RU98123571A - NEW DERIVATIVES 10,11-DIHYDRO-10-OXO-5H-DIBENZE [B, F] -AZEPIN-5-CARBOXAMIDE - Google Patents
NEW DERIVATIVES 10,11-DIHYDRO-10-OXO-5H-DIBENZE [B, F] -AZEPIN-5-CARBOXAMIDEInfo
- Publication number
- RU98123571A RU98123571A RU98123571/04A RU98123571A RU98123571A RU 98123571 A RU98123571 A RU 98123571A RU 98123571/04 A RU98123571/04 A RU 98123571/04A RU 98123571 A RU98123571 A RU 98123571A RU 98123571 A RU98123571 A RU 98123571A
- Authority
- RU
- Russia
- Prior art keywords
- carboxamide
- dibenz
- azepine
- dihydro
- group
- Prior art date
Links
- 125000002877 alkyl aryl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 210000003169 Central Nervous System Anatomy 0.000 claims 3
- 210000001428 Peripheral Nervous System Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005213 alkyl heteroaryl group Chemical group 0.000 claims 2
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000004367 cycloalkylaryl group Chemical group 0.000 claims 2
- 125000005215 cycloalkylheteroaryl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005027 hydroxyaryl group Chemical group 0.000 claims 2
- -1 hydroxycarbonyl groups Chemical group 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N oxygen atom Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- MMEKWHIZCNAOEY-UHFFFAOYSA-N 5-(phenylhydrazinylidene)-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NNC1=CC=CC=C1 MMEKWHIZCNAOEY-UHFFFAOYSA-N 0.000 claims 1
- SDXUCBAWNGBPTC-UHFFFAOYSA-N 5-[(2,4-dinitrophenyl)hydrazinylidene]-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O SDXUCBAWNGBPTC-UHFFFAOYSA-N 0.000 claims 1
- WPTQKOQTHLUKHN-UHFFFAOYSA-N 5-hydrazinylidene-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound NN=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 WPTQKOQTHLUKHN-UHFFFAOYSA-N 0.000 claims 1
- VKSIBVBEGLEBSB-UHFFFAOYSA-N 5-hydroxyimino-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound C1C(=NO)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 VKSIBVBEGLEBSB-UHFFFAOYSA-N 0.000 claims 1
- DNRYRUVGFNBWOP-UHFFFAOYSA-N 5-methoxyimino-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound CON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 DNRYRUVGFNBWOP-UHFFFAOYSA-N 0.000 claims 1
- DWNZBJPWAUCBNM-UHFFFAOYSA-N 5-phenylmethoxyimino-6H-benzo[b][1]benzazepine-11-carboxamide Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NOCC1=CC=CC=C1 DWNZBJPWAUCBNM-UHFFFAOYSA-N 0.000 claims 1
- 208000001183 Brain Injury Diseases 0.000 claims 1
- 206010054938 Cerebral disease Diseases 0.000 claims 1
- 206010015037 Epilepsy Diseases 0.000 claims 1
- LJTFFORYSFGNCT-UHFFFAOYSA-N Thiocarbohydrazide Chemical compound NNC(=S)NN LJTFFORYSFGNCT-UHFFFAOYSA-N 0.000 claims 1
- 206010044652 Trigeminal neuralgia Diseases 0.000 claims 1
- LYQCLWVOGBMKKC-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 LYQCLWVOGBMKKC-UHFFFAOYSA-N 0.000 claims 1
- ITYIBGYIYFWWDT-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] 2-methylpropyl carbonate Chemical compound CC(C)COC(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 ITYIBGYIYFWWDT-UHFFFAOYSA-N 0.000 claims 1
- IZGSTAIJVLRTNY-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] 3-methoxybenzoate Chemical compound COC1=CC=CC(C(=O)ON=C2C3=CC=CC=C3N(C(N)=O)C3=CC=CC=C3C2)=C1 IZGSTAIJVLRTNY-UHFFFAOYSA-N 0.000 claims 1
- ZGKSNZVLGGCUOK-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] acetate Chemical compound CC(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 ZGKSNZVLGGCUOK-UHFFFAOYSA-N 0.000 claims 1
- BCNAHGOVJRYPSK-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] ethyl carbonate Chemical compound CCOC(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 BCNAHGOVJRYPSK-UHFFFAOYSA-N 0.000 claims 1
- OWIZCFOWKOYIPZ-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] naphthalene-1-carboxylate Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NOC(=O)C1=CC=CC2=CC=CC=C12 OWIZCFOWKOYIPZ-UHFFFAOYSA-N 0.000 claims 1
