DK186282A - PROCEDURE FOR PREPARING PHENYL-SUBSTITUTED PYRIDO (1,4) BENZODIAZEPINES AND INTERMEDIATES IN THE PROCEDURE - Google Patents
PROCEDURE FOR PREPARING PHENYL-SUBSTITUTED PYRIDO (1,4) BENZODIAZEPINES AND INTERMEDIATES IN THE PROCEDURE Download PDFInfo
- Publication number
- DK186282A DK186282A DK186282A DK186282A DK186282A DK 186282 A DK186282 A DK 186282A DK 186282 A DK186282 A DK 186282A DK 186282 A DK186282 A DK 186282A DK 186282 A DK186282 A DK 186282A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- benzodiazepines
- intermediates
- substituted pyrido
- preparing phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
II 1 12 hvor R er et hydrogenatom, en lavere alkyl, en -alk -NR R - eller en -alk^-N=CH-OC,H_-gruppe, 12 * * R og R er hver et hydrogenatom eller en lavere alkyl eller en -C(O)0-lavere alkyl-gruppe, eller R* og 2 R kan sammen med det tilstødende nitrogenatom danne en 1-phthalimido-, 1-piperidinyl-, 1-pyrrolidi-nyl-, 4-morpholino-, 1-piperazino- eller 4-substitu-eret piperazin-l-yl-heterocyclisk rest.Wherein R is a hydrogen atom, a lower alkyl, an -alk -NR R - or an -alk 2 -N = CH-OC, H-group, 12 * * R and R are each a hydrogen atom or a lower alkyl or a -C (O) O-lower alkyl group, or R * and 2 R together with the adjacent nitrogen atom may form a 1-phthalimido, 1-piperidinyl, 1-pyrrolidinyl, 4-morpholino, 1-piperazino or 4-substituted piperazin-1-yl heterocyclic residue.
Ar er en 2-, 3- eller 4-pyridinyl-, en 2- eller 3-thienyl- eller en phenyl- eller en substitueret phenyl- gruppe, idet den substituerede phenylgruppe er substitueret med 1-3 halogen-, lavere alkyl-, lavere alkoxy-, trifluormethyl- eller nitrogrupper, der kan være ens eller forskellige,Ar is a 2-, 3- or 4-pyridinyl, a 2- or 3-thienyl or a phenyl or a substituted phenyl group, the substituted phenyl group being substituted with 1-3 halogen, lower alkyl, lower alkoxy, trifluoromethyl or nitro groups which may be the same or different,
Alk^ er ligekædet eller forgrenet carbonhydrid med 1-8 carbonatimer, Z er et hydrogenatom eller et halogenatom eller en lavere alkyl-, lavere alkoxy-, hydroxy- eller nitrogruppe , Y er et hydrogenatom eller 1 eller 2 lavere alkyl-, lavere alkoxy- eller hydroxygrupper, der kan være ens eller forskellige, R og R er grupper,der kan være ens eller forskellige, og som ikke griber ind i cycliseringen af forbindelser med formlen II til forbindelser med form-3 4 len I, idet R og R hver fortrinsvis er et hydrogenatom, og X er =0 eller Q^, hvor er en gruppe eller et atom, der ikke griber ind i cycliseringen af forbindelser med formlen II til forbindelser med formlen I, og som kan fraspaltes før eller vinder cycl i seringsreaktionen til dannelse af en -C=0-gruppe eller et carbonyl-ækvivalent såsom et ketal, thioketal eller et gem-dihalogenid, som selv fås ved omsætning af en halogenaminopyrimidin med formlenAlk 2 is straight or branched hydrocarbon having 1-8 carbon atoms, Z is a hydrogen atom or a halogen atom or a lower alkyl, lower alkoxy, hydroxy or nitro group, Y is a hydrogen atom or 1 or 2 lower alkyl, lower alkoxy