SG10201404308RA - Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo - Google Patents
Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivoInfo
- Publication number
- SG10201404308RA SG10201404308RA SG10201404308RA SG10201404308RA SG10201404308RA SG 10201404308R A SG10201404308R A SG 10201404308RA SG 10201404308R A SG10201404308R A SG 10201404308RA SG 10201404308R A SG10201404308R A SG 10201404308RA SG 10201404308R A SG10201404308R A SG 10201404308RA
- Authority
- SG
- Singapore
- Prior art keywords
- vivo
- life
- fusion proteins
- recombinant human
- human epo
- Prior art date
Links
- 230000000913 erythropoietic effect Effects 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/340,661 US7625564B2 (en) | 2006-01-27 | 2006-01-27 | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201404308RA true SG10201404308RA (en) | 2014-10-30 |
Family
ID=38308802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG201100553-5A SG169351A1 (en) | 2006-01-27 | 2007-01-25 | Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| SG10201404308RA SG10201404308RA (en) | 2006-01-27 | 2007-01-25 | Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG201100553-5A SG169351A1 (en) | 2006-01-27 | 2007-01-25 | Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US7625564B2 (en) |
| EP (2) | EP1994157B1 (en) |
| JP (3) | JP5222153B2 (en) |
| KR (2) | KR101235124B1 (en) |
| CN (3) | CN101321870B (en) |
| AU (1) | AU2007209722B2 (en) |
| BR (1) | BRPI0706742C1 (en) |
| CA (1) | CA2650072C (en) |
| DK (2) | DK1994157T3 (en) |
| ES (2) | ES2539759T3 (en) |
| HK (2) | HK1125673A1 (en) |
| IL (1) | IL192801A (en) |
| MX (1) | MX2008009322A (en) |
| NZ (1) | NZ569702A (en) |
| PL (2) | PL2450373T3 (en) |
| PT (2) | PT2450373E (en) |
| RU (1) | RU2433181C2 (en) |
| SG (2) | SG169351A1 (en) |
| TW (1) | TWI454482B (en) |
| WO (1) | WO2007085084A1 (en) |
| ZA (1) | ZA200805920B (en) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE055861T2 (en) * | 2004-04-21 | 2021-12-28 | Alexion Pharma Inc | Bone delivery conjugates and method of using same to target proteins to bone |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| US7625564B2 (en) * | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| JP4356902B2 (en) * | 2006-12-28 | 2009-11-04 | 信広 益子 | toothbrush |
| WO2009012600A1 (en) | 2007-07-26 | 2009-01-29 | Novagen Holding Corporation | Fusion proteins |
| WO2010087994A2 (en) | 2009-01-30 | 2010-08-05 | Whitehead Institute For Biomedical Research | Methods for ligation and uses thereof |
| EP2752427A1 (en) * | 2009-02-24 | 2014-07-09 | Alexion Pharmaceuticals, Inc. | Antibodies containing therapeutic TPO/EPO mimetic peptides |
| US20110016548A1 (en) * | 2009-07-16 | 2011-01-20 | University Of Southern California | Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems |
| CN103153344A (en) | 2010-04-30 | 2013-06-12 | 阿莱克森国际制药有限公司 | Methods, compositions, and kits for the treatment of matrix mineralization disorders |
| CN102260343A (en) | 2010-05-25 | 2011-11-30 | 健能隆医药技术（上海）有限公司 | Application of recombinant human G-CSF dimer for treating nerve damage disease |
| WO2012088608A1 (en) | 2010-12-27 | 2012-07-05 | Enobia Canada Limited Partnership | Compositions comprising natriuretic peptides and methods of use thereof |
| RU2727452C1 (en) | 2011-06-28 | 2020-07-21 | Инхибркс, Инк. | Fused serpin polypeptides and methods for use thereof |
| US10400029B2 (en) | 2011-06-28 | 2019-09-03 | Inhibrx, Lp | Serpin fusion polypeptides and methods of use thereof |
| EP2737905B1 (en) | 2011-07-25 | 2019-09-11 | Generon (Shanghai) Corporation Ltd. | Use of g-csf dimer in preparation of medicament for treatment of neurodegenerative diseases |
