RU2008102156A - NEW FURO- AND THIENO [2,3-b] -QINOLIN-2-CARBOXAMIDES, METHOD FOR OBTAINING AND ANTI-TUBERCULOSIS ACTIVITY - Google Patents
NEW FURO- AND THIENO [2,3-b] -QINOLIN-2-CARBOXAMIDES, METHOD FOR OBTAINING AND ANTI-TUBERCULOSIS ACTIVITY Download PDFInfo
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- RU2008102156A RU2008102156A RU2008102156/04A RU2008102156A RU2008102156A RU 2008102156 A RU2008102156 A RU 2008102156A RU 2008102156/04 A RU2008102156/04 A RU 2008102156/04A RU 2008102156 A RU2008102156 A RU 2008102156A RU 2008102156 A RU2008102156 A RU 2008102156A
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- optionally substituted
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- carboxamides
- quinoline
- cycloalkyl
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- 0 CC1*(C)C(C)C(*)N(*)C1* Chemical compound CC1*(C)C(C)C(*)N(*)C1* 0.000 description 2
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1. Азагетероциклические соединения, представляющие собой замещенные фуро[2,3-b]хинолин-2-карбоксамиды и замещенные тиено[2,3-b]хинолин-2-карбоксамиды или их рацематы, или их оптические изомеры, а также их фармацевтически приемлемые соли и/или гидраты общей формулы (I) ! ! где каждый из R1, R2, R3, R4 представляет собой заместитель циклической системы, выбранный из водорода, галогена, возможно замещенного алкила; возможно замещенной алкоксигруппы; возможно замещенного циклоалкила, возможно замещенного арила или гетероциклила; ! Х представляет собой гетероатом, выбранный из кислорода или серы; ! R5 и R6 независимо друг от друга представляют собой заместители аминогруппы, выбранные из водорода, возможно замещенного алкила, возможно замещенного циклоалкила, возможно замещенного арила, возможно замещенного гетероциклила, этоксикарбонила, карбоксамида или R5 и R6 вместе с атомом азота, с которым они связаны, образуют необязательно замещенный азагетероцикл. ! 2. Соединения по п.1, представляющие собой замещенные фуро[2,3-b]хинолин-2-карбоксамиды и тиено[2,3-b]хинолин-2-карбоксамиды, содержащие пиперидиновый, пиперазиновый или пирролидиновый фрагмент, общей формулы II: ! ! ! где R1, R2, R3, R4 и Х имеют вышеуказанное значение; W представляет собой замещенные пиперидин, пиперазин или пирролидин; ! R6, R7, R8, R9 и R10 независимо друг от друга представляют собой водород, возможно замещенные алкил, циклоалкил, арил, гетероарил, гетероциклил, этоксикарбонил, гетероароил, карбамоил; ! n - означает число замещенных -C(R11R12)- групп; n принимает значения от 0 до 3; ! R11, R12 представляют собой замещенные алкил, циклоалкил, арил, гетероарил, а также водород; ! У - представляет с�1. Azaheterocyclic compounds, which are substituted furo [2,3-b] quinoline-2-carboxamides and substituted thieno [2,3-b] quinoline-2-carboxamides or their racemates, or their optical isomers, as well as their pharmaceutically acceptable salts and / or hydrates of the general formula (I)! ! where each of R1, R2, R3, R4 represents a substituent of the cyclic system selected from hydrogen, halogen, optionally substituted alkyl; a possibly substituted alkoxy group; optionally substituted cycloalkyl; optionally substituted aryl or heterocyclyl; ! X represents a heteroatom selected from oxygen or sulfur; ! R5 and R6 are independently amino substituents selected from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl, ethoxycarbonyl, carboxamide, or R5 and R6 together with the nitrogen atom to which they are attached form optionally substituted azaheterocycle. ! 2. The compounds according to claim 1, which are substituted furo [2,3-b] quinoline-2-carboxamides and thieno [2,3-b] quinoline-2-carboxamides containing a piperidine, piperazine or pyrrolidine fragment of the general formula II :! ! ! where R1, R2, R3, R4 and X have the above meaning; W represents substituted piperidine, piperazine or pyrrolidine; ! R6, R7, R8, R9 and R10 are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, ethoxycarbonyl, heteroaroyl, carbamoyl; ! n is the number of substituted -C (R11R12) - groups; n takes values from 0 to 3; ! R11, R12 are substituted alkyl, cycloalkyl, aryl, heteroaryl, as well as hydrogen; ! U - represents
Claims (10)
Priority Applications (1)
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RU2008102156/04A RU2371444C1 (en) | 2008-01-24 | 2008-01-24 | FURO- AND THIENO[2,3-b]-QUINOLINE-2-CARBOXAMIDES, METHOD OF PRODUCTION AND ANTITUBERCULOUS ACTIVITY |
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RU2008102156/04A RU2371444C1 (en) | 2008-01-24 | 2008-01-24 | FURO- AND THIENO[2,3-b]-QUINOLINE-2-CARBOXAMIDES, METHOD OF PRODUCTION AND ANTITUBERCULOUS ACTIVITY |
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RU2008102156A true RU2008102156A (en) | 2009-07-27 |
RU2371444C1 RU2371444C1 (en) | 2009-10-27 |
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RU2008102156/04A RU2371444C1 (en) | 2008-01-24 | 2008-01-24 | FURO- AND THIENO[2,3-b]-QUINOLINE-2-CARBOXAMIDES, METHOD OF PRODUCTION AND ANTITUBERCULOUS ACTIVITY |
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Families Citing this family (10)
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PT2935222T (en) * | 2012-12-21 | 2018-12-10 | Epizyme Inc | Prmt5 inhibitors and uses thereof |
WO2014207213A1 (en) | 2013-06-28 | 2014-12-31 | Medizinische Universität Innsbruck | Novel inhibitors of protein kinase c epsilon signaling |
EP3684767B1 (en) | 2017-09-22 | 2024-04-24 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
KR20200071752A (en) | 2017-10-18 | 2020-06-19 | 주빌런트 에피파드 엘엘씨 | Imidazo-pyridine compounds as PAD inhibitors |
US11629135B2 (en) | 2017-11-06 | 2023-04-18 | Jubilant Prodell Llc | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
SG11202004537UA (en) | 2017-11-24 | 2020-06-29 | Jubilant Episcribe Llc | Heterocyclic compounds as prmt5 inhibitors |
JP7279063B6 (en) | 2018-03-13 | 2024-02-15 | ジュビラント プローデル エルエルシー | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
CN109096292B (en) * | 2018-08-24 | 2019-09-10 | 河南大学 | A kind of small organic molecule probe, preparation method and application |
CN112480134B (en) * | 2020-12-17 | 2021-11-05 | 河南大学 | Pair of isomers, preparation method and application thereof |
CN115197240B (en) * | 2021-07-08 | 2024-03-26 | 江南大学 | Quinoline compound, synthesis method, pharmaceutical composition and application |
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