groups. or hydroxy groups which may be the same or different, R and R are groups which may be the same or different and which do not interfere with the cyclization of compounds of formula II to compounds of formula I, wherein R and R are each preferably is a hydrogen atom and X is = 0 or Q 2, where is a group or atom which does not interfere with the cyclization of compounds of formula II to compounds of formula I and which can be cleaved off before or win cycl in the reaction of reaction to forming a -C = O group or a carbonyl equivalent such as a ketal, thioketal or a gem dihalide, which is itself obtained by reacting a halogenaminopyrimidine of the formula
med en (aminophenyl)arylmethanon med formlenwith an (aminophenyl) arylmethanone of the formula
Såvel forbindelserne med formlen I som forbindelserne med formlen II har antidepressiv virkning.Both the compounds of formula I and the compounds of formula II have antidepressant effect.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30508081A | 1981-09-24 | 1981-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK186282A true DK186282A (en) | 1983-03-25 |
Family
ID=23179241
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK186282A DK186282A (en) | 1981-09-24 | 1982-04-26 | PROCEDURE FOR PREPARING PHENYL-SUBSTITUTED PYRIDO (1,4) BENZODIAZEPINES AND INTERMEDIATES IN THE PROCEDURE |
| DK403487A DK403487A (en) | 1981-09-24 | 1987-08-03 | PROCEDURE FOR THE PREPARATION OF PHENYL-SUBSTITUTED PYRIDOOE1,4AABENZODIAZEPINES AND INTERMEDIATES OF THE PROCEDURE |
| DK403387A DK403387A (en) | 1981-09-24 | 1987-08-03 | PROCEDURE FOR THE PREPARATION OF PHENYL-SUBSTITUTED PYRIDOOE1,4AABENZODIAZEPINES AND INTERMEDIATES OF THE PROCEDURE |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK403487A DK403487A (en) | 1981-09-24 | 1987-08-03 | PROCEDURE FOR THE PREPARATION OF PHENYL-SUBSTITUTED PYRIDOOE1,4AABENZODIAZEPINES AND INTERMEDIATES OF THE PROCEDURE |
| DK403387A DK403387A (en) | 1981-09-24 | 1987-08-03 | PROCEDURE FOR THE PREPARATION OF PHENYL-SUBSTITUTED PYRIDOOE1,4AABENZODIAZEPINES AND INTERMEDIATES OF THE PROCEDURE |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5865290A (en) |
| KR (1) | KR890000764B1 (en) |
| BE (1) | BE891666A (en) |
| CA (1) | CA1199324A (en) |
| CH (1) | CH651833A5 (en) |
| DE (1) | DE3150522A1 (en) |
| DK (3) | DK186282A (en) |
| EG (1) | EG15904A (en) |
| ES (6) | ES8303348A1 (en) |
| FI (1) | FI71935C (en) |
| FR (1) | FR2515183B1 (en) |
| GR (1) | GR78473B (en) |
| HU (2) | HU189426B (en) |
| IE (1) | IE52493B1 (en) |
| IL (1) | IL64284A (en) |
| IN (1) | IN156080B (en) |
| IT (1) | IT1146728B (en) |
| LU (1) | LU83865A1 (en) |
| NL (1) | NL8200549A (en) |
| NO (1) | NO157700C (en) |
| NZ (1) | NZ198999A (en) |
| PH (2) | PH17847A (en) |
| PL (6) | PL143596B1 (en) |
| PT (1) | PT74286B (en) |
| SE (2) | SE448629B (en) |
| YU (1) | YU46128B (en) |
| ZA (1) | ZA817866B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3825549A (en) * | 1972-10-24 | 1974-07-23 | Squibb & Sons Inc | Certain dihydropyrido(2,1-b)(1,3)benzodi-azepines and benzodiazocines |
