SE421047B - Method for the continuous mixing of liquid and powder to form a largely homogeneous mixture and arrangement for carrying out the method - Google Patents
Method for the continuous mixing of liquid and powder to form a largely homogeneous mixture and arrangement for carrying out the methodInfo
- Publication number
- SE421047B SE421047B SE7903053A SE7903053A SE421047B SE 421047 B SE421047 B SE 421047B SE 7903053 A SE7903053 A SE 7903053A SE 7903053 A SE7903053 A SE 7903053A SE 421047 B SE421047 B SE 421047B
- Authority
- SE
- Sweden
- Prior art keywords
- wheel
- powder
- liquid
- mixing
- cavity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/53—Mixing liquids with solids using driven stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
Description
7903053-2 bindelse med hjulets ovansida via en runtom gående spalt som myn- nar intill en på periferisidan om spalten liggande likaledes runt- om gående egg, varvid spaltens form motsvarar i huvudsak formen hos mantelytan i en stympad kon med spetsen riktad nedåt, varjäm- te blandarhuset innefattar blandarstift som är anordnade att upp- fånga vätska från dimridån och utslungat pulver från pulverutrym- mena för åstadkommande av blandningen. 7903053-2 connection to the top of the wheel via a circumferential slot adjacent to one on the peripheral side of the gap lying likewise round about walking edge, the shape of the gap substantially corresponding to the shape of the mantle surface in a truncated cone with the tip pointing downwards, The mixing housing comprises mixing pins which are arranged to be capture liquid from the mist curtain and ejected powder from the powder compartment mean for effecting the mixture.
*Bland de fördelar som vinnes medelst uppfinningen kan_nämnas bland annat att ett konstant förhållande mellan pulverandel och _ vätskeandel kan bibehållas under hela blandningsoperationen, vilket är mycket väsentligt exempelvis vid framställning av blandningar inom läkemedelsindustrin. Förhållandet mellan pul- ver och vätska kan inställas godtyckligt för varje speciell bland- ning. Vidare arbetar anordningen enligt uppfinningen kontinuer- ligt till skillnad från kända anordningar där en "degklump" blan- das åt gången exempelvis vid s.k. "batchníng".* Among the advantages gained by the invention may be mentioned among other things, that a constant ratio between powder content and liquid content can be maintained throughout the mixing operation, which is very important, for example, in the production of mixtures in the pharmaceutical industry. The ratio of pulses and liquid can be set arbitrarily for each particular mixture. ning. Furthermore, the device according to the invention operates continuously. Unlike known devices where a "dough lump" is mixed das at a time, for example at so-called "batch".
Uppfinningen beskrivs i detalj i det följande under hänvis- ning till bifogade ritning på vilken en utföringsform av en anord- ning enligt uppfinningen är schematiskt åskådliggjord såsom exem- pel.The invention is described in detail in the following with reference to to the accompanying drawing in which an embodiment of a device according to the invention is schematically illustrated as an example. pel.
Pig. 1 visar en vertikalsektíon genom anordningen enligt uppfinningen. Pig. 2 visar en sektion utefter linjen II-II i fig. l. Pig. 3 visar en del av vertikalsektionen i fig. 1 i större skala. Lika delar i de olika figurerna har samma hänvis- ningsbeteckningar. 7 I I Den på ritningen visade anordningen har ett blandarhus 1 med lock 2. Inuti huset l är anordnat ett hjul, bestående av ett överhjul 3 och ett underhjul 4, som är roterbart lagrat omkring en axel 5 medelst lager 6. Mellan över- och underhjulen 3 resp.Pig. 1 shows a vertical section through the device according to the invention. Pig. 2 shows a section along the line II-II in Fig. 1. Pig. Fig. 3 shows a part of the vertical section in Fig. 1 in larger scale. Similar parts in the different figures have the same reference designations. 7 I I The device shown in the drawing has a mixer housing 1 with lid 2. Inside the housing 1 is arranged a wheel, consisting of one upper wheel 3 and a lower wheel 4, which is rotatably mounted around a shaft 5 by means of bearing 6. Between the upper and lower wheels 3 resp.
H finns ett hålrum 7 som har förbindelse med överhjulets 3 ovan- sida via en runt om gående spalt bestående av tvâ partier 8 och 9 som båda har formen av mantelytan hos var sin stvmpad kon med spetsen riktad nedåt. Överhjulet 3 har på sin ovansida utfrästa skovlar 10 och på sin undersida utfrästa skovlar ll. Mellan \ skovlarna 10 uppstår utrymmen 13 som är avsedda att mottaga pulv- ret för blandningen medan hålrummet 7 som är uppdelat i fack me- delst skovlarna ll är avsett att mottaga den vätska som skall an- vändas vid blandningen. Underhjulet H har en runt om gående egg lä intill mynningen av spalten 9. Vid sin periferi är det undre __ 7903053-2 hjulet U försett med skovlar 15 för utslungning av den färdiga blandningen via en diffusor 16 och utloppet l7. Utloppet kan eventuellt kompletteras med ett munstycke 18 som användes när den färdiga blandningen är mera lättflytande. Locket 2 har ett över hjulets centrum liggande fack 19 för mottagande av pulverfa- sen för vidare transport av denna till utrvmmena 13. Locket är vidare på sin undersida försett med stift 70 som ligger intill eggen ln. Pulverfasen matas tjll_fagket eller utrymmet 19 med _______ U hjälp av en transportör 21, exempelvis en matarskruv. Vätskefa- sen tíllföres till hålrummet 7 genom ett rör 22.H there is a cavity 7 which is connected to the upper part of the upper wheel 3. side via a circumferential column consisting of two parts 8 and 9 which both have the shape of the mantle surface of each with its truncated cone the tip directed downwards. The upper wheel 3 has milled on its upper side vanes 10 and on its underside milled vanes ll. Between \ vanes 10, spaces 13 are formed which are intended to receive powder for the mixture while the cavity 7 which is divided into compartments the vanes 11 are intended to receive the liquid to be used turned in the mixture. The lower wheel H has a circumferential edge lay next to the mouth of the column 9. At its periphery it is lower __ 7903053-2 the wheel U is provided with vanes 15 for throwing out the finished one the mixture via a diffuser 16 and the outlet 17. The outlet can optionally supplemented with a nozzle 18 used when the finished mixture is more fluid. The lid 2 has one compartment 19 lying above the center of the wheel for receiving powder powder then for further transport of this to the compartments 13. The lid is further on its underside provided with pin 70 adjacent eggen ln. The powder phase is fed tjll_fagket or space 19 with _______ U by means of a conveyor 21, for example a feed screw. Fluid- then fed to the cavity 7 through a tube 22.
