SE8003761L - PROCEDURE FOR PREPARING A MODIFIED CRYSTAL FORM OF FLUNISOLIDE - Google Patents

PROCEDURE FOR PREPARING A MODIFIED CRYSTAL FORM OF FLUNISOLIDE

Info

Publication number
SE8003761L
SE8003761L SE8003761A SE8003761A SE8003761L SE 8003761 L SE8003761 L SE 8003761L SE 8003761 A SE8003761 A SE 8003761A SE 8003761 A SE8003761 A SE 8003761A SE 8003761 L SE8003761 L SE 8003761L
Authority
SE
Sweden
Prior art keywords
flunisolide
preparing
procedure
crystal form
modified crystal
Prior art date
Application number
SE8003761A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE431549B (en
Inventor
R E Jones
J A Smithers
Original Assignee
Syntex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Corp filed Critical Syntex Corp
Publication of SE8003761L publication Critical patent/SE8003761L/en
Publication of SE431549B publication Critical patent/SE431549B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A unique crystalline form of flunisolide is prepared by crystallizing flunisolide from a solution thereof in an alkanol of three or four carbon atoms, e.g. n-butanol, containing 0.2 to 5%, preferably 1.0 to 4.0% by volume water.
SE8003761A 1979-05-21 1980-05-20 PROCEDURE FOR PREPARING A CRYSTAL INFORMATION OF FLUNISOLIDE (6ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLIDENIDIOXIPREGNA-1,4-DIENE-3,20-DION) SE431549B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4083079A 1979-05-21 1979-05-21

Publications (2)

Publication Number Publication Date
SE8003761L true SE8003761L (en) 1980-11-22
SE431549B SE431549B (en) 1984-02-13

Family

ID=21913206

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8003761A SE431549B (en) 1979-05-21 1980-05-20 PROCEDURE FOR PREPARING A CRYSTAL INFORMATION OF FLUNISOLIDE (6ALFA-FLUOR-11BETA, 21-DIHYDROXY-16ALFA, 17ALFA-ISOPROPYLIDENIDIOXIPREGNA-1,4-DIENE-3,20-DION)

Country Status (17)

Country Link
JP (1) JPS55154997A (en)
AU (1) AU532084B2 (en)
BE (1) BE883381A (en)
CA (1) CA1153761A (en)
CH (1) CH643567A5 (en)
DE (1) DE3019250C2 (en)
DK (1) DK162530C (en)
FR (1) FR2457303A1 (en)
GB (1) GB2052506B (en)
HK (1) HK40784A (en)
IL (1) IL60128A (en)
IT (1) IT1133092B (en)
MY (1) MY8500694A (en)
NL (1) NL189201C (en)
NZ (1) NZ193778A (en)
SE (1) SE431549B (en)
SG (1) SG37585G (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1121513B (en) * 1979-05-28 1986-04-02 Chiesi Farma Spa PROCESS FOR THE CONVERSION OF ANTI-INFLAMMATORY STEROID UMO IN A SUSCEPTIBLE FORM OF BEING ADMINISTERED AS AN AEROSOL

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX3864E (en) * 1975-05-27 1981-08-26 Syntex Corp A PROCESS TO PREPARE THE CRYSTALLINE COMPOUND 6-FLUIRO-11B 21-DIHIROXI-16 17-ISOPROPILIDENDIOXIPREGNA-1 4-DIEN-3 20-DIONA

Also Published As

Publication number Publication date
JPS6258360B2 (en) 1987-12-05
JPS55154997A (en) 1980-12-02
CH643567A5 (en) 1984-06-15
IL60128A (en) 1984-01-31
HK40784A (en) 1984-05-18
FR2457303A1 (en) 1980-12-19
NL189201C (en) 1993-02-01
BE883381A (en) 1980-11-20
AU5856680A (en) 1980-11-27
CA1153761A (en) 1983-09-13
NL189201B (en) 1992-09-01
FR2457303B1 (en) 1983-05-13
DK219280A (en) 1980-11-22
NL8002902A (en) 1980-11-25
DK162530B (en) 1991-11-11
DE3019250C2 (en) 1982-11-11
IL60128A0 (en) 1980-07-31
SG37585G (en) 1986-01-17
DK162530C (en) 1992-03-30
DE3019250A1 (en) 1980-12-04
AU532084B2 (en) 1983-09-15
MY8500694A (en) 1985-12-31
GB2052506A (en) 1981-01-28
NZ193778A (en) 1982-03-16
IT1133092B (en) 1986-07-09
SE431549B (en) 1984-02-13
IT8067791A0 (en) 1980-05-20
GB2052506B (en) 1983-01-19

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