SE9904222D0 - New functionalized polymeric reagents - Google Patents

New functionalized polymeric reagents

Info

Publication number
SE9904222D0
SE9904222D0 SE9904222A SE9904222A SE9904222D0 SE 9904222 D0 SE9904222 D0 SE 9904222D0 SE 9904222 A SE9904222 A SE 9904222A SE 9904222 A SE9904222 A SE 9904222A SE 9904222 D0 SE9904222 D0 SE 9904222D0
Authority
SE
Sweden
Prior art keywords
functionalized polymeric
polymeric reagent
solid
solution
phase synthesis
Prior art date
Application number
SE9904222A
Other languages
Swedish (sv)
Other versions
SE9904222L (en
SE519326C2 (en
Inventor
Patrick Page
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9904222A priority Critical patent/SE519326C2/en
Publication of SE9904222D0 publication Critical patent/SE9904222D0/en
Priority to EP00981995A priority patent/EP1239949A1/en
Priority to AU19074/01A priority patent/AU769893B2/en
Priority to PCT/SE2000/002263 priority patent/WO2001037983A1/en
Priority to CA002389953A priority patent/CA2389953A1/en
Priority to JP2001539587A priority patent/JP2003514876A/en
Publication of SE9904222L publication Critical patent/SE9904222L/en
Publication of SE519326C2 publication Critical patent/SE519326C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Structural Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to functionalized polymeric reagents useful in solution and solid-phase synthesis. It relates more specifically to functionlized polymeric reagent, comprising an acid labile isonitrile moiety. In further aspects the present invention also relates to use of such functionalized polymeric reagent in solution and solid-phase synthesis, a method for preparing an organic compound by solution and solid-phase synthesis using such functionalized polymeric reagent, a method for preparing such functionalized polymeric reagent and to kits comprising the functionalized polymeric reagent of the invention. The present invention also relates to new intermediates for use in the preparation of the novel functionalized polymeric reagent. In one aspect, the present invention provides a functionalized polymeric reagent for use in solution and solid-phase synthesis, e.g. multicomponent reactions. The functionalized polymeric reagent comprises a linker, and said linker comprises an acid labile isonitrile moiety. The linker is covalently attached to the polymeric support.
SE9904222A 1999-11-22 1999-11-22 Functionalized polymeric reagents comprising an acid labile isonitrile moiety and process for its preparation SE519326C2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SE9904222A SE519326C2 (en) 1999-11-22 1999-11-22 Functionalized polymeric reagents comprising an acid labile isonitrile moiety and process for its preparation
EP00981995A EP1239949A1 (en) 1999-11-22 2000-11-16 New functionalized polymeric reagents
AU19074/01A AU769893B2 (en) 1999-11-22 2000-11-16 New functionalized polymeric reagents
PCT/SE2000/002263 WO2001037983A1 (en) 1999-11-22 2000-11-16 New functionalized polymeric reagents
CA002389953A CA2389953A1 (en) 1999-11-22 2000-11-16 New functionalized polymeric reagents
JP2001539587A JP2003514876A (en) 1999-11-22 2000-11-16 New functionalized polymer reagent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9904222A SE519326C2 (en) 1999-11-22 1999-11-22 Functionalized polymeric reagents comprising an acid labile isonitrile moiety and process for its preparation

Publications (3)

Publication Number Publication Date
SE9904222D0 true SE9904222D0 (en) 1999-11-22
SE9904222L SE9904222L (en) 2001-05-23
SE519326C2 SE519326C2 (en) 2003-02-11

Family

ID=20417810

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9904222A SE519326C2 (en) 1999-11-22 1999-11-22 Functionalized polymeric reagents comprising an acid labile isonitrile moiety and process for its preparation

Country Status (6)

Country Link
EP (1) EP1239949A1 (en)
JP (1) JP2003514876A (en)
AU (1) AU769893B2 (en)
CA (1) CA2389953A1 (en)
SE (1) SE519326C2 (en)
WO (1) WO2001037983A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10150077B4 (en) * 2001-10-10 2004-07-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Process for the preparation of polymer-bound isonitriles
DE10162134A1 (en) * 2001-12-18 2003-07-10 Morphochem Ag Ag Fuer Kombinat Resin-bound isonitriles
FR2856061A1 (en) * 2003-06-11 2004-12-17 Chrysalon ORTHO-CONDENSED POLYCYCLIC DERIVATIVES OF AMINOPYRROLE SUBSTITUTING CHEMOTHERAPY COMBINATORIAL ELECTROATRATEERS OF SAID DERIVATIVES AND PROCESS FOR OBTAINING THEM
CN1997401A (en) 2004-06-08 2007-07-11 阿尔扎公司 Preparation of macromolecular conjugates by four-component condensation reaction
CN104245794A (en) * 2011-12-16 2014-12-24 麻省理工学院 Alpha-aminoamidine polymers and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812532A (en) * 1987-07-29 1989-03-14 Bio-Affinity Systems, Inc. Solid phase oxime reagent
AU1589099A (en) * 1997-11-18 1999-06-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Functionalized resin for the synthesis of amides and peptides

Also Published As

Publication number Publication date
AU769893B2 (en) 2004-02-05
JP2003514876A (en) 2003-04-22
SE9904222L (en) 2001-05-23
WO2001037983A1 (en) 2001-05-31
EP1239949A1 (en) 2002-09-18
SE519326C2 (en) 2003-02-11
CA2389953A1 (en) 2001-05-31
AU1907401A (en) 2001-06-04

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Legal Events

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NUG Patent has lapsed