SE538154C2 - Control mechanism for insertion and withdrawal of a sample holder in an isothermal calorimeter - Google Patents
Control mechanism for insertion and withdrawal of a sample holder in an isothermal calorimeter Download PDFInfo
- Publication number
- SE538154C2 SE538154C2 SE1351147A SE1351147A SE538154C2 SE 538154 C2 SE538154 C2 SE 538154C2 SE 1351147 A SE1351147 A SE 1351147A SE 1351147 A SE1351147 A SE 1351147A SE 538154 C2 SE538154 C2 SE 538154C2
- Authority
- SE
- Sweden
- Prior art keywords
- sample holder
- guiding mechanism
- vials
- contact
- sample
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
- G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
- G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
- G01N25/4853—Details
- G01N25/486—Sample holders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K17/00—Measuring quantity of heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
- G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Abstract
ABSTRACT The present invention relates to a guiding mechanism (1) for insertion andretrieval of a sample holder (2) for sample vials in a sample isothermal calorimeter(3) with horizontal sample insertion and retrieval. The guiding mechanism (1)comprises guide rails (41) and guide pins (51, 52, 53) adapted to provide a verticalmovement of the sample holder (2) during the horizontal inserting and retrievingmovement. The guiding mechanism (1) is adapted to lower the sample holder (2)to place any vials (61, 62, 6n) in the sample holder (2) in contact with theunderlying surface (31) of the calorimeter (3) only when the correct position forsuch contact is reached and to lift the sample holder (2) so that there is no contactbetween any vials (61, 62, 6n)in the sample holder (2) and underlying surface (31) during other parts of the horizontal movement. (Fig. 1)
Description
GUIDING MECHANISM Field of inventionThe present invention relates to a guiding mechanism for insertion andretrieval of a sample holder for sample vials in a sample isothermal calorimeter with horizontal sample insertion and retrieval.
Description of background art Patent publication WO 2007/139498 discloses parallel sample isothermalcalorimetry performed using microtiter plate layout where horizontal sampleloading requires a mechanism to enter the sample plate to the equilibrium andmeasurement positions respectively. Sample insertion by horizontal movementallows contact between the thermostatic regulated inner surfaces of the preheating equilibrium chamber via the vial bottom to allow heat transfer to occur.
Upon transferring the vials to the measurement position the vials arepositioned to heat flow sensitive sensors.
Summary of the present invention Problems A horizontal movement where sample vials are moved across the heat-flow sensors creates a contact friction heat of a magnitude large enough tointerfere with measurements in the nano to micro Watt scale. This results in a longand undesired recovery time prior to equilibrium. Another problem is potentialstatic electricity buildup that needs to be minimized. l\/lechanical and geometrical constraints further prevents the sample vialsto freely pass over multiple rows of sensor used in multi-channel plate formatcalorimetry as described patent publication WO 2007/139498.
Solution From the standpoint of a guiding mechanism according to the field ofinvention and with the purpose of solving one or more of the above mentionedproblems, the present invention teaches that that the guiding mechanism comprises guide rails and guide pins adapted to provide a vertical movement of 2 the sample holder during the horizontal inserting and retrieving movement. Theguiding mechanism is adapted to lower the sample holder to place any vials in thesample holder in contact with the underlying surface of the calorimeter only whenthe correct position for such contact is reached and to lift the sample holder so thatthere is no contact between any vials in the sample holder and underlying surfaceduring other parts of the horizontal movement.
A first position for contact between any vials in the sample holder and theunderlying surface is in a position for equilibrium. ln this position the underlyingsurface may be a thermostatic regulated inner surface of a pre heating equilibriumchamber, where the contact allow heat transfer to occur between the vial sampleand the thermostatic regulated surface via the vial bottom.
A second position for contact between any vials in the sample holder andthe underlying surface is in a position for measurement. ln this position theunderlying surface comprises heat flow sensitive sensors used for measurements.lt is proposed that the second position is adapted to guide the sample holder intoposition where a pairing of sensors and vials is achieved.
The present invention teaches that the vertical movement provided by theguiding mechanism in any position where any vials in the sample holder are to bein contact with the underlying surface is adapted to be at least sufficient to releaseany vial from the vertical lifting force of the sample holder.
The guide rails can be built into a frame of the sample holder, in whichcase the guide pins are built into enclosing material of the calorimeter.
With the guide rails in the frame of the sample holder it is proposed thatthree parts of the guide rails that are adapted to lower the sample holder are builtunto each side of the frame, that the distance between a first and second part onone side differs from the distance between the second and third part on the sameside, and that the guide pins are positioned to match the parts at the correctposition for providing a contact between any vials and the underlying surface. lt is also possible that the guide rails are built into enclosing material of thecalorimeter, in which case the guide pins are built into a frame of the sampleholder.
With the guide pins in the frame of the sample holder it is proposed thatthree guide pins are built unto each side of the frame, that the distance between a first and second guide pin on one side differs from the distance between the 3 second and third guide pin on the same side, and that the parts of the guide railsthat are adapted to lower the sample holder are positioned to match the guide pinsat the correct position for providing a contact between any vials and the underlying surface.