- YAIIALFKOUQPDZ-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] propanoate Chemical compound CCC(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 YAIIALFKOUQPDZ-UHFFFAOYSA-N 0.000 claims 1
- AFHYMKFFBHUTES-UHFFFAOYSA-N [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] pyridine-3-carboxylate Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NOC(=O)C1=CC=CN=C1 AFHYMKFFBHUTES-UHFFFAOYSA-N 0.000 claims 1
- BRWIZMBXBAOCCF-UHFFFAOYSA-N aminothiourea Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims 1
- LZUADZUJUYGSCV-UHFFFAOYSA-N benzyl [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] carbonate Chemical compound C12=CC=CC=C2N(C(=O)N)C2=CC=CC=C2CC1=NOC(=O)OCC1=CC=CC=C1 LZUADZUJUYGSCV-UHFFFAOYSA-N 0.000 claims 1
- YPMHNLXLDZKDDJ-UHFFFAOYSA-N butyl [(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino] carbonate Chemical compound CCCCOC(=O)ON=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 YPMHNLXLDZKDDJ-UHFFFAOYSA-N 0.000 claims 1
- 230000003412 degenerative Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002429 hydrazines Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- AYTJQMJJCDYIMS-UHFFFAOYSA-N methyl 4-[(11-carbamoyl-6H-benzo[b][1]benzazepin-5-ylidene)amino]butanoate Chemical compound COC(=O)CCCN=C1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12 AYTJQMJJCDYIMS-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (8)
где: R представляет собой группу гидрокси, алкил, циклоалкил, алкилциклоалкил, алкиларил или алкилгетероарил, или R представляет собой группу -О-СО-R1, где R1 представляет собой водород, группу алкил, циклоалкил, алкилциклоалкил, алкиларил или гетероарил, или R представляет собой группу -О-СО-ОR1, где заместитель R1 определен выше, или R представляет собой группу -О-R2, где R2 представляет собой алкил или алкиларил, или R представляет собой группу NR3R4, где R3 представляет собой водород, группу -NН-СО-NН2, -NН-СS-NН2, алкил или алкиларил, а R4 представляет собой водород, группу алкил, алкилциклоалкил, алкиларил, алкилкарбонил или арилкарбонил; термин алкил означает углеродную цепь, прямую или разветвленную, содержащую от одного до шести атомов углерода, необязательно замещенную одним или несколькими группами алкокси, галоген, алкоксикарбонил или гидроксикарбонил; термин циклоалкил представляет алициклическую группу, имеющую от трех до шести атомов углерода; термин арил представляет фенильную или нафтильную группу, необязательно замещенные одним или несколькими группами алкокси, галоген или нитро; термин гетероарил представляет пяти или шестичленное ароматическое кольцо, содержащее атом кислорода, серы или азота; термин галоген представляет фтор, хлор, бром или йод.1. Compounds of General Formula I
where: R represents a hydroxy, alkyl, cycloalkyl, alkylcycloalkyl, alkylaryl or alkyl heteroaryl group, or R represents an —O — CO — R 1 group, where R 1 represents hydrogen, an alkyl, cycloalkyl, alkylcycloalkyl, alkylaryl or heteroaryl group, or R represents a group —O — CO — OR 1 where the substituent R 1 is as defined above, or R represents a group —O — R 2 , where R 2 is alkyl or alkylaryl, or R is a group NR 3 R 4 , where R 3 represents hydrogen, a group —NH — CO — NH 2 , —NH — CS — NH 2 , alkyl or alkylaryl, and R 4 represents is hydrogen, an alkyl, alkylcycloalkyl, alkylaryl, alkylcarbonyl or arylcarbonyl group; the term alkyl means a straight or branched carbon chain containing from one to six carbon atoms, optionally substituted with one or more alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term cycloalkyl represents an alicyclic group having from three to six carbon atoms; the term aryl represents a phenyl or naphthyl group optionally substituted with one or more alkoxy, halogen or nitro groups; the term heteroaryl represents a five or six membered aromatic ring containing an oxygen, sulfur or nitrogen atom; the term halogen represents fluoro, chloro, bromo or iodo.
