RU99113024A - METHOD FOR CLEANING COMPLEX ETHERS OF CARBAZOLE PRECURSORS OF 6-CHLOR-α-METHYL-CARBAZOL-2-ACETIC ACID - Google Patents
METHOD FOR CLEANING COMPLEX ETHERS OF CARBAZOLE PRECURSORS OF 6-CHLOR-α-METHYL-CARBAZOL-2-ACETIC ACIDInfo
- Publication number
- RU99113024A RU99113024A RU99113024/04A RU99113024A RU99113024A RU 99113024 A RU99113024 A RU 99113024A RU 99113024/04 A RU99113024/04 A RU 99113024/04A RU 99113024 A RU99113024 A RU 99113024A RU 99113024 A RU99113024 A RU 99113024A
- Authority
- RU
- Russia
- Prior art keywords
- ester
- carbazole
- formula
- specified
- impurities
- Prior art date
Links
- UJOBWOGCFQCDNV-UHFFFAOYSA-N Carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 title claims 10
- 102000014961 Protein Precursors Human genes 0.000 title 1
- 108010078762 Protein Precursors Proteins 0.000 title 1
- PUXBGTOOZJQSKH-UHFFFAOYSA-N carprofen Chemical compound C1=C(Cl)C=C2C3=CC=C(C(C(O)=O)C)C=C3NC2=C1 PUXBGTOOZJQSKH-UHFFFAOYSA-N 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 150000002170 ethers Chemical class 0.000 title 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 7
- -1 carbazole ester Chemical class 0.000 claims 7
- 239000012535 impurity Substances 0.000 claims 6
- 229960000583 Acetic Acid Drugs 0.000 claims 3
- 238000011109 contamination Methods 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 238000005191 phase separation Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 239000007858 starting material Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000002194 synthesizing Effects 0.000 claims 2
- OWNBALBCKYJEQU-UHFFFAOYSA-N 2-(6-chloro-9H-carbazol-2-yl)-2-methylpropanedioic acid Chemical compound C1=C(Cl)C=C2C3=CC=C(C(C(O)=O)(C(O)=O)C)C=C3NC2=C1 OWNBALBCKYJEQU-UHFFFAOYSA-N 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 239000000356 contaminant Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000012362 glacial acetic acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Claims (10)
где Ra и Rb должны быть одинаковыми и выбраны из группы, состоящей из C1-C6 алкила;
включающий фазовое отделение одной или более примесей от указанного сложного эфира карбазола по крайней мере один раз, где растворитель, используемый для проведения указанного фазового отделения, представляет собой уксусную кислоту.1. The method of purification of di (C 1 C 6 alkyl) ester of (6-chloro-2-carbazolyl) methyl malonic acid of the formula (I)
where R a and R b must be the same and selected from the group consisting of C 1 -C 6 alkyl;
including phase separation of one or more impurities from the specified ester of carbazole at least once, where the solvent used to conduct the specified phase separation, is an acetic acid.