| EP2561888A1 (en) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protein comprising NC-1 for treating angiogenesis-related diseases |
| WO2013027191A1 (en) * | 2011-08-25 | 2013-02-28 | Novartis Ag | Methods and compositions using fgf23 fusion polypeptides |
| KR101183615B1 (en) * | 2011-12-28 | 2012-09-17 | 재단법인 경기과학기술진흥원 | Novel fusion protein binding to wnt |
| US9488664B2 (en) | 2012-01-25 | 2016-11-08 | Sbi Pharmaceuticals Co., Ltd. | Diagnostic agent for tumor |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| EP2892919A1 (en) * | 2012-09-07 | 2015-07-15 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| WO2014093387A1 (en) * | 2012-12-10 | 2014-06-19 | Kindred Biosciences, Inc. | Vegf receptor fusion proteins for veterinary use |
| AR096891A1 (en) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | CONJUGATE OF BIOMOLOGICALLY ACTIVE POLYPEPTIDE MONOMER AND CONJUGATE OF FRAGMENTO FC OF IMMUNOGLOBULINA, THAT SHOWS CLEARING THROUGH REDUCED RECEPTOR, AND THE METHOD FOR PREPARING THE SAME |
| AR096890A1 (en) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | CONJUGATING FC OF IMMUNOGLOBULINA, THAT MAINTAINS THE UNION AFFINITY OF THE FC FRAGMENT OF THE IMMUNOGLOBULIN TO FCRN |
| RU2563175C1 (en) * | 2014-06-03 | 2015-09-20 | государственное бюджетное образовательное учреждение высшего профессионального образования "Тюменская государственная медицинская академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ТюмГМА Минздрава России) | Method for preoperative stimulation of erythropoiesis |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| CN107074928B (en) * | 2014-09-18 | 2021-03-12 | 奥美药业有限公司 | Novel feline erythropoietin receptor agonists |
| CN107405390A (en) | 2014-12-05 | 2017-11-28 | 阿雷克森制药公司 | With recombinant basic phosphoric acid enzyme treatment epilepsy |
| CN114159552A (en) * | 2015-01-09 | 2022-03-11 | 格纳西尼有限公司 | Methods of treating anemia using long-acting EPO formulations |
| CA2973883A1 (en) | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| WO2016178087A1 (en) | 2015-05-04 | 2016-11-10 | Biosourcing Sa | Transgenic production of chorionic gonadotropin |
| BR112017023503A2 (en) | 2015-05-04 | 2018-07-31 | Biosourcing Sa | method, composition, and non-human transgenic mammal. |
| EP3337894A1 (en) | 2015-08-17 | 2018-06-27 | Alexion Pharmaceuticals, Inc. | Manufacturing of alkaline phosphatases |
| US11229686B2 (en) | 2015-09-28 | 2022-01-25 | Alexion Pharmaceuticals, Inc. | Reduced frequency dosage regimens for tissue non-specific alkaline phosphatase (TNSALP)-enzyme replacement therapy of hypophosphatasia |
| CN105111315B (en) * | 2015-09-29 | 2018-05-22 | 海南医学院 | MIP3 α-Fc fusion proteins and application thereof |
| KR101847169B1 (en) * | 2015-10-07 | 2018-04-09 | 주식회사 녹십자 | Composition comprising long-acting Erythropoietin |
| US11400140B2 (en) | 2015-10-30 | 2022-08-02 | Alexion Pharmaceuticals, Inc. | Methods for treating craniosynostosis in a patient |
| CN114835795A (en) * | 2015-11-16 | 2022-08-02 | Ubi蛋白公司 | Method for extending protein half-life |
| WO2017155569A1 (en) | 2016-03-08 | 2017-09-14 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| WO2017173413A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Treating muscle weakness with alkaline phosphatases |
| WO2017173395A1 (en) | 2016-04-01 | 2017-10-05 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| EP3464573A4 (en) | 2016-06-06 | 2020-02-19 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| JP7018933B2 (en) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | How to treat bronchomalacia |
| WO2018105988A1 (en) * | 2016-12-05 | 2018-06-14 | 한미약품 주식회사 | Conjugate having attenuated immune response |
