SE8204765D0 - 2- (O-CARBOXYPHENYLAMINO) -6H-PYRIMIDO (2,1-B) -QUINA-ZOLONE-6 AND DERIVATIVES THEREOF, METHOD OF PRODUCING AND APPLICATION - Google Patents

2- (O-CARBOXYPHENYLAMINO) -6H-PYRIMIDO (2,1-B) -QUINA-ZOLONE-6 AND DERIVATIVES THEREOF, METHOD OF PRODUCING AND APPLICATION

Info

Publication number
SE8204765D0
SE8204765D0 SE8204765A SE8204765A SE8204765D0 SE 8204765 D0 SE8204765 D0 SE 8204765D0 SE 8204765 A SE8204765 A SE 8204765A SE 8204765 A SE8204765 A SE 8204765A SE 8204765 D0 SE8204765 D0 SE 8204765D0
Authority
SE
Sweden
Prior art keywords
formula
image
carbon atoms
compound
alkyl
Prior art date
Application number
SE8204765A
Other languages
Swedish (sv)
Other versions
SE440908B (en
SE8204765L (en
Inventor
V A Portnyagina
V K Karp
I S Barkova
F P Trinus
N A Mokhort
A G Fadeicheva
G I Kozhushko
T K Ryabukha
A G Panteleimonov
V V Kljushin
J N Dobrovolsky
L M Kirichek
A A Medvedovsky
G A Getman
J D Usenko
V M Sidelnikov
N F Danilevsky
Y P Solsky
Original Assignee
Ki Nii Farmakologii I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ki Nii Farmakologii I filed Critical Ki Nii Farmakologii I
Priority to SE8204765A priority Critical patent/SE440908B/en
Publication of SE8204765D0 publication Critical patent/SE8204765D0/en
Publication of SE8204765L publication Critical patent/SE8204765L/en
Publication of SE440908B publication Critical patent/SE440908B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pharmaceutically usable 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline 6 with the formula<IMAGE>Further derivative of this compound with the formula<IMAGE>where A+ is an alkaline metal, monoethanolamine or diethylamine.IN addition a derivative of the stated compound with the formula<IMAGE>where R represents OH or alkyloxide with 1-4 carbon atoms or NHR2, where R1 represents H, alkyl with 1-4 carbon atoms or phenyl as well as alkyl and A are salts of inorganic acids.The final derivative of the given compound with the formula<IMAGE>where R represents alkyloxide with 1-4 carbon atoms or R1 represents alkyl with 1-4 carbon atoms.Furthermore, a process for producing the given formula comprising in that 2.4 dichloropyrimidine is converted with a sodium salt of anthranilic acid or subtitesters or amides of anthranilic acid in a hydrous or an organic solution at 90-120 degrees C for several hours.Furthermore, this refers to a hemotherapeutic composition, in which the component contains the above given compound or that and a pharmaceutically approved carrier material.
SE8204765A 1982-08-19 1982-08-19 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline and derivative thereof and compositions thereof SE440908B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8204765A SE440908B (en) 1982-08-19 1982-08-19 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline and derivative thereof and compositions thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8204765A SE440908B (en) 1982-08-19 1982-08-19 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline and derivative thereof and compositions thereof

Publications (3)

Publication Number Publication Date
SE8204765D0 true SE8204765D0 (en) 1982-08-19
SE8204765L SE8204765L (en) 1984-02-20
SE440908B SE440908B (en) 1985-08-26

Family

ID=20347568

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8204765A SE440908B (en) 1982-08-19 1982-08-19 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)quinazoline and derivative thereof and compositions thereof

Country Status (1)

Country Link
SE (1) SE440908B (en)

Also Published As

Publication number Publication date
SE440908B (en) 1985-08-26
SE8204765L (en) 1984-02-20

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