SG10201606285YA - Materials and methods for the synthesis of error-minimized nucleic acid molecules - Google Patents
Materials and methods for the synthesis of error-minimized nucleic acid moleculesInfo
- Publication number
- SG10201606285YA SG10201606285YA SG10201606285YA SG10201606285YA SG10201606285YA SG 10201606285Y A SG10201606285Y A SG 10201606285YA SG 10201606285Y A SG10201606285Y A SG 10201606285YA SG 10201606285Y A SG10201606285Y A SG 10201606285YA SG 10201606285Y A SG10201606285Y A SG 10201606285YA
- Authority
- SG
- Singapore
- Prior art keywords
- synthesis
- error
- materials
- methods
- nucleic acid
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000463 material Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/11—Exodeoxyribonucleases producing 5'-phosphomonoesters (3.1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261593813P | 2012-02-01 | 2012-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201606285YA true SG10201606285YA (en) | 2016-09-29 |
Family
ID=48905917
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201404332RA SG11201404332RA (en) | 2012-02-01 | 2013-02-01 | Materials and methods for the synthesis of error-minimized nucleic acid molecules |
| SG10201606285YA SG10201606285YA (en) | 2012-02-01 | 2013-02-01 | Materials and methods for the synthesis of error-minimized nucleic acid molecules |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201404332RA SG11201404332RA (en) | 2012-02-01 | 2013-02-01 | Materials and methods for the synthesis of error-minimized nucleic acid molecules |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9771576B2 (en) |
| EP (2) | EP3597764A3 (en) |
| JP (3) | JP2015509005A (en) |
| CN (1) | CN104220602B (en) |
| AU (2) | AU2013214771B2 (en) |
| CA (2) | CA2862149C (en) |
| DK (1) | DK2809795T3 (en) |
| IL (1) | IL233687B (en) |
| SG (2) | SG11201404332RA (en) |
| WO (1) | WO2013116771A1 (en) |
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| KR102213886B1 (en) | 2013-03-14 | 2021-02-05 | 다카라 바이오 가부시키가이샤 | Method for using heat-resistant mismatch endonuclease |
| TWI721929B (en) | 2013-08-05 | 2021-03-11 | 美商扭轉生物科技有限公司 | De novo synthesized gene libraries |
| US10975415B2 (en) | 2014-09-11 | 2021-04-13 | Takara Bio Inc. | Methods of utilizing thermostable mismatch endonuclease |
| CA2971205A1 (en) * | 2014-12-16 | 2016-06-23 | Synthetic Genomics, Inc. | Compositions of and methods for in vitro viral genome engineering |
| LT3037530T (en) * | 2014-12-22 | 2017-04-10 | Sandoz Ag | Sequence variants |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| IL258164B (en) | 2015-09-18 | 2022-09-01 | Twist Bioscience Corp | Methods for modulating protein and cellular activity and method for nucleic acid synthesis |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| CN108473984A (en) * | 2015-11-04 | 2018-08-31 | 阿特雷卡公司 | The group of nucleic acid bar code for analyzing nucleic acid associated with individual cells is combined |
| CN108603307A (en) | 2015-12-01 | 2018-09-28 | 特韦斯特生物科学公司 | functionalized surface and its preparation |
| US10793888B2 (en) * | 2015-12-22 | 2020-10-06 | Jiangnan University | In vitro method for fast scarless DNA assembly using thermostable exonucleases and ligase |
| WO2018038772A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| JP6871364B2 (en) | 2016-09-21 | 2021-05-12 | ツイスト バイオサイエンス コーポレーション | Nucleic acid-based data storage |
| EA201991262A1 (en) | 2016-12-16 | 2020-04-07 | Твист Байосайенс Корпорейшн | LIBRARIES OF OPTIONS OF IMMUNOLOGICAL SYNAPSIS AND THEIR SYNTHESIS |
| SG11201907713WA (en) | 2017-02-22 | 2019-09-27 | Twist Bioscience Corp | Nucleic acid based data storage |
| EP3595674A4 (en) | 2017-03-15 | 2020-12-16 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| CN110573616B (en) * | 2017-04-18 | 2023-09-05 | 深圳华大智造科技股份有限公司 | Phi29 DNA polymerase, and coding gene and application thereof |