| CN110719786A (en) | 2017-03-31 | 2020-01-21 | 阿雷克森制药公司 | Methods for treating Hypophosphatasia (HPP) in adults and adolescents |
| WO2018203582A1 (en) * | 2017-05-05 | 2018-11-08 | 주식회사 유비프로틴 | Method for prolonging protein half-life |
| CN110078817B (en) * | 2018-01-26 | 2021-02-19 | 重庆精准生物技术有限公司 | Improved hinge region and application thereof in construction of CAR framework |
| JP2021519590A (en) | 2018-03-30 | 2021-08-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | Glycoprotein production |
| WO2020053661A1 (en) | 2018-09-13 | 2020-03-19 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan |
| RU2696864C1 (en) * | 2018-09-24 | 2019-08-07 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Method for preventing microcirculation disorders in kidneys with asialised erythropoietin in experiment |
| RU2678768C1 (en) * | 2018-09-25 | 2019-02-01 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Method for preventing renal ischemia reperfusion injury by carbamylated darbepoetin in experiment |
| CN113493519B (en) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | Fusion protein with remarkably prolonged half-life for treating ocular angiogenesis diseases |
| US20230357341A1 (en) * | 2020-06-10 | 2023-11-09 | Bica Therapeutics Inc. | Fusion protein containing erythropoietin polypeptide |
| WO2022006601A1 (en) * | 2020-07-02 | 2022-01-06 | Northwestern University | Human recombinant ace2-fc mutants that decouple anti-sars-cov-2 activity from cardiovascular effects |
| CN111704676A (en) * | 2020-07-17 | 2020-09-25 | 上海延立药业有限公司 | Long-acting recombinant erythropoietin and preparation method and application thereof |
| KR102450007B1 (en) * | 2020-10-16 | 2022-10-04 | 주식회사 아이엠바이오로직스 | Fusion protein platform using igm region |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
| EP0464533B1 (en) * | 1990-06-28 | 1998-07-29 | Hoechst Aktiengesellschaft | Fusionproteins with parts of immunoglobulins, their production and use |
| FR2686899B1 (en) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| ITFI940106A1 (en) * | 1994-05-27 | 1995-11-27 | Menarini Ricerche Sud Spa | HYBRID MOLECULE OF GM-CSF-L-EPO OR EPO-L-GM-CSF FORMULA FOR ERYTHROPOIETIC STIMULATION |
| WO1996018412A1 (en) * | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
| US6096871A (en) * | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US7696338B2 (en) | 1995-10-30 | 2010-04-13 | The United States Of America As Represented By The Department Of Health And Human Services | Immunotoxin fusion proteins and means for expression thereof |
| US6936439B2 (en) * | 1995-11-22 | 2005-08-30 | Amgen Inc. | OB fusion protein compositions and methods |
| US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| US6750334B1 (en) * | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO1999002709A1 (en) | 1997-07-10 | 1999-01-21 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
| US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| WO1999058662A1 (en) | 1998-05-14 | 1999-11-18 | Merck Patent Gmbh | Fused protein |
| CA2330527A1 (en) * | 1998-06-15 | 1999-12-23 | Genzyme Transgenics Corporation | Erythropoietin analog-human serum albumin fusion |
| US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| NZ517184A (en) | 1999-07-13 | 2004-02-27 | Bolder Biotechnology Inc | Immunoglobulin fusion proteins that are cytokines or growth factors joined to an Immunoglobulin domain |
| AU1226901A (en) | 1999-10-22 | 2001-05-08 | Amgen, Inc. | Biodegradable microparticles with novel erythropoietin stimulating protein |
| US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| WO2001036489A2 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| ES2306711T3 (en) * | 2000-04-21 | 2008-11-16 | Amgen Inc. | METHOD AND COMPOSITION INTENDED FOR THE PREVENTION AND TREATMENT OF THE ANEMIA. |
