SE8600688D0 - PHENYL-SUBSTITUTED PYRIDO / 1,4 / BENZODIAZEPINES AND INTERMEDIATES IN THE PREPARATION OF THESE - Google Patents
PHENYL-SUBSTITUTED PYRIDO / 1,4 / BENZODIAZEPINES AND INTERMEDIATES IN THE PREPARATION OF THESEInfo
- Publication number
- SE8600688D0 SE8600688D0 SE8600688A SE8600688A SE8600688D0 SE 8600688 D0 SE8600688 D0 SE 8600688D0 SE 8600688 A SE8600688 A SE 8600688A SE 8600688 A SE8600688 A SE 8600688A SE 8600688 D0 SE8600688 D0 SE 8600688D0
- Authority
- SE
- Sweden
- Prior art keywords
- phenyl
- benzodiazepines
- intermediates
- preparation
- loweralkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PHENYL SUBSTITUTED PYRIDO¢1,4!BENZODIAZEPINES AND INTERMEDIATES THEREFOR Pyrido¢1,4!benzodiazepines having antidepressant activity of the formula < IMG > wherein Ar is 2, 3 and 4-pyridinyl, 2 or 3-thienyl, phenyl or a substituted phenyl; R is hydrogen, loweralkyl or an amine on the end of a hydrocarbon chain; Z is hydrogen, halogen, trifluoromethyl, loweralkyl, loweralkoxy, hydroxy or nitro; and Y is hydrogen, loweralkyl, loweralkoxy or hydroxy; and the pharmaceutical salts are prepared from ¢2-¢(aminopyridinyl)amino!phenyl!aryl-methanones which also have antidepressant activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30508081A | 1981-09-24 | 1981-09-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8600688L SE8600688L (en) | 1986-02-17 |
| SE8600688D0 true SE8600688D0 (en) | 1986-02-17 |
| SE455305B SE455305B (en) | 1988-07-04 |
Family
ID=23179241
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8106573A SE448629B (en) | 1981-09-24 | 1981-11-05 | Pyrido / 1,4 / BENZODIAZEPINES |
| SE8600688A SE455305B (en) | 1981-09-24 | 1986-02-17 | / 2 - / (AMINOPYRIDINYL) AMINO / PHENYL / ARYLMETANONES |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8106573A SE448629B (en) | 1981-09-24 | 1981-11-05 | Pyrido / 1,4 / BENZODIAZEPINES |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5865290A (en) |
| KR (1) | KR890000764B1 (en) |
| BE (1) | BE891666A (en) |
| CA (1) | CA1199324A (en) |
| CH (1) | CH651833A5 (en) |
| DE (1) | DE3150522A1 (en) |
| DK (3) | DK186282A (en) |
| EG (1) | EG15904A (en) |
| ES (6) | ES8303348A1 (en) |
| FI (1) | FI71935C (en) |
| FR (1) | FR2515183B1 (en) |
| GR (1) | GR78473B (en) |
| HU (2) | HU187393B (en) |
| IE (1) | IE52493B1 (en) |
| IL (1) | IL64284A (en) |
| IN (1) | IN156080B (en) |
| IT (1) | IT1146728B (en) |
| LU (1) | LU83865A1 (en) |
| NL (1) | NL8200549A (en) |
| NO (1) | NO157700C (en) |
| NZ (1) | NZ198999A (en) |
| PH (2) | PH17847A (en) |
| PL (6) | PL143597B1 (en) |
| PT (1) | PT74286B (en) |
| SE (2) | SE448629B (en) |
| YU (1) | YU46128B (en) |
| ZA (1) | ZA817866B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825549A (en) * | 1972-10-24 | 1974-07-23 | Squibb & Sons Inc | Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines |
| DE2424811C3 (en) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinones, process for their preparation and medicaments containing them |
