RU99116356A - METHOD OF OBTAINING TLTERODINE - Google Patents

METHOD OF OBTAINING TLTERODINE

Info

Publication number
RU99116356A
RU99116356A RU99116356/04A RU99116356A RU99116356A RU 99116356 A RU99116356 A RU 99116356A RU 99116356/04 A RU99116356/04 A RU 99116356/04A RU 99116356 A RU99116356 A RU 99116356A RU 99116356 A RU99116356 A RU 99116356A
Authority
RU
Russia
Prior art keywords
reducing agent
obtaining
tlterodine
stage
carried out
Prior art date
Application number
RU99116356/04A
Other languages
Russian (ru)
Other versions
RU2176246C2 (en
Inventor
Джеймс Р. ГЕЙДЖ
Джон Е. КАБАДЖ
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of RU99116356A publication Critical patent/RU99116356A/en
Application granted granted Critical
Publication of RU2176246C2 publication Critical patent/RU2176246C2/en

Links

Claims (6)

1. 3,4-дигидро-6-метил-4-фенил-2Н-бензопиран-2-ол (IV).1. 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol (IV). 2. Способ получения толтеродина (V)
Figure 00000001

включающий
(1) восстановление лактона (III)
Figure 00000002

восстановителем с образованием гидрокси-соединения (IV)
Figure 00000003

и
(2) восстановительное аминирование гидрокси-соединения (IV) диизопропиламином.2. The method of obtaining tolterodine (V)
Figure 00000001

including
(1) recovery of lactone (III)
Figure 00000002

reducing agent with the formation of hydroxy compound (IV)
Figure 00000003

and
(2) reductive amination of hydroxy compound (IV) with diisopropylamine. 3. Способ по п.2, где восстановитель выбирают из группы, состоящей из гидрида диизобутилалюминия, натрий-бис(2-метоксиэтокси) алюминия и литий три-трет-бутиоксиалюминогидрида. 3. The method according to claim 2, wherein the reducing agent is selected from the group consisting of diisobutylaluminum hydride, sodium bis (2-methoxyethoxy) aluminum and lithium tri-tert-butyoxy aluminum hydride. 4. Способ по п.2, где восстановителем является гидрид диизобутилалюминия. 4. The method according to claim 2, where the reducing agent is diisobutylaluminum hydride. 5. Способ по п.2, где стадию (1) проводят при температуре менее, чем -15°. 5. The method according to claim 2, where the stage (1) is carried out at a temperature less than -15 °. 6. Способ по п.5, где стадию (1) проводят при температуре менее, чем или равной -20°С. 6. The method according to claim 5, where the stage (1) is carried out at a temperature less than or equal to -20 ° C.
RU99116356/04A 1996-12-31 1997-12-18 Method of synthesis of tolterodine and intermediate compound RU2176246C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3396196P 1996-12-31 1996-12-31
US60/033,961 1996-12-31

Publications (2)

Publication Number Publication Date
RU99116356A true RU99116356A (en) 2001-05-20
RU2176246C2 RU2176246C2 (en) 2001-11-27

Family

ID=21873473

Family Applications (1)

Application Number Title Priority Date Filing Date
RU99116356/04A RU2176246C2 (en) 1996-12-31 1997-12-18 Method of synthesis of tolterodine and intermediate compound

Country Status (23)