| EP1342730B1 (en) | 2000-12-11 | 2006-03-15 | Cheil Jedang Corporation | Fusion protein having the enhanced in vivo activity of erythropoietin |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| NZ527591A (en) | 2001-01-17 | 2006-04-28 | Trubion Pharmaceuticals Inc | Binding domain-immunoglobulin fusion proteins |
| KR100900176B1 (en) | 2001-03-07 | 2009-06-02 | 메르크 파텐트 게엠베하 | Expression technology for proteins containing a hybrid isotype antibody moiety |
| US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US6900292B2 (en) * | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| US6797493B2 (en) * | 2001-10-01 | 2004-09-28 | Lee-Hwei K. Sun | Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities |
| KR100467750B1 (en) | 2001-11-29 | 2005-01-24 | 씨제이 주식회사 | Fusion protein having the enhanced in vivo activity of erythropoietin |
| KR100467751B1 (en) | 2001-12-03 | 2005-01-24 | 씨제이 주식회사 | Fusion protein having the enhanced in vivo erythropoietin activity |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| WO2003077834A2 (en) | 2002-03-15 | 2003-09-25 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| DE10227606B3 (en) | 2002-06-20 | 2004-01-22 | Bionethos Holding Gmbh | Use of thrombopoietin for the cultivation of hepatocytes |
| EP1539246A4 (en) | 2002-07-03 | 2007-05-16 | Brigham & Womens Hospital | Central airway administration for systemic delivery of therapeutics |
| WO2004042017A2 (en) | 2002-10-31 | 2004-05-21 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| SI1639011T1 (en) * | 2003-06-30 | 2009-04-30 | Domantis Ltd | Pegylated single domain antibodies (dAb) |
| EP1663306A2 (en) | 2003-09-05 | 2006-06-07 | Genentech, Inc. | Antibodies with altered effector functions |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| CA2551916C (en) | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| EP1586585A1 (en) | 2004-04-14 | 2005-10-19 | F. Hoffmann-La Roche Ag | Expression system for the production of IL-15/Fc fusion proteins and their use |
| WO2006079169A1 (en) | 2005-01-25 | 2006-08-03 | Apollo Life Sciences Limited | Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes |
| EP1966237A2 (en) | 2005-11-24 | 2008-09-10 | Laboratoires Serono SA | Erythropoietin polypeptides and uses thereof |
| US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| WO2009012600A1 (en) * | 2007-07-26 | 2009-01-29 | Novagen Holding Corporation | Fusion proteins |
-
2006
- 2006-01-27 US US11/340,661 patent/US7625564B2/en active Active
-
2007
- 2007-01-25 NZ NZ569702A patent/NZ569702A/en unknown
- 2007-01-25 SG SG201100553-5A patent/SG169351A1/en unknown
- 2007-01-25 ES ES07719348.0T patent/ES2539759T3/en active Active
- 2007-01-25 US US12/162,320 patent/US10117949B2/en active Active
- 2007-01-25 CA CA2650072A patent/CA2650072C/en active Active
- 2007-01-25 PT PT121532329T patent/PT2450373E/en unknown
- 2007-01-25 DK DK07719348.0T patent/DK1994157T3/en active
- 2007-01-25 CN CN2007800004392A patent/CN101321870B/en active Active
- 2007-01-25 PL PL12153232T patent/PL2450373T3/en unknown
- 2007-01-25 EP EP07719348.0A patent/EP1994157B1/en active Active
- 2007-01-25 WO PCT/CA2007/000107 patent/WO2007085084A1/en active Application Filing
- 2007-01-25 DK DK12153232.9T patent/DK2450373T3/en active
- 2007-01-25 JP JP2008551610A patent/JP5222153B2/en active Active
- 2007-01-25 BR BRPI0706742A patent/BRPI0706742C1/en active IP Right Grant
- 2007-01-25 CN CN201210211118.XA patent/CN102816242B/en active Active
- 2007-01-25 CN CN201210004888.7A patent/CN102516399B/en active Active
