SE7707892L - (3-AMINO-5-SUBSTITUTED-6-FLUOROPYRAZINOYL OR PYRAZAMIDO) GUANIDINS AND DERIVATIVES THEREOF, SUBSTITUTING GUANIDINOCVEVENA - Google Patents

(3-AMINO-5-SUBSTITUTED-6-FLUOROPYRAZINOYL OR PYRAZAMIDO) GUANIDINS AND DERIVATIVES THEREOF, SUBSTITUTING GUANIDINOCVEVENA

Info

Publication number
SE7707892L
SE7707892L SE7707892A SE7707892A SE7707892L SE 7707892 L SE7707892 L SE 7707892L SE 7707892 A SE7707892 A SE 7707892A SE 7707892 A SE7707892 A SE 7707892A SE 7707892 L SE7707892 L SE 7707892L
Authority
SE
Sweden
Prior art keywords
fluoropyrazinoyl
derivatives
amino
substituted
pyrazamido
Prior art date
Application number
SE7707892A
Other languages
Swedish (sv)
Other versions
SE428687B (en
Inventor
Jr E J Cragoe
Jr W Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7707892L publication Critical patent/SE7707892L/en
Publication of SE428687B publication Critical patent/SE428687B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention is concerned with (3-amino-5-substituted-6-fluoropyrazinoyl or pyrazinamido)guanidine compounds and derivatives thereof bearing substituents on the guanidine nitrogens. These compounds possess useful natriuretic properties. Also included are processes for preparing these compounds and a novel intermediate used in the preparation of these compounds.
SE7707892A 1976-07-23 1977-07-06 PROCEDURE FOR THE PREPARATION OF (3,5-DIAMINO-6-FLUORO-PYRAZINOYL) GUANIDINE SE428687B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/708,254 US4087526A (en) 1976-07-23 1976-07-23 (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

Publications (2)

Publication Number Publication Date
SE7707892L true SE7707892L (en) 1978-01-24
SE428687B SE428687B (en) 1983-07-18

Family

ID=24845039

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7707892A SE428687B (en) 1976-07-23 1977-07-06 PROCEDURE FOR THE PREPARATION OF (3,5-DIAMINO-6-FLUORO-PYRAZINOYL) GUANIDINE

Country Status (9)

Country Link
US (1) US4087526A (en)
JP (1) JPS5315389A (en)
CH (1) CH634060A5 (en)
DE (1) DE2733291A1 (en)
DK (1) DK145019C (en)
FR (1) FR2366285A1 (en)
GB (1) GB1579035A (en)
NL (1) NL7707511A (en)
SE (1) SE428687B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4246406A (en) * 1979-03-27 1981-01-20 Merck & Co., Inc. Heterocyclic substituted pyrazinoylguanidines
US4224447A (en) * 1979-03-27 1980-09-23 Merck & Co., Inc. Novel pyrazinecarboxamides and processes for preparing same
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4604394A (en) * 1984-10-01 1986-08-05 Merck & Co., Inc. Antiarrhythmic compositions and method
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
ES2619954T3 (en) 2012-12-17 2017-06-27 Parion Sciences, Inc. Chloropiracinocarboxamide derivatives useful for the treatment of diseases favored by insufficient mucous hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299929A (en) * 1962-10-30
BE639386A (en) * 1962-10-30
FR1525670A (en) * 1966-08-25 1968-05-17 Merck & Co Inc Process for manufacturing substituted guanidines
FR7797M (en) * 1968-10-31 1970-03-31

Also Published As

Publication number Publication date
CH634060A5 (en) 1983-01-14
FR2366285A1 (en) 1978-04-28
SE428687B (en) 1983-07-18
DK300977A (en) 1978-01-24
GB1579035A (en) 1980-11-12
DE2733291A1 (en) 1978-01-26
FR2366285B1 (en) 1980-02-01
DK145019C (en) 1982-12-27
US4087526A (en) 1978-05-02
DK145019B (en) 1982-08-02
NL7707511A (en) 1978-01-25
JPS5315389A (en) 1978-02-13

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