SE7905992L - 1-phenyl-1-propanol - Google Patents

1-phenyl-1-propanol

Info

Publication number
SE7905992L
SE7905992L SE7905992A SE7905992A SE7905992L SE 7905992 L SE7905992 L SE 7905992L SE 7905992 A SE7905992 A SE 7905992A SE 7905992 A SE7905992 A SE 7905992A SE 7905992 L SE7905992 L SE 7905992L
Authority
SE
Sweden
Prior art keywords
radical
linear
branched
phenyl
substituted
Prior art date
Application number
SE7905992A
Other languages
Swedish (sv)
Other versions
SE446631B (en
Inventor
G Lambelin
R Roncucci
J Roba
C Gillet
Original Assignee
Continental Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma filed Critical Continental Pharma
Publication of SE7905992L publication Critical patent/SE7905992L/en
Publication of SE446631B publication Critical patent/SE446631B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises derivatives of 1-phenyl-1-propanol of the general formula I: <IMAGE> wherein: (a) R1 represents hydrogen, a linear or branched alkylthio (C1-C3), linear or branched alkylsulfinyl (C1-C3), linear or branched alkylsulfonyl (C1-C3) or mercapto radical; (b) R2 represents: b-1 a hydroxy radical; b-2 an oxo-2-pyrrolidinyl-1 radical which may be substituted by a hydroxy group; b-3 a NHR3 radical wherein R3 represents: -hydrogen -a linear or branched alkyl (C6-C16) radical or a linear alkyl (C2-C4) radical substituted by a phenyl or phenoxy group, with the proviso that R1 is not an alkylthio radical -a linear or branched alkyl (C1-C7) radical substituted by a lower carboxy or carbalkoxy (C1-C3) group in the position omega ; as well as non toxic and pharmaceutically acceptable salts and esters of these derivatives.
SE7905992A 1978-07-13 1979-07-10 1-PHENYL-1-PROPANOL DERIVATIVES AND SETS TO PREPARE THIS SE446631B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU79970A LU79970A1 (en) 1978-07-13 1978-07-13 PROCESS FOR THE PREPARATION OF 1-PHENYL-1-PROPANOL DERIVATIVES

Publications (2)

Publication Number Publication Date
SE7905992L true SE7905992L (en) 1980-01-14
SE446631B SE446631B (en) 1986-09-29

Family

ID=19728955

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7905992A SE446631B (en) 1978-07-13 1979-07-10 1-PHENYL-1-PROPANOL DERIVATIVES AND SETS TO PREPARE THIS

Country Status (18)

Country Link
JP (1) JPS5943943B2 (en)
AT (1) AT368491B (en)
BE (1) BE877694A (en)
CA (1) CA1127164A (en)
CH (1) CH644355A5 (en)
DE (1) DE2927789A1 (en)
DK (1) DK293779A (en)
ES (1) ES482432A1 (en)
FI (1) FI792123A (en)
FR (2) FR2438649A1 (en)
GB (1) GB2025417B (en)
IT (1) IT1122180B (en)
LU (1) LU79970A1 (en)
NL (1) NL7905507A (en)
NO (1) NO148452C (en)
PT (1) PT69909A (en)
SE (1) SE446631B (en)
ZA (1) ZA793554B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128117A1 (en) * 1980-07-29 1982-03-11 Yamanouchi Pharmaceutical Co., Ltd., Tokyo NEW PHENYL-AETHYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF
LU83039A1 (en) * 1980-12-24 1982-07-07 Continental Pharma METHODS OF SYNTHESIS OF 1- (4 ISOPROPYLTHIOPHENYL) -2-N OCTYLAMINOPROPANOL
DE3262620D1 (en) * 1981-05-27 1985-04-25 Maggioni Farma 4-alkyl-thiophenyl-ethanolamines, having an activity on the cerebral circulation, the blood platelet-aggregation and the lipemia
FR2537132B1 (en) * 1982-12-06 1987-01-09 Lafon Labor NOVEL SULFUR DERIVATIVES OF 2-AMINO-1-PHENYL-1-ETHANOL, USE IN THERAPEUTICS AND METHOD OF PREPARATION
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
BE1014245A4 (en) * 2001-04-03 2003-07-01 Malak Jean Chemical compounds octopamine derivatives and uses thereof as agonists beta 3-adrenergic.
US8178077B2 (en) 2004-10-19 2012-05-15 Reverse Proteomics Research Institute Co., Ltd. Drug development target protein and target gene, and method of screening
IL187245A0 (en) * 2007-11-08 2008-12-29 Hadasit Med Res Service Synthetic sphingolipid analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1366096A (en) * 1962-05-28 1964-07-10 Castrol Ltd Copolymers for use in lubricating oil compositions and their intermediates
FR1480780A (en) * 1965-05-24 1967-05-12 Shell Int Research Pyrrolidone production

Also Published As

Publication number Publication date
IT7924357A0 (en) 1979-07-13
FI792123A (en) 1980-01-14
NO792329L (en) 1980-01-15
PT69909A (en) 1979-08-01
DE2927789A1 (en) 1980-01-24
FR2438649A1 (en) 1980-05-09
JPS5943943B2 (en) 1984-10-25
DK293779A (en) 1980-01-14
FR2438649B1 (en) 1983-03-25
FR2443457A1 (en) 1980-07-04
ZA793554B (en) 1980-06-25
LU79970A1 (en) 1980-02-14
NO148452B (en) 1983-07-04
ATA483579A (en) 1982-02-15
SE446631B (en) 1986-09-29
ES482432A1 (en) 1980-04-01
NL7905507A (en) 1980-01-15
AT368491B (en) 1982-10-11
CA1127164A (en) 1982-07-06
IT1122180B (en) 1986-04-23
FR2443457B1 (en) 1983-09-23
NO148452C (en) 1983-10-12
JPS5533467A (en) 1980-03-08
GB2025417B (en) 1983-03-02
GB2025417A (en) 1980-01-23
CH644355A5 (en) 1984-07-31
BE877694A (en) 1979-11-05

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