AdvantagesThe advantages of a guiding mechanism according to the present invention are that the friction between vial and sensor is minimized andmeasurement equilibrium is acquired at a fast pace compared to multiple frictionheat buildup.
The completely mechanical execution of transfer from horizontal to verticalmovement allows for a high degree of reliability and ease of construction.
Brief description of the drawingsA guiding mechanism according to the present invention will now bedescribed in detail with reference to the accompanying drawings, in which:Figure 1 is a schematic and simplified side view of a calorimeter with aninventive guiding mechanism where a sample holder is in afirst position,Figure 2 is a schematic and simplified cross sectional front view of acalorimeter with an inventive guiding mechanism,Figure 3 is a schematic and simplified side view of a calorimeter with aninventive guiding mechanism where a sample holder is in asecond position,Figure 4 is a schematic and simplified side view of a calorimeter and itsdifferent areas for equilibrium and measurement,Figure 5 is a schematic and simplified side view of a calorimeter with aninventive guiding mechanism according to an alternativeembodiment where a sample holder is in a first position,Figure 6 is a schematic and simplified cross sectional front view of acalorimeter with an alternative embodiment of inventive guiding mechanism, and 4 Figure 7 is a schematic and Simplified side view of a calorimeter with aninventive guiding mechanism according to an alternative embodiment where a sample holder is in a second position.
Description of embodiments as presently preferred The present invention will now be described with reference to figure 1showing a guiding mechanism 1 for insertion and retrieval of a sample 2 holder forsample vials in a sample isothermal calorimeter 3 with horizontal sample insertionand retrieval. lt can be seen that the guiding mechanism 1 comprises guide rails 41 andguide pins 51, 52, 53 adapted to provide a vertical movement of the sample holder2 during the horizontal inserting and retrieving movement. Figure 2 is a crosssectional front view of the guiding mechanism 1 showing both guide rails 41, 42 onboth sides of the sample holder 2 and guide pins 51, 54 in the calorimeter 3.
Figure 1 shows a position where the sample holder 2 lowered by theguiding mechanism 1 to place any vials 61, 62, 6n in the sample holder 2 incontact with the underlying surface 31 of the calorimeter 3. The guidingmechanism 1 is adapted to provide such vertical lowering movement only whenthe correct position for such contact is reached and, as can be seen in figure 3, tolift the sample holder so that there is no contact between any vials 61, 62, 6n inthe sample holder 2 and underlying surface 31 during other parts of the horizontalmovement.
Figure 4 shows a calorimeter 3 with horizontal sample insertion andretrieval where it can be seen that a first position P1 for contact between any vialsin the sample holder and the underlying surface 311 is in a position for equilibrium.
The underlying surface 311 in the first position P1 is a thermostaticregulated inner surface 32 of a pre heating equilibrium chamber. ln this positionthe contact allow heat transfer to occur between the vial sample and thethermostatic regulated surface 32 via the vial bottom in its contact with the surface31 1.
A second position P2 for contact between any vials in the sample holderand the underlying surface 312 is in a position for measurement.
The underlying surface 312 in the second position P2 comprises heat flow sensitive sensors 33 used for measurements. ln this position the guiding 5 mechanism is adapted to guide the sample holder into a position where pairing ofsensors 33 and vials is achieved.
Uneven sizes of the vials, an uneven surface in the equilibrium chamberand sensors in the measurement position that are not all positioned in the exactsame horizontal plane will cause the vials to stand on different heights in relationto each other and to the sample holder when in contact with the underlyingsurface. Hence, the present invention teaches that the vertical movement providedby the guiding mechanism in any position where any vials in the sample holder areto be in contact with the underlying surface is adapted to be at least sufficient torelease any vial from the vertical lifting force of the sample holder in order for eachvial to rest on the surface and have a good thermal contact with the surface.
Figures 1, 2 and 3 shows an embodiment where the guide rails 41, 42 arebuilt into a frame of the sample holder 2 and the guide pins 51, 52, 53, 54 are builtinto enclosing material of the calorimeter 3.
Here it can be seen that three parts 41 a, 41 b, 41 c of the guide rails 41 thatare adapted to lower the sample holder 2 are built unto each side of the frame.With the purpose of providing a reliable movement of the sample holder 2 it isproposed that the distance d1 between a first and second part 41 a, 41 b on oneside differs from the distance d2 between the second and third part 41 b, 41 c onthe same side, and that the guide pins 51, 52, 53 are positioned to match the partsat the correct position providing for a contact between any vials and the underlyingsurface.
Figures 1 and 3 shows guide pins required to lower the sample holder inone position so it can be understood that at least six guide pins are used for oneside in order to provide two separate positions where the sample holder can belowered.
Figures 5, 6 and 7 shows an alternative embodiment where the guide rails43, 44 are built into enclosing material of the calorimeter 3 and that the guide pins55, 56, 57, 58 are built into a frame of the sample holder 2.