| DE2424811C3 (en) * | 1974-05-22 | 1981-08-20 | Dr. Karl Thomae Gmbh, 7950 Biberach | Pyrido-benzodiazepinones, process for their preparation and medicaments containing them |
| SE422799B (en) * | 1975-05-28 | 1982-03-29 | Merck & Co Inc | ANALOGY PROCEDURE FOR PREPARATION OF 1,3-DIHYDROIMIDAZO (4,5-B) PYRIDIN-2-ONER |
-
1981
- 1981-11-05 SE SE8106573A patent/SE448629B/en not_active IP Right Cessation
- 1981-11-12 NO NO813839A patent/NO157700C/en unknown
- 1981-11-12 ZA ZA817866A patent/ZA817866B/en unknown
- 1981-11-13 IN IN1261/CAL/81A patent/IN156080B/en unknown
- 1981-11-13 IL IL64284A patent/IL64284A/en unknown
- 1981-11-17 GR GR66553A patent/GR78473B/el unknown
- 1981-11-18 PH PH26507A patent/PH17847A/en unknown
- 1981-11-25 IE IE2769/81A patent/IE52493B1/en unknown
- 1981-12-09 IT IT68605/81A patent/IT1146728B/en active
- 1981-12-10 FI FI813976A patent/FI71935C/en not_active IP Right Cessation
- 1981-12-15 ES ES507971A patent/ES8303348A1/en not_active Expired
- 1981-12-15 HU HU843212A patent/HU189426B/en not_active IP Right Cessation
- 1981-12-15 HU HU813777A patent/HU187393B/en not_active IP Right Cessation
- 1981-12-21 DE DE19813150522 patent/DE3150522A1/en not_active Withdrawn
- 1981-12-23 PL PL1981253538A patent/PL143596B1/en unknown
- 1981-12-23 FR FR8124111A patent/FR2515183B1/en not_active Expired
- 1981-12-23 PL PL1981253540A patent/PL143322B1/en unknown
- 1981-12-23 PL PL1981253539A patent/PL143597B1/en unknown
- 1981-12-23 PL PL1981241409A patent/PL139381B1/en unknown
- 1981-12-23 PL PL1981234426A patent/PL138859B1/en unknown
- 1981-12-23 PL PL1981241410A patent/PL137068B1/en unknown
- 1981-12-30 BE BE0/206969A patent/BE891666A/en not_active IP Right Cessation
-
1982
- 1982-01-05 LU LU83865A patent/LU83865A1/en unknown
- 1982-01-12 EG EG11/82A patent/EG15904A/en active
- 1982-01-14 JP JP57004813A patent/JPS5865290A/en active Pending
- 1982-01-15 PT PT74286A patent/PT74286B/en unknown
- 1982-01-18 CA CA000394367A patent/CA1199324A/en not_active Expired
- 1982-02-02 KR KR8200420A patent/KR890000764B1/en active
- 1982-02-12 NL NL8200549A patent/NL8200549A/en not_active Application Discontinuation
- 1982-02-18 NZ NZ198999A patent/NZ198999A/en unknown
- 1982-03-23 YU YU62582A patent/YU46128B/en unknown
- 1982-04-15 CH CH2288/82A patent/CH651833A5/en not_active IP Right Cessation
- 1982-04-26 DK DK186282A patent/DK186282A/en not_active Application Discontinuation
- 1982-09-29 ES ES516052A patent/ES8402295A1/en not_active Expired
- 1982-09-29 ES ES516051A patent/ES516051A0/en active Granted
-
1983
- 1983-10-19 ES ES526562A patent/ES526562A0/en active Granted
- 1983-10-19 ES ES526563A patent/ES8604531A1/en not_active Expired
-
1984
- 1984-08-17 PH PH31120A patent/PH20536A/en unknown
-
1985
- 1985-05-21 ES ES543328A patent/ES8607726A1/en not_active Expired
-
1986
- 1986-02-17 SE SE8600688A patent/SE455305B/en not_active IP Right Cessation
-
1987
- 1987-08-03 DK DK403487A patent/DK403487A/en not_active Application Discontinuation
- 1987-08-03 DK DK403387A patent/DK403387A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |