SA113340780B1 - A formulation useful for spraying - Google Patents

Abstract

There is provided a formulation suitable for spraying comprising an oil phase comprising at least one active ingredient and a stabiliser， wherein the stabiliser comprises at least one epoxidised vegetable oil， and optionally at least one emulsifier and/or a vapour retardant additive. The formulation may further comprise an aqueous phase comprising at least one dispersing agent and optionally at least one antifoam agent and/or thickening agent.

Description

— \ — A formulation useful for spraying FULL DESCRIPTION BACKGROUND The present invention relates to fixed formulations suitable for spraying eg Baie; to spray an insecticide insecticide; and/or a herbicide; and/or a fungicide; and/or insect repellent; and/or a deodorizer deodoriser and/or for taking and taking drugs.

The appropriate formulations for spraying are well known. For example JBL EP No. 1-64 describes spray formulations comprising an oil phase comprising a component (Jd) and an emulsifier; and an agent 33k or LE: for evaporation retardant eg However, the oil in water emulsions (EW) is of

0 An issue is the lack of stability that may compromise the effectiveness of Jie these formulations when they are used as spray formulations. Specifically; The instability leads to an increase in particle sizes (EW) with the passage of time »+ and leads to a poor storage life. According to I, there is a diligent dala to manufacture fully stable or more highly stable sprayable (EW) formulations.

10 General Description of the Invention The present invention, Ss, is concerned with the aforementioned problems, and specifically it provides new formulations with the degree of EWES FLAT and according to a first feature of the present invention; suitable formulation for spraying is provided; comprising an oil phase comprising at least one active ingredient and a stabilizer where idl includes

— having at least one epoxidised vegetable oil” and optionally at least one emulsifer; And/or sale Abie vapor retardant additive. According to another feature of the present invention; A method for preparing a composition according to any feature of the present invention is provided; dads that an oil phase is prepared comprising at least one active ingredient and a residual oo where the residual includes an epoxidised vegetable oil it is vegetable one on JY and optionally one emulsifying agent on the least; and/or a vapor retardant additive. lay, of another feature of the invention Jal A spray pan containing the composition is provided in accordance with any feature of the present invention. According to another feature of the present invention; A use of the composition is provided in accordance with any feature of the present invention; Optionally, it is diluted with water. or the use of a spray pan in accordance with any feature of the present invention; to control and control insects; or on ticks and lice; Or on unwanted plants. 1 Brief explanation of the drawings Figure 1 shows: the results obtained from the stability test that was carried out for two installations, one of which includes the stabilizer wis and the other does not include win 1560 8011 (5). The particle sizes of the two formulations were measured over (YE) months to compare their relative stability. Specifically; [Fig. (1b) that the mean diameter of the particle size of the formulation (VY) [or comparison formulation No. 1]) includes epoxidised soybean oil [commercially available Amepon ( sal 5) ) as a stabilizer at a ratio of (0.00 pounds) w/w. The medium diameter of the size

_ _ (vd 0 °) is the diameter in which the distribution (Cu %) of the particle size Cu (lef %) of the particle size is lowest on a volume basis. The steps for preparing the two formulations that are being compared in the examples that will be presented are eam lad, i.e. in the manufacturing example No. (1) (with a stabilizer); and in the comparative manufacturing example No. (1) © (without the presence of an Figure 7: Results of Bley profiles or evaporative fixation of the two formulations compared with a commercial standard formulation Resigen EW (Bayer CropScience 8008). Both formulations are formulation (VY) = F) [or Composition No. 1; including evaporation retardant (E) and Formula -00174(F) [or comparator Composition No. oY) and 0 does not include Ge or Lis for vapor evaporation retardant]. to evaluate the same profile for obstruction or inhibition of evaporation as described in EP (N= FYVEVE); A small droplet of a dilute emulsion is suspended over a very thin wire through a small (ala) Gib Petri dish. Slat bacteria ('als) measure its cross-sectional area under a microscope over a period of (yo) minutes. This may be repeated. over several repeated dilutions of a particular formulation. (1) (with a Lief evaporation retardant); and in Comparative Manufacturing Example No. (V) (without a vapor retardant or Lis). Primarily or primarily in fixed formulations suitable for spraying Bade materials (eg JBN) to spray an insecticide and/or herbicide; and/or a fungicide; and/ or an acaricide Jal and lice repellent; Jf an insect repellent; an insect repellent; an insect growth regulator; and/or a sal plant growth regulator; and/or or dye 6 no and/a And

El

Abeer perfume jhe; and/or a bactericide and/or a lubricant

» and/or medication; and/or coating; and/or polishing varnishes; and/or textile processing; and/or remover

“deodoriser” and/or taking and using drugs.

Considering an example of an insecticide formulation; Some embodiments of the present invention may be concerned with a composition

0 oil-in-la may be suitable for spraying or suitable for diluting with water to form a spray formulation for use

Inside buildings or enclosed spaces and outside buildings or enclosed spaces in the open air

health field (celal) or in order to control the epidemic (pest control) and germ vectors

abe) (from insects, etc.). (eg Jha) These sprayable formulations may be in the form of

A very low and low volume spray or in the form of a thermal fog space spray 0.

The terms “8; 80” as used herein to an indefinite article means one or more of

one (any at least one) according to the grammatical intent of the indefinite articles. By giving an example; the expression

An "element" means uate one or more than one element.

An emulsion is a mixture of two or more liquids; For liquids that are not normally ALE Vo for miscibility. in emulsifiers; in emulsions; One or more fluids (phase

The dispersed phase in the other liquid (continuous phase).

shal This may happen for example after a violent shuffle procedure" or (continuous phase

homogeneity Or, exposure of immiscible liquids to ultrasonic energy is also performed

Ultrasound energy and thus; “Oil-in-water emulsions” refers to emulsions comprising 0 oil phase dispersed within an aqueous phase Jk . Because of nature is not

miscible with liquids; Many emulsions are unstable and tend to separate

many different phases with the passage of time 3 for example (JEL), the Cu emulsion in water may separate into

,. aqueous phase Jk and an oil phase

— a — Oil-in-water emulsions may be made to a more stable composition by the addition of emulsifiers; Jie Additive Emulsifiers are commercially available; and surfactants such as those that are commercially available under the famed trade name BRIJ (http://www.sigmaaldrich.com/materials —science /material-science-products.html?TablePage= 9541703 ©

and Genapol (http://www.essentialingredients.com/pdf/GenapolO200TechnicaiDataShe et.pdf).

0 however; Typical formulations containing such emulsions and surfactants still show instability in their particle sizes. An example can be seen by [Fig.

Vo pest control refers to the organization and management of the epidemic and control cad because it is usual to fully realize al very harmful js of one's health; or prediction (the environment of organisms); or economy. Specifically; Control of different epidemic types or classes indicates that the population of epidemic types is maintained at a level where it is not detrimental to a person's health or prognosis; or economics.

0 Examples of epidemics harmful to health (insects harmful to health / ticks and lice harmful to health); Against which the present compound shows effective control and control effect; Comprises: Hemiptera (insects with wings that are half membranous and half leathery) Hemiptera

Ed Delphacidae (planthoppers) such as Laodelphax striate/Jus (small brown planthopper), Nilaparvata lugens (brown planthopper), Sogate/Ja furcifere (white backed rice planthopper); leathoppers such as Nephotettix cincticeps, Aphididae (aphids); plant bugs; Aleyrodidae (whiteflies); scales; © Tingidae (lace bugs); Psyllidae; etc...; Lepidoptera Pyralidae such as Chilo suppressalis (rice stem borer), Cnaphalocrocis medinafis (rice leafroller), Plodia interpunctelfa (Indian meal moth); Noctuidae such as Spodoptera litura (tobacco cutworm), Pseudaletia separate (rice armyworm), Mamestra brassicae (cabbage armywormm); Pieridae such as Pieris rapae 0 such as Adoxophyes crucivora (common cabbageworm), Tortricidae spp.; Carposinidae; Lyonetiidae; Lymantriidae; Plusiinae; Agrotis spp. such as Agrotis segetum (turnip cutworm), Agrotis epsilon (black Heliotis spp.; Plutella xyloste/la .5 mm cutworm); Helicoverpa (diamondback moth); 790 Pamara guttata (rice skipper); Tinea pelfionefla (casemaking clothes moth); Tinea/a

- Bisse/Jiella (webbing clothes moth); ; etc....؛,

Diptera Diptera (with two wings).

Culex pipiens palm/ens (common mosquito), such as Culex spp.