| CN111566209A (en) | 2017-06-12 | 2020-08-21 | 特韦斯特生物科学公司 | Seamless nucleic acid assembly method |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| US11407837B2 (en) | 2017-09-11 | 2022-08-09 | Twist Bioscience Corporation | GPCR binding proteins and synthesis thereof |
| KR20240024357A (en) | 2017-10-20 | 2024-02-23 | 트위스트 바이오사이언스 코포레이션 | Heated nanowells for polynucleotide synthesis |
| US10936953B2 (en) | 2018-01-04 | 2021-03-02 | Twist Bioscience Corporation | DNA-based digital information storage with sidewall electrodes |
| GB201814590D0 (en) * | 2018-09-07 | 2018-10-24 | Oxford Biomedica Ltd | Viral vector production system |
| JP7032976B2 (en) * | 2018-03-30 | 2022-03-09 | 日揮触媒化成株式会社 | Metal particle dispersion and its manufacturing method |
| KR20210013128A (en) | 2018-05-18 | 2021-02-03 | 트위스트 바이오사이언스 코포레이션 | Polynucleotides, reagents and methods for nucleic acid hybridization |
| CN111349673A (en) * | 2018-12-20 | 2020-06-30 | 江苏金斯瑞生物科技有限公司 | Single-stranded DNA synthesis and error correction method |
| AU2020229349A1 (en) | 2019-02-26 | 2021-10-14 | Twist Bioscience Corporation | Variant nucleic acid libraries for GLP1 receptor |
| SG11202109283UA (en) | 2019-02-26 | 2021-09-29 | Twist Bioscience Corp | Variant nucleic acid libraries for antibody optimization |
| EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| IL301396A (en) | 2020-09-30 | 2023-05-01 | Nobell Foods Inc | Recombinant milk proteins and food compositions comprising the same |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4615974A (en) | 1981-08-25 | 1986-10-07 | Celltech Limited | Yeast expression vectors |
| US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| US4977092A (en) | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4661454A (en) | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
| US5139936A (en) | 1983-02-28 | 1992-08-18 | Collaborative Research, Inc. | Use of the GAL1 yeast promoter |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| ATE54167T1 (en) | 1984-12-06 | 1990-07-15 | Fina Research | PROMOTERS FOR THE EXPRESSION OF FOREIGN GENES IN YEAST, PLASMIDS CONTAINING THESE PROMOTERS AND THEIR USE TO PRODUCTION POLYPEPTIDES. |
| GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
| US5063154A (en) | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
| US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| US5162228A (en) | 1988-12-28 | 1992-11-10 | Takeda Chemical Industries, Ltd. | Gylceraldehyde-3-phosphate dehydrogenase gene and promoter |
| US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
| CA2144651A1 (en) | 1992-09-14 | 1994-03-31 | Timothy J. Miller | Immortalized cells and uses therefor |
| EP0862640A2 (en) | 1995-11-09 | 1998-09-09 | ZymoGenetics, Inc. | Production of gad65 in methylotrophic yeast |
| ES2231872T3 (en) | 1996-06-05 | 2005-05-16 | Fox Chase Cancer Center | ENDONUCLEASAS DEAPAREAMIENTO AND USE OF THESE FOR THE IDENTIFICATION OF MUTATIONS IN DIANA POLINUCLEOTIDES CHAINS. |
| US5869245A (en) | 1996-06-05 | 1999-02-09 | Fox Chase Cancer Center | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands |
| WO1998002536A2 (en) | 1996-07-17 | 1998-01-22 | Zymogenetics, Inc. | Preparation of pichia methanolica auxotrophic mutants |
| IL128073A0 (en) | 1996-07-17 | 1999-11-30 | Zymogenetics Inc | Transformation of pichia methanolica |
| US6699980B1 (en) | 2000-02-28 | 2004-03-02 | Fox Chase Cancer Center | Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof |
| US6391557B1 (en) | 2000-02-22 | 2002-05-21 | Fox Chase Cancer Center | Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof |
| US7838219B2 (en) * | 2001-02-02 | 2010-11-23 | Novici Biotech Llc | Method of increasing complementarity in a heteroduplex |
| WO2002079468A2 (en) | 2001-02-02 | 2002-10-10 | Large Scale Biology Corporation | A method of increasing complementarity in a heteroduplex polynucleotide |
