SE8302345L - PLEUROMUTILIN DERIVATIVES, THE PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT - Google Patents
PLEUROMUTILIN DERIVATIVES, THE PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCTInfo
- Publication number
- SE8302345L SE8302345L SE8302345A SE8302345A SE8302345L SE 8302345 L SE8302345 L SE 8302345L SE 8302345 A SE8302345 A SE 8302345A SE 8302345 A SE8302345 A SE 8302345A SE 8302345 L SE8302345 L SE 8302345L
- Authority
- SE
- Sweden
- Prior art keywords
- alkylamino
- procedures
- preparation
- medicinal product
- unsubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Abstract
Compounds of formula I <IMAGE> wherein R1 represents ethyl or vinyl, R2 represents lower alkoxy, amino, lower alkylamino which may be unsubstituted or substituted by amino, lower alkylamino, di-(lower)-alkylamino or hydroxy, di-(lower)-alkylamino or a five or six membered, saturated heterocycle which contains one or two nitrogens as heteroatoms and which may be unsubstituted or substituted by lower alkyl and R3 and R4 represent, independently, hydrogen or lower alkyl, in free base o; acid addition or quaternary salt form, exhibit pharmacological activity, particularly against bacteria and obligatory anaerobes, and can be incorporated into chemotherapeutic compositions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT165182 | 1982-04-28 | ||
| AT427082 | 1982-11-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8302345D0 SE8302345D0 (en) | 1983-04-26 |
| SE8302345L true SE8302345L (en) | 1983-10-29 |
Family
ID=25596422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8302345A SE8302345L (en) | 1982-04-28 | 1983-04-26 | PLEUROMUTILIN DERIVATIVES, THE PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT |
Country Status (12)
| Country | Link |
|---|---|
| AU (1) | AU1393783A (en) |
| DE (1) | DE3314479A1 (en) |
| DK (1) | DK185683A (en) |
| ES (1) | ES8406431A1 (en) |
| FI (1) | FI831367L (en) |
| FR (1) | FR2526019A1 (en) |
| GB (1) | GB2121035A (en) |
| IL (1) | IL68508A0 (en) |
| IT (1) | IT1197634B (en) |
| NL (1) | NL8301448A (en) |
| PT (1) | PT76598B (en) |
| SE (1) | SE8302345L (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0153277B1 (en) * | 1984-02-17 | 1987-08-26 | Sandoz Ag | Pleuromutilin derivatives, process for their preparation and their use |
| HU208115B (en) * | 1989-10-03 | 1993-08-30 | Biochemie Gmbh | New process for producting pleuromutilin derivatives |
| GB0017031D0 (en) | 2000-07-11 | 2000-08-30 | Biochemie Gmbh | Antimicrobials |
| GB0218578D0 (en) | 2002-08-09 | 2002-09-18 | Glaxo Group Ltd | Novel method |
| CN104961666B (en) * | 2014-07-08 | 2017-04-12 | 南通大学 | 2-mercaptoacetamide pleuromutilin derivatives, and preparation method and medical application thereof |
| CN104447450B (en) * | 2014-07-08 | 2016-09-28 | 南通大学 | Cysteine amide-type pleuromutilin derivative and preparation method and medical usage |
| CN109384698B (en) * | 2017-08-04 | 2022-07-08 | 保定加合精细化工有限公司 | Preparation method of diterpene antibiotic for livestock and poultry |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT301752B (en) * | 1969-07-21 | 1972-09-25 | Biochemie Gmbh | Process for the preparation of new pleuromutilin derivatives |
| US3919290A (en) * | 1972-10-03 | 1975-11-11 | Sandoz Ltd | Substituted 14-desoxy-mutilins |
| IE44428B1 (en) * | 1975-09-30 | 1981-12-02 | Squibb & Sons Inc | New derivatives of pleuromutilin and compositions containig same |
| DE2823712A1 (en) * | 1978-05-31 | 1979-12-06 | Sandoz Ag | 14-Amino-alkylthio-acetoxy-multiline derivs. prodn. - from amino-alkane:thiol and sulphonate ester, for use as veterinary antibiotics |
-
1983
- 1983-04-19 FR FR8306523A patent/FR2526019A1/en active Granted
- 1983-04-21 DE DE19833314479 patent/DE3314479A1/en not_active Withdrawn
- 1983-04-21 FI FI831367A patent/FI831367L/en not_active Application Discontinuation
- 1983-04-25 GB GB08311194A patent/GB2121035A/en not_active Withdrawn
- 1983-04-25 NL NL8301448A patent/NL8301448A/en not_active Application Discontinuation
- 1983-04-26 AU AU13937/83A patent/AU1393783A/en not_active Abandoned
- 1983-04-26 PT PT76598A patent/PT76598B/en unknown
- 1983-04-26 ES ES521847A patent/ES8406431A1/en not_active Expired
- 1983-04-26 SE SE8302345A patent/SE8302345L/en not_active Application Discontinuation
- 1983-04-26 DK DK185683A patent/DK185683A/en not_active Application Discontinuation
- 1983-04-27 IL IL68508A patent/IL68508A0/en unknown
- 1983-04-27 IT IT48162/83A patent/IT1197634B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| PT76598A (en) | 1983-05-01 |
| FI831367L (en) | 1983-10-29 |
| AU1393783A (en) | 1983-11-03 |
| ES521847A0 (en) | 1984-08-01 |
| IT8348162A0 (en) | 1983-04-27 |
| IL68508A0 (en) | 1983-07-31 |
| GB8311194D0 (en) | 1983-06-02 |
| ES8406431A1 (en) | 1984-08-01 |
| DK185683A (en) | 1983-10-29 |
| DE3314479A1 (en) | 1983-11-03 |
| IT1197634B (en) | 1988-12-06 |
| SE8302345D0 (en) | 1983-04-26 |
| FR2526019B1 (en) | 1985-04-26 |
| DK185683D0 (en) | 1983-04-26 |
| FI831367A0 (en) | 1983-04-21 |
| FR2526019A1 (en) | 1983-11-04 |
| GB2121035A (en) | 1983-12-14 |
| NL8301448A (en) | 1983-11-16 |
| PT76598B (en) | 1986-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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