Culex tritaeniorhynchus; Aedes spp. such as Aedes aegypti, Aedes © albopictus; Anopheles spp. such as Anopheles sinensis; Chironomidae (midges); Muscidae such as Musca domestica (housefly), Muscina stabulans (false stablefly); Calliphoridae; Sarcophagidae;

Antomyiidae such as Delia platura (seedcom maggot), Fannia canicularis 0 (little housefly), Delia antiqua (onion maggot); Tephritidae (fluiting flies);

Drosophilidae; Psychodidae (moth flies); tabanidae; Simuliidae (black flies); Stomoxyidae; ....; etc; Coleoptera beetles Vo corn rootworms such as Diabrotica virgifera (western com rootworm),

Oiabrotica undecimpunctata howardi (southern corn rootworm);

Scarabaeidae such as Anomala cuprea (cupreous chafer), Anomala rufocuprea (soybean beetle); weevils such as Sitophifus zeamais (maize weevil), Lissorhoptrus oryzophilus (ricewater weevil), ball weevil, 0

Callosobruchus chinensis (adzukibean weevil); Tenebrionidae (darkling beetles) a

_ q —_ such as Tenebrio molitor (yellow mea! worm), Tribolium castaneum (red flour beetle); Chrysomelidae (leaf beetles) such as Ou/ema oryzae (rice leaf beetle), Phyllotreta striolata (striped flea beetle), Aulacophora femorafis {cucurbit leaf beetle); Anobiidae; Epllachna spp., such as

Epilachna vigintioctopunctata (twenty-eight-spotted ladybird); ©

Lyctidae (powderpost beetles); Bostrychidae (false powderpost beetles);

Cerambycidae;

Paederus fuscipes (robe beetle); .... etc. Dictyoptera 0 # germanica (German cockroach); Periplaneta fuliginosa (smokybrown cockroach); Periplaneta americana (American cockroach);

Periplaneta brunnea (brown cockroach); Blatta orientafis (oriental cockroach) X etc....; yo; Thysanoptera fringe wings ....; & Thrips palmi; western flower thrips; Thrips hawaiiensis ¢ Hymenoptera Lepidoptera

Formicidae (ants); Vespidae (hornets); Bethylidae; Tenthredinidae such as Athafis rosae ruficomis (cabbage sawfly); (sawflies) 0 etc....; a

-1 “=

Gryllotalpidae (mole crickets); Acrididae : Orthoptera orthoptera (grasshoppers); etc....;

Pulex irritans; Ctenocephalides felis (cat : Siphonaptera flea); 2 etc....؛‎

Pediculus humanus humanus (body loose); Pthirus pubis: Anoplura (crab louse); etc....;

Reticulitermes speratus, Coptotermes : Isoptera 0 toes etc. formosanus (Formosan subterranean termite); House-dust mites: mites and moths for household dust

Dermanyssidae such as Dermatophagoides farinae (American house dust mite) ,

Dermatophagoides pteronyssinus; Acaridae such as Tyrophagus 0 putrescentiae (mold mite), Aleuroglyphus ovatus; Etc...;: The Other Mites, mites and other moths

Glycyphagidae such as Glycyphagus privatus. glycyphagus domesticus,

Glycyphagus destructor, Cheyletidae such as Chelacaropsis 0 a

_— \ \ _ Malaccensis, Cheyletus fortis; Tarsonemidae; Chortog/yphus spp.; Haplochthonius simplex and the like; Tetranychus kanzawai (Kanzawa spider mite); Panonychus citri (citrus red mite); © Panonychus ulm i (European red mite); etc...; Ticks The term "tadd" or "creature" includes both human and animal organisms; and 0 parts thereof. Animal organisms include, but are not limited to, mammals.” And on domestic animals pampered (dat) and on cattle, animals and poultry. Jaks has animal beings including but not limited to dogs; cats (pussies); birds, horses, and cattle; pigs, sheep, goats, and poultry; And ducks and turkeys. Tay of a first feature of the present invention; Provide a suitable composition (ll comprising an oil phase 0 comprising at least one active ingredient stabilizer iy where the stabilizer cael comprises at least one epoxidised vegetable oil; optionally at least one emulsifier; and/or a vapor retardant additive. The term 'containing with' is defined and defined as 'containing essentially; but Yo is not necessarily a whole'. Furthermore it. The term 'comprising [le comprising of' is automatically read by one of those Sead's practicing and experienced in the Jie this field of this art as including the 'BSE of'. Also, the changes in the word 'to include' include; like to be a

-117- and so on; they have the same variable meanings according to the fdas include that as

REIL epoxidised vegetable Sl Jiccstabilizer Cail Oil by adding excellent lead grade to be of Jal; Compositions according to any feature of the invention oll the stability of the particle size distribution with the passage of time and over a given range of temperatures. An example of 5 might be epoxidised vegetable oil, epoxidised vegetable oil, that oil available from suppliers such as Jie; epoxidised soybean oil epoxide under the name of the product: SRL) 15/008000 SB/ According to (http: //www.ametech.it/pr_agro_ad_stabilizing_agents_print.php 00 showing the occurrence of Stabilizer cin can be seen from [Fig. No. (1)a]», the formula without A rapid increase of the average diameter of the size with the passage of time and across a certain range of different temperatures; in comparison, the instability in particle sizes indicates the instability in particle sizes lee maintains the size of the stabiliser [Fig. No. (1) B] shows that the formulations in the presence of the stabilizer are relatively stable when they are stored in the same range of temperatures.By comparing the average size aa 0 diameters of the two formulations, the particle sizes were larger than the previous art formulation across most of the

Sal “period of two years” during which tests were carried out under all storage conditions/degrees The steps for preparing the two formulations being compared may be obtained in the following examples (1) (in the presence of a validator); and in a comparative manufacturing example No. (1) Hereafter i.e. in Manufacturing Example No. (without stabilizer cus 0) it must be understood that the embodiments of the present invention are not restricted or limited to embodiments which Ja ie eg epoxidised soybean is an oil Soybean epoxide stabilizer in which the stabilizer is Embodiments of the present invention may include at least one JB epoxidised vegetable oil Je. oll derived from at least one aly epoxidised vegetable oil

Q1 His selection from the group consisting of “Jatropha cy” soybean oil, lindseed oil, lindseed oil, neem oil, AA 06600; palm oil palm oil » coconut oil coconut oil coconut oil cottonseed oil cottonseed oil oil; peanut oil peanut oil olive oil olive oil oil © ¢ rapeseed oil rapeseed oil « safflower oil safflower oil (safflower); sesame oil sesame oil sesame oil sunflower oil sunflower oil almond oil almond oil almond oil; beechnutoil beechnut oll »; cashew oil cashew oil dus hazelnut oil hazelnut oil ; macadamia oil; Mongongo Oil 0 he 00090090 » pecan oil pecan oil; pine nut oil; pistachio oil; Walnut oil 0 and in some embodiments the “stabiliser” idl is epoxidised soybean oil. Embodiments of the present invention may additionally comprise an aqueous phase Vo comprising one dispersing agent (J) and optionally at least one antifoaming agent; and/or a thickening agent. In some embodiments of the present invention, the composition may also include in addition to the above an aqueous phase comprising at least one dispersing agent. Yo antifoam agents and thickening agents Dispersing agents are substances that are added to a Ble, to a colloid (colloidal substance), or to an emulsion to improve separation of particles and to prevent settling, sedimentation, or aggregation For example, some embodiments of the present invention may include one or more polyvinyl alcohol (Jie) dispersing agents [commercially available for example under Gohsenol (awk Yo (51-A6)] by ((Gohsenol.com) and/or gum arabic; or sodium salt

— ¢ \ — Lignosulphonate sodium salt “ and/or polycarboxilic acid sodium salt . An anti-foam agent Ble is a substance that reduces and inhibits foam formation. For example JE Some embodiments of the invention Jal may include an anti-foaming agent one or more anti-foaming agents Jie active silicone polymer © or the like. Commercially available examples may include Antifoaming Emulsion (Dow Corning Asia, Corp.) Antifoam C gall and/or Silcolapse 000 (Rhodia). Thickening agents are substances that increase the viscosity of a solution or A “liquid/solid” mixture. Suitable thickeners may include Xanthan gum and Mineral silicates. For example; Some embodiments of the present invention may include a thickening agent and one or more thickening agents (Jie gum (Veegum G) [magnesium aluminum silicate derived or derived from Ss]).1. Vanderbilt gum 5 (Kelzan [Xanthan gum available from «(PC Kelco) and/or Carboxy methyl cellulose « and/or gum "0818968080" and/or Guar' jaa 15 - In order to extend and prolong the shelf life of proposed or imposed formulations, Lad Jam has added some embodiments of the present invention to preservatives such as Benzisothiazolin—-3-one 1,2 [available commercially from ( LoONnza) as “[(Proxel GXL) and/or a mixture of both: 5—chloro—-2-methyl-4- isothazolin-3-on, 2-methyl-4-isothiazolin—- 3- one Y. » and the compound bronopol' [commercially available from (KI Kasel) as [(Biohope L) The term 'optional' or 'optionally' refers to any component or A claim, method of expression, or phrase; to be intended to mean that the subject matter is required; or interchangeably not to be required. This is to mean that both alternatives must fall within the scope of the claim or method