10. The method according to claim 1, wherein said one or more impurities include a spirooxindole dimer of formula (IV)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8948098P | 1998-06-16 | 1998-06-16 | |
US60/089,480 | 1998-06-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU99113024A true RU99113024A (en) | 2001-04-27 |
RU2182148C2 RU2182148C2 (en) | 2002-05-10 |
Family
ID=22217887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU99113024/04A RU2182148C2 (en) | 1998-06-16 | 1999-06-15 | Method of purification of (6-chloro-2- carbazolyl)methylmalonic acid di-(c1-c6)-alkyl ester |
Country Status (26)
Country | Link |
---|---|
US (1) | US6013808A (en) |
EP (1) | EP0965586B1 (en) |
JP (1) | JP3449602B2 (en) |
KR (1) | KR100342148B1 (en) |
CN (1) | CN1119329C (en) |
AR (1) | AR016726A1 (en) |
AT (1) | ATE237588T1 (en) |
AU (1) | AU745058C (en) |
BR (1) | BR9902279A (en) |
CA (1) | CA2274355C (en) |
CZ (1) | CZ293399B6 (en) |
DE (1) | DE69906876T2 (en) |
DK (1) | DK0965586T3 (en) |
ES (1) | ES2196723T3 (en) |
HK (1) | HK1023999A1 (en) |
HU (1) | HUP9901989A3 (en) |
ID (1) | ID23297A (en) |
IL (1) | IL130428A (en) |
PL (1) | PL333741A1 (en) |
PT (1) | PT965586E (en) |
RU (1) | RU2182148C2 (en) |
SG (1) | SG76627A1 (en) |
TR (1) | TR199901330A2 (en) |
TW (1) | TW491839B (en) |
YU (1) | YU26999A (en) |
ZA (1) | ZA993974B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20020049283A (en) * | 2000-12-19 | 2002-06-26 | 이계안 | Method of starting torque control for hybrid electric vehicles |
JP4467880B2 (en) | 2002-12-09 | 2010-05-26 | 株式会社日立製作所 | Project evaluation system and method |
TWI692598B (en) | 2019-05-03 | 2020-05-01 | 愛烙達股份有限公司 | Deformable candlewick and combustion device using the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193923A (en) * | 1978-08-21 | 1980-03-18 | Hoffmann-La Roche Inc. | Tetrahydro 2-carbazolyl methyl malonate derivatives |
CH637117A5 (en) * | 1979-03-02 | 1983-07-15 | Hoffmann La Roche | METHOD FOR PRODUCING A CARBAZOL DERIVATIVE. |
JPS62263153A (en) * | 1986-05-28 | 1987-11-16 | エフ・ホフマン―ラ ロシユ アーゲー | Carbazole derivative |
DE3814887C1 (en) * | 1988-05-02 | 1989-09-21 | Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co Kg, 5860 Iserlohn, De |
-
1999
- 1999-04-15 US US09/292,138 patent/US6013808A/en not_active Expired - Fee Related
- 1999-05-05 ES ES99303509T patent/ES2196723T3/en not_active Expired - Lifetime
- 1999-05-05 PT PT99303509T patent/PT965586E/en unknown
- 1999-05-05 EP EP99303509A patent/EP0965586B1/en not_active Expired - Lifetime
- 1999-05-05 DK DK99303509T patent/DK0965586T3/en active
- 1999-05-05 DE DE69906876T patent/DE69906876T2/en not_active Expired - Fee Related
- 1999-05-05 AT AT99303509T patent/ATE237588T1/en not_active IP Right Cessation
- 1999-06-02 JP JP15520099A patent/JP3449602B2/en not_active Expired - Fee Related
- 1999-06-10 TW TW088109709A patent/TW491839B/en not_active IP Right Cessation
- 1999-06-10 IL IL13042899A patent/IL130428A/en not_active IP Right Cessation
- 1999-06-11 AR ARP990102821A patent/AR016726A1/en not_active Application Discontinuation
- 1999-06-11 SG SG1999002908A patent/SG76627A1/en unknown
- 1999-06-14 CA CA002274355A patent/CA2274355C/en not_active Expired - Fee Related
- 1999-06-14 YU YU26999A patent/YU26999A/en unknown
- 1999-06-15 RU RU99113024/04A patent/RU2182148C2/en not_active IP Right Cessation
- 1999-06-15 HU HU9901989A patent/HUP9901989A3/en unknown
- 1999-06-15 AU AU35038/99A patent/AU745058C/en not_active Ceased
- 1999-06-15 CZ CZ19992142A patent/CZ293399B6/en not_active IP Right Cessation
- 1999-06-15 PL PL99333741A patent/PL333741A1/en not_active IP Right Cessation
- 1999-06-15 KR KR1019990022158A patent/KR100342148B1/en not_active IP Right Cessation
- 1999-06-15 ZA ZA9903974A patent/ZA993974B/en unknown
- 1999-06-15 ID IDP990580A patent/ID23297A/en unknown
- 1999-06-15 TR TR1999/01330A patent/TR199901330A2/en unknown
- 1999-06-15 CN CN99108607A patent/CN1119329C/en not_active Expired - Fee Related
- 1999-06-16 BR BR9902279-6A patent/BR9902279A/en not_active IP Right Cessation
-
2000
- 2000-05-30 HK HK00103190A patent/HK1023999A1/en not_active IP Right Cessation
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