Country Link
US (1) US5922914A (en)
EP (1) EP0960109B1 (en)
JP (1) JP4199310B2 (en)
KR (2) KR20000057548A (en)
CN (1) CN1151141C (en)
AT (1) ATE226949T1 (en)
AU (1) AU717985B2 (en)
CA (1) CA2273789C (en)
CZ (1) CZ295477B6 (en)
DE (1) DE69716767T2 (en)
DK (1) DK0960109T3 (en)
ES (1) ES2186018T3 (en)
FI (1) FI991477A0 (en)
HK (1) HK1023566A1 (en)
HU (1) HUP0000527A3 (en)
NO (1) NO317158B1 (en)
NZ (1) NZ336533A (en)
PL (1) PL191603B1 (en)
PT (1) PT960109E (en)
RU (1) RU2176246C2 (en)
SI (1) SI0960109T1 (en)
SK (1) SK283591B6 (en)
WO (1) WO1998029402A1 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU728395B2 (en) * 1996-07-19 2001-01-11 Gunnar Aberg S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders
EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
PT1459750E (en) * 1999-07-01 2005-08-31 Pharmacia & Upjohn Co Llc (S, S) - REBOXETINE FOR TREATING FIBROMYALGIA OR OTHER SOMATOFORM PERTURBACTIONS
SE9904850D0 (en) 1999-12-30 1999-12-30 Pharmacia & Upjohn Ab Novel process and intermediates
US6566537B2 (en) 1999-12-30 2003-05-20 Pharmacia Ab Process and intermediates
DE10028443C1 (en) * 2000-06-14 2002-05-29 Sanol Arznei Schwarz Gmbh Production of optically active 3,3-diaryl-propylamine derivatives comprises six step process from 4-hydroxybenzoic acid or alkyl 4-hydroxybenzoate and cinnamic acid
DE10033016A1 (en) * 2000-07-07 2002-01-24 Sanol Arznei Schwarz Gmbh Process for the preparation of 3,3-diarylpropylamines
PE20020547A1 (en) 2000-10-24 2002-06-12 Upjohn Co USE OF TOLTERODINE IN ASTHMA TREATMENTS
US20030027856A1 (en) * 2001-06-29 2003-02-06 Aberg A.K. Gunnar Tolterodine metabolites
IN191835B (en) 2001-08-03 2004-01-10 Ranbaxy Lab Ltd
SG168451A1 (en) 2001-10-26 2011-02-28 Upjohn Co Quarternary ammonium compounds and their use as antimuscarinic agents
US7005449B2 (en) * 2002-04-23 2006-02-28 Pharmacia & Upjohn Company Tolterodine salts
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
ATE396969T1 (en) 2002-07-31 2008-06-15 Ranbaxy Lab Ltd 3,6-DISUBSTITUTED AZABICYCLO (3.1.0)HEXANE DERIVATIVES THAT ARE SUITABLE AS MUSCARINE RECEPTOR ANTAGONISTS
AU2002321711A1 (en) 2002-08-09 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
EP1536780A1 (en) * 2002-08-28 2005-06-08 Pharmacia Corporation Oral liquid tolterodine composition
US7232835B2 (en) 2002-12-10 2007-06-19 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2517824A1 (en) * 2003-03-06 2004-09-16 Neela Praveen Kumar 3,3-diarylpropylamine derivatives and processes for isolation thereof
WO2004089281A2 (en) * 2003-04-08 2004-10-21 Hetero Drugs Limited Novel polymorphs of tolterodine tartrate
DE10315917A1 (en) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Highly pure bases of 3,3-diphenylpropylamine monoesters
WO2004089898A1 (en) 2003-04-09 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
ATE362364T1 (en) 2003-04-10 2007-06-15 Ranbaxy Lab Ltd SUBSTITUTED AZABICYCLO HEXANE DERIVATIVES AS MUSCARINE RECEPTOR ANTAGONISTS
EP1615887A1 (en) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US20070021487A1 (en) 2003-04-11 2007-01-25 Mohammad Salman Azabicyclo derivatives as muscarinic receptor antagonists
ITMI20031354A1 (en) * 2003-07-02 2005-01-03 Istituto Di Chimica Biomolecolare D El Cnr Sezione ENANTIOSELECTIVE SYNTHESIS OF ENANTIOMERICALLY ENRICHED COMPOUNDS.
ES2235648B1 (en) * 2003-12-22 2006-11-01 Ragactives, S.L. PROCEDURE FOR OBTAINING TOLTERODINE.
KR101154023B1 (en) * 2003-12-24 2012-06-07 씨아이피엘에이 엘티디. Tolterodine, compositions and uses thereof, and preparation of the same
EP1629834A1 (en) 2004-08-27 2006-03-01 KRKA, D.D., Novo Mesto Sustained release pharmaceutical composition of tolterodine
ITMI20041920A1 (en) * 2004-10-11 2005-01-11 Chemi Spa PROCESS FOR THE PREPARATION OF N, N-DIISOPROPYL-3-2-HYDROXY-5-METHYLPHENYL-3-PHENYL-PROPABAMMINE
US7355077B2 (en) * 2004-10-28 2008-04-08 Dr. Reddy's Laboratories Limited Process for preparing tolterodine
JP4513535B2 (en) * 2004-12-03 2010-07-28 住友化学株式会社 Method for producing tolterodine
WO2006074479A1 (en) * 2005-01-10 2006-07-13 Teva Pharmaceutical Industries, Ltd. Process for preparing tolterodine tartrate
US7528267B2 (en) 2005-08-01 2009-05-05 Girindus America, Inc. Method for enantioselective hydrogenation of chromenes
ES2268987B1 (en) 2005-08-05 2008-02-01 Ragactives, S.L. PROCEDURE FOR OBTAINING 3,3-DIFENYLPROPILAMINS.
WO2007039918A1 (en) * 2005-10-06 2007-04-12 Natco Pharma Limited Novel process for the preparation of tolterodine
RU2008119323A (en) 2005-10-19 2009-11-27 Рэнбакси Лабораториз Лимитед (In) PHARMACEUTICAL COMPOSITIONS OF THE MUSCARINE RECEPTOR
KR100686351B1 (en) * 2006-01-12 2007-02-22 주식회사 카이로제닉스 Method of preparing racemic tolterodine
ITMI20060110A1 (en) * 2006-01-24 2007-07-25 Dipharma Spa PROCEDURE FOR PURIFICATION OF TOLTERODINE
CA2651978C (en) * 2006-05-24 2011-06-07 Pfizer Limited Process for the production of benzopyran-2-ol derivatives
US7268257B1 (en) 2006-05-31 2007-09-11 Sumitomo Chemical Company, Limited Process for producing tolterodine
CZ302585B6 (en) * 2007-02-26 2011-07-20 Zentiva, A. S. Crystalline salt of 2-[(1R)-3-bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol with (2R,3R)-2,3-dihydroxybutandioic acid
US8486452B2 (en) 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
WO2009019599A2 (en) 2007-08-08 2009-02-12 Themis Laboratories Private Limited Extended release compositions comprising tolterodine
KR101188333B1 (en) 2008-02-20 2012-10-09 에스케이케미칼주식회사 Crystalline tolterodine acid addition salts having effective stability for transdermal medicine
US20090214665A1 (en) * 2008-02-26 2009-08-27 Lai Felix S Controlled Release Muscarinic Receptor Antagonist Formulation
ITMI20082055A1 (en) * 2008-11-19 2009-02-18 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF (R) -TOLTERODINE BASE FREE
WO2010092500A2 (en) 2009-02-12 2010-08-19 Alembic Limited A process for the preparation of tolterodine tartrate
US20120041235A1 (en) * 2009-02-17 2012-02-16 Pharmathen S.A. Process for the preparation of (r)-2-(3-diisopropylamino)-1-phenylpropyl)-4methylphenol and salts thereof
ES2604705T3 (en) 2010-03-31 2017-03-08 Ono Pharmaceutical Co., Ltd. Preventive agent and / or remedy for hand-foot syndrome
EP2476665A1 (en) 2011-01-17 2012-07-18 Cambrex Profarmaco Milano S.r.l. Process for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
WO2012098044A1 (en) 2011-01-17 2012-07-26 Cambrex Profarmaco Milano S.R.L. Process for the preparation of n,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)- 3-phenyl propylamine and its salts starting from a novel intermediate
CN102516098B (en) * 2011-12-09 2014-06-18 北京联本医药化学技术有限公司 Preparation method of tolterodine tartrate
CN103044274B (en) * 2012-11-29 2014-10-22 珠海保税区丽珠合成制药有限公司 Method for synthesizing tolterodine tartrate without solvent
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
CN110229072B (en) * 2019-06-25 2022-04-08 中国药科大学 Synthetic method of tolterodine and enantiomer thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (en) * 1988-01-22 1988-01-22 Kabivitrum Ab NEW AMINES, THEIR USE AND MANUFACTURING
US5382600A (en) * 1988-01-22 1995-01-17 Pharmacia Aktiebolag 3,3-diphenylpropylamines and pharmaceutical compositions thereof
DE69315920T2 (en) * 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Condensed heterocyclic compounds, their production and use

