10-11 2010-02-11 Siemens Communications Inc. Eliminating unreachable subscribers in voice-over-ip networks
US8652466B2 (en) 2006-12-08 2014-02-18 Macrogenics, Inc. Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
CN103408661B (en) 2007-01-05 2016-04-06 苏黎世大学 The method of disease-specific binding molecules and target is provided
WO2008091954A2 (en) 2007-01-23 2008-07-31 Xencor, Inc. Optimized cd40 antibodies and methods of using the same
WO2008092117A2 (en) 2007-01-25 2008-07-31 Xencor, Inc. Immunoglobulins with modifications in the fcr binding region
WO2008114011A2 (en) 2007-03-19 2008-09-25 Medimmune Limited Fc polypeptide variants obtained by ribosome display methodology
NZ581395A (en) 2007-05-14 2012-08-31 Biogen Idec Inc Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
LT2176298T (en) 2007-05-30 2018-04-10 Xencor, Inc. Methods and compositions for inhibiting cd32b expressing cells
JOP20080381B1 (en) 2007-08-23 2023-03-28 Amgen Inc Antigen Binding Proteins to Proprotein Convertase subtillisin Kexin type 9 (pcsk9)
PE20140132A1 (en) 2007-09-26 2014-02-14 Chugai Pharmaceutical Co Ltd IL-6 ANTI-RECEPTOR ANTIBODY
CN106519025B (en) 2007-09-26 2021-04-23 中外制药株式会社 Method for changing isoelectric point of antibody by using amino acid substitution of CDR
AU2008305851B2 (en) * 2007-09-28 2014-12-18 Chugai Seiyaku Kabushiki Kaisha Anti-glypican-3 antibody having improved kinetics in plasma
KR100888133B1 (en) 2007-10-02 2009-03-13 에스케이에너지 주식회사 Method of preparing multicomponent bismuth molybdate catalysts comprising four metal components and method of preparing 1,3-butadiene using said catalysts
EP2203474A1 (en) 2007-10-22 2010-07-07 Merck Serono S.A. Method for purifying fc-fusion proteins
US20120039871A1 (en) 2007-11-08 2012-02-16 Pikamab, Inc. Methods and compositions for antibody therapy
US8414893B2 (en) 2007-12-21 2013-04-09 Amgen Inc. Anti-amyloid antibodies and uses thereof
SI2808343T1 (en) 2007-12-26 2019-10-30 Xencor Inc Fc variants with altered binding to FcRn
US8426141B2 (en) 2008-01-18 2013-04-23 Stichting Sanquin Bloedvoorziening Methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies
JP5373823B2 (en) 2008-01-29 2013-12-18 アブリンクス エン．ヴェー． Methods for stabilizing proteins and polypeptides
KR102469853B1 (en) 2008-04-11 2022-11-22 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
CA2722082C (en) 2008-04-25 2021-11-09 Christopher Tenhoor Fc receptor binding proteins
EP2816059A1 (en) 2008-05-01 2014-12-24 Amgen, Inc Anti-hepcidin antibodies and methods of use
JP6146949B2 (en) 2008-06-20 2017-06-21 ノバルティス アーゲー Immunoglobulin with reduced aggregation
EA027575B1 (en) 2008-08-05 2017-08-31 Новартис Аг Antibody or antigen binding fragment thereof, binding human c5 protein, composition comprising same, nucleic acid encoding antibody or antigen binding fragment thereof, vector and host cell comprising said acid, and use of antibody or antigen binding fragment thereof
JP5028372B2 (en) 2008-09-26 2012-09-19 京セラドキュメントソリューションズ株式会社 Image processing apparatus, image processing method, and image processing program
TWI440469B (en) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
KR20190025057A (en) 2008-10-14 2019-03-08 제넨테크, 인크. Immunoglobulin variants and uses thereof
WO2010058860A1 (en) * 2008-11-18 2010-05-27 株式会社シノテスト Measurement method and measurement reagent for c-reactive protein in sample
JO3672B1 (en) 2008-12-15 2020-08-27 Regeneron Pharma High Affinity Human Antibodies to PCSK9
RU2636046C2 (en) 2009-01-12 2017-11-17 Сайтомкс Терапьютикс, Инк Modified antibodies composition, methods of production and application
EP2389192A4 (en) 2009-01-23 2013-01-16 Biogen Idec Inc Stabilized fc polypeptides with reduced effector function and methods of use
WO2010098863A1 (en) 2009-02-26 2010-09-02 Lpath, Inc. Humanized platelet activating factor antibody design using anti-lipid antibody templates
TWI440470B (en) 2009-03-19 2014-06-11 Chugai Pharmaceutical Co Ltd Pharmaceutical formulation containing improved antibody molecules
JP5787446B2 (en) 2009-03-19 2015-09-30 中外製薬株式会社 Antibody constant region variants