где R представляет собой группу гидрокси, алкил, циклоалкил, алкилциклоалкил, алкиларил или алкилгетероарил или R представляет собой группу -О-СО-R1, где R1 представляет собой водород, группу алкил, циклоалкил, алкилциклоалкил, алкиларил или гетероарил, или R представляет собой группу -O-СО-ОR1 где заместитель R1 определен выше, или R представляет собой группу -O-R2, где R2 представляет собой группу алкил или алкиларил, или R представляет собой группу NR3R4, где R3 представляет собой водород, группу -NН-СО-NН2, -NН-СS-NН2, алкил или алкиларил, а R4 представляет собой водород, группу алкил, алкилциклоалкил, алкиларил, алкилкарбонил или арилкарбонил; термин алкил означает углеродную цепь, прямую или разветвленную, содержащую от одного до шести атомов углерода, необязательно замещенную одним или несколькими группами алкокси, галоген, алкоксикарбонил или гидроксикарбонил; термин циклоалкил представляет алициклическую группу, содержащую от трех до шести атомов углерода; термин арил представляет фенильную или нафтильную группу, необязательно замещенные группами алкокси, галоген или нитро; термин гетероарил представляет пяти или шестичленное ароматическое кольцо, содержащее атом кислорода, серы или азота; термин галоген представляет фтор, хлор, бром или йод, путем взаимодействия соединения формулы II
с гидроксиламином или его производным формулы III
H2NOR2
где заместитель R2 определен выше, или путем взаимодействия соединения формулы II с тиокарбазидом, тиосемикарбазидом или производным гидразина формулы IV
H2NNR3R4
где заместители R3 и R4 определены выше, или путем взаимодействия соединения формулы V
с ацилирующим агентом формулы VI
A-CO-R1
где R1 такой, как определен выше для общей формулы I; А представляет группу гидрокси, галоген или -О-СО-R1 или -О-СО-ОR1, где R1 представляет низший алкил (С1-С4), или путем взаимодействия соединения формулы V с ацилирующим агентом формулы VII
Cl-CO-OR1
где R1 такой, как определен выше для общей формулы I.3. A method of obtaining a compound of General formula I
where R is a hydroxy, alkyl, cycloalkyl, alkylcycloalkyl, alkylaryl or alkyl heteroaryl group, or R is a —O — CO — R 1 group, where R 1 is hydrogen, an alkyl, cycloalkyl, alkylcycloalkyl, alkylaryl or heteroaryl group, or R is is a group —O — CO — OR 1 where R 1 is as defined above, or R is an —OR 2 group, where R 2 is an alkyl or alkylaryl group, or R is an NR 3 R 4 group, where R 3 is hydrogen, a group —NH — CO — NH 2 , —NH — CS — NH 2 , alkyl or alkylaryl, and R 4 is is hydrogen, an alkyl, alkylcycloalkyl, alkylaryl, alkylcarbonyl or arylcarbonyl group; the term alkyl means a straight or branched carbon chain containing from one to six carbon atoms, optionally substituted with one or more alkoxy, halogen, alkoxycarbonyl or hydroxycarbonyl groups; the term cycloalkyl represents an alicyclic group containing from three to six carbon atoms; the term aryl represents a phenyl or naphthyl group optionally substituted with alkoxy, halogen or nitro groups; the term heteroaryl represents a five or six membered aromatic ring containing an oxygen, sulfur or nitrogen atom; the term halogen represents fluoro, chloro, bromo or iodo, by reacting a compound of formula II
with hydroxylamine or a derivative of formula III
H 2 NOR 2
wherein R 2 is as defined above, or by reacting a compound of formula II with thiocarbazide, thiosemicarbazide or a hydrazine derivative of formula IV
H 2 NNR 3 R 4
where the substituents R 3 and R 4 are defined above, or by reacting a compound of formula V
with an acylating agent of formula VI
A-CO-R 1
where R 1 is as defined above for general formula I; A represents a hydroxy, halogen or —O — CO — R 1 or —O — CO — OR 1 group, where R 1 is lower alkyl (C1-C4), or by reacting a compound of formula V with an acylating agent of formula VII
Cl-CO-OR 1
where R 1 is as defined above for general formula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT101876A PT101876B (en) | 1996-05-27 | 1996-05-27 | NEW DERIVATIVES OF 10,11-DIHYDRO-10-OXO-5H-DIBENZO (B, F) AZEPINE-5-CARBOXAMIDE |