- 2007-01-25 PL PL07719348T patent/PL1994157T3/en unknown
- 2007-01-25 EP EP12153232.9A patent/EP2450373B1/en active Active
- 2007-01-25 ES ES12153232.9T patent/ES2539778T3/en active Active
- 2007-01-25 KR KR1020087021042A patent/KR101235124B1/en active IP Right Grant
- 2007-01-25 SG SG10201404308RA patent/SG10201404308RA/en unknown
- 2007-01-25 MX MX2008009322A patent/MX2008009322A/en active IP Right Grant
- 2007-01-25 PT PT77193480T patent/PT1994157E/en unknown
- 2007-01-25 KR KR1020117031687A patent/KR20120014936A/en active Search and Examination
- 2007-01-25 RU RU2008134389/10A patent/RU2433181C2/en active
- 2007-01-25 AU AU2007209722A patent/AU2007209722B2/en active Active
- 2007-07-20 TW TW096126612A patent/TWI454482B/en active
-
2008
- 2008-07-08 ZA ZA200805920A patent/ZA200805920B/en unknown
- 2008-07-14 IL IL192801A patent/IL192801A/en active IP Right Grant
-
2009
- 2009-04-17 HK HK09103538.4A patent/HK1125673A1/en unknown
- 2009-09-08 US US12/555,742 patent/US7964375B2/en active Active
- 2009-09-08 US US12/555,743 patent/US8431132B2/en active Active
-
2012
- 2012-11-08 HK HK12111281.1A patent/HK1170507A1/en unknown
- 2012-12-06 JP JP2012267451A patent/JP6103579B2/en active Active
-
2013
- 2013-04-29 US US13/872,790 patent/US9375487B2/en active Active
-
2015
- 2015-09-14 JP JP2015180997A patent/JP2016006116A/en active Pending
-
2016
- 2016-06-27 US US15/194,306 patent/US10233223B2/en active Active
-
2018
- 2018-05-29 US US15/992,068 patent/US11279742B2/en active Active
-
2022
- 2022-03-21 US US17/700,251 patent/US20230265143A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1170507A1 (en) | Recombinant human epo-fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo epo-fc | |
| IL266122A (en) | Serum-free stable transfection and production of recombinant human proteins in human cell lines | |
| EP2007884A4 (en) | Enzyme fusion proteins and their use | |
| IL188420A (en) | Methods and compositions with enhanced therapeutic activity | |
| IL184763A0 (en) | Conjugates of biologically active proteins having a modified in vivo half-life | |
| EP2173377A4 (en) | Antibody-endostatin fusion protein and its variants | |
| PL1877090T3 (en) | Trimeric ox40-immunoglobulin fusion protein and methods of use | |
| ZA200707413B (en) | Cat allergen fusion proteins and uses thereof | |
| EP2102237A4 (en) | Recombinant human factor ix and use thereof | |
| EP2223999A4 (en) | Epha4 polypeptide having novel activity and use thereof | |
| IL185657A0 (en) | Human skin equivalents expressing exogenous polypeptides | |
| ATE460483T1 (en) | FUSION PROTEIN WITH INCREASED IN VIVO ERYTHROPOIETIN ACTIVITY | |
| GB0516058D0 (en) | New protein isoforms and uses thereof | |
| IL198659A (en) | Targeting signals and recombinant proteins containing them | |
| ZA200804095B (en) | Nucleic acids and proteins associated with galactomannan synthesis in coffee | |
| ZA200707006B (en) | Conjugates of biologically active proteins having a modified in vivo half-life | |
| IL206334A0 (en) | Sarp-i fusion proteins and their use | |
| DE602006021315D1 (en) | GENE AND POLYPEPTIDE IN CONNECTION WITH BREAST CANCER | |
| IL192400A (en) | Polypeptide having esterase activity and recombinant esterase and use thereof | |
| IL188824A (en) | Plant cells expressing recombinant human glucocerebrosidase and therapeutic uses thereof | |
| GB0522667D0 (en) | New protein isoforms and uses thereof | |
| IL183341A0 (en) | Lupac polypeptide, its preparation and use in protein production | |
| SI2241575T1 (en) | IGF-1 fusion polypeptides and therapeutic uses thereof | |
| GB0614911D0 (en) | New protein isoforms and uses thereof | |
| GB0519145D0 (en) | Improvements in and relating to syringes |