SE8006870L - DISUBSTITUTED BENZOYL-ALFA-PHENOXIAL CANOYL ESTERS - Google Patents

DISUBSTITUTED BENZOYL-ALFA-PHENOXIAL CANOYL ESTERS

Info

Publication number
SE8006870L
SE8006870L SE8006870A SE8006870A SE8006870L SE 8006870 L SE8006870 L SE 8006870L SE 8006870 A SE8006870 A SE 8006870A SE 8006870 A SE8006870 A SE 8006870A SE 8006870 L SE8006870 L SE 8006870L
Authority
SE
Sweden
Prior art keywords
loweralkyl
hydrogen
image
carbon atoms
phenoxial
Prior art date
Application number
SE8006870A
Other languages
Swedish (sv)
Inventor
C W Ours
C M Lee
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of SE8006870L publication Critical patent/SE8006870L/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/90Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Described are compounds of the formula <IMAGE> wherein R1 is <IMAGE> wherein R5 and R6 are hydrogen, loweralkyl or alkylene of 4 or 5 carbon atoms, R2 is hydrogen, halo, haloloweralkyl, loweralkyl, loweralkoxy, loweralkylthio or <IMAGE> wherein R5 and R6 are as previously defined, R3 is hydroxy, alkoxy, branched alkoxy, adamantyloxy, morpholino, amino or amino substituted by loweralkyl or alkylene of 4 or 5 carbon atoms, R4 is hydrogen or loweralkyl, and X1 and X2 are hydrogen, loweralkyl, halo or when substituted on adjacent carbon atoms of the benzene ring form a 1,3-butadienylene linkage, with the proviso that X1 and X2 are not both hydrogen, and pharmaceutically acceptable salts thereof, the compounds are effective as diuretic agents in increasing urinary excretion.
SE8006870A 1979-10-09 1980-10-01 DISUBSTITUTED BENZOYL-ALFA-PHENOXIAL CANOYL ESTERS SE8006870L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8300879A 1979-10-09 1979-10-09

Publications (1)

Publication Number Publication Date
SE8006870L true SE8006870L (en) 1981-04-10

Family

ID=22175236

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8006870A SE8006870L (en) 1979-10-09 1980-10-01 DISUBSTITUTED BENZOYL-ALFA-PHENOXIAL CANOYL ESTERS

Country Status (16)

Country Link
JP (1) JPS56115746A (en)
AR (1) AR228139A1 (en)
AU (1) AU538125B2 (en)
BE (1) BE885586A (en)
CA (1) CA1149803A (en)
CH (1) CH646135A5 (en)
DE (1) DE3038011A1 (en)
ES (1) ES495751A0 (en)
FR (1) FR2467193A1 (en)
GB (1) GB2060628B (en)
GR (1) GR70775B (en)
IT (1) IT1132929B (en)
NL (1) NL8005566A (en)
PH (1) PH16254A (en)
SE (1) SE8006870L (en)
ZA (1) ZA805738B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
GB2216515A (en) * 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
US5883294A (en) * 1997-06-18 1999-03-16 The Regeants Of The University Of California Selective thyroid hormone analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5195049A (en) * 1975-02-12 1976-08-20 * **********so*****no***tsu*****************************************ni*no
US4058559A (en) 1975-09-24 1977-11-15 Abbott Laboratories 4-Aroyl-substituted phenoxy acetic acids

Also Published As

Publication number Publication date
AU6262680A (en) 1981-04-16
FR2467193A1 (en) 1981-04-17
GB2060628A (en) 1981-05-07
ZA805738B (en) 1981-09-30
AU538125B2 (en) 1984-08-02
GR70775B (en) 1983-03-22
CA1149803A (en) 1983-07-12
IT8025204A0 (en) 1980-10-08
ES8201119A1 (en) 1981-12-01
NL8005566A (en) 1981-04-13
ES495751A0 (en) 1981-12-01
GB2060628B (en) 1984-01-11
AR228139A1 (en) 1983-01-31
IT1132929B (en) 1986-07-09
FR2467193B1 (en) 1983-06-10
DE3038011A1 (en) 1981-04-23
BE885586A (en) 1981-04-08
CH646135A5 (en) 1984-11-15
JPS56115746A (en) 1981-09-11
PH16254A (en) 1983-08-16

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