SE0003980D0 - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- SE0003980D0 SE0003980D0 SE0003980A SE0003980A SE0003980D0 SE 0003980 D0 SE0003980 D0 SE 0003980D0 SE 0003980 A SE0003980 A SE 0003980A SE 0003980 A SE0003980 A SE 0003980A SE 0003980 D0 SE0003980 D0 SE 0003980D0
- Authority
- SE
- Sweden
- Prior art keywords
- group
- alkyl
- hydrogen atom
- atom
- alkylthio
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new compounds of the formula (I): wherein m = 0, 1, 2 or 3; each R1 represents independently halogen atom, cyano-group, hydroxyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy-group, (C1-C6)-halogenalkyl, (C1-C6)-halogenalkoxy-group, -NR9R10, (C3-C6)-cycloalkylamino-, (C1-C6)-alkylthio-, (C1-C6)-alkylcarbonylamino-group or (C1-C6)-alkyl; X represents -O- or CH2-, OCH2-, CH2O-, CH2NH-, NH-; Y represents nitrogen atom (N) or group CH under condition that when X represents -O- or CH2O-, CH2NH- or NH-group then Y represents group CH; Z1 represents a bond or group (CH2)q wherein q = 1 or 2; Z2 represents a bond or group CH2 under condition that both Z1 and Z2 can't represent a bond simultaneously; Q represents -O- or sulfur atom (S) or group CH2 or NH; R2 represents group of the formula: n = 0; each R4, R5, R6 and R7 represents independently hydrogen atom (H), (C1-C6)-alkyl either R4, R5, R6 and R7 represent in common (C1-C4)-alkylene chain joining two carbon atoms to which they are bound to form 4-7-membered saturated carbon ring, either each R5, R6 and R7 represents hydrogen atom, and R4 and R8 in common with carbon atoms to which they are bound form 5-6-membered saturated carbon ring; R8 represents hydrogen atom (H), (C1-C6)-alkyl or it is bound with R4 as determined above; each R9 and R10 represents independently hydrogen atom (H), (C1-C6)-alkyl; R15 represents (C2-C6)-alkyl, (C2-C6)-alkenyl, (C3-C6)-cycloalkyl, (C5-C6)-cycloalkenyl, adamantyl, phenyl or saturated or unsaturated 5-10-membered heterocyclic ring system comprising at least one heteroatom taken among nitrogen, oxygen and sulfur atoms wherein each group can be substituted with one or more substitute taken independently among nitro-group, hydroxyl, oxo-group, halogen atom, carboxyl, (C1-C6)-alkyl, (C1-C6)-alkoxy-, (C1-C6)-alkylthio-group, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxycarbonyl, phenyl and -NHC(O)-R17 under condition that R15 doesn't represent unsubstituted 1-pyrrolidinyl, unsubstituted 1-piperidinyl or unsubstituted 1-hexamethyleneiminyl group; t = 0, 1, 2 or 3; each R16 represents independently halogen atom, cyano-group, hydroxyl, (C3-C6)-cycloalkyl, (C1-C6)-alkoxy-group, (C1-C6)-halogenalkyl, (C1-C)-halogenalkoxy-group, -NR18R19, (C1-C6)-cycloalkylamino-, (C1-C6)-alkylthio-, (C1-C6)-alkylcarbonylamino-group, (C1-C6)-alkyl; R17 means (C1-C6)-alkykl, amino-group, phenyl; each R18 and R19 means independently hydrogen atom (H), (C1-C6)-alkyl, or its pharmaceutically acceptable salt or solvate. Compounds of the formula (I) elicit activity of a modulating agent with respect to activity of chemokine MIP-1alpha receptors that allows their using in pharmaceutical composition in treatment of inflammatory diseases. ^ EFFECT: valuable medicinal properties of new compounds. ^ 14 cl, 98 ex
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0003980A SE0003980D0 (en) | 2000-10-31 | 2000-10-31 | Novel compounds |
ARP010102757A AR028947A1 (en) | 2000-06-20 | 2001-06-11 | NEW COMPOUNDS |
EP01941407A EP1299356B1 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
NZ523110A NZ523110A (en) | 2000-06-20 | 2001-06-14 | A compound that is a modulator of chemokine receptor |
MXPA02012426A MXPA02012426A (en) | 2000-06-20 | 2001-06-14 | Novel compounds. |
PT01941407T PT1299356E (en) | 2000-06-20 | 2001-06-14 | NEW COMPOUNDS |
JP2002504228A JP2004501137A (en) | 2000-06-20 | 2001-06-14 | New compound |
AU7476401A AU7476401A (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
IL15316801A IL153168A0 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
CZ20024147A CZ20024147A3 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
CA002411255A CA2411255A1 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
SK1794-2002A SK17942002A3 (en) | 2000-06-20 | 2001-06-14 | Phenyl derivatives, process for the preparation thereof, pharmaceutical compositions comprising same, and their use |
DE60102020T DE60102020T2 (en) | 2000-06-20 | 2001-06-14 | NEW CONNECTIONS |
PCT/SE2001/001378 WO2001098272A1 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
ES01941407T ES2214427T3 (en) | 2000-06-20 | 2001-06-14 | NEW COMPOUNDS. |
BR0111669-0A BR0111669A (en) | 2000-06-20 | 2001-06-14 | New compounds |
KR1020027017280A KR20030017547A (en) | 2000-06-20 | 2001-06-14 | Novel Compounds |
TR2004/01052T TR200401052T4 (en) | 2000-06-20 | 2001-06-14 | New compounds |
PL01359414A PL359414A1 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
DK01941407T DK1299356T3 (en) | 2000-06-20 | 2001-06-14 | Hitherto unknown compounds |
SI200130076T SI1299356T1 (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
RU2002132380/04A RU2261245C2 (en) | 2000-10-31 | 2001-06-14 | New compounds |
CN01814211A CN1447794A (en) | 2000-06-20 | 2001-06-14 | Novel compounds |
AT01941407T ATE259354T1 (en) | 2000-06-20 | 2001-06-14 | NEW CONNECTIONS |
EEP200200697A EE200200697A (en) | 2000-06-20 | 2001-06-14 | New compounds, process for their preparation and their use |
HU0301254A HUP0301254A3 (en) | 2000-06-20 | 2001-06-14 | Novel compounds, process fo their preparation and pharmaceutical compositions containing them |
US10/311,667 US7005439B2 (en) | 2000-06-20 | 2001-06-14 | Compounds |
IS6657A IS6657A (en) | 2000-06-20 | 2002-12-17 | New compounds |
NO20026081A NO20026081L (en) | 2000-06-20 | 2002-12-18 | New connections |
HK03103703A HK1051372A1 (en) | 2000-06-20 | 2003-05-26 | Novel compounds |
US11/157,742 US20050239801A1 (en) | 2000-06-20 | 2005-06-21 | Novel compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0003980A SE0003980D0 (en) | 2000-10-31 | 2000-10-31 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0003980D0 true SE0003980D0 (en) | 2000-10-31 |
Family
ID=20281652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0003980A SE0003980D0 (en) | 2000-06-20 | 2000-10-31 | Novel compounds |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2261245C2 (en) |
SE (1) | SE0003980D0 (en) |
-
2000
- 2000-10-31 SE SE0003980A patent/SE0003980D0/en unknown
-
2001
- 2001-06-14 RU RU2002132380/04A patent/RU2261245C2/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2261245C2 (en) | 2005-09-27 |
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