“yoo/Jie” includes the expression or phrase in question. The use of the terms should be understood broadly, including “; 'includes/includes'; that / that of; etc. in order to provide support and reinforcement for more narrow terms; such as consist of; consist of mainly; consist of mainly and to a large extent; etc. with pesticide formulations sah that The embodiments of the present invention are not specific or aed) it should and epidemics. Hence, embodiments of the present invention may include at least one active ingredient selected as a herbicide and/or insecticide from the group of Insecticide and/or insect repellent Jails acaricide and/or fungicide; and/or fungicide and/or insect growth regulator sail; and/or regulator insect repellent and/or perfume jhe; and/or aroma; dye; and/or plant growth regulator; medicine and/or paint; and/or lubricant and/or Agent “a bactericidal lubricant ae 0 textiles; and/or a deodorant dalle varnish; and/or a drug deodoriser.” For the purposes of this detailed written description For the patent, the term 'active ingredient' is used to mean 'active' biologically (bioactively) such as a compound that is capable of aiding the desired and desired biological effect (biological effect); For example; Helping Impact 1 Insects”; and/or weeding; and/or fungicidal; sal) which is biologically active on insects; and/or in assisting in the biological effect of pla and/or in the tick (Jails sal) and/or in the active deodorant; and/or in the therapeutic effect. For the purposes of this written description, it also includes the works of “Detailed Jd of the Patent.” It must also be understood that the term “component

Al Additives to make the drug stronger oy The synergist and synergist 0 The synergist (cooperator) and the auxiliary additive is any suitable agent to modify the effect and / or herbicidal «insecticide Insecticide agents Jie agents other AY, lice and/or acaricide; and/or a fungicide; and/or herbicide “ insect growth regulator gal” and/or insectrepellent he and/or dye; and/or plant growth regulator dye and/or plant growth regulator Yo d

1- Perfume and/or bactericide and/or sake lubricant and/or cols and/or paint; and/or polishing varnishes; and/or textile processing; And/or “Sold” deodorizer deodoriser and/or taking and using drugs. For example; Synergists (synergists or synergists) and additive©s may be used in combination with herbicides; and with insecticides; with fungicides and with other pesticidal and epidemiological agents that control or eliminate unwanted pests and pests; In order to enhance its effects and activities. may not be synergistic (factors of synergy and synergy); or adjuvants are by themselves effective in controlling or killing ally epidemics; or in providing the required treatment. Instead; The synergists, synergies, or 0 adjuvants produce an effect on the epidemic or on evidence of disease; so that the ability of the epidemic killer or drug to be implemented and penetrated is enhanced; the goal; Or protect the target member. For example; The combined pesticidal agent piperonyl butoxide 3 is believed to inhibit the breakdown of pesticidal compounds in insects. From oF, inhibition of this degradation allows for the formation of high concentrations of pesticides and pesticides [eg 0 Jad] 'pyrethroid' located within the target pesticide for a prolonged period of time (http://npic.orst.edu). ffactsheets/pbogen.pdf) and accordingly, formulations of the present invention may also include an adjuvant and one or more adjuvants. Concentrations of the present invention may also include one or more adjuvants Jie Substances (compounds -0 surfactants; emulsifiers; vapor retarders; oils; salts. These additives may be able to improve these properties of the composition, such as spreading, permeability, or combustion. some embodiments of the present invention may be diluted with water in order to be used in an ultra low volume (ULV) Or to spray thermal foggy space d

-11/- Such applications may require extremely small aerosolized droplets to move and travel over a long distance (about 100m) with minimal water evaporation to hit target areas or epidemics at a size eld formulations may include a desirable small droplet In order to achieve the minimum level of vaporization of the present invention on one or more vapor retarding or vapor retarding materials, the vapor retarding or vapor retarding materials are materials capable of retarding and inhibiting the evaporation of water from Small droplets of spray specifically contained in a formulation prepared for spraying over a target area The target area may be a horde of pests and pests that are known to be harmful to a person's health; a predictor (the environment of living organisms); or by limitation. Vaporization or fumigation is well known for the preparation of formulations for spraying purposes. A suitable formulation for spraying comprising an oily phase AH (1-0371 EVE) EP No. 0 describes vapor retarding or vapor retarding sales includes active ingredient and emulsifier; phase .retardant. Embodiments of the invention may include current on one or more additive materials; as a vapor retarder or vapor retarder one or more sale (JE) retarders or vapor retarders. In particular, the compositions of the present invention may include more than one of 5 fatty jell E816050 E061 and/or Stearic acid Jie vapor retarding substances or vapor retarders At least one Particularly more A single fatty acid may include at least 0. palmitic acid and/or stearic acid A composition without substance Vapor retarding oY) and as can be seen from Figure 1 or for evaporation a rapid decrease in the cross-sectional area of a small droplet over a time period of 0 minutes. In comparison; A combination of vapor retarding or vapor retarding materials maintains, over (01) the same time period, the cross sectional area of the relatively stable small droplet. The side section of the vapor retarding or vapor retarding material of the composition is similar to that which is Aqua resign (Bayer Crop Science for Commercial Standard Profiles). The steps for preparing the two compositions being compared can be obtained in the examples that follow Yo

m \ _ can in Manufacturing Je (1) (with sale vapor retarder or vapor retarder); and in Comparative Manufacturing Example No. (7) (without vapor retarder or vapor retarder In some embodiments of the present invention, the composition may include an active ingredient, wherein the active ingredient includes at least the compound “als” pyrethroid “(compound similar to the Spanish 'chrysanthemum' chamomile). Roughly speaking to a so-called super lethal or epileptic agent in lethal effect and to a so-called super lethal agent in lethal effect. Examples of epilepsy or super lethal agents and killing agents include sla at '0810110110 ' 'cyphenothrin' at Specifically, it is particularly desirable that these compounds have both superior lethality and sila-killing properties with respect to insecticide, but at present, no single “pyrethroid” compounds are known yet to have Both or both of these effects are cost-effective and, in specially defined embodiments of the present invention, are associated with or related to insecticidal formulations. for pests and epidemics; The compositions according to any feature of the present invention may include as the active ingredient at least one “pyrethroid” compound; Optionally a synergistic agent or at least one synergistic pesticide. The pyrethroid compound may be selected from the group consisting of: allethrin, phthalthrin, prallethrin, furamethrin, empenthrin, phenothrin, permethrin, cyphenothrin, cypermethrin, decamethrin, tralomethrin, deltamethrin, bifenthrin, cyfluthrin, etofenprox, transfluthrin, cycloprothrin, acrinathrin, fenvalerate, esfenvalerate, flucythrinate, tefluthrin, esbiothrin, 0 fenpropathrin, tetramethrin, fluvalinate, cyhalothrin, resmethrin, meperfluthrin, teflumethrin, dimefluthrin, Pyrethrin |, Pyrethrin II, Cinerin I, Cinerin II, jasmolin |, jasmolin 11 and metofluthrin. £1V

q —_ \_ “cyphenothrin” is the common name for the “pyrethroid” insecticide with the name: (IUPAC) [cyano—(3-phenoxyphenyl)methyl]- 2,2-dimethyl-3—(2-methylprop-1- enyl)cyclopropane~—1- carboxylate.0 It is also known by the trade name (GOKILAHT) and has the following structural formula and the following identifying and identifying groups: (1R)-trans—isomer N | 0 0 0 ,hd " 0 | ~ 1 1 0 Pp (1R)-cis—isomer N | 0 0 ru© tahy Appellation: Vo Common name: 'cyphenothrin' (see Composition) - (BSI, E-ISO); cyphenothrine ((f) 0 (50 A. Name H A

=« \ _ (RS}-a-cyano-3-phenoxybenzyl (1RS,3RS;1RS, 3SR)-2,2-dimethyl-3- (2-methylprop—1- enyl)cyclopropanecarboxylate (see formula). (RS}-a—-cyano-3-phenoxybenzyl (1R)-cis-trans-2,2-dimethy 3-)2- cyclopropanecarboxylate methylprop-1-enyl) © Name of chemical extracts: cyano(3 -phenoxyphenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl) cyclopropanecarboxylate Other names: [Y40Y0-£.-YCAS RN ] cyphenothrin —d V. Stereochemistry not specified ; development codes-5 006001687767 Forte (Sumitomo ) and for the purposes of this written description of the patent”; It should be understood that the term “cyphenothrin” means that it is a pure and optically pure isomer of the compound ‘cyphenothrin’ or is a mixture of isomers of a compound such as J’eyphenothrin (JB). Embodiments of the invention may include The present Vo contains (-5;((R) isomers of the 'cyphenothrin' compound with varying degrees of covalent increase. Specifically, some embodiments of the present invention may include the racemic compound "070060007" as the active ingredient; and Other embodiments include the -5 isomer of “07700860015010” known by the trade name (GOKILAHT=S) as the active ingredient. insecticide with the name: a

2,3,5,6- tetrafluoro—4-(methoxymethyl)benzyl (EZ)-(1RS,3RS;1RS,3SR)- 2,2—dimethyl-3-prop-1- enylcyclopropanecarboxylate. The following structural form aly (SUMIONE) commercial aul dads is also known and the following instrumental and identifying groups are also known: >

AND

9 : I( A H as rap" = YO a o Designation: metofluthrin (BSI, E-1SO); metofluthrine 0 F-1SO) Common name:

H The name is 2,3,5,6-tetrafluoro—4—(methoxymethyl\)benzyl (EZ}-(1RS,3RS;1RS,3SR}- 2,2—dimethyl- 0 prop—1-enylcyclopropanecarboxylate but See composition. Name of chemical extracts:

— \ \ —

[2,3,5,6-tetrafluoro—4-(methoxymethyl)phenyl]methy\2,2-dimethyl-3—(1-

propenyl)cyclopropanecarboxylate CAS RN [240494-70--6)

development codes 1714-5); Smiles (Sumitomo Chemical) Smiles code without 0 Compositions of the present invention containing insecticidal active ingredients have been shown to be effective

better annihilation, lethality and killing compared to the compositions of previous art »; This is based on laboratory tests

And data of field trials that were implemented in Malaysia and Turkey.

