SE8304132L - Antitumor antibiotic - Google Patents

Antitumor antibiotic

Info

Publication number
SE8304132L
SE8304132L SE8304132A SE8304132A SE8304132L SE 8304132 L SE8304132 L SE 8304132L SE 8304132 A SE8304132 A SE 8304132A SE 8304132 A SE8304132 A SE 8304132A SE 8304132 L SE8304132 L SE 8304132L
Authority
SE
Sweden
Prior art keywords
antitumor antibiotic
bbm
inhibits
bacteria
actinomadura
Prior art date
Application number
SE8304132A
Other languages
Swedish (sv)
Other versions
SE8304132D0 (en
Inventor
M Konishi
F Sakai
T Miyaki
H Kawaguchi
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8304132D0 publication Critical patent/SE8304132D0/en
Publication of SE8304132L publication Critical patent/SE8304132L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/03—Actinomadura
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/825—Actinomadura

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A polypeptide antitumor antibiotic designated herein as BBM- 1644 is produced by fermentation of Actinomadura sp. strain H710-49 (ATCC 39144). BBM-1644 inhibits gram-positive and acid-fast bacteria, induces prophage in lysogenic bacteria and inhibits the growth of tumors such as P388 leukemia in mice.
SE8304132A 1982-07-26 1983-07-25 Antitumor antibiotic SE8304132L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40146882A 1982-07-26 1982-07-26

Publications (2)

Publication Number Publication Date
SE8304132D0 SE8304132D0 (en) 1983-07-25
SE8304132L true SE8304132L (en) 1984-01-27

Family

ID=23587892

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8304132A SE8304132L (en) 1982-07-26 1983-07-25 Antitumor antibiotic

Country Status (29)

Country Link
JP (1) JPS5948084A (en)
KR (1) KR840005484A (en)
AU (1) AU567105B2 (en)
BE (1) BE897381A (en)
CA (1) CA1215337A (en)
CH (1) CH657778A5 (en)
CS (1) CS251077B2 (en)
DD (1) DD210075A5 (en)
DE (1) DE3326917A1 (en)
DK (1) DK339683A (en)
ES (1) ES524405A0 (en)
FI (1) FI832676A (en)
FR (1) FR2530663A1 (en)
GB (1) GB2124234B (en)
GR (1) GR78648B (en)
HU (1) HU192165B (en)
IE (1) IE55800B1 (en)
IL (1) IL69313A0 (en)
IT (1) IT1163847B (en)
LU (1) LU84930A1 (en)
MY (1) MY8800125A (en)
NL (1) NL8302610A (en)
NO (1) NO832689L (en)
NZ (1) NZ204965A (en)
OA (1) OA07503A (en)
PT (1) PT77091B (en)
SE (1) SE8304132L (en)
YU (1) YU158583A (en)
ZA (1) ZA835337B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208013A (en) * 1983-05-16 1987-07-31 Bristol Myers Co Antitumour antibiotic bbm-1675 and production by cultivating actinomadura verrucosospora
JPS606194A (en) * 1983-06-23 1985-01-12 Meiji Seika Kaisha Ltd Novel antibiotic substance sf-2288 and its preparation
GB8425685D0 (en) * 1984-10-11 1984-11-14 Lepetit Spa Antibiotic a 40926 complex
US5304373A (en) * 1991-10-22 1994-04-19 Bristol-Myers Squibb Co. Antitumor antibiotic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148882A (en) * 1977-06-24 1979-04-10 Pfizer Inc. Polycyclic ether antibiotics produced by new species of actinomycete
JPS56113791A (en) * 1980-02-15 1981-09-07 Kaken Pharmaceut Co Ltd Novel antibiotic and its preparation
CA1198386A (en) * 1981-10-22 1985-12-24 Donald B. Borders ANTIBACTERIAL AGENTS LL-C23024.beta. AND IOTA AND MICROORGANISM ACTINOMADURA YUMAENSE NRRL 12515
US4578271A (en) * 1982-05-24 1986-03-25 Fujisawa Pharmaceutical Co., Ltd. Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
NZ208013A (en) * 1983-05-16 1987-07-31 Bristol Myers Co Antitumour antibiotic bbm-1675 and production by cultivating actinomadura verrucosospora

Also Published As

Publication number Publication date
JPS5948084A (en) 1984-03-19
NO832689L (en) 1984-01-27
CA1215337A (en) 1986-12-16
IE831740L (en) 1984-01-26
AU567105B2 (en) 1987-11-12
ES8502161A1 (en) 1984-12-16
IT8322219A0 (en) 1983-07-25
NZ204965A (en) 1986-09-10
MY8800125A (en) 1988-12-31
DK339683D0 (en) 1983-07-25
CH657778A5 (en) 1986-09-30
IE55800B1 (en) 1991-01-16
IL69313A0 (en) 1983-11-30
BE897381A (en) 1984-01-26
PT77091A (en) 1983-08-01
GB2124234B (en) 1986-04-03
DE3326917A1 (en) 1984-02-02
HUT37167A (en) 1985-11-28
KR840005484A (en) 1984-11-14
FR2530663A1 (en) 1984-01-27
FI832676A (en) 1984-01-27
IT1163847B (en) 1987-04-08
FI832676A0 (en) 1983-07-22
HU192165B (en) 1987-05-28
ZA835337B (en) 1984-03-28
GR78648B (en) 1984-09-27
GB8320026D0 (en) 1983-08-24
SE8304132D0 (en) 1983-07-25
LU84930A1 (en) 1984-03-22
ES524405A0 (en) 1984-12-16
YU158583A (en) 1985-12-31
DK339683A (en) 1984-01-27
NL8302610A (en) 1984-02-16
CS251077B2 (en) 1987-06-11
GB2124234A (en) 1984-02-15
JPH0526799B2 (en) 1993-04-19
AU1720083A (en) 1984-02-02
PT77091B (en) 1986-06-26
OA07503A (en) 1985-03-31
DD210075A5 (en) 1984-05-30

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