SE8705139D0 - PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS - Google Patents

PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS

Info

Publication number
SE8705139D0
SE8705139D0 SE8705139A SE8705139A SE8705139D0 SE 8705139 D0 SE8705139 D0 SE 8705139D0 SE 8705139 A SE8705139 A SE 8705139A SE 8705139 A SE8705139 A SE 8705139A SE 8705139 D0 SE8705139 D0 SE 8705139D0
Authority
SE
Sweden
Prior art keywords
analogs
leu
vip
dna sequences
hosts
Prior art date
Application number
SE8705139A
Other languages
Swedish (sv)
Inventor
T Bartfai
M-L Tjornhammar
A Simoncsits
M Kalman
I Cserpan
Original Assignee
Trion Forskning & Utveckling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trion Forskning & Utveckling filed Critical Trion Forskning & Utveckling
Priority to SE8705139A priority Critical patent/SE8705139D0/en
Publication of SE8705139D0 publication Critical patent/SE8705139D0/en
Priority to EP89900676A priority patent/EP0391957A1/en
Priority to JP1500471A priority patent/JPH03502880A/en
Priority to PCT/SE1988/000696 priority patent/WO1989005857A1/en
Priority to DD88323713A priority patent/DD294500A5/en
Priority to HU886575A priority patent/HUT50494A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A method of simultaneously producing a large number of individual C-terminally extended analogs of Leu<17>-VIP is described. Said method comprises the steps of synthesizing two separate mixtures of equally long oligonucleotides coding for N-terminal and C-terminal portions of Leu<17>-VIP analogs, respectively, each having a few defined triplets which are made ambiguous and a few identical bases at the 3'-end, mixing said two mixtures to form a mixture of partially double stranded equally long DNA sequences, which are enzymatically converted into double stranded DNA sequences, subjecting the last mentioned mixture to cleavage, with two different enzymes to produce DNA sequences, which are inserted into similarly cleaved vectors by ligation, whereupon the vectors, are transformed into hosts, propagating said hosts to form colonies, which are analyzed one by one to establish the DNA sequences which code for a single protein, propagating separately under expression conditions those hosts which contain vectors having identified protein coding sequences, whereupon the separately expressed proteins are cleaved to release the C-terminally extended analogs of Leu<17>-VIP. Additionally there are disclosed new C-terminally extended analogs of Leu<17>-VIP and plasmids containing genes coding for the new analogs of Leu<17>-VIP.
SE8705139A 1987-12-23 1987-12-23 PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS SE8705139D0 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SE8705139A SE8705139D0 (en) 1987-12-23 1987-12-23 PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS
EP89900676A EP0391957A1 (en) 1987-12-23 1988-12-21 A METHOD OF SIMULTANEOUSLY PRODUCING A LARGE NUMBER OF Leu?17 -VIP-ANALOGS AND NEW Leu?17 -VIP-ANALOGS
JP1500471A JPH03502880A (en) 1987-12-23 1988-12-21 Methods for producing numerous peptide analogs and novel peptide analogs
PCT/SE1988/000696 WO1989005857A1 (en) 1987-12-23 1988-12-21 A METHOD OF SIMULTANEOUSLY PRODUCING A LARGE NUMBER OF Leu17-VIP-ANALOGS AND NEW Leu17-VIP-ANALOGS
DD88323713A DD294500A5 (en) 1987-12-23 1988-12-22 METHOD FOR PRODUCING A LARGE NUMBER OF PEPTIDE ANALOGS
HU886575A HUT50494A (en) 1987-12-23 1988-12-22 Process for producing peptide analogs in large numbers, as well as new type peptide analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8705139A SE8705139D0 (en) 1987-12-23 1987-12-23 PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS

Publications (1)

Publication Number Publication Date
SE8705139D0 true SE8705139D0 (en) 1987-12-23

Family

ID=20370695

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8705139A SE8705139D0 (en) 1987-12-23 1987-12-23 PROCEDURE FOR MANUFACTURING A LARGE NUMBER OF PEPTID ANALOGS AND NEW PEPTID ANALOGS

Country Status (6)

Country Link
EP (1) EP0391957A1 (en)
JP (1) JPH03502880A (en)
DD (1) DD294500A5 (en)
HU (1) HUT50494A (en)
SE (1) SE8705139D0 (en)
WO (1) WO1989005857A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs
WO1992019261A1 (en) * 1991-04-25 1992-11-12 Korman Louis Y Use of vasoactive intestinal peptide (vip) to induce temporary paralysis of the gastrointestinal tract
WO1994004563A1 (en) * 1992-08-14 1994-03-03 Shino-Test Corporation PEPTIDES CONTAINING RESPECTIVE AMINO ACID SEQUENCES SELECTED FROM AMONG THOSE OF LIPOPROTEIN(a) AND APOLIPOPROTEIN(a), ANTIBODIES RESPECTIVELY RECOGNIZING THESE AMINO ACID SEQUENCES, AND METHOD OF ASSAYING WITH THESE ANTIBODIES
JPH06306100A (en) * 1993-04-26 1994-11-01 Sanwa Kagaku Kenkyusho Co Ltd Fused protein for preparing vip analog, production of vip analog, gene recombination plasmid therefor and transformant microorganism
AU682638B2 (en) * 1995-06-09 1997-10-09 ILS, Inc. Peptide, bronchodilator and blood flow ameliorant
GB2313376A (en) * 1996-05-22 1997-11-26 Diapharm Limited Polypeptide immunologically cross-reactive with NTM peptide and with vasoactive intestinal peptide (VIP)
JP2004514697A (en) 2000-11-28 2004-05-20 モンドバイオテック・ソシエテ・アノニム Compounds with vasoactive intestinal peptide biological activity for the treatment of pulmonary and arteriolar hypertension
DE60326723D1 (en) 2002-06-10 2009-04-30 Mondobiotech Licensing Out Ag USE OF COMPOSITIONS WITH THE BIOLOGICAL ACTIVITY OF VASOACTIVE INTESTINAL PEPTIDES FOR THE TREATMENT OF SARCOIDOSIS
AU2003284428B2 (en) * 2002-11-27 2010-08-26 Ils Inc. Peptides and medicinal compositions containing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
US4605641A (en) * 1984-10-09 1986-08-12 Hoffmann-La Roche Inc. Synthetic vasoactive intestinal peptide analogs
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
DE3685044D1 (en) * 1985-02-01 1992-06-04 Ici Plc ANALOG INTERFERON POLYPEPTIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
GB8525852D0 (en) * 1985-10-19 1985-11-20 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
DD294500A5 (en) 1991-10-02
WO1989005857A1 (en) 1989-06-29
EP0391957A1 (en) 1990-10-17
HUT50494A (en) 1990-02-28
JPH03502880A (en) 1991-07-04

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