According to another feature of the present invention; A spray pan is provided containing the composition according to any aspect of the

Features of the present invention.

0 “The embodiments of the present invention associated with or relating to insecticidal formulations are mainly and primarily used for the preparation of liquid agents Jie oil sprays; and emulsifiable substrates and aerosols. It may also be used to prepare mosquito net coils; mat or braid for electric steamers; and incense materials (AY) volatile or volatile non-heating formulations applied to resin or paper; hazy textures; poisonous taste; grains; toxic earth dust; And

.Ultra low volume application Vo of another feature of the present invention; A method for preparing a suitable formulation for spraying is provided; Includes Tay, where stabiliser includes at least one active ingredient and a stabilizer oil phase one oil phase epoxidised vegetable oil containing epoxidized vegetable oil stabilizer includes at least one dis or stabilizer ; and/or at least one emulsifier; Optionally an emulsifying agent

,. vapor retardant additive 0 aqueous and in some embodiments; The method also includes in addition to the foregoing the addition of an aqueous phase comprising at least one dispersing agent; and optionally on a phase anti-slug agent. thickening agent and/or on one JN 070 thickening agent

Ad — \ — A some forms; The method may include the following steps: (1) Mixing and heating the oil phase to dissolve the components of the oil phase; (1) Mixing and heating the thickening solution (0) to dissolve the components of the thickening solution; (?) Cooling both the oil phase, the aqueous phase, and the thickening solution; With a continuous stirring procedure to form a mixture; (1) 0 A continuous stirring procedure to achieve the homogeneity of the mixture of the previous step (V) until a homogeneous mixture is obtained; (V) the mixture of the thickening solution with the homogeneous mixture to form the pesticide composition For the purposes of this detailed written description of the patent”; the terms “ambient temperature”; dadd CHEN temperature “Cal conditions” “ARAN conditions” are used interchangeably 1 or synonymously to denote to room temperatures that are practiced in tropical countries; that is, at temperatures of approximately (70 C + C); and it is preferable to be about 1 (m + (oY) in some models; The method may include preparation of an oil phase comprising at least one stabilizer; Where ‎ddl dad had an epoxide vegetable oil | at least one epoxidised vegetable oil; where at least one epoxide vegetable oil is derived from Yo at least one vegetable oil selected from the group consisting of soybean oil Jatropha' oil Lindseed oil ; neem oil; palm oil; coconut oil; coconut oil; cottonseed oil; bean oil

_— ¢ \ _ Sudanese Peanut oil Olive oil Rapeseed oil Rapeseed oil ; safflower oil; sesame oil “sunflower oil” ¢ almond oil 801000; beechnut oll yal nut oil; cashew oll « © hazelnut oil; macadamia oil » mongongo oil; pecan oil GE (a type of pecan tree nut); pine nut oil; pistachio oil ¢ walnut oil . and in some embodiments; The stabilizer cid is a soybean epoxide. A some models; The method may comprise the preparation of an oil phase comprising one active ingredient 0 on JY (JY) where at least one active ingredient is at least one active ingredient selected from the group of insecticides ; herbicide, fungicide, acaricide, insect repellent, deodorizer, and drug abuse. “at least one. VO and in some embodiments; the pyrethroid compounds” “ are selected from the group consisting of: allethrin, phtalthrin, prallethrin, furamethrin, empenthrin, cypermethrin, decamethrin, phenothrin, permethrin, cyphenothrin, tralomethrin, deltamethrin, bifenthrin, cyfluthrin, etofenprox, transfluthrin, cycloprothrin, acrinathrin, fenvalerate, esfenvalerate, flucythrinate, tefluthrin, esbiothrin, fenpropathrin, tetramethrin, 90. a dimef luthrin, Pyrethrin 0, Pyrethrin Il, Cinerin Cinerin Il, jasmolin 0, jasmolin 11 and metofluthrin.

a J \ -

and in some embodiments; The formulation may include '008100110/a0' and/or 'metofluthrin' and optionally

piperonyl butoxide. According to another feature of the present invention; use is provided

a combination according to any feature of the present invention; optionally diluted with water; or use slog

to spray in accordance with any feature of the present invention; to control or control insects; or on pests and epidemics of ticks and lice; Or on unwanted plants

and undesirable.

And now that the invention has been described in general; the same description would be already more understandable than

By referring to the following examples and using Bahaa, which were provided and presented for the purpose of clarification; and not

daly to be specific or restrictive of the present invention.

0 EXAMPLES The present invention will now be described in more detail by setting examples of preparation and test examples” which are the following examples to which the present invention is not limited or limited and which are

Terminology part(s) is part(s) expressed by weight. Manufacturing Example No. (1) Vo Composition No. (V) is obtained by performing the following steps: An oil phase was prepared by dissolving (V) a fraction by weight of “metofluthrin” (1) parts by weight of (V+) <'cyphenothrin® parts by weight of piperonyl butoxide, in (3.80) parts by weight of an aromatic hydrocarbon solvent. After that, both were added to the resulting mixture solution. of (4400) parts by weight of Se stabilizer 0 or stabilizing agent (sy) stabilizer epoxidized soybean oil (Y.Y0) ¢( epoxidised soybean oll) part by weight of additive (A) of a vapor retarder or vapor retarder (cetyl alcohol) (A); and an additive (8) of a vapor retarder or vapor retarder (B) (a mixture of stearic acid and palmitic 8610) (0.1) part ye ((0-46 Clariant Int. Ltd)]) aul product ¢(A) [ (Genopol © Y. +) by weight of emulsion

CRODA ( aul product ¢ (B) [ (Brij SY:-PA-8G) pwt -55-110) [(Brij O) pwt (+.4¢) ( SINGAPORE PTELTO )] where [(CRODA EUROPELTD, Roweliffe Bridge, UK) aul product “(RB) was added; then mixing was done well by shaking and continuous stirring to obtain the oil phase 0 (oil phase) previously described; Cull (oil phase) was prepared. Separately from the polyvinyl phase, a part by weight of (V0) was prepared by dissolving the aqueous phase Jk (+2) phase preparation in (0£) part by weight of deionized water. The ions, after which the alcohol was also added

Dow (Product Name ¢(C) antifoam fraction by weight of antifoaming agent 0000109.)]; Then the mixing was carried out by continuous stirring to obtain the Asia, Corp 0 phase, separately from the previous preparations. polyvinyl alcohol from aqueous phase jk described for the preparation of both the oil phase and the aqueous phase; A mixture of (+) by weight of (0.101) ¢ (1,2-benzisothiazolin—3-one) preservative (that is (+.+Ve) ¢) aluminum magnesium was performed. silicate (a thickening agent by weight of (VE) (xanthan gum)” thickening agent by weight of a thickening agent 10, where good mixing was carried out by continuous stirring to obtain lind) deionized water as a thickening solution. An 'oil-in-water' emulsion was obtained by adding (71.7) parts by weight of (3+) parts by weight of the previously described oil phase, then shaking was performed. for (VY) an aqueous solution to in per minute to be emulsified and dispersed. After that, Ad (0001) min at a rotational speed of 0-part by weight of the previously described thickening solution was added to the emulsion 'oil-in' (15.575) by weight of deionized water eda (1.975) obtained; then ele (1) was also added to obtain the total amount of composition No. deionised water ions (1) Example manufacturing number d

Composition No. (Y) was obtained by the same previous preparation procedure that is completely identical to the manufacturing example No. (1) except that the type of solvent used was changed in an amount of (3080) parts by weight of cule aromatic hydrocarbon solvent 4 Manufacturing Example No. (V) to (2.60) parts by weight of solvent 1-phenyl-1-xylylethane © _Manufacture Example No. 7: Composition No. 7 was obtained by the same procedure The previous preparation is exactly the same as manufacturing example No. (1), except that the type of solvent used was changed in an amount of (3080) parts by weight of cule aromatic hydrocarbon solvent 4 Manufacturing example No. (V) to (3.80) (Part by weight of solvent 1-phenyl-1-ethylphenylethane 4). Oil phase A regular solution is prepared for an oily phase 1 part by weight of (Yo) "070080010710" 1 part by weight of (V.0) metofluthrin® from an aromatic 1 part by weight of an aromatic hydrocarbon solvent (V0) And that in piperonyl butoxide. hydrocarbon solvent 101 part by weight of a solid (0.75) To the resulting mixture solution was added both old and after an epoxy soybean oil (sy) stabilizer stabilizer part by weight of a substance Addition of retardant or (¢.+) epoxidised soybean oil

