SE8203273L - PROCEDURE FOR PYRAZINE DERIVATIVES - Google Patents

PROCEDURE FOR PYRAZINE DERIVATIVES

Info

Publication number
SE8203273L
SE8203273L SE8203273A SE8203273A SE8203273L SE 8203273 L SE8203273 L SE 8203273L SE 8203273 A SE8203273 A SE 8203273A SE 8203273 A SE8203273 A SE 8203273A SE 8203273 L SE8203273 L SE 8203273L
Authority
SE
Sweden
Prior art keywords
formula
pyrazine derivatives
group
diaminomaleonitrile
img
Prior art date
Application number
SE8203273A
Other languages
Swedish (sv)
Other versions
SE462971B (en
Inventor
P Giardino
G Roffia
E Oppici
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of SE8203273L publication Critical patent/SE8203273L/en
Publication of SE462971B publication Critical patent/SE462971B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

The present invention relates to the preparation of pyrazine derivatives having the formula (1) < IMG > (1) wherein R1 is a hydrogen atom or lower alkyl; R2 is a hydroxy group, an alkoxy group having from 1 to 6 carbon atoms or a group of formula -NR3R4, in which R3 and R4 independently represent a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; and n is 1 or 0. Compounds of formula (1) whrein n is 0 are prepared starting from diaminomaleonitrile, having formula (2) < IMG > (2) The diaminomaleonitrile is condensed with a compound of formula CHOCOR1 and the resultant compound is reacted with an acid obtaining the pyrazine derivatives of formula (1). Some of the compounds of formula (1) show hypolipaemic and hypoglycaemic activities which are free from side effects of pyridine derivatives; the others are useful intermediates therefor.
SE8203273A 1981-05-28 1982-05-26 PROCEDURES FOR THE PREPARATION OF 5-ALKYL-2-PYRAZINE CARBONIC ACID SE462971B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8116263 1981-05-28

Publications (2)

Publication Number Publication Date
SE8203273L true SE8203273L (en) 1982-11-29
SE462971B SE462971B (en) 1990-09-24

Family

ID=10522093

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8203273A SE462971B (en) 1981-05-28 1982-05-26 PROCEDURES FOR THE PREPARATION OF 5-ALKYL-2-PYRAZINE CARBONIC ACID

Country Status (20)

Country Link
JP (1) JPS57200368A (en)
AT (1) AT387217B (en)
AU (1) AU8412682A (en)
BE (1) BE893317A (en)
CA (1) CA1237724A (en)
CH (1) CH649763A5 (en)
CS (1) CS226741B2 (en)
DE (1) DE3219407A1 (en)
DK (1) DK155325C (en)
FI (1) FI73669C (en)
FR (1) FR2506768B1 (en)
GR (1) GR76417B (en)
HU (1) HU187716B (en)
IE (1) IE52992B1 (en)
IL (1) IL65864A (en)
IT (1) IT1210478B (en)
NL (1) NL8202105A (en)
SE (1) SE462971B (en)
YU (1) YU42766B (en)
ZA (1) ZA823660B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1201417B (en) * 1985-05-17 1989-02-02 Montedison Spa PROCEDURE FOR THE PREPARATION OF 2-CARBOXYPYRAZINE 4 OXIDE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU470007B2 (en) * 1972-04-28 1976-02-26 Farmitalia Carlo Erba S.R.L. Pyrazine 4-oxide derivatives and process for their preparation
JPS565742B2 (en) * 1973-09-29 1981-02-06
JPS5134175A (en) * 1974-09-18 1976-03-23 Sagami Chem Res Pirajinjudotai no seizohoho
JPS52153980A (en) * 1976-06-17 1977-12-21 Nippon Soda Co Ltd Synthesis of 2,3-dicyanopyrazine
JPS5488281A (en) * 1977-12-20 1979-07-13 Nitsupou Kagaku Kk Manufacture of pyrazine monocarboxylic acid
JPS5488280A (en) * 1977-12-20 1979-07-13 Nitsupou Kagaku Kk Manufacture of dicyanopyradines

