RU99124224A - NEW HYDROCHLORIDES OF SUBSTITUTED ACETYLENE AMINOSPIRTS-ACTIVE AND LOW TOXIC ANTAGONISTS OF HALOPERIDOL - Google Patents

NEW HYDROCHLORIDES OF SUBSTITUTED ACETYLENE AMINOSPIRTS-ACTIVE AND LOW TOXIC ANTAGONISTS OF HALOPERIDOL

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Publication number
RU99124224A
RU99124224A RU99124224/04A RU99124224A RU99124224A RU 99124224 A RU99124224 A RU 99124224A RU 99124224/04 A RU99124224/04 A RU 99124224/04A RU 99124224 A RU99124224 A RU 99124224A RU 99124224 A RU99124224 A RU 99124224A
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RU
Russia
Prior art keywords
new
hydrochlorides
aminospirts
haloperidol
active
Prior art date
Application number
RU99124224/04A
Other languages
Russian (ru)
Other versions
RU2174510C2 (en
Inventor
Валерий Борисович Долго-Сабуров
Алексей Борисович Космачев
Елена Алексеевна Евдокимова
Натан Менделевич Либман
Станислав Михайлович Рамш
Владимир Валентинович Петров
Валерий Дмитриевич Тонкопий
Ольга Александровна Филько
Лариса Георгиевна Кубарская
Original Assignee
Государственное учреждение науки Институт токсикологии Министерства здравоохранения Российской Федерации
Filing date
Publication date
Application filed by Государственное учреждение науки Институт токсикологии Министерства здравоохранения Российской Федерации filed Critical Государственное учреждение науки Институт токсикологии Министерства здравоохранения Российской Федерации
Priority to RU99124224A priority Critical patent/RU2174510C2/en
Priority claimed from RU99124224A external-priority patent/RU2174510C2/en
Publication of RU99124224A publication Critical patent/RU99124224A/en
Application granted granted Critical
Publication of RU2174510C2 publication Critical patent/RU2174510C2/en

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Claims (1)

Новые гидрохлориды ацетиленовых аминоспиртов общей формулы I
Figure 00000001

где
Iа) R1-C6H5; R2
Figure 00000002

Am-N[CH(CH3 2)]2;
Iб) R1-C6H5; R2
Figure 00000003
Figure 00000004

Iв) R1-C6H5;
Figure 00000005
Figure 00000006

Iг) R1-C6H5; R2-C6H5 N[CH(CH3 2)]2;
Iд) R1-C6H5; R2-C6H5;
Figure 00000007

Iе) R1, R2 и карбинольный углерод составляют Am-N(CH2CH3)2;
Figure 00000008

Iж) R1, R2 и карбинольный углерод составляют
Figure 00000009
Figure 00000010

обладающие высокой антигалоперидоловой активностью и низкой токсичностью.New acetylenic amino alcohol hydrochlorides of general formula I
Figure 00000001

Where
Ia) R 1 -C 6 H 5 ; R 2
Figure 00000002

Am-N [CH (CH 3 2 )] 2 ;
Ib) R 1 -C 6 H 5 ; R 2
Figure 00000003
Figure 00000004

Ib) R 1 -C 6 H 5 ;
Figure 00000005
Figure 00000006

Ig) R 1 -C 6 H 5 ; R 2 -C 6 H 5 N [CH (CH 3 2 )] 2 ;
Id) R 1 -C 6 H 5 ; R 2 -C 6 H 5 ;
Figure 00000007

I) R 1 , R 2 and carbinol carbon constitute Am-N (CH 2 CH 3 ) 2 ;
Figure 00000008

I) R 1 , R 2 and carbinol carbon constitute
Figure 00000009
Figure 00000010

possessing high antihaloperidol activity and low toxicity.
RU99124224A 1999-11-15 1999-11-15 Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists RU2174510C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU99124224A RU2174510C2 (en) 1999-11-15 1999-11-15 Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU99124224A RU2174510C2 (en) 1999-11-15 1999-11-15 Hydrochlorides of substituted acetylenic aminoalcohol-active and low-toxic haloperidol antagonists

Publications (2)

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RU99124224A true RU99124224A (en) 2001-08-10
RU2174510C2 RU2174510C2 (en) 2001-10-10

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
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ITRM20120131A1 (en) * 2012-03-30 2013-10-01 Consiglio Nazionale Ricerche USEFUL INHIBITORS OF THE TCR / MHCII-COLLAGEN INTERACTION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS.

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