Similar Documents

Publication Publication Date Title
RU99116356A (en) METHOD OF OBTAINING TLTERODINE
NZ336533A (en) Process to prepare tolterodine using the intermediate 3,4-Dihydro-6-methyl-4-phenyl-2H-benzopyran-2-ol
BR8401095A (en) PERFECT PROCESS FOR CO2 RECOVERY FROM COMBUSTION GASES
JPS5420213A (en) Exhaust gas turbine supercharger
AU9077282A (en) Ni base super alloy with y (h) for gas turbine engines
CA2279964A1 (en) Metal recovery from salt cake and other compositions
JPS5326443A (en) Window frame for use in remodelling of window
IT1161861B (en) HAT FOR EXHAUST GAS PIPES
DE3766097D1 (en) METHOD FOR HARD SOLDERING ALUMINUM ALLOYS WITHOUT ADDITIONAL METALS.
JPS5414932A (en) Purification of phenylhydrazine
JPS5384876A (en) Regenerating method for adsorpting tower
JPS544813A (en) Copper recevering method
JPS5326444A (en) Method of remodelling window
JPS51117904A (en) A method for collecting gas generated in metal winning by the wet elec trolytic process
JPS5244713A (en) Method of producing metallic gallium
JPS5226502A (en) Method for purifying coke-oven gas
JPS548233A (en) Exhaust pipe
SU986070A1 (en) Method of extracting germanium from alkali solutions
JPS5392562A (en) Method of and apparatus for removing matters attaching to submarine structu re
JPS51130697A (en) Exhaust gas desulfurization method recovering so2 as aluminum sulfate
JPS5394230A (en) Corrosion preventing method of aluminum heat exchanger
JPS5312685A (en) Sampling method for combustion exhaust gas
JPS51128824A (en) Aluminum or aluminum alloy sash fixing method
JPS5419500A (en) Method of producing aluminium hydroxide
JPS5420937A (en) Coiling method for strip of down-coiler