EP2233500A1 (en) 2009-03-20 2010-09-29 LFB Biotechnologies Optimized Fc variants
JP2010250827A (en) 2009-04-16 2010-11-04 Accenture Global Services Gmbh Touchpoint customization system
AU2010265933B2 (en) 2009-06-26 2015-05-14 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
EP2448972A4 (en) 2009-06-30 2012-11-28 Res Dev Foundation Immunoglobulin fc polypeptides
EP2486053B1 (en) 2009-10-06 2017-01-18 Medimmune Limited Rsv-specific binding molecule
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
US9096877B2 (en) 2009-10-07 2015-08-04 Macrogenics, Inc. Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
US8362210B2 (en) 2010-01-19 2013-01-29 Xencor, Inc. Antibody variants with enhanced complement activity
JP5705242B2 (en) 2010-02-19 2015-04-22 ゼンコア インコーポレイテッド Novel CTLA4-IG immune adhesin
WO2011111007A2 (en) 2010-03-11 2011-09-15 Rinat Neuroscience Corporation ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
JP2011184418A (en) * 2010-03-11 2011-09-22 Tokyo Institute Of Technology Affinity variable antibody
TWI667257B (en) 2010-03-30 2019-08-01 中外製藥股份有限公司 Antibodies with modified affinity to fcrn that promote antigen clearance
RU2745989C9 (en) 2010-03-30 2022-03-18 Чугаи Сейяку Кабусики Кайся ANTIBODIES WITH MODIFIED AFFINITY TO FcRn THAT INCREASE ANTIGEN CLEARANCE
HUE027146T2 (en) 2010-06-07 2016-10-28 Univ Missouri Conjugated polymeric material and uses thereof
WO2012033953A1 (en) 2010-09-08 2012-03-15 Halozyme, Inc. Methods for assessing and identifying or evolving conditionally active therapeutic proteins
EP2622074B1 (en) 2010-09-30 2014-11-12 Board Of Trustees Of Northern Illinois University Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents
AU2011337704B2 (en) * 2010-11-30 2017-06-15 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
WO2012133782A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
WO2012132067A1 (en) 2011-03-30 2012-10-04 中外製薬株式会社 Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
MX352889B (en) 2011-02-25 2017-12-13 Chugai Pharmaceutical Co Ltd Fcî“riib-specific fc antibody.
JP5972915B2 (en) * 2011-03-16 2016-08-17 アムジエン・インコーポレーテツド Fc variant
US9328170B2 (en) * 2011-05-25 2016-05-03 Merck Sharp & Dohme Corp. Method for preparing Fc containing polypeptides having improved properties
UA117901C2 (en) 2011-07-06 2018-10-25 Ґенмаб Б.В. Antibody variants and uses thereof
AU2012313594C1 (en) 2011-09-30 2018-05-10 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
WO2013047748A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
KR102239138B1 (en) 2011-09-30 2021-04-12 추가이 세이야쿠 가부시키가이샤 Antigen-binding molecule inducing immune response to target antigen
WO2013047752A1 (en) 2011-09-30 2013-04-04 中外製薬株式会社 Antigen-binding molecule for promoting loss of antigens
TW201817745A (en) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance
JP6271251B2 (en) 2011-10-05 2018-01-31 中外製薬株式会社 An antigen-binding molecule that promotes elimination of an antigen containing a sugar chain receptor-binding domain from plasma
WO2013081143A1 (en) 2011-11-30 2013-06-06 中外製薬株式会社 Drug containing carrier into cell for forming immune complex
JP6138108B2 (en) 2012-02-24 2017-05-31 中外製薬株式会社 Antigen-binding molecule that promotes disappearance of antigen via FcγRIIB
CN107827979A (en) 2012-03-16 2018-03-23 瑞泽恩制药公司 The engineered light chain antibody of histidine and the non-human animal through genetic modification for generating the antibody
RU2014141536A (en) 2012-03-16 2016-05-10 Регенерон Фармасьютикалз, Инк. MICE WHICH PRODUCE ANTIGEN-BINDING PROTEINS WITH PH-DEPENDENT BINDING CHARACTERISTICS
SI2825037T1 (en) 2012-03-16 2019-08-30 Regeneron Pharmaceuticals, Inc. Rodents expressing ph-sensitive immunoglobulin sequences
TWI619729B (en) 2012-04-02 2018-04-01 再生元醫藥公司 Anti-hla-b*27 antibodies and uses thereof
US20150353630A1 (en) 2012-05-30 2015-12-10 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for eliminating aggregated antigens
DK2857420T3 (en) 2012-05-30 2020-11-23 Chugai Pharmaceutical Co Ltd TARGET TISSUE SPECIFIC ANTIGIN BINDING MOLECULE
