RU99124184A - INTERMEDIATE DERIVATIVES OF CEPHALOSPORIN AND METHOD FOR PRODUCING CEPHALOSPORIN - Google Patents

INTERMEDIATE DERIVATIVES OF CEPHALOSPORIN AND METHOD FOR PRODUCING CEPHALOSPORIN

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Publication number
RU99124184A
RU99124184A RU99124184/04A RU99124184A RU99124184A RU 99124184 A RU99124184 A RU 99124184A RU 99124184/04 A RU99124184/04 A RU 99124184/04A RU 99124184 A RU99124184 A RU 99124184A RU 99124184 A RU99124184 A RU 99124184A
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RU
Russia
Prior art keywords
hydrogen
formula
compound
silyl group
group
Prior art date
Application number
RU99124184/04A
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Russian (ru)
Other versions
RU2225411C2 (en
Inventor
Герд Ашер
Иоганнес ЛУДЕШЕР
Хуберт Штурм
Йозеф ВИЗЕР
Original Assignee
Биохеми Гезельшафт Мбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from AT0085894A external-priority patent/AT402072B/en
Priority claimed from AT85794A external-priority patent/AT402927B/en
Priority claimed from AT0106694A external-priority patent/AT402929B/en
Application filed by Биохеми Гезельшафт Мбх filed Critical Биохеми Гезельшафт Мбх
Publication of RU99124184A publication Critical patent/RU99124184A/en
Application granted granted Critical
Publication of RU2225411C2 publication Critical patent/RU2225411C2/en

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Claims (7)

1. Соединение формулы IA
Figure 00000001

в которой Ra обозначает водород или силильную группу; Rb обозначает группу формулы -ORe, в которой Re обозначает водород или алкил; a Rc и Rd вместе обозначают связь; или
Ra и Rd обозначает водород или силильную группу; a Rb и Rc совместно обозначают иминогруппу формулы =N-Y, в которой Y обозначает фенил; или
Rd обозначает водород или силильную группу; Ra обозначает водород, если Rd обозначает водород; либо Ra обозначает водород или силильную группу, если Rd обозначает силильную группу;
Rb и Rc совместно обозначают оксогруппу;
и силильная группа обозначает три (низш. алкил) силильную группу; в свободной форме или в форме соли, в качестве промежуточного продукта для получения цефалоспоринов.1. The compound of formula IA
Figure 00000001

in which R a represents hydrogen or a silyl group; R b is a group of the formula —OR e in which R e is hydrogen or alkyl; a R c and R d together represent a bond; or
R a and R d are hydrogen or a silyl group; a R b and R c together denote the imino group of the formula = NY, in which Y is phenyl; or
R d is hydrogen or a silyl group; R a is hydrogen, if R d is hydrogen; or R a is hydrogen or a silyl group, if R d is a silyl group;
R b and R c together represent an oxo group;
and a silyl group represents a tri (ness. alkyl) silyl group; in free or salt form, as an intermediate for cephalosporins. 2. Соединение по п.1, представляющее собой соединение формулы Iб
Figure 00000002

в которой Re обозначает водород или алкил.2. The compound according to claim 1, which is a compound of formula IB
Figure 00000002

in which R e denotes hydrogen or alkyl. 3. Соединение по п.1, представляющее собой соединение формулы I
Figure 00000003

в которой X- обозначает анион неорганической или органической кислоты и R1 обозначает водород или алкил.3. The compound according to claim 1, which is a compound of formula I
Figure 00000003

in which X - denotes the anion of an inorganic or organic acid and R 1 denotes hydrogen or alkyl. 4. Соединение по п.1, представляющее собой соединение формулы Iа
Figure 00000004

в которой Ra обозначает водород или силильную группу.4. The compound according to claim 1, which is a compound of formula Ia
Figure 00000004

in which R a represents hydrogen or a silyl group. 5. Соединение по п.1, представляющее собой соединение формулы II
Figure 00000005

