SE8305072D0 - PROCEDURES FOR THE RECOVERY OF 3,3-DIPHENYL-1-METHYL-PROPYLAMINE DERIVATIVES UNDER THE ACID ADDITIONAL SALT - Google Patents
PROCEDURES FOR THE RECOVERY OF 3,3-DIPHENYL-1-METHYL-PROPYLAMINE DERIVATIVES UNDER THE ACID ADDITIONAL SALTInfo
- Publication number
- SE8305072D0 SE8305072D0 SE8305072A SE8305072A SE8305072D0 SE 8305072 D0 SE8305072 D0 SE 8305072D0 SE 8305072 A SE8305072 A SE 8305072A SE 8305072 A SE8305072 A SE 8305072A SE 8305072 D0 SE8305072 D0 SE 8305072D0
- Authority
- SE
- Sweden
- Prior art keywords
- diphenyl
- general formula
- procedures
- recovery
- methyl
- Prior art date
Links
- DJMZXBCLPVSJPI-UHFFFAOYSA-N 4,4-diphenylbutan-2-amine Chemical class C=1C=CC=CC=1C(CC(N)C)C1=CC=CC=C1 DJMZXBCLPVSJPI-UHFFFAOYSA-N 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 238000011084 recovery Methods 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 230000002829 reductive effect Effects 0.000 abstract 2
- FPHXYKLKNOEKTQ-UHFFFAOYSA-N 4,4-diphenylbutan-2-one Chemical compound C=1C=CC=CC=1C(CC(=O)C)C1=CC=CC=C1 FPHXYKLKNOEKTQ-UHFFFAOYSA-N 0.000 abstract 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a novel process for preparing 3,3-diphenyl-1-methylpropylamine derivatives of the general formula I <IMAGE> in which R1 is hydrogen, and R2 is tert-butyl, or R1 and R2 are, independent of each other, C1-2-alkyl, and pharmaceutically acceptable acid addition salts thereof, by reacting 4,4-diphenyl-2-butanone with an amine of the general formula II <IMAGE> in which R1 and R2 have the abovementioned meanings, with the process being characterized in that the condensation step in the reductive condensation process which is carried out using the amine of the general formula II is performed in an inert organic solvent in the presence of aluminium trichloride, and in that the reductive reaction with catalytically activated hydrogen is performed at 1- 10 atm., preferably at atmospheric pressure, and at a temperature of 20-150 DEGREE C, preferably at 70-80 DEGREE C, and in that, where appropriate, the resulting 3,3-diphenyl-1- methylpropylamine derivatives of the general formula I are converted into pharmaceutically acceptable acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU823023A HU186122B (en) | 1982-09-21 | 1982-09-21 | Process for producing 3,3-diphenyl-1-methyil-propylamine derivatives and acid additional salts thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8305072D0 true SE8305072D0 (en) | 1983-09-20 |
| SE8305072L SE8305072L (en) | 1984-03-22 |
| SE462161B SE462161B (en) | 1990-05-14 |
Family
ID=10962152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8305072A SE462161B (en) | 1982-09-21 | 1983-09-20 | Process for preparing 3,3-diphenyl-1-methylpropylamine derivatives and their acid addition salts |
Country Status (2)
| Country | Link |
|---|---|
| HU (1) | HU186122B (en) |
| SE (1) | SE462161B (en) |
-
1982
- 1982-09-21 HU HU823023A patent/HU186122B/en not_active IP Right Cessation
-
1983
- 1983-09-20 SE SE8305072A patent/SE462161B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU186122B (en) | 1985-06-28 |
| SE462161B (en) | 1990-05-14 |
| SE8305072L (en) | 1984-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2061479T3 (en) | AMINOURETHANES, PROCEDURE OF OBTAINING AND USES. | |
| ES8201572A1 (en) | 2-(1,4-Benzodioxanyl)-methoxy-propanol amines, process for their preparation and their use as medicines. | |
| DE3883456D1 (en) | Process for the preparation of substituted indolinone derivatives. | |
| KR840000508A (en) | Method for preparing 4-anilinopyrimidine derivative | |
| EP0269258A3 (en) | Process for the preparation of a pyrrolidinol compound | |
| ATE35417T1 (en) | PROCESS FOR THE PREPARATION OF PHOSPHORUS-CONTAINING CYANHYDRINE DERIVATIVES. | |
| CH612431A5 (en) | Process for the preparation of novel indole derivatives | |
| DE3767993D1 (en) | METHOD FOR THE PRODUCTION OF THIENYLAETHYLAMINES, AND DITHIENYLAETHYLAMINE PRODUCED BY THE METHOD. | |
| SE8305072D0 (en) | PROCEDURES FOR THE RECOVERY OF 3,3-DIPHENYL-1-METHYL-PROPYLAMINE DERIVATIVES UNDER THE ACID ADDITIONAL SALT | |
| AU1779188A (en) | Guanidine-related compounds comprising a substituted tetraphenylborate ion, process for obtaining these compounds, and use of the compounds | |
| DE59300094D1 (en) | Process for the preparation of 2-chloro-5-chloromethyl-pyridine. | |
| BG50162A3 (en) | Method for preparing of alcandiol dicarboxilates | |
| KR850007590A (en) | Method for producing 4- (nitrophenyl) -tetrahydropyridines | |
| ATE101391T1 (en) | PROCESS FOR THE PREPARATION OF CYCLOPROPANECARBONIC ACID DERIVATIVES SUBSTITUTED IN POSITION 3 BY A HALOGENATED SATURATED CHAIN. | |
| ES557208A0 (en) | A PROCEDURE FOR PREPARING DERIVATIVES OF DIHYDROPYROL (112-B) -ISOQUINOLEIN | |
| ATE63107T1 (en) | PROCESS FOR THE SYNTHESIS OF CARBON ACIDS. | |
| ATE9152T1 (en) | PROCESS FOR THE PREPARATION OF HYDRAZIDINS. | |
| KR840006654A (en) | Process for preparing trans-4aR-5-n-propyl-4,4a, 5,6,7,8,8a, 9-octahydro-1H (and 2H) pyrazolo [3,4-g] quinoline | |
| ATE13528T1 (en) | PROCESS FOR THE PREPARATION OF HYDRAZIDINS. | |
| SE7609391L (en) | METHOD OF PREPARING 1-BENZOYL-2- (2 ', 6'-DICHLOROPHENYLAMINO) -2-IMIDAZOLINE AND SALTS thereof | |
| ATE11046T1 (en) | PROCESS FOR THE PREPARATION OF 2-OXO- AND 2UN-SUBSTITUTED HEXAHYDROAZEPINE DERIVATIVES. | |
| DK222087A (en) | AENE PROCEDURE FOR THE PREPARATION OF CHEMICAL RELATIONSHIPS | |
| SU559921A1 (en) | Method for preparing phthalimidines | |
| ATE1094T1 (en) | PROCESS FOR THE PREPARATION OF N,N'-DIFORMYLHYDRAZINE. | |
| ES416094A1 (en) | Chemical products |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
Ref document number: 8305072-4 Format of ref document f/p: F |
|
| NUG | Patent has lapsed |
Ref document number: 8305072-4 Format of ref document f/p: F |