(C)) fraction by weight of the emulsion (( 0.8 ); cetyl alcohol (A) vapor retarder or vapor retarder

CRODA EUROPELTD, Roweliffe Bridge, ) aul product «(=SS-RBY.[(Brij © | 0) where added; then mixing was done well by shaking and continuous stirring to obtain (UK) by setting the aqueous phase on the oil phase (oil phase). An aqueous phase is prepared 1 part by weight of deionized water; 20 parts by weight of anti-slurry agent (£4) by part V.o (Dow Corning Asia, Corp.) ]) aul ¢(C) antifoaming product 0

m \ — by weight of polyvinyl alcohol in another container and then stirred constantly. An 'oil-in-water' emulsion was obtained by adding (0£) part by weight of the previously described oily phase to (81.7) part by weight of the previously described AW phase; then shaking was performed for (90) times at a rotational speed (Teer) rpm to be emulsified and dispersed.Furthermore, Ala) 0 (3.8) parts by weight of a thickening solution containing (1) parts by weight of aluminum magnesium silicate (a) thickening agent ( (++) 1 part by weight of thickening agent (xanthan gum); (00) 1 part by weight of preservatives (1,2 06-3-6A05602150101820); water" obtained; Then (;) part by weight of (deionized) water was also added to 0 to obtain the total amount of formula No. (4). Manufacturing Example for Comparison No. ((): Comparison Composition No. (1) was obtained by making the exact same preparation as for Manufacturing Example No. (1) except that (0) was not added. 55) part by weight of CRY 5185111560 “stabilizing agent” (which is epoxidised soybean oil Vo) to Manufacturing Example No. (1) “Furthermore, it was then changed The amount of solvent used ranges from (1.45) parts by weight of cule aromatic hydrocarbon solvent to (01) parts by weight of an aromatic hydrocarbon solvent. Manufacturing example for comparison No. (g): The formula obtained Comparison No. (7) By using the Ales image, the exact same preparation was made that 01 was made for the manufacturing example No. (1) except that no (7.75) part by weight of sale was added (A) (0.75) ¢ ( cetyl alcohol) part by weight of additive (8) of vapor retarder or vapor retarder (mixture of stearic acid and palmitic 8610 ); furthermore; the amount of solvent has changed user from (1.45)

q — \ — parts by weight of an aromatic hydrocarbon solvent to (VY. £0) parts by weight of cule. Comparative Study No. (): The following study evaluates the role of each of the stabilizer caf and the dispersing agent towards the degree of stability of the final product, specifically the proposed or assumed formulation for the spraying procedure; SAY F [formula] (1) which It includes a stabilizer “is” and a dispersing agent. There are three variables taken on the preparation method for (VY eT) [Composition No.] (1) that was prepared i.e.: 1-7 - 1F without stabilizer cus (without stabilizer); The commercial standard (Aqua K-Othrine «Aqua Resigen EW)) was prepared in the study in the form of compounds that act as control samples for comparison purposes. using the following recipe Ve method: Procedure Method | (7) w/w | 774710-0f |779571-0f -174| and Recipe (without Oey) | Cull Factor | 1f (without Dispersing) stabilized and without dispersing agent) zetbi phase 25.1 | oll for EE 0(g) for EE 0(g)0 EE 0( pha se g

=« So

SumiOne TG | AT (pure) A( .20( +4.V+ Lot: 0 9 1.10 | Gokilaht-S TG 19 ( 9 0 19 g 9 0 19 g ATA )

(5) Tos «AY VY Lot: 101 g. Jm 101. gm 101.1 101 peronyl butoxide internal 0 .m 16

0 (pure) Lot: 00015 km YY.0u Y.Yo cetyl alcohol g YY.0u g YY.0u g Lot: M 1101446 Edenor ST 1 So Y.Cu g Y.0u g Y.0u g MY BD stearic Li) palmitic 5 acid acid ( Lot: M 7110 L

Lot: SG

YAYY «a VE

N/A 06 g N/A Amepon 98/5 01711" 11AH01: L 0 0M6608 vol 001 5 g Tavs g Tavs g Lot: 0115906 0 .. —PA-Y Brij 5 g. Adht 0 approximate total or mixed gm gm subtotal -1774[ an Yar 177 7-fa 1 fas weight (7) | Procedure method factor | 1f (without Oey) | (Cull) and the recipe (without distraction) is fixed and unfactored

_- \ so

Mane phase 0 +. 0 a.g. il - / > 10.01 | Gohsenoi GL - approx. g N/A N/A 0“ approx. total or EAT 6 g | EAT g EAT g semi-total Procedure | (7) Weight / Weight | 774710-10F | SAYYAE [GE 1-1779 and the recipe (without Oey) | Cull operator | 1f (without

distracting) installed and without

dispersing agent) THICKENING SOLUTION 0 0 0.0 g 5 g 5 g Proxel GXL 1 (5) Bama Calca E

ah il - . 06 No Veegum G g 0 g 0 g Lot: 01014 0 Yo vo Yo Kelzan S g 0 Yo g 0 Yo g “YAAT Lot: Approximate total or 09 0.72g 1005g 005g Semi-Total Rinse Water 440.¢ (balance) £4.90g £4.90g 58g Pure Pure Water Total Total No 0g 06g No. g Each of (1-1744 Ca) 1-1"797 (F) was prepared using the following steps: 0 Preparation of oil length (oil phase) (1) An oil phase was prepared by weighing each of Gokilant=S “Sumi One TG” ude 16 piperonyl butoxide (TG) emulsions; Then, the vessel was heated to a temperature of (001°C). (Y) Then Edenor ST 11/750 “cetyl alcohol (a mixture of 0 5188-16 and 8610 o palmitic) was added gradually. In the oily mixture with constant stirring regularly.

(?) Continuous stirring was performed steadily and regularly for about (Yh) minutes until all the items (contents) were completely dissolved. (0) Thereafter, the solution was cooled to room temperature. (b) The aqueous solution was prepared (1) 5 The anti-foaming emulsion (©) was weighed; then it was placed in the vessel; then followed by water ( Y) Then, the solution was stirred at room temperature. ( ) Then slowly and gradually added (10 µof) (Gohsenol GL—found) into the resulting aqueous solution with regular constant continuous stirring. Continuous stirring was carried out in a constant and regular manner for a period of about (10) minutes at room temperature until all the solid (GL-.0) Gohsenol granules were distributed regularly. () After that, the vessel was heated to a temperature of (10 °C). (0) Thereafter, the solution was cooled to room temperature. (c) The thickening solution (1) Vo weight (Proxel GXL(S) was prepared and placed in the vessel; then This was followed by pure, pure water. (Y) Next; the solution was stirred using a laboratory stirrer at room temperature. ( ) Then slowly and gradually adding (© (Veegum) in the aqueous phase was carried out with regular, steady continuous stirring. After Then, (5) (Kelzan) was added to the same solution. Then the shal was continuously stirred steadily and regularly for about (01) minutes at room temperature until all the solid granules were distributed. regularly.() After that, the vessel was heated to a temperature of (10°C).

(0) After that, the solution was cooled to room temperature. (d) Homogenization and final mixing procedure (1) Mixing was carried out under the influence of Jab for high shear strength using a homogenizing unit of type TK (Robomic (Premix) Type Ahomogenizer. Under these conditions, the oily shall © was slowly and gradually added to the solution (*). (©) Finally, the resulting thickening solution was added into the emulsion, then stirring was performed using a laboratory stirrer at room temperature AW for about (Ye.) minutes to form a homogeneous Cu in a water emulsion. 0 an the following tests have been carried out: (a) Particle size/VMD of finished products: This measurement can be performed by using (+++) Malvern Mastersizery based on basic operating procedures. (b) Emulsion stability test: Examination of freshly homologated samples or examination of primary samples for “separation or sedimentation” operations; oiling (1); or creaming (Y) after sha) 05 dilution steps oF) over a period of (1) hours at oY + To) and after (VY) 1 hour at room temperature conditions. Lubrication: (1) The formation of the liquid phase is not SUE for mixing with water; at the top or bottom of the emulsion. Creaming (7): the formation of a layer containing a percentage of the dispersed phase higher than that which is in the remainder of the emulsion; at the top or bottom of the emulsion. Yo Dilution Steps (7): d

©

- (30) ml of standard or standard water (£) was poured into a measuring cylinder with a capacity of (001) ml 5335

with a stopper. after that; The cylinder is immersed or immersed in playa water to maintain a temperature

Its temperatures are at (70 + HY) for (1) hour;

Then, (01) ml of water emulsions (EW) spray was added to the vacuum space.

