RU98106104A - Pyrimidine derivatives - Google Patents
Pyrimidine derivativesInfo
- Publication number
- RU98106104A RU98106104A RU98106104/04A RU98106104A RU98106104A RU 98106104 A RU98106104 A RU 98106104A RU 98106104/04 A RU98106104/04 A RU 98106104/04A RU 98106104 A RU98106104 A RU 98106104A RU 98106104 A RU98106104 A RU 98106104A
- Authority
- RU
- Russia
- Prior art keywords
- group
- disease
- endothelin
- substituent
- salt
- Prior art date
Links
- 150000003230 pyrimidines Chemical class 0.000 title claims 4
- 229940083082 Pyrimidine derivatives acting on arteriolar smooth muscle Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 claims 12
- 102000002045 Endothelin Human genes 0.000 claims 6
- 108050009340 Endothelin Proteins 0.000 claims 6
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N Endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- -1 phenyloxy group Chemical group 0.000 claims 1
Claims (10)
где R1 представляет гидроксильную группу, низшую алкоксигруппу, фенилоксигруппу, которая может иметь заместитель, аралкилоксигруппу, которая может иметь заместитель, или NR2R3;
Х представляет атом кислорода или N-R4;
m равно 2 или 3;
n равно 1 или 2
(где каждый из R2 и R3, которые могут быть идентичными или могут отличаться друг от друга, представляет атом водорода, гидроксильную группу, низшую алкильную группу, которая может иметь заместитель, фенильную группу, которая может иметь заместитель, аралкильную группу, которая может иметь заместитель, или гетероциклическую группу, которая может иметь заместитель; R4 представляет низшую алкильную группу, фенильную группу, формильную группу или низшую алкоксикарбонильную группу).1. A pyrimidine derivative of the following formula (I) or a salt of this derivative:
where R 1 represents a hydroxyl group, a lower alkoxy group, a phenyloxy group which may have a substituent, an aralkyloxy group which may have a substituent, or NR 2 R 3 ;
X represents an oxygen atom or NR 4 ;
m is 2 or 3;
n is 1 or 2
(where each of R 2 and R 3 , which may be identical or may differ from each other, represents a hydrogen atom, a hydroxyl group, a lower alkyl group that may have a substituent, a phenyl group that may have a substituent, an aralkyl group that may have a substituent, or a heterocyclic group which may have a substituent; R 4 represents a lower alkyl group, a phenyl group, a formyl group or a lower alkoxycarbonyl group).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22890795 | 1995-09-06 | ||
JP7/228907 | 1995-09-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98106104A true RU98106104A (en) | 2000-03-27 |
RU2170734C2 RU2170734C2 (en) | 2001-07-20 |
Family
ID=16883731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98106104/04A RU2170734C2 (en) | 1995-09-06 | 1996-09-04 | Derivatives of pyrimidine, pharmaceutical composition and method of prophylaxis and treatment of disease |
Country Status (15)
Country | Link |
---|---|
US (1) | US5883092A (en) |
EP (1) | EP0852226B1 (en) |
KR (1) | KR100453097B1 (en) |
CN (1) | CN1105711C (en) |
AT (1) | ATE254607T1 (en) |
AU (1) | AU703892B2 (en) |
CA (1) | CA2230516C (en) |
DE (1) | DE69630799T2 (en) |
ES (1) | ES2210384T3 (en) |
HK (1) | HK1016591A1 (en) |
HU (1) | HUP9903526A3 (en) |
NO (1) | NO310235B1 (en) |
PT (1) | PT852226E (en) |
RU (1) | RU2170734C2 (en) |
WO (1) | WO1997009318A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2207100C (en) * | 1994-12-28 | 2008-02-19 | Kowa Co., Ltd. | Pyrimidine derivatives |
CN1295477A (en) | 1998-03-31 | 2001-05-16 | 田边制药株式会社 | Preventives/remedies for urinary disorder |
CA2315614C (en) * | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
KR100495550B1 (en) * | 2000-01-25 | 2005-06-16 | 에프. 호프만-라 로슈 아게 | Preparation of sulfonamides |
US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
