SE8103778L - OXYTOCIN ANALOGS AND SETS FOR PREPARING THEREOF - Google Patents

OXYTOCIN ANALOGS AND SETS FOR PREPARING THEREOF

Info

Publication number
SE8103778L
SE8103778L SE8103778A SE8103778A SE8103778L SE 8103778 L SE8103778 L SE 8103778L SE 8103778 A SE8103778 A SE 8103778A SE 8103778 A SE8103778 A SE 8103778A SE 8103778 L SE8103778 L SE 8103778L
Authority
SE
Sweden
Prior art keywords
oxytocin
deamino
carba
amino
preparing
Prior art date
Application number
SE8103778A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE448303B (en
Inventor
M Lebl
K Jost
A Machova
P Hrbas
J Skopkova
J Slaninova
T Barth
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of SE8103778L publication Critical patent/SE8103778L/en
Publication of SE448303B publication Critical patent/SE448303B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Analogs of oxytocin of general formula I <IMAGE> where all amino acids are L-isomers and X is phenylalanine or phenylalanine substituted in the p-position by alkyl, ethoxy, amino, substituted amino, or nitro group, suitable for medical applications, and a method for their preparation consisting in the cyclization of linear octapeptides of general formula II <IMAGE> where X has the aforesaid meaning and Act is a group activating the carboxylic group of S-carboxyethylhomocysteine residue, e.g. an active ester. Two methods may be used for the preparation of [2-p-aminophenylalanine] deamino-6-carba-oxytocin, either the reduction of [2-p-nitrophenylalanine]- deamino-6-carba-oxytocin or deprotection of [2-p- benzyloxycarbonylaminophenylalanine] deamino-6-carba-oxytocin.
SE8103778A 1980-06-24 1981-06-16 OXYTOCIN ANALOGS WITH NATURURETIC EFFECT SE448303B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS804465A CS216722B1 (en) 1980-06-24 1980-06-24 Oxytocine analogues and method of making the same

Publications (2)

Publication Number Publication Date
SE8103778L true SE8103778L (en) 1981-12-25
SE448303B SE448303B (en) 1987-02-09

Family

ID=5387463

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8103778A SE448303B (en) 1980-06-24 1981-06-16 OXYTOCIN ANALOGS WITH NATURURETIC EFFECT

Country Status (9)

Country Link
JP (1) JPS5753448A (en)
CA (1) CA1179328A (en)
CH (1) CH649090A5 (en)
CS (1) CS216722B1 (en)
DE (1) DE3124818A1 (en)
FR (1) FR2485527B1 (en)
GB (1) GB2078755B (en)
IT (1) IT1136670B (en)
SE (1) SE448303B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK199983A (en) * 1982-05-10 1983-11-11 Ceskoslovenska Akademie Ved ANALOGUE FOR NEUROHYPOPHYSICAL HORMONS WITH INHIBITIVE PROPERTIES
JPS60198113A (en) * 1984-03-21 1985-10-07 松下電器産業株式会社 Juice squeezer of citrus fruits
JPS60166706U (en) * 1984-04-13 1985-11-06 ナショナル住宅産業株式会社 Fixed structure of exterior wall panels
ZA87275B (en) * 1986-01-16 1988-08-31 Smithkline Beckman Corp Polypeptide compounds
AT398767B (en) * 1988-05-26 1995-01-25 Gebro Broschek Gmbh Process for the purification of a crude peptide by preparative medium pressure liquid chromatography
US5225528A (en) * 1990-02-27 1993-07-06 Merck & Co., Inc. Cyclic hexapeptide oxytocin antagonists
TWI463990B (en) * 2009-09-21 2014-12-11 Ferring Bv Oxytocin receptor agonists
CN111454333B (en) * 2019-01-22 2023-06-27 南京济群医药科技股份有限公司 Preparation method of high-purity oxytocin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS194980B1 (en) * 1976-07-16 1979-12-31 Joseph H Cort Agent for current induction,fertilization facilitating and milkability increasing at mammals,especially at utility cattle

Also Published As

Publication number Publication date
FR2485527B1 (en) 1985-08-02
SE448303B (en) 1987-02-09
JPS5753448A (en) 1982-03-30
CH649090A5 (en) 1985-04-30
JPS6330318B2 (en) 1988-06-17
IT1136670B (en) 1986-09-03
FR2485527A1 (en) 1981-12-31
CA1179328A (en) 1984-12-11
DE3124818A1 (en) 1982-04-08
IT8122390A0 (en) 1981-06-17
GB2078755A (en) 1982-01-13
CS216722B1 (en) 1982-11-26
GB2078755B (en) 1984-01-18

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