© in the cylinder; Where the addition was made slowly and gradually drop by drop using a measuring pipette;

- Then; The cylinder was sealed with a plug and turned (Lud) upside down continuously (01) times;

- after that; The cylinder was re-immersed or immersed in the sad water bath (7) hours at temp

(oY + Y 0 )

Lubrication (1), cream formation (Y), separation or sedimentation was observed after Y (ae) hours and then another 3% after (VY) hours.

Standard or standard water 4: Ble has two types as follows:

Standard or standard jue water:

(TE) g of (VV) (Jk Y calcium chloride) g of

magnesium chloride hexahydrate in distilled water until the volume of the solution becomes 1, resulting in Jal (1).

.calcium carbonate

5 standard or standard soft water:

One sia of standard or standard hard water was diluted with (9) parts distilled water

To give Abra Jara (a) mg/l. Ye (c) Separation rate and active content test: If there was separation, the total height was measured.

the total of the sample; The height of each layer is to be calculated and the separation rate is estimated. Layers have been isolated or separated

_ 7 By using a syringe needle; It was then analyzed in relation to the active content so that regularity and analogues were reviewed and examined after the separation procedure. RESULTS, DISCUSSION AND EXPLANATION: (a) Emulsion stability test of samples dilution over (Y) hours in dilution over (YY) hours in a 97 dan water bath at temperature (WT) under room temperature water conditions pe Standard Soft Water Standard Hard Water Standard Soft Water Soft or Standard or Standard or Standard or (WHO) (WHO) (WHO) Standard (WHO) F-7957"1 Stabilized Emulsion Emulsion cull emulsion cull fixed emulsion (without iis) 0-1" emulsion cB stable emulsion deo (1)_lubrication (1)ml lubrication f | (without over surface aha dispersing agent (F-7957) 1 stable emulsion emulsion cull (7) ml lubrication (7) ml lubrication (without supersurface stabilizer and without dispersing agent) (Composition No. “1”) (with Cue and in

A — as dele asm dispersion) VY TEC emulsion cull stable emulsion da (1) composition (1) ml composition sa) (aqua or cream sa) or cream Resigen on the surface (EW) VY TEC emulsion cull emulsion da (Y) cull composition (Y) ml composition sa) sam J sa) (Aqua K- or cream Othrine on abd surface (EW) All freshly prepared formulations appeared as a whitish viscous liquid. When dispersed in standard or standard water (1 4); All formulations formed stable emulsions over the first two hours. (VY) hours [i.e. (©) days] after the dilution has been made; The dispersing agent (V=IYYAY) 5f and (a) 1-1"794 and both commercial standards or standards were significantly lubricating or creamy. The proposed or borrowed formulation (VY ov) F) [Composition No. 1](1) and Formula 1-1"17497(F) [without stabilizer «fis or stabilizer; but in the presence of a dispersing agent] both remained stable. ( b) Separation rate and effective content test 0 To study the separation rate, each formulation was mixed well, then it was filled in bottles of (100) ml of light transparent glass [where each sample was placed in (7 ) bottles]; then stored under conditions of ( ¢ 8 C 3 ) ( ot 3 0 room temperature [i.e. ) +0 "C - C).

Samples were imported weekly and examined according to the following parameters: (i) Physical appearance and separation rate: Aqua K-Othrine EW temporal si/ | (29( )+) room temperature | (-2C) atl conditions! white ged (1) oil over | oil over | oil over | no separation surface; separation | surface; separation | surface; separation to dak (Y) to dak (1) to (Y) layer: - top layer | - top layer | - top layer VARI height» | 771 height» | 4 75 height; tan color» | yellow color» | yellow; Anda - bottom layer | - bottom layer | - dad bottom LAN height” | 7146 height” | 46 7 height; light colored flashing light colored flashing light flashing c ged (7) lubrication over | lubrication over | lubrication over | no surface separation detachment | surface detachment | surface detachment into (7) layers: | into (7) layers: | into (7) layers: - top layer | - top layer | - top layer

=” _ VAR high xR og high Jot og high; yellow-coloured.” yellowish in colour cial dk - middle | - ‎Gk Mafilia | - Ae Hh LAY height; yar high ER og high; FE - Light Luminous | Luminous light eg lay) ZY in Luminous light color psd (7) | lubrication over | lubrication over | lubrication over | there is no surface separation; surface separation; surface separation; Separation into (7) layers: | to (7) layers: | into (7) layers: - top layer | - top layer | - top layer (VES) height VA 0 height (Jo) og height; yellow-coloured.” yellowish in colour cial dk - middle | - ‎Gk Mafilia | - Ae Hh 7 H at 0 H (VES) og H; off-white; - bottom layer 4 H; pastel luminous (?) week ‎awd up | lubrication over lubrication; no surface separation; surface separation; detachment | on the roof; To (7) Layers: | To (7) Layers: | Separation into (7)

- top layer | - top layer | Layers: ht arta 6 wy sold © |- layer Le n fal n fal yellowish color | 51 cial height » color - middle layer | - bottom layer | chlorotic ar height ar og height layer . La. | . 18 . Fuchsia | bright bone ‎pi ea | Fe is white; Luminous Light Gk - Flat A Ve High Light Luminous Aqua K-Othrine EW Period/ | ‎Aa (2+) (po) lane | (Po) Storage conditions Initial chamber/coloured liquid | color liquid | dil-coloured liquid with a whitish primary color | ola to | ba to bal to (1) week lubrication over | lubrication over | separation to (1) | no separation dan separation | surface separation | layer: (Y) layer: (Y layer: to (1) layer [pe no] EEO] dd - upper a - upper layer 1 7997 H; La dh - mfulya | - bottom layer | 77 li) in color

9 H; color | zv height; color | Translucent Translucent Translucent Translucent (Y) Lubrication week above | lubrication over | detachment to (1) | no detachment surface; detachment detachment; detachment | layer: A (Y) layers: (Y 11 layers: to (1) layers | to hd | PEER) dd - upper a - top layer \d 7997 1 p; Gel |All wl - bottom | 73 H; VAR color HV LH HH Semi-transparent in semi-transparent color | in semi-transparent color () week Lubrication over | Lubrication over | Separation to (1) No surface separation ; surface separation; separation | layer: a ?) layers: ‎(YY 11 layers: to (©) layers: | to (0) layers | kd dd - upper a - upper layer | 797 \d p; ey 7 height p 5 yA height tawny” tawny” 1 tawny ' -|1 layer Li. - middle layer | - middle layer \d YAY VARY High A og High Translucent Off-white | White Gh - Flecked - Li Hl Y¢ 7 High Vo og 7 rose p

ES Ea There is no chapter | (1) (?) a week of lubrication over | lubrication over | detachment to detachment | surface” detachment | layer: clad layers: (V 1 | a ¢) layers: top layer -| OH (7) to 1 to (;) layers: top coat | - top coat | 797 H;

Li. layer -|1 'yellow 1 yellowish' 2nd layer | Middle class | 78 high; Solid color - high, semi-transparent, AA, ld) EE! A La Layer J... | off-white) color high for white; 4 lower dak - 0 . Lower layer - m high

TE height in color 218. fee translucent color Ng ("Vy F (formula 1-4 time period/ | (24m)) ) +(0 degree slash| (-mm) storage room initial/liquid-colour | liquid-colour | liquid in color | liquid in color to lal to ola | to ola | primary off-white white white white

(Y) week cpl minuscule | lubrication | diminutive | There is no chapter, but there is no important chapter above | pe important above the surface does not exist a for the surface does not exist

wii gad (7) minuscule | pf is insignificant, there is no chapter, there is no insignificant chapter above | pe important above a for a surface does not exist the surface does not exist

cmd] gad (4) diminutive | wii] Minor No ood No unimportant chapter above | pe Important Above the roof does not exist The roof does not exist

stabilizer F (without stabilizer) - 17

EIEN EE Temporal / | (24m) 53

Room storage

[ads liquid color | color liquid | dil color liquid

Primary Thumbs Up | ola to | ola to lal to white white white white

(Y) week cpl minuscule | lubrication | diminutive | There is no chapter, but there is no important chapter above | pe important above the surface does not exist a for the surface does not exist

AG _ (©) wk | lubrication. diminutive | Cuff is insignificant, there is no chapter, there is no insignificant chapter above | pe is significant above the surface; there is no surface; no chapter cmd] gad (4) diminutive | wii] Minor No ood No unimportant chapter above | pe is significant above the surface; there is no surface; No class Class 1 -7 F (No Dispersion Agent) IEEE (+) temp | (-mm) conditions 2a primary/primary gin neighborhood | off-white liquid | dl] oh liquid dl] in color to white la to offbeat | to off-white white white (1) week | sedimentation; 7 no season no season no season height at base level esd (V) lubrication Secondary | There is no separation but there is no separation There is little separation above the surface + sedimentation; (ld) YA 1 p at the level of Lal) 3

h —_ _ secondary lubrication Jia above the surface; (1) 1 week Lubrication (gsi | no season No season No season Jia above the surface + sedimentation; 71 height 2 at base level Secondary lubrication Jia above the surface; (2) 1 week lubrication (gsi | no separation no separation no separation Jia above the surface + sedimentation; 1 raised 2 at the base level minor minor above the surface; 1 -1 584 F (without (yu stabilizer “iis) dispersing agent) for the period of time / (04 m) (+) IEE conditions of the storage room

