SE8206073D0 - Tumor imaging with radiolabeled monoclonal antibodies - Google Patents

Tumor imaging with radiolabeled monoclonal antibodies

Info

Publication number
SE8206073D0
SE8206073D0 SE8206073A SE8206073A SE8206073D0 SE 8206073 D0 SE8206073 D0 SE 8206073D0 SE 8206073 A SE8206073 A SE 8206073A SE 8206073 A SE8206073 A SE 8206073A SE 8206073 D0 SE8206073 D0 SE 8206073D0
Authority
SE
Sweden
Prior art keywords
monoclonal antibodies
tumor imaging
radiolabeled monoclonal
tumour
antibody
Prior art date
Application number
SE8206073A
Other languages
Swedish (sv)
Other versions
SE8206073L (en
Inventor
T H Adams
G S David
S E Halpern
Original Assignee
Hybritech Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc, Univ California filed Critical Hybritech Inc
Publication of SE8206073D0 publication Critical patent/SE8206073D0/en
Publication of SE8206073L publication Critical patent/SE8206073L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1066—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Monoclonal antibodies to tumour associated antigens have bound to them a metallic radionuclide, either directly or by means of a chelating agent such as diethylenetriaminepentaacetic acid (DTPA) conjugated to the antibody. When parenterally administered to a subject, the labelled monoclonal antibody localizes in the tumour and can be detected by photoscanning to detect emitted radiation.
SE8206073A 1981-10-27 1982-10-26 Tumor imaging with radiolabeled monoclonal antibodies SE8206073L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31528681A 1981-10-27 1981-10-27

Publications (2)

Publication Number Publication Date
SE8206073D0 true SE8206073D0 (en) 1982-10-26
SE8206073L SE8206073L (en) 1983-04-28

Family

ID=23223718

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8206073A SE8206073L (en) 1981-10-27 1982-10-26 Tumor imaging with radiolabeled monoclonal antibodies

Country Status (18)

Country Link
JP (1) JPS58135820A (en)
AT (1) AT392004B (en)
BE (1) BE894829A (en)
CA (1) CA1202892A (en)
CH (1) CH653040A5 (en)
DE (1) DE3239410A1 (en)
DK (1) DK164682C (en)
ES (2) ES8404857A1 (en)
FI (1) FI82379C (en)
FR (1) FR2515046B1 (en)
GB (1) GB2109407B (en)
IL (1) IL67068A0 (en)
IT (1) IT1153857B (en)
LU (1) LU84441A1 (en)
NL (1) NL8204108A (en)
NO (1) NO169947C (en)
SE (1) SE8206073L (en)
ZA (1) ZA827806B (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
GB2122641B (en) * 1982-06-07 1986-08-06 Otto A Gansow Metal chelate conjugated monoclonal antibodies where in the metal is an emitter
US4741900A (en) * 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
SE8401946L (en) * 1983-04-08 1984-11-13 Kureha Chemical Ind Co Ltd ANTIBODY AGAINST HUMAN PROSTATACANCES
GB2140030A (en) * 1983-04-08 1984-11-21 Kureha Chemical Ind Co Ltd Monoclonal antibody to human urinary bladder cancer
JPS59199636A (en) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk Radioactive diagnostic agent and production thereof
US4677058A (en) * 1983-05-19 1987-06-30 Karl Tryggvason Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JPS60201260A (en) * 1984-03-27 1985-10-11 Yamasa Shoyu Co Ltd Myocardial myosin diagnosing agent
JP2507982B2 (en) * 1984-04-10 1996-06-19 武田薬品工業株式会社 Method for producing human carcinoembryonic antigen-reactive monoclonal antibody
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4986256A (en) * 1985-02-28 1991-01-22 The United States Of America As Represented By The Department Of Health And Human Services Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4830847A (en) * 1985-06-28 1989-05-16 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
CA1340014C (en) * 1986-10-27 1998-08-25 Bryan Michael Longenecker Carcinoma-marking monoclonal antibodies elicited with synthetic asialo-gmi antigen
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (en) * 1987-03-31 1988-10-20 Schering Ag SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US5177192A (en) * 1987-04-02 1993-01-05 Centocor, Incorporated Method for labeling antibodies with a metal ion
US4838274A (en) * 1987-09-18 1989-06-13 Air Products And Chemicals, Inc. Perfluoro-crown ethers in fluorine magnetic resonance imaging
US5217704A (en) * 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5648471A (en) * 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
US4867962A (en) * 1988-02-26 1989-09-19 Neorx Corporation Functionally specific antibodies
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
US5550160A (en) * 1992-07-31 1996-08-27 Australian Nuclear Science & Technology Organization Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323546A (en) * 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4272503A (en) * 1978-05-25 1981-06-09 New England Nuclear Corporation Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
DE3173342D1 (en) * 1980-03-03 1986-02-13 Milton David Goldenberg Agent for tumor localization and therapy with labeled antibodies and antibody fragments

Also Published As

Publication number Publication date
DK474182A (en) 1983-04-28
CH653040A5 (en) 1985-12-13
ES8505482A1 (en) 1985-05-16
AT392004B (en) 1991-01-10
ZA827806B (en) 1983-08-31
BE894829A (en) 1983-02-14
SE8206073L (en) 1983-04-28
ES516797A0 (en) 1984-05-16
JPH0564130B2 (en) 1993-09-14
CA1202892A (en) 1986-04-08
IT8223932A0 (en) 1982-10-26
FI82379C (en) 1991-03-11
ES8404857A1 (en) 1984-05-16
FR2515046A1 (en) 1983-04-29
NO169947B (en) 1992-05-18
FI823633L (en) 1983-04-28
DE3239410C2 (en) 1991-12-19
DK164682C (en) 1992-12-21
GB2109407A (en) 1983-06-02
IT1153857B (en) 1987-01-21
ATA391682A (en) 1990-07-15
NO169947C (en) 1992-08-26
DE3239410A1 (en) 1983-05-19
IL67068A0 (en) 1983-02-23
NO823530L (en) 1983-04-28
LU84441A1 (en) 1983-06-13
NL8204108A (en) 1983-05-16
JPS58135820A (en) 1983-08-12
GB2109407B (en) 1985-12-18
DK164682B (en) 1992-08-03
FI823633A0 (en) 1982-10-25
FR2515046B1 (en) 1985-11-29
ES529310A0 (en) 1985-05-16
FI82379B (en) 1990-11-30

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