RU99124224A - NEW HYDROCHLORIDES OF SUBSTITUTED ACETYLENE AMINOSPIRTS-ACTIVE AND LOW TOXIC ANTAGONISTS OF HALOPERIDOL - Google Patents
NEW HYDROCHLORIDES OF SUBSTITUTED ACETYLENE AMINOSPIRTS-ACTIVE AND LOW TOXIC ANTAGONISTS OF HALOPERIDOLInfo
- Publication number
- RU99124224A RU99124224A RU99124224/04A RU99124224A RU99124224A RU 99124224 A RU99124224 A RU 99124224A RU 99124224/04 A RU99124224/04 A RU 99124224/04A RU 99124224 A RU99124224 A RU 99124224A RU 99124224 A RU99124224 A RU 99124224A
- Authority
- RU
- Russia
- Prior art keywords
- new
- hydrochlorides
- aminospirts
- haloperidol
- active
- Prior art date
Links
- LNEPOXFFQSENCJ-UHFFFAOYSA-N Haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 title 1
- 150000000475 acetylene derivatives Chemical class 0.000 title 1
- 230000003042 antagnostic Effects 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229960003878 haloperidol Drugs 0.000 title 1
- 150000003840 hydrochlorides Chemical class 0.000 title 1
- 230000002588 toxic Effects 0.000 title 1
- 231100000331 toxic Toxicity 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- -1 amino alcohol hydrochlorides Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 231100000053 low toxicity Toxicity 0.000 claims 1
Claims (1)
где
Iа) R1-C6H5; R2
Am-N[CH(CH3 2)]2;
Iб) R1-C6H5; R2
Iв) R1-C6H5;
Iг) R1-C6H5; R2-C6H5 N[CH(CH3 2)]2;
Iд) R1-C6H5; R2-C6H5;
Iе) R1, R2 и карбинольный углерод составляют Am-N(CH2CH3)2;
Iж) R1, R2 и карбинольный углерод составляют
обладающие высокой антигалоперидоловой активностью и низкой токсичностью.New acetylenic amino alcohol hydrochlorides of general formula I
Where
Ia) R 1 -C 6 H 5 ; R 2
Am-N [CH (CH 3 2 )] 2 ;
Ib) R 1 -C 6 H 5 ; R 2
Ib) R 1 -C 6 H 5 ;
Ig) R 1 -C 6 H 5 ; R 2 -C 6 H 5 N [CH (CH 3 2 )] 2 ;
Id) R 1 -C 6 H 5 ; R 2 -C 6 H 5 ;
I) R 1 , R 2 and carbinol carbon constitute Am-N (CH 2 CH 3 ) 2 ;
I) R 1 , R 2 and carbinol carbon constitute
possessing high antihaloperidol activity and low toxicity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU99124224A RU2174510C2 (en) | 1999-11-15 | 1999-11-15 | Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU99124224A RU2174510C2 (en) | 1999-11-15 | 1999-11-15 | Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
RU99124224A true RU99124224A (en) | 2001-08-10 |
RU2174510C2 RU2174510C2 (en) | 2001-10-10 |
Family
ID=20227075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU99124224A RU2174510C2 (en) | 1999-11-15 | 1999-11-15 | Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists |
Country Status (1)
Country | Link |
---|---|
RU (1) | RU2174510C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20120131A1 (en) * | 2012-03-30 | 2013-10-01 | Consiglio Nazionale Ricerche | USEFUL INHIBITORS OF THE TCR / MHCII-COLLAGEN INTERACTION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS. |
-
1999
- 1999-11-15 RU RU99124224A patent/RU2174510C2/en not_active IP Right Cessation
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