в которой Y имеет значение, определенное в п.1, a Ra имеет значение, определенное в п.3, в свободной форме или в форме соли.5. The compound according to claim 1, which is a compound of formula II
Figure 00000005

in which Y has the meaning defined in claim 1, a R a has the meaning defined in claim 3, in free form or in salt form. 6. Соединение по п.1, представляющее собой соединение формулы I, определенной в п.3, где R1 обозначает водород, или соединения формулы Ib, определенной в п.2, в свободной форме, где Re обозначает водород, или соединения формулы Iа, определенной в п.4, свободная или латентная альдегидная функциональная группа которого в положении 3 кольца взаимодействует с азотсодержащим альдегидным реагентом с образованием соответствующего продукта.6. The compound according to claim 1, which is a compound of formula I as defined in claim 3, where R 1 is hydrogen, or a compound of formula Ib as defined in claim 2, in free form, where R e is hydrogen, or compounds of formula Ia, as defined in claim 4, whose free or latent aldehyde functional group in the 3-position of the ring interacts with a nitrogen-containing aldehyde reagent to form the corresponding product. 7. Способ получения цефалоспорина, включающий получение соединения формулы VI
Figure 00000006

в которой R5 и R6 одинаковы или различны и обозначают водород или органическую группу, либо R5 и R6 вместе обозначают замещенное или незамещенное кольцо, и превращение полученного продукта в другие цефалоспорины.7. A method of producing cephalosporin, comprising obtaining a compound of formula VI
Figure 00000006

in which R 5 and R 6 are the same or different and represent hydrogen or an organic group, or R 5 and R 6 together represent a substituted or unsubstituted ring, and the conversion of the resulting product to other cephalosporins.
RU99124184/04A 1994-04-25 1995-04-24 Intermediate derivatives of cephalosporin and method for preparing cephalosporin RU2225411C2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AT0085894A AT402072B (en) 1994-04-25 1994-04-25 Cephem derivatives and process for their preparation
ATA857/94 1994-04-25
AT85794A AT402927B (en) 1994-04-25 1994-04-25 Novel cephalosporin derivatives, process for their preparation and their use
ATA858/94 1994-04-25
ATA1066/94 1994-05-25
AT0106694A AT402929B (en) 1994-05-25 1994-05-25 Novel cephalosporin derivatives, process for their preparation and their use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU96122784/04A Division RU2150471C1 (en) 1994-04-25 1995-04-24 Intermediate derivative of cephalosporin and method of synthesis of cephalosporin

Publications (2)

Publication Number Publication Date
RU99124184A true RU99124184A (en) 2001-09-27
RU2225411C2 RU2225411C2 (en) 2004-03-10

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RU96122784/04A RU2150471C1 (en) 1994-04-25 1995-04-24 Intermediate derivative of cephalosporin and method of synthesis of cephalosporin
RU99124184/04A RU2225411C2 (en) 1994-04-25 1995-04-24 Intermediate derivatives of cephalosporin and method for preparing cephalosporin

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US (4) US5856474A (en)
EP (2) EP1340762B1 (en)
JP (1) JP3302369B2 (en)
KR (1) KR100487833B1 (en)
CN (3) CN1145629C (en)
AT (2) ATE244247T1 (en)
AU (1) AU686380B2 (en)
BR (1) BR9507512A (en)
CA (2) CA2533837A1 (en)
CY (1) CY2494B1 (en)
CZ (1) CZ297565B6 (en)
DE (2) DE69531203T2 (en)
DK (1) DK0757691T3 (en)
ES (1) ES2202362T3 (en)
FI (1) FI963761A (en)
HU (3) HUT75229A (en)
MX (1) MX9604353A (en)
NO (1) NO318020B1 (en)
NZ (2) NZ285084A (en)
PL (2) PL182864B1 (en)
PT (1) PT757691E (en)
RU (2) RU2150471C1 (en)
SI (1) SI0757691T1 (en)
SK (1) SK285948B6 (en)
TW (1) TW427992B (en)
WO (1) WO1995029182A1 (en)

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