PT101876 | 1996-05-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98123571A true RU98123571A (en) | 2000-09-27 |
RU2187503C2 RU2187503C2 (en) | 2002-08-20 |
Family
ID=20085604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98123571/04A RU2187503C2 (en) | 1996-05-27 | 1997-05-27 | New derivatives of 10,11-dihydro-10-oxo-5h-dibenzo- -[b,f]azepine-5- carboxamide, methods of their synthesis, pharmaceutical composition, method of treatment of convulsant states |
Country Status (19)
Country | Link |
---|---|
US (1) | US5866566A (en) |
EP (1) | EP0810216B1 (en) |
JP (1) | JP3592892B2 (en) |
CN (1) | CN1101382C (en) |
AR (1) | AR007291A1 (en) |
AT (1) | ATE199901T1 (en) |
AU (1) | AU713807B2 (en) |
BR (1) | BR9703403B1 (en) |
CA (1) | CA2206172C (en) |
DE (1) | DE69704297T2 (en) |
DK (1) | DK0810216T3 (en) |
ES (1) | ES2156319T3 (en) |
GR (1) | GR3035910T3 (en) |
PL (1) | PL189298B1 (en) |
PT (1) | PT101876B (en) |
RU (1) | RU2187503C2 (en) |
SI (1) | SI0810216T1 (en) |
TR (1) | TR199802462T2 (en) |
WO (1) | WO1997045416A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2449992C2 (en) * | 2001-05-25 | 2012-05-10 | Биал-Портела Энд Ка. С.А. | METHOD FOR PREPARING 10,11-DIHYDRO-10-OXO-5N-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9930058D0 (en) * | 1999-12-20 | 2000-02-09 | Novartis Ag | Organic compounds |
AU2004203644B2 (en) * | 1999-12-20 | 2008-04-17 | Novartis Ag | Pharmaceutical compositions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH500196A (en) * | 1969-03-10 | 1970-12-15 | Ciba Geigy Ag | Process for the production of new azepine derivatives |
FI75561C (en) * | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Process for the preparation of 5-carbamoyl-10-oxo-10,11-dihydro-5H-di benz / b, f / azepine and necessary intermediates thereto. |
CH649080A5 (en) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5H-DIBENZ (B, F) AZEPINE-5-CARBOXAMIDES AS A MEDICINE FOR PROPHYLAXIS AND TREATMENT OF CEREBRAL PERFORMANCE INSUFFICIENCY. |
US5466683A (en) * | 1994-08-25 | 1995-11-14 | Teva Pharmaceutical Industries Ltd. | Water-soluble analogs of carbamazepine |
-
1996
- 1996-05-27 PT PT101876A patent/PT101876B/en not_active IP Right Cessation
-
1997
- 1997-05-23 US US08/862,196 patent/US5866566A/en not_active Expired - Fee Related
- 1997-05-26 EP EP97108465A patent/EP0810216B1/en not_active Expired - Lifetime
- 1997-05-26 AR ARP970102233A patent/AR007291A1/en active IP Right Grant
- 1997-05-26 DK DK97108465T patent/DK0810216T3/en active
- 1997-05-26 AT AT97108465T patent/ATE199901T1/en not_active IP Right Cessation
- 1997-05-26 ES ES97108465T patent/ES2156319T3/en not_active Expired - Lifetime
- 1997-05-26 DE DE69704297T patent/DE69704297T2/en not_active Expired - Fee Related
- 1997-05-26 SI SI9730129T patent/SI0810216T1/xx unknown
- 1997-05-27 CN CN97196803A patent/CN1101382C/en not_active Expired - Fee Related
- 1997-05-27 TR TR1998/02462T patent/TR199802462T2/en unknown
- 1997-05-27 RU RU98123571/04A patent/RU2187503C2/en not_active IP Right Cessation
- 1997-05-27 AU AU29740/97A patent/AU713807B2/en not_active Ceased
- 1997-05-27 CA CA002206172A patent/CA2206172C/en not_active Expired - Fee Related
- 1997-05-27 WO PCT/IB1997/000691 patent/WO1997045416A1/en active IP Right Grant
- 1997-05-27 PL PL97330141A patent/PL189298B1/en not_active IP Right Cessation
- 1997-05-27 BR BRPI9703403-7A patent/BR9703403B1/en not_active IP Right Cessation
- 1997-05-27 JP JP13716397A patent/JP3592892B2/en not_active Expired - Fee Related
-
2001
- 2001-05-22 GR GR20010400764T patent/GR3035910T3/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2449992C2 (en) * | 2001-05-25 | 2012-05-10 | Биал-Портела Энд Ка. С.А. | METHOD FOR PREPARING 10,11-DIHYDRO-10-OXO-5N-DIBENZ(b,f)AZEPINE-5-CARBOXAMIDE |
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