SE9302334D0 - NEW COMPOUNDS - Google Patents
NEW COMPOUNDSInfo
- Publication number
- SE9302334D0 SE9302334D0 SE9302334A SE9302334A SE9302334D0 SE 9302334 D0 SE9302334 D0 SE 9302334D0 SE 9302334 A SE9302334 A SE 9302334A SE 9302334 A SE9302334 A SE 9302334A SE 9302334 D0 SE9302334 D0 SE 9302334D0
- Authority
- SE
- Sweden
- Prior art keywords
- phenylmethanol
- compounds
- lower alkyl
- oxazolyl
- thiazolyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of oxazolyl- or thiazolylmethanol of the general formula (I) <EMI ID=0.102 HE=21 WI=42 TI=CHI> where X means O or S; R<SB>2</SB> means H; R<SB>2</SB> means H or lower alkyl; W means O or NH; R<SB>3</SB> means H, lower alkyl or lower acyl; A means phenyl furyl, thienyl, naphthyl, pyridyl or pyrrolyl possibly substituted with R<SB>6</SB> where R<SB>6</SB> means one or some groups taken among lower alkyl, halogen atom, lower alkoxy-group, CF<SB>3</SB>, OH, NO<SB>2</SB> or NR<SB>4</SB>R<SB>5</SB> where R<SB>4</SB> and R<SB>5</SB> mean independently H, lower alkyl or lower acyl, and pharmaceutically acceptable acid-additive salts under conditions that the following five compounds are not the subject of the present invention: 1-(4-methyl-5-thiazolyl)-1-phenylmethanol, 1-(2,4- -dimethyl-5-oxazolyl)-1-phenylmethanol, 1-(5-thiazolyl)-1- -phenylmethanol, 1-(4-oxazolyl)-1-phenylmethanol and 1-(2,4- -dimethyl-5-thiazolyl)-1-(2-chlorophenyl)-methanol. Compounds of the formula (I) elicite neuroprotective properties and can be used in medicine for treatment of patients with neurodegenerative disorders. Invention describes also a pharmaceutical composition based on the above indicated compounds. EFFECT: improved methods of synthesis, enhanced curative effectiveness of compounds. 12 cl, 58 ex
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9302334A SE9302334D0 (en) | 1993-07-06 | 1993-07-06 | NEW COMPOUNDS |
IS4184A IS1743B (en) | 1993-07-06 | 1994-06-23 | Analogous method of producing novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives |
ZA944647A ZA944647B (en) | 1993-07-06 | 1994-06-28 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclcl)methylamine derivatives |
IL11015894A IL110158A (en) | 1993-07-06 | 1994-06-29 | (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine and pharmaceutical compositions containing them |
US08/379,469 US5712299A (en) | 1993-07-03 | 1994-07-05 | (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl methylamine derivatives |
CN94192710A CN1047169C (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives |
SG1996006908A SG48081A1 (en) | 1993-07-06 | 1994-07-05 | Novel(1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
MYPI94001747A MY111111A (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl -1-heterocyclyl) methylamine drrivatives |
HU9503743A HUT74671A (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives and pharmaceutical compositions containing them |
BR9406925A BR9406925A (en) | 1993-07-06 | 1994-07-05 | Compound process to prepare the same pharmaceutical formulation use of a compound and process for the treatment of neurodegenerative disorders and / or convulsive and / or restlessness and sleep disorders |
PCT/SE1994/000665 WO1995001968A1 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
AU71979/94A AU691821B2 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
JP7504000A JPH08512314A (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives |
MX9405111A MX9405111A (en) | 1993-07-06 | 1994-07-05 | NEW DERIVATIVES OF (1-PHENYL-1-HETEROCICLIL) METHANOL AND (1-PHENYL-1-HETEROCICLIL-METHYLAMINE). |
NZ268691A NZ268691A (en) | 1993-07-06 | 1994-07-05 | Oxazole and thiozole derivatives, preparation and medicaments thereof |
CZ9642A CZ4296A3 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
CA002164960A CA2164960A1 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
EP94921149A EP0707574A1 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
EG40394A EG20920A (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl -1- heterocyclic) methanol and (1-phenyl and)1- phenyl -1- heterocyclyl methylamine derivatives |
RU96102848A RU2139863C1 (en) | 1993-07-06 | 1994-07-05 | Derivatives of oxazolyl- or thiazolylmethanol, methods of their synthesis (variants), pharmaceutical preparation and method of treatment of patients with neurodegenerative disorders |
SK1600-95A SK160095A3 (en) | 1993-07-06 | 1994-07-05 | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclyl)methylamine derivatives |
PL94312428A PL179015B1 (en) | 1993-07-06 | 1994-07-05 | New (1-phenyl-1-heterocyclo)methanol derivatives, and (1-phenyl-1-heterocyclo)methylamines |
EE9400406A EE03156B1 (en) | 1993-07-06 | 1994-11-23 | (1-Aryl-1-heterocyclyl) -methanol and (1-aryl-1-heterocyclyl) -methylamine derivatives, process for their preparation, pharmaceutical preparations containing them and their use |
NO960030A NO305953B1 (en) | 1993-07-06 | 1996-01-04 | New (1-phenyl-1-hydrocyclyl) methanol and (1-phenyl-heterocyclyl) methylamine derivatives, pharmaceutical preparations containing such derivatives and their use |
FI960078A FI960078A0 (en) | 1993-07-06 | 1996-01-08 | New (1-phenyl-1-heterocyclyl) methanol and (1-phenyl-1-heterocyclyl) methylamine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9302334A SE9302334D0 (en) | 1993-07-06 | 1993-07-06 | NEW COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9302334D0 true SE9302334D0 (en) | 1993-07-06 |
Family
ID=20390541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9302334A SE9302334D0 (en) | 1993-07-03 | 1993-07-06 | NEW COMPOUNDS |
Country Status (6)
Country | Link |
---|---|
EE (1) | EE03156B1 (en) |
EG (1) | EG20920A (en) |
IS (1) | IS1743B (en) |
MY (1) | MY111111A (en) |
RU (1) | RU2139863C1 (en) |
SE (1) | SE9302334D0 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1476429A (en) | 2000-11-27 | 2004-02-18 | �Ʒ� | EP4 receptor selective agonists in treatment of osteoporosis |
AU2010347183A1 (en) * | 2010-02-25 | 2012-09-06 | Snu R&Db Foundation | Selenalzole derivative having ligand which activates peroxisome proliferator activated receptor (PPAR), preparing method thereof and usage of the chemical compounds |
-
1993
- 1993-07-06 SE SE9302334A patent/SE9302334D0/en unknown
-
1994
- 1994-06-23 IS IS4184A patent/IS1743B/en unknown
- 1994-07-05 MY MYPI94001747A patent/MY111111A/en unknown
- 1994-07-05 EG EG40394A patent/EG20920A/en active
- 1994-07-05 RU RU96102848A patent/RU2139863C1/en active
- 1994-11-23 EE EE9400406A patent/EE03156B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EE03156B1 (en) | 1999-02-15 |
IS1743B (en) | 2000-02-21 |
MY111111A (en) | 1999-08-30 |
RU2139863C1 (en) | 1999-10-20 |
IS4184A (en) | 1995-01-07 |
EG20920A (en) | 2000-06-28 |
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