Here it can be seen that three guide pins 55, 56, 57 are built unto eachside of the frame, that the distance d3 between a first and second guide pin 55, 56on one side differs from the distance d4 between the second and third guide pin56, 57 on the same side, and that the parts 43a, 43b, 43c of the guide rails 43 that are adapted to lower the sample holder 2 are positioned to match the guide pins 6 55, 56, 57 at the correct position for providing a contact between any vials 61, 62,6n and the underlying surface 31.
It will be understood that the invention is not restricted to the aforede-scribed and illustrated exemplifying embodiments thereof and that modificationscan be made within the scope of the invention as defined by the accompanyingClaims.
Claims (11)
1. A guiding mechanism for insertion and retrieval of a sample holder forsample vials in a sample isothermal calorimeter with horizontal sample insertionand retrieval, characterized in, that the guiding mechanism comprises guide railsand guide pins adapted to provide a vertical movement of the sample holderduring the horizontal inserting and retrieving movement, that the guidingmechanism is adapted to lower the sample holder to place any vials in the sampleholder in contact with the underlying surface of the calorimeter only when thecorrect position for such contact is reached and to lift the sample holder so thatthere is no contact between any vials in the sample holder and underlying surfaceduring other parts of the horizontal movement.
2. A guiding mechanism according to claim 1, characterized in, that a firstposition for contact between any vials in the sample holder and the underlying surface is in a position for equilibrium.
3. A guiding mechanism according to claim 2, characterized in, that theunderlying surface in the first position is a thermostatic regulated inner surface of apre heating equilibrium chamber, and that the contact allow heat transfer to occurbetween the vial sample and the thermostatic regulated surface via the vial bottom.
4. A guiding mechanism according to any preceding claim, characterized in,that a second position for contact between any vials in the sample holder and the underlying surface is in a position for measurement.
5. A guiding mechanism according to claim 4, characterized in, that theunderlying surface in the second position comprises heat flow sensitive sensors USGÖ fOl' meaSUfementS.
6. A guiding mechanism according to claim 5, characterized in, that thesecond position is adapted to guide the sample holder into a position where pairing of sensors and vials is achieved.
7. A guiding mechanism according to any preceding claim, characterized in,that the vertical movement provided by the guiding mechanism in any positionwhere any vials in the sample holder are to be in contact with the underlyingsurface is adapted to be at least sufficient to release any vial from the verticallifting force of the sample holder.
8. A guiding mechanism according to any preceding claim, characterized in,that the guide rails are built into a frame of the sample holder and that the guide pins are built into enclosing material of the calorimeter.
9. A guiding mechanism according to claim 8, characterized in, that threeparts of the guide rails that are adapted to lower the sample holder are built untoeach side of the frame, that the distance between a first and second part on oneside differs from the distance between the second and third part on the same side,and that the guide pins are positioned to match the parts at the correct position providing for a contact between any vials and the underlying surface.
10.characterized in, that the guide rails are built into enclosing material of the A guiding mechanism according to any one of claims 1 to 7, calorimeter and that the guide pins are built into a frame of the sample holder.
11. A guiding mechanism according to claim 10, characterized in, that threeguide pins are built unto each side of the frame, that the distance between a firstand second guide pin on one side differs from the distance between the secondand third guide pin on the same side, and that the parts of the guide rails that areadapted to lower the sample holder are positioned to match the guide pins at thecorrect position for providing a contact between any vials and the underlying surface.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351147A SE538154C2 (en) | 2013-09-30 | 2013-09-30 | Control mechanism for insertion and withdrawal of a sample holder in an isothermal calorimeter |
| PCT/SE2014/050954 WO2015047159A1 (en) | 2013-09-30 | 2014-08-20 | Guiding mechanism for a sample holder in a sample isothermal calorimeter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1351147A SE538154C2 (en) | 2013-09-30 | 2013-09-30 | Control mechanism for insertion and withdrawal of a sample holder in an isothermal calorimeter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE1351147A1 SE1351147A1 (en) | 2015-03-31 |
| SE538154C2 true SE538154C2 (en) | 2016-03-22 |
Family
ID=52744096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE1351147A SE538154C2 (en) | 2013-09-30 | 2013-09-30 | Control mechanism for insertion and withdrawal of a sample holder in an isothermal calorimeter |
Country Status (2)
| Country | Link |
|---|---|
| SE (1) | SE538154C2 (en) |
| WO (1) | WO2015047159A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106546358B (en) * | 2015-09-23 | 2019-05-24 | 深圳市易流科技股份有限公司 | A kind of temperature-sensing probe and vehicle electronics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE530138C2 (en) * | 2006-05-30 | 2008-03-11 | Symcel Ab | Device and method for measuring heat flow from at least one sample and vessel unit for placement in said device |
-
2013
- 2013-09-30 SE SE1351147A patent/SE538154C2/en unknown
-
2014
- 2014-08-20 WO PCT/SE2014/050954 patent/WO2015047159A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| SE1351147A1 (en) | 2015-03-31 |
| WO2015047159A1 (en) | 2015-04-02 |
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