Preparatory / Elementary | color liquid | color liquid | dil-coloured liquid wba to ba to off-white white white white (1) week. |sedimentation; rise | no separation no separation no separation YAY ( ) at lal) 32 ged (Y) | lubrication. dia There is no separation There is no separation There is no insignificant separation above the surface ¢ sedimentation ¢ la) (% V) p at thin de lubrication Jia very Gs surface ' gad (V) Low lubrication Slight lubrication, no separation, no separation, insignificant over insignificant above the surface ¢ sedimentation ¢ surface ¢ sedimentation ¢ la) (% V) p at thinness (de (4) week [ci] negligible wf] Insignificant, there is no ood, there is no insignificant separation over insignificant above the surface ¢ precipitation ¢ the surface ¢ precipitation ¢ la) (% A) p at the thinnest de AUR

from the study conducted; It can be seen that both commercial products of Bayer (Aqua K- (Othrine EW 4 Aqua Resigen EW) separated at room temperature conditions and at high temperature storage conditions. However, Ja, formulation No. (1) Remained stable without separating or disintegrating 0 ( ) the particle size of the finished product Aqua K-Othrine EW time sal | (-hm) degrees (an )=( for test chamber one | upper lower | upper | lower a upper middle [alin] singular [no chapter] time period | (VV) | (01) µm | (VY) µm | (VV) µm first µm three 1st week tA] Yee 1.111 ah ah..Va = | Yeo microm | microm | microm | microm | microm | microm microm

week NVA 4.1 va 01" tph lv | vot second µm | µm | µm | µm | µm | µm | µm | µm A A A A A A A A A week 3rd v.04 0.1 1 2 V.¢ 1011 1 except CEA] LYE µm | µm | µm | µm | µm | µm | µm | µm A A A A A A A A A Week 4 A TA Y.o +07 ¥.4 AY Y.o Yoo µm | µm | µm | µm | µm | μm | μm | μm A A A A A A A A A Note: For the first week and the sample in storage conditions at Sha (08) degree, a separation into two layers was observed. For the following weeks (the third week and forward), a separation into (7) was observed. layers. layer A layer | layer there | upper [dans] dle | Ala] | lower | second | third (Aaa) fourth trimester period | 7.5 | VE µm 7.4 µm ;. µm prime time d

Qo = _¢ µm micro ¢ first ohmmeter µm µm spo v0 0.1 1) 1.0 v4 0.4 Y.¢ 2 µa|micro 1|µm | micro A second ohm | meter | micro a meter fe | meter mic meter Jes aspo | 0 OY | +. Y.o 1.8 v4 5.7 | 1.1 µm GUL See ¢ |micro | 1 micro |micro | Micro | micro A lB | m m m m micro | m m m m Sel μm Jes week 79 6 and 29.1 .a 00.” 0.0 a lala | a ¢ micro |micro VI micro |micro |micro se] |micro |micro | 1 fourth ohmmeter ammeter micrometer |meter el ammeter ammeter ammeter |micrmeter Jes -1 0 * 4 f [formula number 1](1) 55 temporal / | )>( das free | (0 then) (9) room conditions a bin d yen primary / primary | TY + µm | TY µm | TY µm VAY µm (0) week ba µm AY µm d oy

VE] µm 0 TY | 1.27 μm | Sieg See 7 weeks (Y) LAA

VAY micrometer | 17 µm 1.77 | Sieg See 7 weeks (7) LAA

VAY] micrometer vl TY | 227 μm | Sieg See 7 weeks (£) a ha ha [( stabilizer +©51851115(no stabilizer) Cafe [without 1 fa-1 7 (2) (£0) [hn strip time period / | (-m) Room Conditions Storage 0.76 | 1074 µm | 174 µm | 1074 µm | Primary/Primary Either as A A A F (No Dispersion Agent) 0-17 (2) (£0) [hn Aa (2) | Time Period / Room Condition Storage

_— \g 1 - 4 F (without stabilizer and without dispersant) time/ | (7) Free degree | CRN (4) room conditions A, B, D, The granular sizes of the commercial standard Bayer products were larger compared to the granular size of composition No. (1). And when separation occurred, for each of (( Aqua Aqua K-Othrine EW ((Resigen EW 0), the particle size of each layer was also different in a significant and important degree; that is, the grains of the upper layer were larger than the particles of the middle layer or than the particles of the lower layer. And in temperature conditions The storage temperature” JS granules of “Aqua K-Othrine EW” (Aqua Resigen EW) tended to increase in size, but the granules of manufacturing Example No. (1) remained constant; without an increase or Decreased granular size under all storage conditions.

-.” g From the previous results, it can be seen that the small droplets of the composition present in the samples without “iis 518511283 have grown to nearly 1 times their volume. Accordingly, the presence of the oS stabilizer (Amepon 58/65 (Necessary to reduce the increase in particle size to a minimum. As seen by Lad previously; the presence of a dispersing agent (Gohsenol GL_05) in the 0 formulation helped to achieve a small particle size to be less than 1) In addition, the presence of a dispersing agent (Gohsenol GL-05) is necessary to obtain a pan of fine particles [with a particle size of less than (1) μm]. (7) The content of the active ingredients for each layer when Separate Product/Conditions | Class Effective Content | Gal vs | Effective Content Storage alias (7 | Declared Content | Declared | (7 w/(cus)%) w/(cus) 4 F upper parts | SumiOne: no difference | SumiOne: 4 hemostasis La 0111 | has its value | 0.1 OR FE . | . a b [(1) from the roof) Gokilaht-s: [<*> | Gokilaht-s:| the declared verb lower part | 5.95 l i! 4 high piperonyl nh | © 9 pi Ronel n base There is a difference from the base) Butoxide: Not 7 Butoxide 01 La has a value of 1 LI 7 About the content SumiOne: The declared active ingredient is Gokilaht-S:

— g 0.47 piperonyl butoxide : 4.41 Aqua K- | Delta Methrin Top Layer: Higher Foyer | Delta Mithrine: (AY) LL Othrine EW : Delta Mithrine Substrate: [ais (EY) 0.20 dnd less heat | Weight (Y) dau (787) weeks] H | Aqua | Top layer piperonyl 5- Biolithizrin: | 5- Bioallethrin: othrine EW a. 0 butoxide is higher by | 2.04 Lon 4 i [permethrin temperature radii: piperonyl (£) Aad permethrin: higher | 001011 weeks] top butoxide layer | by 71646 i by 7715 high piperonyl "1 butoxide: butoxide daha :1.921 lower -S 0 -S biopolyetherin: biolithizine: higher [I Y lo) by permethrin ratio: 0001 | permethrin: Less by 0 M piperonyl butoxide: EY

top.| LA Aqua Top Coat | ,—S Bioallethrin: | 5- BioLiterine: -S i VYY Resigen pnsa | Bubu lepthrin: 9 bottom layer on the ratio | Biolithisin, AR Joy. EW Permethrin: 11.77 coud 1 NY Y 5 viperonyl (Y) «(po)] Permethrin: Higher | Permethrin A by 7977 101.1 weeks] butoxide:| 5 x piperonyl piperonyl butoxide |: butoxide 1: i in proportion | 4.47 Bioallethrin: Sula ERY AT Permethrin: 00111 piperonyl butoxide: higher.| In the ratio of AT aul 5- Biolithrin: CR} q 0 piperonyl butoxide : -S 0 Biolithrin: less

- g by 7771 permethrin: less by 7717 piperonyl butoxide: less by 778 tertiary -S biolithrin: r,t Y ¢ permethrin: Y.vo piperonyl piperonyl Aqua butoxide : butoxide Resigen : -S 7 -5 1.18 EW : Polyurethane: Less than Polyurethane: mm (9). by 7971 _ oy by wk] PNSD 5- Bioallethrin: | Higher Bensd Wen Bel eden ddl Permethrin: Less JARRE EE Permethrin: Less Permethrin: Less: 197 by 798 Se piperonyl butoxide: Less | piperonyl piperonyl by 70977 butoxide | putoxide: “. - 1 0 layer lower by 1 792 higher by 1

— 7 g lower (fourth) | LAA piperonyl 5- 010106 : Bioallethrin: 9.41A upper (primary) CI 0 A permethrin S-layer: TA | Bottom 5- Biolethrin: : Biolethrin: F piperonyl vole butoxide : Permethrin: 0 Permethrin: Yeo A piperonyl Vout butoxide : 4.71 51- Biolethrin: higher by 7971 Permethrin: 799% higher Permethrin: mA and by Active Ingredient Content Analysis; Ang found that the content of the compound "delta" in (Aqua K-Othrine EW) was not homogeneous across the entire vessel when the composition was separated. The active content in the bottom layer was (XAT) lower than the advertised content. a

The same result was observed for (Aqua Resigen EW) where the active contents were higher in the upper layer compared to Tall in both the middle and lower layers. any way; The effective content in formulation No. (1) remained uniform and similar. As can be seen from the above, the presence of the stabilizer and dispersing agent leads to improving the degree of stability of the spray formulation. There are many benefits and advantages in having a stable formulation. Vs unstable formulation (disjointed / adie) In unstable formulations which disintegrate and separate into layers, the active ingredient is not distributed uniformly and uniformly throughout the entire formulation. Shake the product well before use. Failure to ensure good homogeneity before use will affect the efficiency and efficacy of the product. On the one hand (al) if the product does not separate to any extent (lad) there is less need for the bottle to be shaken Also, there is less chance of applying dosage errors which may then come into play.

