SE9302334D0 - NEW COMPOUNDS - Google Patents

NEW COMPOUNDS

Info

Publication number
SE9302334D0
SE9302334D0 SE9302334A SE9302334A SE9302334D0 SE 9302334 D0 SE9302334 D0 SE 9302334D0 SE 9302334 A SE9302334 A SE 9302334A SE 9302334 A SE9302334 A SE 9302334A SE 9302334 D0 SE9302334 D0 SE 9302334D0
Authority
SE
Sweden
Prior art keywords
phenylmethanol
compounds
lower alkyl
oxazolyl
thiazolyl
Prior art date
Application number
SE9302334A
Other languages
Swedish (sv)
Inventor
Robin *Boar Bernard
John *Cross Alan
Alastair *Gray Duncan
Richard *Green Alfred
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Priority to SE9302334A priority Critical patent/SE9302334D0/en
Publication of SE9302334D0 publication Critical patent/SE9302334D0/en
Priority to IS4184A priority patent/IS1743B/en
Priority to ZA944647A priority patent/ZA944647B/en
Priority to IL11015894A priority patent/IL110158A/en
Priority to AU71979/94A priority patent/AU691821B2/en
Priority to CA002164960A priority patent/CA2164960A1/en
Priority to MYPI94001747A priority patent/MY111111A/en
Priority to HU9503743A priority patent/HUT74671A/en
Priority to BR9406925A priority patent/BR9406925A/en
Priority to PCT/SE1994/000665 priority patent/WO1995001968A1/en
Priority to CN94192710A priority patent/CN1047169C/en
Priority to JP7504000A priority patent/JPH08512314A/en
Priority to MX9405111A priority patent/MX9405111A/en
Priority to NZ268691A priority patent/NZ268691A/en
Priority to CZ9642A priority patent/CZ4296A3/en
Priority to SG1996006908A priority patent/SG48081A1/en
Priority to EP94921149A priority patent/EP0707574A1/en
Priority to EG40394A priority patent/EG20920A/en
Priority to RU96102848A priority patent/RU2139863C1/en
Priority to SK1600-95A priority patent/SK160095A3/en
Priority to PL94312428A priority patent/PL179015B1/en
Priority to US08/379,469 priority patent/US5712299A/en
Priority to EE9400406A priority patent/EE03156B1/en
Priority to NO960030A priority patent/NO305953B1/en
Priority to FI960078A priority patent/FI960078A0/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of oxazolyl- or thiazolylmethanol of the general formula (I) <EMI ID=0.102 HE=21 WI=42 TI=CHI> where X means O or S; R<SB>2</SB> means H; R<SB>2</SB> means H or lower alkyl; W means O or NH; R<SB>3</SB> means H, lower alkyl or lower acyl; A means phenyl furyl, thienyl, naphthyl, pyridyl or pyrrolyl possibly substituted with R<SB>6</SB> where R<SB>6</SB> means one or some groups taken among lower alkyl, halogen atom, lower alkoxy-group, CF<SB>3</SB>, OH, NO<SB>2</SB> or NR<SB>4</SB>R<SB>5</SB> where R<SB>4</SB> and R<SB>5</SB> mean independently H, lower alkyl or lower acyl, and pharmaceutically acceptable acid-additive salts under conditions that the following five compounds are not the subject of the present invention: 1-(4-methyl-5-thiazolyl)-1-phenylmethanol, 1-(2,4- -dimethyl-5-oxazolyl)-1-phenylmethanol, 1-(5-thiazolyl)-1- -phenylmethanol, 1-(4-oxazolyl)-1-phenylmethanol and 1-(2,4- -dimethyl-5-thiazolyl)-1-(2-chlorophenyl)-methanol. Compounds of the formula (I) elicite neuroprotective properties and can be used in medicine for treatment of patients with neurodegenerative disorders. Invention describes also a pharmaceutical composition based on the above indicated compounds. EFFECT: improved methods of synthesis, enhanced curative effectiveness of compounds. 12 cl, 58 ex
SE9302334A 1993-07-03 1993-07-06 NEW COMPOUNDS SE9302334D0 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE9302334A SE9302334D0 (en) 1993-07-06 1993-07-06 NEW COMPOUNDS
IS4184A IS1743B (en) 1993-07-06 1994-06-23 Analogous method of producing novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives
ZA944647A ZA944647B (en) 1993-07-06 1994-06-28 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclcl)methylamine derivatives
IL11015894A IL110158A (en) 1993-07-06 1994-06-29 (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine and pharmaceutical compositions containing them
