SE7700077L - PROCEDURE FOR THE PREPARATION OF 3-ACYLOXIMETHYL-2-CEFEM COMPOUNDS - Google Patents

PROCEDURE FOR THE PREPARATION OF 3-ACYLOXIMETHYL-2-CEFEM COMPOUNDS

Info

Publication number
SE7700077L
SE7700077L SE7700077A SE7700077A SE7700077L SE 7700077 L SE7700077 L SE 7700077L SE 7700077 A SE7700077 A SE 7700077A SE 7700077 A SE7700077 A SE 7700077A SE 7700077 L SE7700077 L SE 7700077L
Authority
SE
Sweden
Prior art keywords
preparation
acyloximethyl
procedure
acyloxymethyl
delta
Prior art date
Application number
SE7700077A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE433849B (en
Inventor
G A Koppel
T-S Chou
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/650,583 external-priority patent/US4029651A/en
Priority claimed from US05/650,585 external-priority patent/US4031082A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE7700077L publication Critical patent/SE7700077L/en
Publication of SE433849B publication Critical patent/SE433849B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02Preparation
    • C07D501/04Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

3-Acyloxymethyl-delta<2>-cephem compounds of the formula (I) <IMAGE> in which the substituents are defined in Claim 1, are obtained by reacting a 3-exomethylenecepham sulphoxide with a mixture of an acyl compound and of an appropriate anhydride at a temperature from 70 to 140 DEG C. The 3-acyloxymethyl-delta<2>-cephem esters of the formula I are generally valuable intermediates in the preparation of cephalosporins with antibiotic activity.
SE7700077A 1976-01-19 1977-01-04 PROCEDURE FOR PREPARING 3 ACYLOXIMETHYL-2-CEFEM SUBSTANCES SE433849B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/650,583 US4029651A (en) 1976-01-19 1976-01-19 Process for preparing 3-acyloxymethyl-2-cephem compounds
US05/650,585 US4031082A (en) 1976-01-19 1976-01-19 Process for preparing 3-acycloxymethyl-2-cephem compounds

Publications (2)

Publication Number Publication Date
SE7700077L true SE7700077L (en) 1977-07-20
SE433849B SE433849B (en) 1984-06-18

Family

ID=27095900

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7700077A SE433849B (en) 1976-01-19 1977-01-04 PROCEDURE FOR PREPARING 3 ACYLOXIMETHYL-2-CEFEM SUBSTANCES

Country Status (25)

Country Link
JP (1) JPS5289698A (en)
AR (1) AR213426A1 (en)
AT (1) AT348121B (en)
AU (1) AU503930B2 (en)
BG (1) BG30473A3 (en)
CH (1) CH628059A5 (en)
CS (1) CS192474B2 (en)
DD (1) DD128734A5 (en)
DE (1) DE2656144C2 (en)
DK (1) DK17977A (en)
FR (1) FR2338280A1 (en)
GB (1) GB1566526A (en)
GR (1) GR65892B (en)
HU (1) HU173592B (en)
IE (1) IE44133B1 (en)
IL (1) IL51021A (en)
MX (1) MX3766E (en)
NL (1) NL7700500A (en)
NZ (1) NZ182737A (en)
PL (1) PL104370B1 (en)
PT (1) PT66007B (en)
RO (1) RO69710A (en)
SE (1) SE433849B (en)
SU (1) SU703023A3 (en)
YU (1) YU8677A (en)

Also Published As

Publication number Publication date
IE44133B1 (en) 1981-08-26
GB1566526A (en) 1980-04-30
IL51021A0 (en) 1977-01-31
JPS5289698A (en) 1977-07-27
ATA28177A (en) 1978-06-15
CH628059A5 (en) 1982-02-15
SE433849B (en) 1984-06-18
NL7700500A (en) 1977-07-21
DE2656144A1 (en) 1977-07-21
MX3766E (en) 1981-06-25
CS192474B2 (en) 1979-08-31
DE2656144C2 (en) 1985-08-29
PL195386A1 (en) 1978-02-27
AU2023876A (en) 1978-06-08
PT66007B (en) 1978-06-16
PT66007A (en) 1977-01-01
IE44133L (en) 1977-07-19
YU8677A (en) 1982-06-30
AU503930B2 (en) 1979-09-27
JPS6120557B2 (en) 1986-05-22
HU173592B (en) 1979-06-28
RO69710A (en) 1980-07-15
DD128734A5 (en) 1977-12-07
FR2338280A1 (en) 1977-08-12
AR213426A1 (en) 1979-01-31
GR65892B (en) 1980-12-01
IL51021A (en) 1979-09-30
BG30473A3 (en) 1981-06-15
NZ182737A (en) 1978-04-28
DK17977A (en) 1977-07-20
SU703023A3 (en) 1979-12-05
PL104370B1 (en) 1979-08-31
AT348121B (en) 1979-01-25
FR2338280B1 (en) 1979-09-28

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