Vid blandningsoperntionen roterar hjulet 3,H inuti huset 1,? runt axeln 5 med ett varvtal som kan ligga mellan lÛ0n och 5000 varv per minut. Våtfasen eller vätskan tillföras därvid till blandaren via röret 22 till hålrummet 7. Med hjälp av cen- trifugalkraften och skovlarna ll slungas vätskan utåt genom spalten 8 och vidare genom spalten 9. Vätskan har därvid formen av en hinna som utvidgar sig utåt hela tiden samtidigt som den blir tunnare. När vätskehinnan lämnar spalten 9 träffar den eg- gen lH och slites därvid sönder till mikroskopiska droppar så att en dimridå bildas. Samtidigt med tillförsel av vätskan ge- nom röret 22 tillföres pulver medelst transportören 21 till facket 19 och vidare till utrymmena 13. Därifrån slungas pulv- ret med hjälp av centrifugalkraften och skovlarna 10 utåt mot överhjulets 3 periferi samtidigt som det sönderpískas och träf- far dimridån vid eggen lä. De båda faserna, vätska och pulver, slungas nu vidare utåt tillsammans och kolliderar med stiften 20 där den momentana blandningen sker. Den färdiga blandningen upp- fångas omedelbart av skovlarna 15 som slungar ut blandningen via diffusorn l6 till utloppet 17. Granulat och styva blandningar lämnar blandaren vid utloppet l7 medan vid mera lättflytande pro- dukter blandningen uttages via munstycket 18.At the mixing operation, the wheel 3, H rotates inside the housing 1 ,? around the axis 5 at a speed which may be between lÛ0n and 5000 rpm. The wet phase or liquid is then added to the mixer via the tube 22 to the cavity 7. By means of the trifugal force and the vanes ll the liquid is thrown outwards through column 8 and further through column 9. The liquid then has the shape of a membrane that expands outward all the time at the same time as it becomes thinner. When the liquid membrane leaves the gap 9, it hits the gene lH and thereby breaks down into microscopic droplets so that a fog curtain is formed. At the same time as the supply of the liquid through the tube 22 powder is supplied by means of the conveyor 21 to the compartment 19 and on to the spaces 13. From there the powder by means of the centrifugal force and the vanes 10 outwards the periphery of the upper wheel 3 at the same time as it is whipped and far the fog curtain at the edge lä. The two phases, liquid and powder, is now thrown further outwards together and collides with the pins 20 where the instantaneous mixing takes place. The finished mixture is is immediately captured by the vanes 15 which eject the mixture via diffuser l6 to outlet 17. Granules and stiff mixtures leaves the mixer at outlet 17 while at more fluid flow- pro- The mixture is taken out via the nozzle 18.
Uppfinningen är inte begränsad till den speciella i det fö- regående beskrivna utföringsformen utan omfattar alla utförings- former inom ramen för patentkraven. Speciellt bör vad gäller ut- trycken “hålrum" och "pulverutrvmme" observeras att det som be- tecknats såsom "ett hälrum" i princip kan sägas bestå av "flera hålrum" och att det som angetts vara "pulverutrymmen" lika väl kan sägas utgöra Vett pulverutrvmme".The invention is not limited to the particular one in the present invention. described as described above but includes all embodiments forms within the scope of the claims. In particular, with regard to the pressures "cavity" and "powder space" are observed that what is drawn as "a heel space" can in principle be said to consist of "several cavities "and that what is stated to be" powder spaces "as well can be said to constitute Vett powder powder ".
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7903053A SE421047B (en) | 1979-04-05 | 1979-04-05 | Method for the continuous mixing of liquid and powder to form a largely homogeneous mixture and arrangement for carrying out the method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7903053A SE421047B (en) | 1979-04-05 | 1979-04-05 | Method for the continuous mixing of liquid and powder to form a largely homogeneous mixture and arrangement for carrying out the method |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7903053L SE7903053L (en) | 1980-10-06 |
SE421047B true SE421047B (en) | 1981-11-23 |
Family
ID=20337739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7903053A SE421047B (en) | 1979-04-05 | 1979-04-05 | Method for the continuous mixing of liquid and powder to form a largely homogeneous mixture and arrangement for carrying out the method |
Country Status (1)
Country | Link |
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SE (1) | SE421047B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0305356A1 (en) | 1987-08-31 | 1989-03-01 | Nicasystem Aktiebolag | Granular product (I) |
AU585630B2 (en) * | 1985-02-04 | 1989-06-22 | Lejus Medical Aktiebolag | Process for coating solid particles |
-
1979
- 1979-04-05 SE SE7903053A patent/SE421047B/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU585630B2 (en) * | 1985-02-04 | 1989-06-22 | Lejus Medical Aktiebolag | Process for coating solid particles |
EP0305356A1 (en) | 1987-08-31 | 1989-03-01 | Nicasystem Aktiebolag | Granular product (I) |
Also Published As
Publication number | Publication date |
---|---|
SE7903053L (en) | 1980-10-06 |
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