SE8204117L - PROCEDURE FOR PREPARING CARNITINE CHLORIDE - Google Patents

PROCEDURE FOR PREPARING CARNITINE CHLORIDE

Info

Publication number
SE8204117L
SE8204117L SE8204117A SE8204117A SE8204117L SE 8204117 L SE8204117 L SE 8204117L SE 8204117 A SE8204117 A SE 8204117A SE 8204117 A SE8204117 A SE 8204117A SE 8204117 L SE8204117 L SE 8204117L
Authority
SE
Sweden
Prior art keywords
procedure
hours
carnitine chloride
carnitine
preparing
Prior art date
Application number
SE8204117A
Other languages
Swedish (sv)
Other versions
SE448724B (en
SE8204117D0 (en
Inventor
M O Tinti
C Bagolini
E T Quaresima
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of SE8204117D0 publication Critical patent/SE8204117D0/en
Publication of SE8204117L publication Critical patent/SE8204117L/en
Publication of SE448724B publication Critical patent/SE448724B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/115—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

D-L carnitine is converted into D,L- carnitine acid chloride by treating it, without previously protecting the hydroxyl group, with a halogenating agent at room temperature for a reaction period comprised between 1.5 hours and 12 hours. If the foregoing reaction conditions are not strictly complied with, a sharp decrease in the yield and the formation of by-products, primarily crotonylbetaine, will take place.
SE8204117A 1981-07-03 1982-07-02 PROCEDURE FOR PREPARING CARNITINE CHLORIDE SE448724B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48817/81A IT1171360B (en) 1981-07-03 1981-07-03 PROCEDURE FOR THE PREPARATION OF CARNITINE ACID CHLORIDE

Publications (3)

Publication Number Publication Date
SE8204117D0 SE8204117D0 (en) 1982-07-02
SE8204117L true SE8204117L (en) 1983-01-04
SE448724B SE448724B (en) 1987-03-16

Family

ID=11268676

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8204117A SE448724B (en) 1981-07-03 1982-07-02 PROCEDURE FOR PREPARING CARNITINE CHLORIDE

Country Status (18)

Country Link
JP (1) JPS5815943A (en)
KR (1) KR860001886B1 (en)
AT (1) AT390057B (en)
BE (1) BE893713A (en)
CA (1) CA1186332A (en)
CH (1) CH648546A5 (en)
DE (1) DE3224666A1 (en)
DK (1) DK154425C (en)
ES (1) ES8304064A1 (en)
FR (1) FR2510559B1 (en)
GB (1) GB2101133B (en)
GR (1) GR76546B (en)
IE (1) IE53279B1 (en)
IL (1) IL66251A0 (en)
IT (1) IT1171360B (en)
LU (1) LU84244A1 (en)
NL (1) NL189666C (en)
SE (1) SE448724B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1190358B (en) * 1985-05-24 1988-02-16 Sclavo Spa PROCEDURE FOR THE PREPARATION OF L-CARNITINA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3940439A (en) * 1973-11-14 1976-02-24 G. D. Searle & Co. Acid chloride synthesis
IT1116037B (en) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti ACIL CARNITINE ESTERS AND AMIDS THEIR PREPARATION PROCEDURES AND THERAPEUTIC USE
DE2943433A1 (en) * 1979-10-26 1981-05-07 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING CARBONIC ACID HALOGENIDES

Also Published As

Publication number Publication date
FR2510559B1 (en) 1986-05-09
IE53279B1 (en) 1988-09-28
ES513658A0 (en) 1983-03-01
AT390057B (en) 1990-03-12
KR840000475A (en) 1984-02-22
JPH0244300B2 (en) 1990-10-03
DK295482A (en) 1983-01-04
GB2101133A (en) 1983-01-12
JPS5815943A (en) 1983-01-29
SE448724B (en) 1987-03-16
LU84244A1 (en) 1983-01-20
DE3224666A1 (en) 1983-01-20
IT8148817A0 (en) 1981-07-03
KR860001886B1 (en) 1986-10-24
ES8304064A1 (en) 1983-03-01
ATA257382A (en) 1989-08-15
IL66251A0 (en) 1982-11-30
CA1186332A (en) 1985-04-30
SE8204117D0 (en) 1982-07-02
IT1171360B (en) 1987-06-10
NL189666C (en) 1993-06-16
GB2101133B (en) 1985-08-14
BE893713A (en) 1982-10-18
DK154425B (en) 1988-11-14
IE821524L (en) 1983-01-03
NL8202677A (en) 1983-02-01
CH648546A5 (en) 1985-03-29
DK154425C (en) 1989-04-10
FR2510559A1 (en) 1983-02-04
GR76546B (en) 1984-08-10
DE3224666C2 (en) 1991-01-24
NL189666B (en) 1993-01-18

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