SE8300914D0 - COMPOSITIONS FOR GLAUKOM TREATMENT - Google Patents
COMPOSITIONS FOR GLAUKOM TREATMENTInfo
- Publication number
- SE8300914D0 SE8300914D0 SE8300914A SE8300914A SE8300914D0 SE 8300914 D0 SE8300914 D0 SE 8300914D0 SE 8300914 A SE8300914 A SE 8300914A SE 8300914 A SE8300914 A SE 8300914A SE 8300914 D0 SE8300914 D0 SE 8300914D0
- Authority
- SE
- Sweden
- Prior art keywords
- opt
- coor
- aralkyl
- glaucoma
- alkynyl
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- -1 acetamido, amino Chemical group 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000001384 anti-glaucoma Effects 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 229940097320 beta blocking agent Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000004410 intraocular pressure Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Glaucoma or high intraocular pressure is treated by the topical ocular application of a 3-aryloxy-2-hydroxypropylamine of the formula - Ar-O-CH2-CH(OH)-CH2-NH-Y-(COOR)x (I) % or its salts:- (where Y is opt. branched (1-10C) carbon chain or (8-20C) aralkyl (sic), R is lower alkyl, lower alkenyl, lower alkynyl, aryl or aralkyl; x is 1, 2 or 3, provided that when x is 2 or 3, COOR may be same or different; Ar is aromatic opt. substd. by lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halogen, acetamido, amino, nitro, lower alkylamino, OH, lower hydroxyalkyl, acetyl, CN or ROCO.A-; A is a bond, (1-10C) alkylene or (2-10C) alkenylene). (I) have sustained antiglaucoma activity when in the eye, but are short lived on reaching the general circulation. Side effects are thus much reduced as compared with the usual beta-blockers used for treating glaucoma. Examples of tests for the effects of (I) on the eyes of rabbits are given in the specification,but no results.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1982/000850 WO1983000015A1 (en) | 1981-06-23 | 1982-06-23 | Compositions for treating glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8300914L SE8300914L (en) | 1983-02-18 |
| SE8300914D0 true SE8300914D0 (en) | 1983-02-18 |
Family
ID=22168057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8300914A SE8300914D0 (en) | 1982-06-23 | 1983-02-18 | COMPOSITIONS FOR GLAUKOM TREATMENT |
Country Status (1)
| Country | Link |
|---|---|
| SE (1) | SE8300914D0 (en) |
-
1983
- 1983-02-18 SE SE8300914A patent/SE8300914D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8300914L (en) | 1983-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8300914-2 Effective date: 19941223 |
|
| NAV | Patent application has lapsed |
Ref document number: 8300914-2 |