SE8504659L - PROCEDURE FOR PREPARING N? 72 SUBSTITUTED DERIVATIVES OF MITOMUCIN C - Google Patents

PROCEDURE FOR PREPARING N? 72 SUBSTITUTED DERIVATIVES OF MITOMUCIN C

Info

Publication number
SE8504659L
SE8504659L SE8504659A SE8504659A SE8504659L SE 8504659 L SE8504659 L SE 8504659L SE 8504659 A SE8504659 A SE 8504659A SE 8504659 A SE8504659 A SE 8504659A SE 8504659 L SE8504659 L SE 8504659L
Authority
SE
Sweden
Prior art keywords
methoxymitosane
amino
mitomucin
preparing
procedure
Prior art date
Application number
SE8504659A
Other languages
Swedish (sv)
Other versions
SE8504659D0 (en
Inventor
H S L Wong
T Kaneko
T W Doyle
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8504659D0 publication Critical patent/SE8504659D0/en
Publication of SE8504659L publication Critical patent/SE8504659L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N<7>-Substituted mitomycin C derivatives are prepared by 1) deprotonating mitomycin C or an N<1a> substituted derivative thereof such as porfiromycin using a non-nucleophilic strong base to provide the anionic form thereof and 2) reacting the anion with an electrophile. Products include novel compounds which are 7-(3-ethylenedioxypropyl)amino-9a-methoxymitosane, 7-(methoxymethyl)amino-9a-methoxymitosane, 7-(methoxyethyl)amino-9a-methoxymitosane, and 7-(cyclopropylmethyl)amino-9a-methoxymitosane. The compounds are anti-tumour agents.
SE8504659A 1984-10-09 1985-10-08 PROCEDURE FOR PREPARING N? 72 SUBSTITUTED DERIVATIVES OF MITOMUCIN C SE8504659L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65912884A 1984-10-09 1984-10-09

Publications (2)

Publication Number Publication Date
SE8504659D0 SE8504659D0 (en) 1985-10-08
SE8504659L true SE8504659L (en) 1986-04-10

Family

ID=24644154

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8504659A SE8504659L (en) 1984-10-09 1985-10-08 PROCEDURE FOR PREPARING N? 72 SUBSTITUTED DERIVATIVES OF MITOMUCIN C

Country Status (7)

Country Link
JP (1) JPS6191189A (en)
DK (1) DK460285A (en)
FR (1) FR2571373A1 (en)
GB (1) GB2165249A (en)
HU (1) HUT38943A (en)
IT (1) IT1187749B (en)
SE (1) SE8504659L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354380A (en) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative
DE3871836T2 (en) * 1987-03-25 1993-01-14 Kyowa Hakko Kogyo Kk MITOMYCIN DERIVATIVES.
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
SE8504659D0 (en) 1985-10-08
GB8524725D0 (en) 1985-11-13
DK460285D0 (en) 1985-10-08
DK460285A (en) 1986-04-10
JPS6191189A (en) 1986-05-09
IT8522385A0 (en) 1985-10-08
GB2165249A (en) 1986-04-09
HUT38943A (en) 1986-07-28
IT1187749B (en) 1987-12-23
FR2571373A1 (en) 1986-04-11

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