SE7504719L - Forfarande for framstellning av 1,3-bis(2-kloretyl)-1-nitrosokarbamid - Google Patents
Forfarande for framstellning av 1,3-bis(2-kloretyl)-1-nitrosokarbamidInfo
- Publication number
- SE7504719L SE7504719L SE7504719A SE7504719A SE7504719L SE 7504719 L SE7504719 L SE 7504719L SE 7504719 A SE7504719 A SE 7504719A SE 7504719 A SE7504719 A SE 7504719A SE 7504719 L SE7504719 L SE 7504719L
- Authority
- SE
- Sweden
- Prior art keywords
- compounds
- bis
- solvents
- nitrosourea
- chloroethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- LZDSILRDTDCIQT-UHFFFAOYSA-N dinitrogen trioxide Chemical compound [O-][N+](=O)N=O LZDSILRDTDCIQT-UHFFFAOYSA-N 0.000 abstract 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000003125 aqueous solvent Substances 0.000 abstract 2
- 150000002170 ethers Chemical class 0.000 abstract 2
- -1 ethyl acetate Chemical class 0.000 abstract 2
- 238000007034 nitrosation reaction Methods 0.000 abstract 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 1
- VBWBRZHAGLZNST-UHFFFAOYSA-N 1,3-bis(2-chloroethyl)urea Chemical compound ClCCNC(=O)NCCCl VBWBRZHAGLZNST-UHFFFAOYSA-N 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical class CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 150000001336 alkenes Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 150000002690 malonic acid derivatives Chemical class 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
- 230000009935 nitrosation Effects 0.000 abstract 1
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
- C07C275/68—N-nitroso ureas
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/523,334 US4028410A (en) | 1974-11-13 | 1974-11-13 | Process of preparing 1,3-bis(2-chloroethyl)-1-nitrosourea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7504719L true SE7504719L (sv) | 1976-05-14 |
Family
ID=24084603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7504719A SE7504719L (sv) | 1974-11-13 | 1975-04-23 | Forfarande for framstellning av 1,3-bis(2-kloretyl)-1-nitrosokarbamid |
Country Status (8)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56120662A (en) * | 1980-02-28 | 1981-09-22 | Kowa Co | Novel nitrosourea derivative and its preparation |
| JPS57116043A (en) * | 1981-01-12 | 1982-07-19 | Tetsuo Suami | New nitrosourea derivative and its preparation |
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| GB9719426D0 (en) * | 1997-09-13 | 1997-11-12 | Johnson Matthey Plc | Novel process |
| WO2007085026A2 (en) * | 2006-01-20 | 2007-07-26 | The Board Of Regents Of The University Of Texas System | Compositions and methods for the direct therapy of tumors |
| JP6325139B2 (ja) * | 2016-03-02 | 2018-05-16 | ネルファルマ・エッセ・エッルレ・エッレ | カルムスチンの安全で効率的な製造方法 |
| WO2017154019A1 (en) * | 2016-03-11 | 2017-09-14 | Msn Laboratories Private Limited | An improved process for the preparation of 1,3-bis(2-chloroethyl)-1-nitrosourea |
| EP3442941B1 (en) | 2016-04-16 | 2021-12-01 | Intas Pharmaceuticals Limited | Process for preparation of carmustine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3465025A (en) * | 1966-11-17 | 1969-09-02 | Allied Chem | Process for the preparation of isocyanates |
-
1974
- 1974-11-13 US US05/523,334 patent/US4028410A/en not_active Expired - Lifetime
-
1975
- 1975-04-03 GB GB1363475A patent/GB1469381A/en not_active Expired
- 1975-04-23 SE SE7504719A patent/SE7504719L/xx unknown
- 1975-04-29 FR FR7513437A patent/FR2291187A1/fr active Granted
- 1975-05-14 CA CA226,863A patent/CA1082223A/en not_active Expired
- 1975-05-19 JP JP50059538A patent/JPS5156414A/ja active Pending
- 1975-06-25 DE DE19752528365 patent/DE2528365A1/de not_active Withdrawn
- 1975-07-04 CH CH881175A patent/CH598204A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU8007675A (en) | 1976-10-14 |
| DE2528365A1 (de) | 1976-05-20 |
| CH598204A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-04-28 |
| US4028410A (en) | 1977-06-07 |
| JPS5156414A (en) | 1976-05-18 |
| GB1469381A (en) | 1977-04-06 |
| CA1082223A (en) | 1980-07-22 |
| FR2291187A1 (fr) | 1976-06-11 |
| FR2291187B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-04-04 |
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