| SE422799B (en) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | ANALOGY PROCEDURE FOR PREPARATION OF 1,3-DIHYDROIMIDAZO (4,5-B) PYRIDIN-2-ONER |
-
1981
- 1981-11-05 SE SE8106573A patent/SE448629B/en not_active IP Right Cessation
- 1981-11-12 ZA ZA817866A patent/ZA817866B/en unknown
- 1981-11-12 NO NO813839A patent/NO157700C/en unknown
- 1981-11-13 IL IL64284A patent/IL64284A/en unknown
- 1981-11-13 IN IN1261/CAL/81A patent/IN156080B/en unknown
- 1981-11-17 GR GR66553A patent/GR78473B/el unknown
- 1981-11-18 PH PH26507A patent/PH17847A/en unknown
- 1981-11-25 IE IE2769/81A patent/IE52493B1/en unknown
- 1981-12-09 IT IT68605/81A patent/IT1146728B/en active
- 1981-12-10 FI FI813976A patent/FI71935C/en not_active IP Right Cessation
- 1981-12-15 HU HU813777A patent/HU187393B/en not_active IP Right Cessation
- 1981-12-15 HU HU843212A patent/HU189426B/en not_active IP Right Cessation
- 1981-12-15 ES ES507971A patent/ES8303348A1/en not_active Expired
- 1981-12-21 DE DE19813150522 patent/DE3150522A1/en not_active Withdrawn
- 1981-12-23 PL PL1981253539A patent/PL143597B1/en unknown
- 1981-12-23 PL PL1981241410A patent/PL137068B1/en unknown
- 1981-12-23 PL PL1981241409A patent/PL139381B1/en unknown
- 1981-12-23 PL PL1981253538A patent/PL143596B1/en unknown
- 1981-12-23 PL PL1981234426A patent/PL138859B1/en unknown
- 1981-12-23 PL PL1981253540A patent/PL143322B1/en unknown
- 1981-12-23 FR FR8124111A patent/FR2515183B1/en not_active Expired
- 1981-12-30 BE BE0/206969A patent/BE891666A/en not_active IP Right Cessation
-
1982
- 1982-01-05 LU LU83865A patent/LU83865A1/en unknown
- 1982-01-12 EG EG11/82A patent/EG15904A/en active
- 1982-01-14 JP JP57004813A patent/JPS5865290A/en active Pending
- 1982-01-15 PT PT74286A patent/PT74286B/en unknown
- 1982-01-18 CA CA000394367A patent/CA1199324A/en not_active Expired
- 1982-02-02 KR KR8200420A patent/KR890000764B1/en active
- 1982-02-12 NL NL8200549A patent/NL8200549A/en not_active Application Discontinuation
- 1982-02-18 NZ NZ198999A patent/NZ198999A/en unknown
- 1982-03-23 YU YU62582A patent/YU46128B/en unknown
- 1982-04-15 CH CH2288/82A patent/CH651833A5/en not_active IP Right Cessation
- 1982-04-26 DK DK186282A patent/DK186282A/en not_active Application Discontinuation
- 1982-09-29 ES ES516052A patent/ES516052A0/en active Granted
- 1982-09-29 ES ES516051A patent/ES516051A0/en active Granted
-
1983
- 1983-10-19 ES ES526563A patent/ES8604531A1/en not_active Expired
- 1983-10-19 ES ES526562A patent/ES8504148A1/en not_active Expired
-
1984
- 1984-08-17 PH PH31120A patent/PH20536A/en unknown
-
1985
- 1985-05-21 ES ES543328A patent/ES8607726A1/en not_active Expired
-
1986
- 1986-02-17 SE SE8600688A patent/SE455305B/en not_active IP Right Cessation
-
1987
- 1987-08-03 DK DK403487A patent/DK403487D0/en not_active Application Discontinuation
- 1987-08-03 DK DK403387A patent/DK403387A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8600688-9 Effective date: 19910611 Format of ref document f/p: F |