SE8303385L - 1,4-DIHYDROPYRIDINE DERIVATIVES, OPTICALLY ACTIVE OR RACEMAT FORM AND THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS - Google Patents

1,4-DIHYDROPYRIDINE DERIVATIVES, OPTICALLY ACTIVE OR RACEMAT FORM AND THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Info

Publication number
SE8303385L
SE8303385L SE8303385A SE8303385A SE8303385L SE 8303385 L SE8303385 L SE 8303385L SE 8303385 A SE8303385 A SE 8303385A SE 8303385 A SE8303385 A SE 8303385A SE 8303385 L SE8303385 L SE 8303385L
Authority
SE
Sweden
Prior art keywords
optically active
racemat
preparation
pharmaceutical compositions
compounds
Prior art date
Application number
SE8303385A
Other languages
Swedish (sv)
Other versions
SE8303385D0 (en
Inventor
A Vogel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8303385D0 publication Critical patent/SE8303385D0/en
Publication of SE8303385L publication Critical patent/SE8303385L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compounds having the formula (I) wherein one of the two residues R1 and R2 is the methyl group and the other one is a group selected among isopropyl, n-butyl, isobutyl, cyclopentyl or isopropoxy-ethyl groups and the residue R3 is hydrogen or an optionally substituted alkyl group; these compounds are either in an optically active form when R3 is hydrogen, or in a racemic form or in an optically active form when R3 is an alkyl residue with 1 to 6 atoms of carbon, optionally substituted. Such compounds are used for the treatment of the deficiency of coronaries, cerebro-vascular deficiency, troubles of peripheral circulation, hypertension or asthma.
SE8303385A 1982-06-15 1983-06-14 1,4-DIHYDROPYRIDINE DERIVATIVES, OPTICALLY ACTIVE OR RACEMAT FORM AND THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS SE8303385L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH369282 1982-06-15
CH369382 1982-06-15

Publications (2)

Publication Number Publication Date
SE8303385D0 SE8303385D0 (en) 1983-06-14
SE8303385L true SE8303385L (en) 1983-12-16

Family

ID=25693638

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8303385A SE8303385L (en) 1982-06-15 1983-06-14 1,4-DIHYDROPYRIDINE DERIVATIVES, OPTICALLY ACTIVE OR RACEMAT FORM AND THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Country Status (19)

Country Link
AU (1) AU1575383A (en)
BE (1) BE897000A (en)
CA (1) CA1208639A (en)
CH (1) CH660593A5 (en)
DE (1) DE3320616A1 (en)
DK (1) DK271183A (en)
ES (2) ES8504179A1 (en)
FI (1) FI832072L (en)
FR (1) FR2528431B1 (en)
GB (1) GB2122192B (en)
HU (1) HU191853B (en)
IT (1) IT1178353B (en)
NL (1) NL8302067A (en)
NZ (1) NZ204536A (en)
PH (1) PH23436A (en)
PT (1) PT76870B (en)
SE (1) SE8303385L (en)
WO (1) WO1984000033A1 (en)
ZA (1) ZA834409B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3431152A1 (en) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt METHOD FOR PRODUCING OPTICALLY ACTIVE, SUBSTITUTED 1,4-DIHYDROPYRIDINE AND THEIR USE AS A MEDICINAL PRODUCT
GB8428552D0 (en) * 1984-11-12 1984-12-19 Sandoz Ltd Organic compounds
US5260321A (en) * 1984-11-12 1993-11-09 Sandoz Ltd. Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins
DE3447169A1 (en) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen OPTICALLY ACTIVE NITRODIHYDROPYRIDINE, METHOD FOR THE PRODUCTION AND THEIR USE IN MEDICINAL PRODUCTS
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
EP0287828A1 (en) * 1987-03-27 1988-10-26 Byk Gulden Lomberg Chemische Fabrik GmbH Intermediates and their preparation
DE4041814A1 (en) * 1990-12-24 1992-07-02 Byk Gulden Lomberg Chem Fab METHOD FOR PRODUCING DIHYDROPHYRIDINE CARBONIC ACIDS
US5135936A (en) * 1991-03-05 1992-08-04 Marion Merrell Dow Inc. Isomers of 1-azabicyclo[2.2.2]oct-3-yl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinediacarboxylic and their use as calcium antagonists
CN100425599C (en) * 2005-12-31 2008-10-15 清华大学 Organic electroluminescent material and its application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639659A5 (en) * 1978-12-18 1983-11-30 Sandoz Ag NEW 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR PRODUCTION AND USE.
DK149855C (en) * 1977-06-20 1987-04-21 Sandoz Ag METHOD OF ANALOGY FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINE DERIVATIVES
DE2949464A1 (en) * 1978-12-18 1980-06-26 Sandoz Ag BENZOXADIAZOLES AND BENZOTHIADIAZOLES, THEIR PRODUCTION AND USE
FI813460L (en) * 1980-11-10 1982-05-11 Sandoz Ag NYA 4- (2,1,3-BENZOXADIAZOL-4-YL) -1,4-DIHYDRO-PYRIDIN DERIVATIVES DERAS FRAMSTAELLNINGSFOERFARANDE OCH DESSA INNEHAOLLANDE PHARMACEUTICAL COMPOSITION

Also Published As

Publication number Publication date
DE3320616A1 (en) 1983-12-15
AU1575383A (en) 1983-12-22
ZA834409B (en) 1985-02-27
FI832072L (en) 1983-12-16
IT8348488A0 (en) 1983-06-13
WO1984000033A1 (en) 1984-01-05
ES523243A0 (en) 1985-04-01
PT76870B (en) 1986-02-27
FI832072A0 (en) 1983-06-08
CA1208639A (en) 1986-07-29
PH23436A (en) 1989-08-07
GB8316054D0 (en) 1983-07-20
CH660593A5 (en) 1987-05-15
NZ204536A (en) 1986-09-10
ES8504179A1 (en) 1985-04-01
PT76870A (en) 1983-07-01
DK271183D0 (en) 1983-06-13
NL8302067A (en) 1984-01-02
IT1178353B (en) 1987-09-09
SE8303385D0 (en) 1983-06-14
FR2528431A1 (en) 1983-12-16
GB2122192A (en) 1984-01-11
HU191853B (en) 1987-04-28
GB2122192B (en) 1985-12-18
BE897000A (en) 1983-12-09
ES8604578A1 (en) 1986-02-01
DK271183A (en) 1983-12-16
ES538157A0 (en) 1986-02-01
FR2528431B1 (en) 1986-01-10

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