RU99107562A - NEW DERIVATIVES 2,4-DIOXOPIRROLIDINE AND 2,4-DIOXOTOTRAHYDROFURANE AND MEDICINES CONTAINING THEM AS AN ACTIVE INGREDIENT - Google Patents
NEW DERIVATIVES 2,4-DIOXOPIRROLIDINE AND 2,4-DIOXOTOTRAHYDROFURANE AND MEDICINES CONTAINING THEM AS AN ACTIVE INGREDIENTInfo
- Publication number
- RU99107562A RU99107562A RU99107562/04A RU99107562A RU99107562A RU 99107562 A RU99107562 A RU 99107562A RU 99107562/04 A RU99107562/04 A RU 99107562/04A RU 99107562 A RU99107562 A RU 99107562A RU 99107562 A RU99107562 A RU 99107562A
- Authority
- RU
- Russia
- Prior art keywords
- group
- following formula
- formula
- compound
- salt
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 7
- 239000004480 active ingredient Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000004432 carbon atoms Chemical group C* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atoms Chemical group 0.000 claims 1
- DPKOWUCJNMBPGX-UTCJRWHESA-N C/C=C(/C(C1)=O)\NC1=C Chemical compound C/C=C(/C(C1)=O)\NC1=C DPKOWUCJNMBPGX-UTCJRWHESA-N 0.000 description 1
- 0 CCN1C(*I)CC(C2)N2C(C2)C2(C)C1C Chemical compound CCN1C(*I)CC(C2)N2C(C2)C2(C)C1C 0.000 description 1
Claims (1)
где Х является группой следующей формулы II или III:
Y представляет собой группу следующей формулы IV или V:
R1 и R2 независимо представляют атом водорода, алкильную группу, имеющую 1 - 6 атомов углерода, галогеналкильную группу, имеющую 1 - 6 атомов углерода, циклоалкильную группу, имеющую 3 - 6 атомов углерода, арильную группу, галогенированную арильную группу, аралкильную группу или гетероциклическую группу, содержащую по крайней мере один атом в кольце, выбранный из атома кислорода, атома серы и атома азота.1. The compound of the following formula I or its salt:
where X is a group of the following formula II or III:
Y represents a group of the following formula IV or V:
R 1 and R 2 independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an aryl group, a halogenated aryl group, an aralkyl group or a heterocyclic group containing at least one atom in the ring selected from an oxygen atom, a sulfur atom, and a nitrogen atom.
и Y представляет собой группу следующей формулы IV:
3. Соединение или его соль по п. 1, где в указанной формуле I Х представляет собой группу следующей формулы
и Y представляет собой группу следующей формулы V:
4. Соединение или его соль по п. 1, где в указанной формуле I Х представляет собой группу следующей формулы III:
и Y представляет собой группу следующей формулы IV:
5. Соединение или его соль по п. 1, где в указанной формуле I Х представляет собой группу следующей формулы III
и Y представляет собой группу следующей формулы V:
6. Лекарственная композиция, содержащая терапевтически эффективное количество антагониста рецептора ангиотензина II и приемлемый, с точки зрения медицины, носитель и/или разбавитель, где указанный антагонист рецептора ангиотензина II выбран из соединения формулы I по п. 1 или его приемлемых, с точки зрения медицины, солей.2. The compound or its salt according to claim 1, wherein in said formula I, X represents a group of the following formula II:
and Y is a group of the following formula IV:
3. The compound or its salt according to claim 1, wherein in said formula I, X is a group of the following formula
and Y is a group of the following formula V:
4. The compound or its salt according to claim 1, wherein in said formula I, X represents a group of the following formula III:
and Y is a group of the following formula IV:
5. The compound or its salt according to claim 1, wherein in said formula I, X represents a group of the following formula III
and Y is a group of the following formula V:
6. A pharmaceutical composition comprising a therapeutically effective amount of an angiotensin II receptor antagonist and an acceptable, from the point of view of medicine, carrier and / or diluent, where the specified angiotensin II receptor antagonist is selected from the compound of formula I according to claim 1 or acceptable from the point of view of medicine , salt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8-268014 | 1996-09-18 | ||
| JP26801496A JP3890453B2 (en) | 1996-09-18 | 1996-09-18 | Novel 2,4-dioxopyrrolidine and 2,4-dioxotetrahydrofuran derivatives and pharmaceuticals containing the compound as an active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99107562A true RU99107562A (en) | 2001-03-20 |
| RU2179976C2 RU2179976C2 (en) | 2002-02-27 |
Family
ID=17452710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99107562/04A RU2179976C2 (en) | 1996-09-18 | 1997-09-17 | Novel derivatives of 2,4-dioxopyrrolidine and 2,4-dioxotetra-hydrofuran and medicinal agents containing their as active component |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6232335B1 (en) |
| EP (1) | EP0936221A4 (en) |
| JP (1) | JP3890453B2 (en) |
| KR (1) | KR20000036238A (en) |
| CN (2) | CN1074412C (en) |
| AU (1) | AU727549B2 (en) |
| CA (1) | CA2266447A1 (en) |
| RU (1) | RU2179976C2 (en) |
| WO (1) | WO1998012194A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1386915A4 (en) * | 2001-05-09 | 2004-11-10 | Sumitomo Chem Takeda Agro Co | Azole compounds, process for preparation of the same and use thereof |
| GB201504763D0 (en) | 2015-03-20 | 2015-05-06 | Mironid Ltd | Compounds and uses |
| GB201616439D0 (en) | 2016-09-28 | 2016-11-09 | Mironid Limited | Compounds and uses |
| GB201805527D0 (en) | 2018-04-04 | 2018-05-16 | Mironid Ltd | Compounds and their use as pde4 activators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5671073A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS5671074A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| CA1338238C (en) | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
| EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
| US5098920A (en) * | 1990-05-04 | 1992-03-24 | G. D. Searle & Co. | 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders |
| WO1991018888A1 (en) * | 1990-05-25 | 1991-12-12 | G.D. Searle & Co. | N-substituted-1,2,4-triazolone compounds for treatment of cardiovascular disorders |
| US5240953A (en) * | 1992-01-30 | 1993-08-31 | Ortho Pharmaceutical Corporation | Substituted triazoles as angiotensin ii inhibitors |
| EP0577023A3 (en) * | 1992-07-01 | 1996-12-18 | Hoechst Ag | Angiotensin-ii receptor-antagonists for the treatment of arrhythmices |
| JP3128365B2 (en) | 1992-12-18 | 2001-01-29 | 株式会社トプコン | Laser level position detection method and position detector |
-
1996
- 1996-09-18 JP JP26801496A patent/JP3890453B2/en not_active Expired - Lifetime
-
1997
- 1997-09-17 US US09/254,685 patent/US6232335B1/en not_active Expired - Lifetime
- 1997-09-17 WO PCT/JP1997/003274 patent/WO1998012194A1/en not_active Application Discontinuation
- 1997-09-17 CN CN97198934A patent/CN1074412C/en not_active Expired - Fee Related
- 1997-09-17 AU AU43183/97A patent/AU727549B2/en not_active Ceased
- 1997-09-17 RU RU99107562/04A patent/RU2179976C2/en active
- 1997-09-17 KR KR1019997002321A patent/KR20000036238A/en not_active Application Discontinuation
- 1997-09-17 EP EP97941183A patent/EP0936221A4/en not_active Withdrawn
- 1997-09-17 CA CA002266447A patent/CA2266447A1/en not_active Abandoned
-
2000
- 2000-08-11 US US09/637,613 patent/US6358984B1/en not_active Expired - Lifetime
-
2001
- 2001-04-06 CN CN01116224A patent/CN1346830A/en active Pending
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