WO2003099773A1 (en) | 2002-05-24 | 2003-12-04 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
WO2011078143A1 (en) * | 2009-12-22 | 2011-06-30 | 塩野義製薬株式会社 | Pyrimidine derivatives and pharmaceutical composition containing same |
WO2014192903A1 (en) | 2013-05-31 | 2014-12-04 | 興和株式会社 | Novel form of pyrimidinic compound having dibenzylamine structure |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
CA2207100C (en) * | 1994-12-28 | 2008-02-19 | Kowa Co., Ltd. | Pyrimidine derivatives |
-
1996
- 1996-09-04 WO PCT/JP1996/002494 patent/WO1997009318A1/en active IP Right Grant
- 1996-09-04 US US09/029,244 patent/US5883092A/en not_active Expired - Fee Related
- 1996-09-04 KR KR10-1998-0701163A patent/KR100453097B1/en not_active IP Right Cessation
- 1996-09-04 CN CN96196812A patent/CN1105711C/en not_active Expired - Fee Related
- 1996-09-04 DE DE69630799T patent/DE69630799T2/en not_active Expired - Lifetime
- 1996-09-04 ES ES96929512T patent/ES2210384T3/en not_active Expired - Lifetime
- 1996-09-04 EP EP96929512A patent/EP0852226B1/en not_active Expired - Lifetime
- 1996-09-04 AT AT96929512T patent/ATE254607T1/en not_active IP Right Cessation
- 1996-09-04 HU HU9903526A patent/HUP9903526A3/en unknown
- 1996-09-04 AU AU68890/96A patent/AU703892B2/en not_active Ceased
- 1996-09-04 PT PT96929512T patent/PT852226E/en unknown
- 1996-09-04 CA CA002230516A patent/CA2230516C/en not_active Expired - Fee Related
- 1996-09-04 RU RU98106104/04A patent/RU2170734C2/en not_active IP Right Cessation
-
1998
- 1998-03-05 NO NO19980959A patent/NO310235B1/en not_active IP Right Cessation
-
1999
- 1999-04-13 HK HK99101534A patent/HK1016591A1/en not_active IP Right Cessation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2221795C2 (en) | Imidazolyl-cyclic acetals, intermediate compounds, pharmaceutical composition and treatment method | |
CA2443918A1 (en) | Visual function disorder improving agents containing rho kinase inhibitors | |
RU2003116648A (en) | SUBSTITUTED IMIDAZOPYRIDINES | |
RU2000115577A (en) | NEW PYRIDASINE DERIVATIVES AND MEDICINES CONTAINING THEM AS EFFECTIVE INGREDIENTS | |
KR970001327A (en) | Substituted Piperidine Derivatives | |
KR890000434A (en) | New amino acid derivatives, preparation method thereof and pharmaceutical composition containing the same | |
KR920021523A (en) | Novel urea derivatives, methods for their preparation and pharmaceutical compositions containing them | |
KR970704435A (en) | Use of Heterocyclic Compounds as Dopamine-D Ligands (Use of Heterocyclic Compounds as Dopamine-D Ligands) | |
CA2369560A1 (en) | Agent for prophylaxis and treatment of liver disease | |
KR880002840A (en) | Imidazole compound, preparation method thereof, and pharmaceutical composition which consists of this | |
RU97107338A (en) | NEW COMPOUNDS | |
HUP0202490A2 (en) | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | |
RU2008133654A (en) | METHOD AND MEDICINE FOR TREATMENT OF SEVERE HEART FAILURE | |
KR890005124A (en) | Cefem compound and preparation method thereof | |
RU2002100058A (en) | 1-Methylcarbapenem Crystal Derivatives | |
KR910015562A (en) | Drugs for the treatment of brain failure diseases, novel 2- (1-piperazinyl) -4-phenylcycloalkano pyrimidine derivatives, and preparations thereof | |
CZ288382B6 (en) | Pharmaceutical preparation for treating viral infections | |
RU98106104A (en) | Pyrimidine derivatives | |
KR940702491A (en) | Oxazolidone derivatives | |
RU2001126348A (en) | 4-HETEROCYCLICULESULFONAMIDIL-6-METHOXY-5- (2-METHOXYPHENOXY) -2-PYRIDYL PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | |
KR870005641A (en) | Hypertension Treatment Composition | |
JP2749593B2 (en) | Mild stabilizer composition | |
DE60009517D1 (en) | A-500359 DERIVATIVES | |
KR950702544A (en) | Biphenylmethane Derivatives and Pharmaceuticals Containing the Same | |
ATE254607T1 (en) | PYRIMIDINE DERIVATIVES |