SE8300432L - REACTIVE CINNIC ACID DERIVATIVES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE AMIDES - Google Patents

REACTIVE CINNIC ACID DERIVATIVES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE AMIDES

Info

Publication number
SE8300432L
SE8300432L SE8300432A SE8300432A SE8300432L SE 8300432 L SE8300432 L SE 8300432L SE 8300432 A SE8300432 A SE 8300432A SE 8300432 A SE8300432 A SE 8300432A SE 8300432 L SE8300432 L SE 8300432L
Authority
SE
Sweden
Prior art keywords
preparation
reactive
biologically active
acid derivatives
cinnic
Prior art date
Application number
SE8300432A
Other languages
Swedish (sv)
Other versions
SE8300432D0 (en
Inventor
E Grivsky
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of SE8300432L publication Critical patent/SE8300432L/en
Publication of SE8300432D0 publication Critical patent/SE8300432D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C07C69/618—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The compounds of the formula I are prepared by reacting a compound of the formula III R.NH.W, in which W denotes hydrogen or a group which can be eliminated, with an acid of the formula II . Instead of the free acid, an active derivative of this acid can be used. The substituents in the formulae have the meanings given in Claim 1. The compounds of the formula I possess useful pharmacological properties.

Claims (1)

PATENTKRAV Reaktiva kanelsyraderivat med formeln dar X Ar fluor eller trifluormetyl och Y Ar halogen eller alkoxi medCLAIMED Reactive cinnamic acid derivatives of the formula wherein X is fluorine or trifluoromethyl and Y is halogen or alkoxy with 1. -4 kolatomer, folutsatt att X inte ar fluor nar Y dr etoxi, till anvandning som utgAngsmaterial fbr framstAllning no biologiskt aktiva amider.1. -4 carbon atoms, provided that X is not fluorine when Y contains ethoxy, for use as a starting material for the preparation of biologically active amides.
SE8300432A 1976-02-03 1983-01-28 REACTIVE CINNIC ACID DERIVATIVES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE AMIDES SE8300432D0 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB4168/76A GB1568401A (en) 1976-02-03 1976-02-03 Biologically active amides
GB416976 1976-02-03
GB417076 1976-02-03
US71231876A 1976-08-06 1976-08-06
US71213576A 1976-08-06 1976-08-06
US71213476A 1976-08-06 1976-08-06

Publications (2)

Publication Number Publication Date
SE8300432L true SE8300432L (en) 1983-01-28
SE8300432D0 SE8300432D0 (en) 1983-01-28

Family

ID=27546490

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7701107A SE436870B (en) 1976-02-03 1977-02-02 SET TO MAKE NEW N-SUBSTITUTED Cinnamic Acid Amides
SE8300432A SE8300432D0 (en) 1976-02-03 1983-01-28 REACTIVE CINNIC ACID DERIVATIVES FOR THE PREPARATION OF BIOLOGICALLY ACTIVE AMIDES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7701107A SE436870B (en) 1976-02-03 1977-02-02 SET TO MAKE NEW N-SUBSTITUTED Cinnamic Acid Amides

Country Status (20)

Country Link
JP (1) JPS6056700B2 (en)
AR (1) AR218865A1 (en)
AT (1) AT363926B (en)
BE (1) BE851020A (en)
CA (1) CA1109076A (en)
CH (1) CH634551A5 (en)
CS (2) CS245756B2 (en)
DD (1) DD130349A5 (en)
DE (1) DE2704365C2 (en)
DK (1) DK43177A (en)
FI (1) FI69625C (en)
FR (1) FR2340303A1 (en)
GB (1) GB1568401A (en)
GR (1) GR66474B (en)
HU (1) HU175435B (en)
IE (1) IE44862B1 (en)
IL (1) IL51373A (en)
NL (1) NL7701088A (en)
PL (2) PL119716B1 (en)
SE (2) SE436870B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116877A (en) * 1989-02-02 1992-05-26 Taisho Pharmaceutical Co., Ltd. Pharmaceutical use for cinnamamide derivatives
DE19931116A1 (en) * 1999-07-06 2001-01-11 Bayer Ag Process for the production of phenethylamines and new chemical compounds
CN104513172B (en) * 2013-09-30 2018-02-02 天士力医药集团股份有限公司 Acid amides alkaloid, preparation method and its medicinal usage containing trifluoromethyl
CN104432097B (en) * 2014-12-16 2016-08-17 广州渔夫堡医药科技有限公司 A kind of natural enriching substance of alleviating physical fatigue

Also Published As

Publication number Publication date
HU175435B (en) 1980-07-28
DK43177A (en) 1977-08-04
AT363926B (en) 1981-09-10
FR2340303A1 (en) 1977-09-02
FR2340303B1 (en) 1979-04-13
DE2704365A1 (en) 1977-08-04
JPS52116437A (en) 1977-09-29
DD130349A5 (en) 1978-03-22
IE44862L (en) 1977-08-03
CS245756B2 (en) 1986-10-16
IL51373A (en) 1981-12-31
FI69625C (en) 1986-03-10
CS245758B2 (en) 1986-10-16
AR218865A1 (en) 1980-07-15
GB1568401A (en) 1980-05-29
CA1109076A (en) 1981-09-15
PL195740A1 (en) 1979-05-07
DE2704365C2 (en) 1986-03-20
FI770365A (en) 1977-08-04
PL119314B1 (en) 1981-12-31
JPS6056700B2 (en) 1985-12-11
SE7701107L (en) 1977-08-04
PL119716B1 (en) 1982-01-30
CH634551A5 (en) 1983-02-15
IL51373A0 (en) 1977-04-29
BE851020A (en) 1977-08-02
NL7701088A (en) 1977-08-05
FI69625B (en) 1985-11-29
ATA65277A (en) 1981-02-15
SE8300432D0 (en) 1983-01-28
SE436870B (en) 1985-01-28
GR66474B (en) 1981-03-23
IE44862B1 (en) 1982-04-21

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Effective date: 19840929