| US7078211B2 (en) * | 2002-02-01 | 2006-07-18 | Large Scale Biology Corporation | Nucleic acid molecules encoding endonucleases and methods of use thereof |
| US20030157495A1 (en) | 2002-02-01 | 2003-08-21 | Padgett Hal S. | Nucleic acid molecules encoding CEL I endonuclease and methods of use thereof |
| DE10248258A1 (en) * | 2002-10-16 | 2004-05-06 | Biopsytec Analytik Gmbh | Mutant nucleic acid of a Cel I endonuclease and method for the production of the recombinant complete Cel I protein |
| US7129075B2 (en) | 2002-10-18 | 2006-10-31 | Transgenomic, Inc. | Isolated CEL II endonuclease |
| JP2008503210A (en) | 2004-06-17 | 2008-02-07 | トランスジェノミック，インク． | Nucleic acid sequence encoding CELII endonuclease |
| CA2584984A1 (en) * | 2004-10-18 | 2006-04-27 | Codon Devices, Inc. | Methods for assembly of high fidelity synthetic polynucleotides |
| WO2008112683A2 (en) * | 2007-03-13 | 2008-09-18 | President And Fellows Of Harvard College | Gene synthesis by circular assembly amplification |
| WO2009103027A2 (en) | 2008-02-15 | 2009-08-20 | Synthetic Genomics, Inc. | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules |
| WO2011102802A1 (en) * | 2010-02-18 | 2011-08-25 | Agency For Science, Technology And Research | Method for reducing mismatches in double-stranded dna molecules |
| EP2768607B1 (en) * | 2011-09-26 | 2021-08-18 | Thermo Fisher Scientific GENEART GmbH | Multiwell plate for high efficiency, small volume nucleic acid synthesis |
-
2013
- 2013-02-01 DK DK13743710.9T patent/DK2809795T3/en active
- 2013-02-01 JP JP2014555797A patent/JP2015509005A/en active Pending
- 2013-02-01 WO PCT/US2013/024496 patent/WO2013116771A1/en active Application Filing
- 2013-02-01 SG SG11201404332RA patent/SG11201404332RA/en unknown
- 2013-02-01 EP EP19193201.1A patent/EP3597764A3/en active Pending
- 2013-02-01 AU AU2013214771A patent/AU2013214771B2/en active Active
- 2013-02-01 EP EP13743710.9A patent/EP2809795B1/en active Active
- 2013-02-01 SG SG10201606285YA patent/SG10201606285YA/en unknown
- 2013-02-01 CA CA2862149A patent/CA2862149C/en active Active
- 2013-02-01 CN CN201380009031.7A patent/CN104220602B/en active Active
- 2013-02-01 US US13/757,633 patent/US9771576B2/en active Active
- 2013-02-01 CA CA3156904A patent/CA3156904A1/en active Pending
-
2014
- 2014-07-17 IL IL233687A patent/IL233687B/en active IP Right Grant
-
2017
- 2017-08-02 US US15/667,515 patent/US10704041B2/en active Active
- 2017-12-06 AU AU2017272206A patent/AU2017272206B2/en active Active
- 2017-12-22 JP JP2017245919A patent/JP6663904B2/en active Active
-
2020
- 2020-02-17 JP JP2020023979A patent/JP7175290B2/en active Active
- 2020-07-02 US US16/920,204 patent/US11884916B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2862149A1 (en) | 2013-08-08 |
| AU2017272206B2 (en) | 2020-01-16 |
| US11884916B2 (en) | 2024-01-30 |
| CN104220602B (en) | 2018-10-30 |
| IL233687B (en) | 2021-05-31 |
| AU2017272206A1 (en) | 2018-01-04 |
| CA2862149C (en) | 2022-07-26 |
| JP2020078330A (en) | 2020-05-28 |
| JP2015509005A (en) | 2015-03-26 |
| SG11201404332RA (en) | 2014-08-28 |
| US10704041B2 (en) | 2020-07-07 |
| AU2013214771A1 (en) | 2014-08-14 |
| JP2018068311A (en) | 2018-05-10 |
| US9771576B2 (en) | 2017-09-26 |
| EP2809795A1 (en) | 2014-12-10 |
| US20180051280A1 (en) | 2018-02-22 |
| DK2809795T3 (en) | 2019-12-16 |
| JP7175290B2 (en) | 2022-11-18 |
| WO2013116771A1 (en) | 2013-08-08 |
| AU2013214771B2 (en) | 2017-09-07 |
| CN104220602A (en) | 2014-12-17 |
| EP3597764A2 (en) | 2020-01-22 |
| US20200332286A1 (en) | 2020-10-22 |
| IL233687A0 (en) | 2014-09-30 |
| JP6663904B2 (en) | 2020-03-13 |
| EP3597764A3 (en) | 2020-05-06 |
| EP2809795B1 (en) | 2019-09-18 |
| EP2809795A4 (en) | 2016-03-16 |
| CA3156904A1 (en) | 2013-08-08 |
| US20130225451A1 (en) | 2013-08-29 |
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