SE9101586L - MODIFIED TIOREDOXIN AND ITS USE - Google Patents

MODIFIED TIOREDOXIN AND ITS USE

Info

Publication number
SE9101586L
SE9101586L SE9101586A SE9101586A SE9101586L SE 9101586 L SE9101586 L SE 9101586L SE 9101586 A SE9101586 A SE 9101586A SE 9101586 A SE9101586 A SE 9101586A SE 9101586 L SE9101586 L SE 9101586L
Authority
SE
Sweden
Prior art keywords
thioredoxin
tioredoxin
modified
processes
active
Prior art date
Application number
SE9101586A
Other languages
Swedish (sv)
Other versions
SE468480B (en
SE9101586D0 (en
Inventor
Arne Holmgren
Gunter Krause
Johanna Lundstroem
Original Assignee
Arne Holmgren
Gunter Krause
Johanna Lundstroem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arne Holmgren, Gunter Krause, Johanna Lundstroem filed Critical Arne Holmgren
Priority to SE9101586A priority Critical patent/SE468480B/en
Publication of SE9101586D0 publication Critical patent/SE9101586D0/en
Publication of SE9101586L publication Critical patent/SE9101586L/en
Publication of SE468480B publication Critical patent/SE468480B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Thioredoxin comprising a redox-active Cys32-X-Pro34-Cys35 site (E.coli numbering) or a functional derivative thereof in which the amino residue Pro in position 34 has been replaced with His and in which the amino acid residue X in position 33 is selected from Gly and Ala; processes for preparing folded biologically active disulphide-crosslinked proteins in vitro using such thioredoxin; and these processes carried out in the presence of a catalytic quantity of a selenite.
SE9101586A 1991-05-24 1991-05-24 Modified thioredoxin and its use SE468480B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE9101586A SE468480B (en) 1991-05-24 1991-05-24 Modified thioredoxin and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9101586A SE468480B (en) 1991-05-24 1991-05-24 Modified thioredoxin and its use

Publications (3)

Publication Number Publication Date
SE9101586D0 SE9101586D0 (en) 1991-05-24
SE9101586L true SE9101586L (en) 1992-11-25
SE468480B SE468480B (en) 1993-01-25

Family

ID=20382839

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9101586A SE468480B (en) 1991-05-24 1991-05-24 Modified thioredoxin and its use

Country Status (1)

Country Link
SE (1) SE468480B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5149470B2 (en) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド Novel factor VIII formulation without albumin
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations

Also Published As

Publication number Publication date
SE468480B (en) 1993-01-25
SE9101586D0 (en) 1991-05-24

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