SE8302158L - NEW PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-5-AROYL-1H-PYRROL-2-ETHY ACETIC ACID DERIVATIVES - Google Patents

NEW PROCEDURE FOR THE PREPARATION OF 1-ALKYL OR 1,4-DIALKYL-5-AROYL-1H-PYRROL-2-ETHY ACETIC ACID DERIVATIVES

Info

Publication number
SE8302158L
SE8302158L SE8302158A SE8302158A SE8302158L SE 8302158 L SE8302158 L SE 8302158L SE 8302158 A SE8302158 A SE 8302158A SE 8302158 A SE8302158 A SE 8302158A SE 8302158 L SE8302158 L SE 8302158L
Authority
SE
Sweden
Prior art keywords
alkyl
carbon atoms
hydrogen
general formula
acid
Prior art date
Application number
SE8302158A
Other languages
Swedish (sv)
Other versions
SE8302158D0 (en
SE447105B (en
Inventor
K Harsanyi
E Agai
G Domany
G Szepesi
M Szollosy
M Gazdag
J Lorant
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8302158D0 publication Critical patent/SE8302158D0/en
Publication of SE8302158L publication Critical patent/SE8302158L/en
Publication of SE447105B publication Critical patent/SE447105B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

The invention relates to a process for the preparation of 1-alkyl-5-aroyl-1H-pyrrole-2-acetic acid. derivatives of the general formula (I) < IMG > (I) wherein Ar is phenyl optionally substituted with halogen, alkyl having one to 4 carbon atoms or alkoxy having one to 4 carbon atoms; R is alkyl having one to 4 carbon atoms; R1 is hydrogen or alkyl having one to 4 carbon atoms; X is an imino group and R2 is hydrogen or an alkyl group having one to 4 carbon atoms, or X is oxygen and R2 is hydrogen, and acid addition salts (if X=imino) and alkali metal or alkali earth metal salts (if R2=H) thereof, The above compounds are prepared. by reacting a pyrrole derivative of the general formula (II) < IMG > (II) wherein Y stands for a -COOR3 group and. R3 is an alkyl group having one to 4 carbon atoms, with an aromatic nitrile of the general formula Ar-CN wherein Ar is as defined above, in an organic solvent, preferably aromatic hydrocarbon, saturated with dry hydrochloric acid gas and, if desired, hydrolysing a ketimino ester obtained into a corresponding ketimino acid or keto acid or a salt thereof. The process affords the desired products with a good yield, selectively, and, if desired, can be carried out in one pot, without isolating the intermediates.
SE8302158A 1982-04-19 1983-04-18 PROCEDURE FOR PREPARING 1-ALKYL OR 1,4-DIALKYL-5-AROYL-1H-PYRROL-2-ETHYAC Acid DERIVATIVES SE447105B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU118782A HU187131B (en) 1982-04-19 1982-04-19 Process for producing 1-alkyl-5-aroyl-pyrrol-2-acetic acid derivatives

Publications (3)

Publication Number Publication Date
SE8302158D0 SE8302158D0 (en) 1983-04-18
SE8302158L true SE8302158L (en) 1983-10-20
SE447105B SE447105B (en) 1986-10-27

Family

ID=10953241

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8302158A SE447105B (en) 1982-04-19 1983-04-18 PROCEDURE FOR PREPARING 1-ALKYL OR 1,4-DIALKYL-5-AROYL-1H-PYRROL-2-ETHYAC Acid DERIVATIVES

Country Status (12)

Country Link
JP (1) JPS58213754A (en)
AT (1) AT376205B (en)
BE (1) BE896472A (en)
CA (1) CA1193608A (en)
CH (1) CH652711A5 (en)
DK (1) DK153396C (en)
ES (1) ES8501749A1 (en)
FI (1) FI831310L (en)
HU (1) HU187131B (en)
IN (1) IN156527B (en)
NO (1) NO161973C (en)
SE (1) SE447105B (en)

Also Published As

Publication number Publication date
FI831310L (en) 1983-10-20
FI831310A0 (en) 1983-04-19
JPS58213754A (en) 1983-12-12
DK170583A (en) 1983-10-20
SE8302158D0 (en) 1983-04-18
CA1193608A (en) 1985-09-17
NO161973B (en) 1989-07-10
SE447105B (en) 1986-10-27
CH652711A5 (en) 1985-11-29
DK153396C (en) 1988-11-28
AT376205B (en) 1984-10-25
ATA140283A (en) 1984-03-15
NO831375L (en) 1983-10-20
BE896472A (en) 1983-10-17
DK153396B (en) 1988-07-11
NO161973C (en) 1989-10-18
HU187131B (en) 1985-11-28
IN156527B (en) 1985-08-24
ES521631A0 (en) 1984-12-01
DK170583D0 (en) 1983-04-19
ES8501749A1 (en) 1984-12-01

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