SE8305072D0 - PROCEDURES FOR THE RECOVERY OF 3,3-DIPHENYL-1-METHYL-PROPYLAMINE DERIVATIVES UNDER THE ACID ADDITIONAL SALT - Google Patents

PROCEDURES FOR THE RECOVERY OF 3,3-DIPHENYL-1-METHYL-PROPYLAMINE DERIVATIVES UNDER THE ACID ADDITIONAL SALT

Info

Publication number
SE8305072D0
SE8305072D0 SE8305072A SE8305072A SE8305072D0 SE 8305072 D0 SE8305072 D0 SE 8305072D0 SE 8305072 A SE8305072 A SE 8305072A SE 8305072 A SE8305072 A SE 8305072A SE 8305072 D0 SE8305072 D0 SE 8305072D0
Authority
SE
Sweden
Prior art keywords
diphenyl
general formula
procedures
recovery
methyl
Prior art date
Application number
SE8305072A
Other languages
Swedish (sv)
Other versions
SE462161B (en
SE8305072L (en
Inventor
K Harsanyi
I Szabadkai
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8305072D0 publication Critical patent/SE8305072D0/en
Publication of SE8305072L publication Critical patent/SE8305072L/en
Publication of SE462161B publication Critical patent/SE462161B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a novel process for preparing 3,3-diphenyl-1-methylpropylamine derivatives of the general formula I <IMAGE> in which R1 is hydrogen, and R2 is tert-butyl, or R1 and R2 are, independent of each other, C1-2-alkyl, and pharmaceutically acceptable acid addition salts thereof, by reacting 4,4-diphenyl-2-butanone with an amine of the general formula II <IMAGE> in which R1 and R2 have the abovementioned meanings, with the process being characterized in that the condensation step in the reductive condensation process which is carried out using the amine of the general formula II is performed in an inert organic solvent in the presence of aluminium trichloride, and in that the reductive reaction with catalytically activated hydrogen is performed at 1- 10 atm., preferably at atmospheric pressure, and at a temperature of 20-150 DEGREE C, preferably at 70-80 DEGREE C, and in that, where appropriate, the resulting 3,3-diphenyl-1- methylpropylamine derivatives of the general formula I are converted into pharmaceutically acceptable acid addition salts.
SE8305072A 1982-09-21 1983-09-20 Process for preparing 3,3-diphenyl-1-methylpropylamine derivatives and their acid addition salts SE462161B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU823023A HU186122B (en) 1982-09-21 1982-09-21 Process for producing 3,3-diphenyl-1-methyil-propylamine derivatives and acid additional salts thereof

Publications (3)

Publication Number Publication Date
SE8305072D0 true SE8305072D0 (en) 1983-09-20
SE8305072L SE8305072L (en) 1984-03-22
SE462161B SE462161B (en) 1990-05-14

Family

ID=10962152

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8305072A SE462161B (en) 1982-09-21 1983-09-20 Process for preparing 3,3-diphenyl-1-methylpropylamine derivatives and their acid addition salts

Country Status (2)

Country Link
HU (1) HU186122B (en)
SE (1) SE462161B (en)

Also Published As

Publication number Publication date
HU186122B (en) 1985-06-28
SE462161B (en) 1990-05-14
SE8305072L (en) 1984-03-22

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