US08/379,469 US5712299A (en) 1993-07-03 1994-07-05 (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl methylamine derivatives
CN94192710A CN1047169C (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives
SG1996006908A SG48081A1 (en) 1993-07-06 1994-07-05 Novel(1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
MYPI94001747A MY111111A (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl -1-heterocyclyl) methylamine drrivatives
HU9503743A HUT74671A (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives and pharmaceutical compositions containing them
BR9406925A BR9406925A (en) 1993-07-06 1994-07-05 Compound process to prepare the same pharmaceutical formulation use of a compound and process for the treatment of neurodegenerative disorders and / or convulsive and / or restlessness and sleep disorders
PCT/SE1994/000665 WO1995001968A1 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
AU71979/94A AU691821B2 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
JP7504000A JPH08512314A (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives
MX9405111A MX9405111A (en) 1993-07-06 1994-07-05 NEW DERIVATIVES OF (1-PHENYL-1-HETEROCICLIL) METHANOL AND (1-PHENYL-1-HETEROCICLIL-METHYLAMINE).
NZ268691A NZ268691A (en) 1993-07-06 1994-07-05 Oxazole and thiozole derivatives, preparation and medicaments thereof
CZ9642A CZ4296A3 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
CA002164960A CA2164960A1 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
EP94921149A EP0707574A1 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
EG40394A EG20920A (en) 1993-07-06 1994-07-05 Novel (1-phenyl -1- heterocyclic) methanol and (1-phenyl and)1- phenyl -1- heterocyclyl methylamine derivatives
RU96102848A RU2139863C1 (en) 1993-07-06 1994-07-05 Derivatives of oxazolyl- or thiazolylmethanol, methods of their synthesis (variants), pharmaceutical preparation and method of treatment of patients with neurodegenerative disorders
SK1600-95A SK160095A3 (en) 1993-07-06 1994-07-05 Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives
PL94312428A PL179015B1 (en) 1993-07-06 1994-07-05 New (1-phenyl-1-heterocyclo)methanol derivatives, and (1-phenyl-1-heterocyclo)methylamines
EE9400406A EE03156B1 (en) 1993-07-06 1994-11-23 (1-Aryl-1-heterocyclyl) -methanol and (1-aryl-1-heterocyclyl) -methylamine derivatives, process for their preparation, pharmaceutical preparations containing them and their use
NO960030A NO305953B1 (en) 1993-07-06 1996-01-04 New (1-phenyl-1-hydrocyclyl) methanol and (1-phenyl-heterocyclyl) methylamine derivatives, pharmaceutical preparations containing such derivatives and their use
FI960078A FI960078A0 (en) 1993-07-06 1996-01-08 New (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9302334A SE9302334D0 (en) 1993-07-06 1993-07-06 NEW COMPOUNDS

Publications (1)

Publication Number Publication Date
SE9302334D0 true SE9302334D0 (en) 1993-07-06

Family

ID=20390541

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9302334A SE9302334D0 (en) 1993-07-03 1993-07-06 NEW COMPOUNDS

Country Status (6)

Country Link
EE (1) EE03156B1 (en)
EG (1) EG20920A (en)
IS (1) IS1743B (en)
MY (1) MY111111A (en)
RU (1) RU2139863C1 (en)
SE (1) SE9302334D0 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1476429A (en) 2000-11-27 2004-02-18 �Ʒ� EP4 receptor selective agonists in treatment of osteoporosis
AU2010347183A1 (en) * 2010-02-25 2012-09-06 Snu R&Db Foundation Selenalzole derivative having ligand which activates peroxisome proliferator activated receptor (PPAR), preparing method thereof and usage of the chemical compounds

Also Published As

Publication number Publication date
EE03156B1 (en) 1999-02-15
IS1743B (en) 2000-02-21
MY111111A (en) 1999-08-30
RU2139863C1 (en) 1999-10-20
IS4184A (en) 1995-01-07
EG20920A (en) 2000-06-28

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