Also Published As

Publication number Publication date
BE893317A (en) 1982-11-29
FI73669C (en) 1987-11-09
SE462971B (en) 1990-09-24
JPS57200368A (en) 1982-12-08
FR2506768B1 (en) 1985-06-21
FI73669B (en) 1987-07-31
DE3219407C2 (en) 1990-09-06
DK155325B (en) 1989-03-28
DK239482A (en) 1982-11-29
AU8412682A (en) 1982-12-02
IL65864A0 (en) 1982-08-31
IT1210478B (en) 1989-09-14
IT8221517A0 (en) 1982-05-27
DE3219407A1 (en) 1983-01-05
ATA203682A (en) 1988-05-15
ZA823660B (en) 1983-03-30
HU187716B (en) 1986-02-28
AT387217B (en) 1988-12-27
FR2506768A1 (en) 1982-12-03
IL65864A (en) 1985-08-30
DK155325C (en) 1989-09-18
NL8202105A (en) 1982-12-16
YU113182A (en) 1985-03-20
YU42766B (en) 1988-12-31
IE52992B1 (en) 1988-04-27
CH649763A5 (en) 1985-06-14
GR76417B (en) 1984-08-10
CA1237724A (en) 1988-06-07
CS226741B2 (en) 1984-04-16
JPH0456034B2 (en) 1992-09-07
FI821832A0 (en) 1982-05-24
IE821261L (en) 1982-11-28

Similar Documents

Publication Publication Date Title
AU679859B2 (en) Novel compound, process for producing the same, and antitumor agent
KR830002757A (en) Process for preparing pyrimidine compound
HUT59563A (en) Insecticide compositions containing aryl-imidazol derivatives as active components and process for producing the active components
ES8507507A1 (en) Substituted 2-mercapto-imidazoles and their preparation and use.
IL94265A0 (en) 1-arylimidazoles,process for the preparation thereof and pesticidal compositions containing the same
JPS6114148B2 (en)
SE8203273L (en) PROCEDURE FOR PYRAZINE DERIVATIVES
ES8302723A1 (en) Process for preparing substituted pyrimidinones and intermediates therefor.
ES8706610A1 (en) Amino-alcohol derivatives and processes for their preparation.
KR830007484A (en) Method for preparing novel cinnamoyl-cinnamic acid derivatives
ES8305729A1 (en) intermediates, useful in their preparation and a process for the preparation thereof.
RO82014B (en) Process for the preparation of 4-quinolone derivatives with antihypertensive action
CA1205075A (en) Preparation of pyrazine derivatives
FR2380271A1 (en) HALOGEN-BENZOFURANONE-CARBOXYLIC ACIDS USEFUL AS SYNTHESIS INTERMEDIARIES
NO861973L (en) PROCEDURE FOR THE PREPARATION OF 2-CARBOXYPYRAZINE-4-OXYDE DERIVATIVES.
GB2108106A (en) Novel macrocyclic compounds and salts thereof useful for dissolving barium sulphate scale
ES8400111A1 (en) Pyrimidinecarbamate derivatives as intermediates
ATE6858T1 (en) PROCESS FOR THE PREPARATION OF 5-AMINOISOXAZOLES.
ES8100246A1 (en) Long chain amine derivatives and process for their preparation.
FR2377378A1 (en) NEW AMIDINES
KR840002848A (en) Method for preparing organophosphate
KR840006645A (en) Method for preparing 1-phthalidyl-5-fluorouracil derivative
FR2312255B1 (en)
KR860000285A (en) Method for preparing 1,4-dihydropyridine derivative
KR840001554A (en) Preparation of Benzamide Derivatives

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8203273-1

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8203273-1

Format of ref document f/p: F