Claims (2)

4E- Elements of Protection 1- A formulation suitable for spraying; Includes an oil phase Contains at least one active ingredient, a stabilizer, a vapor retardant additive, and an aqueous phase ©0085 80116015 Includes one dispersing agent on JN where the stabilizer includes at least one Sl epoxidised vegetable oil©; optionally at least one emulsifier; and a vapor retardant additive comprising a base ingredient cetyl alcohol stearic acid and palmitic acid—Y YL the composition according to claim No. (1); also comprising in addition to the foregoing at least one agent selected from the group of antifoaming agents and thickening agents »- the composition according to claim 1 or © where the epoxide vegetable oil led by this vegetable 00101560©_one is derived at least from one vegetable oil on The least is chosen from the group consisting of soybean oil » Jatropha oil; linden seed oil 005860 neem oil; palm oil; coconut oil; coconut oil; cottonseed oil; peanut oil; olive oil; rapeseed oil ‎rapeseed oil; safflower oil; Yo Sesame Oil; sunflower oil; almond oil » beechnut ol Shall nut oil; cashew oil, American or Western; hazelnut oil; Macadamia oil; sai sai ge 00007901790 “oil Pecan oil Gill (a type of pecan tree walnut); pine nut oll » pistachio oil; das walnut oil qa Sle stabilizer where the stabilizer is oF to 1; - Composition according to any of the protection element. epoxidised soybean oil from epoxidized soybean oil. Where 1 d - the composition according to the claims of at least one selected from the group consisting of an insecticide active ingredient ©; a fungicide; a herbicide; an insecticide; insect repellent; 060001158 acaricide and lice repellent; and drug abuse to © in which the active ingredient comprises a compound 1 the composition according to claims of 1 0 at least one. Where the pyrethroid compound is selected - “from the group of furamethrin furamethrin » prallethrin cp iL; phtalthrin op iG » 801610010 leithrin Yo; cyphenothrin; phenothrin; empenthrin (finned “decamethrin” permethrin + cypermethrin acrinarine + bifenthrin + deltamethrin ¢ acrinathrin fenvalerate » fenvalerate cycloprothrin ¢ 180510110 | Meperflutrin “resmethrin” cyhalothrin “cihalothrin + fluvalinate” pyrethizin “dimefluthrin”; dimefluthrin; “teflumethrin”; Pyrethrin (a) » pyrethrin Pyrethrin +5 .metofluthrin Metofluthrin ¢ (11) jasmolin (a); Protection from - A. piperonyl butoxide and selection O “metofluthrin and/or” cyphenothrin at least 8 to 1. Contains formulation according to protective elements spray container 4-spray container includes oil phase Method for preparing formulation suitable for spraying ; It includes an oil-phase preparation © - 01 contains at least one ingredient 801176, a stabilizer and a vapor retardant additive; and emulsification of an oil phase using an aqueous phase containing at least one dispersing agent. epoxidised vegetable oil an epoxidised vegetable oil stabilizer where the stabilizer includes at least 0; and at least one aly emulsifier; Optionally an emulsifying agent comprising a basic component vapor retardant additive sale .palmitic acid 5 stearic acid « cetyl alcohol 11 1 - The method according to Claim No. (10); it also includes in addition to the foregoing the addition of an aqueous phase comprising one dispersing agent on “JAY” and optionally an antifoaming agent at least one agent; and/or a thickening agent VY 0 - The method according to claim No. 01 to 11 in which at least one epoxidised vegetable oil is derived from at least one vegetable oil selected from the group consisting of soybean oil » Jatropha oil; linden seed oil 005860 neem oil; palm oil; coconut oil; coconut oil; cottonseed oil; peanut oil; oil Yo olive oil; rapeseed oil; rapeseed oil; safflower oil; sesame oil; sunflower oil « almond oil »+ beechnut ol Shall nut oil; American or Western cashew 085767 oil; hazelnut oil; Macadamia oil; sai sai ge 00007901790 “oil pecan oil”; pine nut oll » pistachio oil; das walnut oil lo} 0 - The method according to any of the previous protection elements from No. 01 to No. 11 in which the stabilizer Cadel) is epoxidised soybean oil. 04 - The method according to any An element of the previous claims from No. 01 to No. OF, where it is 0 in which the active ingredient is at least one active ingredient selected from the group consisting of an insecticide and a herbicide; a fungicide; and acaricide Jal and acaricide lice; insect repellent; odor eliminator 060001158; and drug abuse Yo 1 the method according to any of the preceding claims No. 01 to No. 094; Where the active ingredient includes at least one pyrethroid compound. - The method according to Claim No. V0 where the pyrethroid compound “led” is selected from the group consisting of: furamethrin; phtalthrin op iG allethrin allethrin 0 ; cyphenothrin; phenothrin; empenthrin (finned “decamethrin” permethrin + cypermethrin acrinarine + bifenthrin + deltamethrin ¢ acrinathrin transfluthrin | © ¢ cycloprothrin; fenvalerate » esfenvalerate ¢ flucythrinate ¢ teflutrin 1611010010 ¢ esbiothrin » + fenpropathrin » tetramethrin; Flewa yen S fluvalinate + cyhalothrin «resmethrin» meperfluthrin; teflumethrin; dimefluthrin « pyrethrin (A); Pyrethrin (AA); Cinerin (A); Cinerin “(Il) Cinerin jasmolin (a); Jasmolin (11) ¢ metofluthrin lo }-11 The method according to any of the previous claims from No. 01 to No. OT in which the composition includes cyphenothrin “and / or metofluthrin “and optionally piperonyl butoxide sav 0 WG rein formulas in public baths IS with BS Lo 1 1 L: L 8 JE: Glossy ~ RK a ay 3 pag Tah A L A L AAR RRA 3 H & B® 3 a xX RS MB RS a Ay 3 Eg = i ed = 1] § CE. FY ECLA A da ree SSS? Be Toh RPT toil te 3 # 0 x aa aa Vi IX 3 pA wa aa aa aa at smoy 8 8 8 8 8 8 8 8 8 8 8 limjay jah jah mohayyyy The yam hayy maha is a > : 2 3 i 1 1 a+ i 1 8 8 8 & 1 LN Ohm aa aa aa aa maha Allah ma ala aa aaar : : 1 : 1 1 a 3 ES i 2 8 8 . 8 . 8 8 2. <70: . 1 oy i 1 3 RIFE 2) 8 7 8: A and y AA LA Role 3 FOTN A AAA AAA AAR AAS AA AA AAA AAA SAYER LE An 0 x 1 1 1 1 1 1 1 1 co 4 . Knit 4 3 ¥ 3 4 8 1 8 = 3 8 : . 8 3 . 0 A Yoo ¥ ¥ « A Yoo HY OXE BY TRY. TYOXY BA t) x eT) Alice L L L L L L L L L L L L L L L L L L L L L L A 0 : i SE D RRs Resmi Semin } 3 essen AA ATA 8 1 H: = oF SER 1 3 L A L L A L A L H A A M RNA :: A i FR SE for NNN So: > Na 3 C: = L 3 = A den Messiah A TT EE AE EA AAA The A 4 Wi, : ; TA: 8 ALA: 5 BAGTSA:: A: 1: SA MAN AA A A AA AA AA AA A A, AA AA A SA A AA A A AC AA mat a a a ma mm be RE oR : 8 J : the w oF § A A RA AA RAR RRR SR AA A A A A A A A A A A E A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A A E A A A A A A A A A A A A A A A A A A A A A E Point x SEY Ge be YY : =e % 3: . A Kha Yo Jed Lib 3: Form? sneak The validity period of this patent is twenty years from the date of filing the application, provided that the annual financial fee is paid for the patent and that it is not invalid or forfeited for violating any of the provisions of the patent system, layout designs of integrated circuits, plant varieties, and industrial designs, or its executive regulations issued by King Abdulaziz City for Science and Technology; Saudi Patent Office P.O. Box TAT Riyadh 57??11 ¢ Kingdom of Saudi Arabia Email: Patents @kacst.edu.sa