WO2014028354A1 (en) 2012-08-13 2014-02-20 Regeneron Pharmaceuticals, Inc. Anti-pcsk9 antibodies with ph-dependent binding characteristics
SG10201709559PA (en) 2012-08-24 2017-12-28 Chugai Pharmaceutical Co Ltd Fcγriib-specific fc region variant
EP3597747B1 (en) 2012-08-24 2023-03-15 Chugai Seiyaku Kabushiki Kaisha Mouse fcgammarii-specific fc antibody
JO3532B1 (en) 2013-03-13 2020-07-05 Regeneron Pharma Anti-il-33 antibodies and uses thereof
PL2970497T3 (en) 2013-03-15 2018-05-30 Bayer Healthcare Llc Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics
EP2968985A2 (en) 2013-03-15 2016-01-20 Amgen, Inc. Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
WO2014140366A1 (en) 2013-03-15 2014-09-18 Affibody Ab New polypeptides
AU2014235430A1 (en) 2013-03-15 2015-09-24 Amgen Inc. Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 (PCSK9)
US11267868B2 (en) 2013-04-02 2022-03-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
US10111953B2 (en) 2013-05-30 2018-10-30 Regeneron Pharmaceuticals, Inc. Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
RU2694728C2 (en) 2013-09-18 2019-07-16 Регенерон Фармасьютикалз, Инк. Antibodies with histidine built in light chains and genetically modified animals different from humans for their production
EA201691027A1 (en) 2013-11-20 2016-12-30 Ридженерон Фармасьютикалз, Инк. APLNR MODULATORS AND THEIR APPLICATION
NZ711451A (en) 2014-03-07 2016-05-27 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
US10183994B2 (en) 2014-06-30 2019-01-22 Merck Patent Gmbh Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearence
RU2746356C2 (en) 2014-12-19 2021-04-12 Чугаи Сейяку Кабусики Кайся C5 antibodies and their application methods
PE20221834A1 (en) 2014-12-19 2022-11-29 Chugai Pharmaceutical Co Ltd ANTIMYOSTATIN ANTIBODIES
KR20170110129A (en) 2015-02-05 2017-10-10 추가이 세이야쿠 가부시키가이샤 Antibodies comprising ionic concentration dependent antigen binding domains, Fc region variants, antibodies that bind to IL-8, and their use
EP3595720A4 (en) 2017-03-14 2021-05-26 Five Prime Therapeutics, Inc. Antibodies binding to vista at acidic ph

Also Published As

Publication number Publication date
US11820793B2 (en) 2023-11-21
KR20140100532A (en) 2014-08-14
JP2020055872A (en) 2020-04-09
WO2013081143A1 (en) 2013-06-06
EP2787081A4 (en) 2015-10-07
JP6124800B2 (en) 2017-05-10
SG11201402750SA (en) 2014-10-30
US20150056182A1 (en) 2015-02-26
CN113416256A (en) 2021-09-21
MX358220B (en) 2018-08-10
CA2857159A1 (en) 2013-06-06
RU2739792C1 (en) 2020-12-28
KR20230143201A (en) 2023-10-11
US20190218309A1 (en) 2019-07-18
CN113416257A (en) 2021-09-21
MX2018009688A (en) 2020-11-12
MX2014006558A (en) 2014-10-24
CN104080909A (en) 2014-10-01
JP7441284B2 (en) 2024-02-29
EP2787081A1 (en) 2014-10-08
HK1198771A1 (en) 2015-06-05
KR20210074395A (en) 2021-06-21
EP3517550A1 (en) 2019-07-31
JP2022180444A (en) 2022-12-06
BR112014013081A2 (en) 2020-10-20
CA3233142A1 (en) 2013-06-06
JPWO2013081143A1 (en) 2015-04-27
JP2017171660A (en) 2017-09-28

Similar Documents

Publication Publication Date Title
HK1198771A1 (en) Drug containing carrier into cell for forming immune complex ()
IL235608A0 (en) Carriers for improved drug delivery
EP2667748A4 (en) Baby carrier
IL232989A0 (en) Syringe carrier
IL232988A0 (en) Syringe carrier
HK1198140A1 (en) Syringe carrier
EP2719235A4 (en) Carrier aggregation
PT2502675E (en) Container holder and container carrier
EP2526711A4 (en) Methods for carrier aggregation
AU341094S (en) Capsule for infusion
EP2667747A4 (en) Baby carrier
EP2742526A4 (en) Wafer carrier
GB201402766D0 (en) Spillproof container assemblies
PL2709700T3 (en) Dose container
EP2740171A4 (en) Multi cell carriers
EP2678240A4 (en) Flat pack containers
EP2707306A4 (en) Carrier with retention features
ZA201305752B (en) Multi-cell container
EP2699131A4 (en) Food carrier
EP2692326A4 (en) Drug storage container
EP2789327A4 (en) Tablet packaging body
PL2714542T3 (en) Charge carrier
GB2496316B (en) Planet carrier arrangements
EP2702976A4 (en) Container for administering medication
GB201220632D0 (en) Medication container