RU2001105536A - AMINOMETHYL CARBOXYLIC ACID DERIVATIVES - Google Patents

AMINOMETHYL CARBOXYLIC ACID DERIVATIVES

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Publication number
RU2001105536A
RU2001105536A RU2001105536/04A RU2001105536A RU2001105536A RU 2001105536 A RU2001105536 A RU 2001105536A RU 2001105536/04 A RU2001105536/04 A RU 2001105536/04A RU 2001105536 A RU2001105536 A RU 2001105536A RU 2001105536 A RU2001105536 A RU 2001105536A
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RU
Russia
Prior art keywords
methyl
aminomethylcarboxylic acid
pharmaceutically acceptable
aminomethyl
aminomethylcarboxylic
Prior art date
Application number
RU2001105536/04A
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Russian (ru)
Other versions
RU2225389C2 (en
Inventor
Сэмьюэл Джордж ГИБСОН
Дэвид Роберт ДЖААП
Саймон Николас ТОРН
Роберт ГИЛФИЛЛАН
Original Assignee
Акцо Нобель Н.В.
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Application filed by Акцо Нобель Н.В. filed Critical Акцо Нобель Н.В.
Publication of RU2001105536A publication Critical patent/RU2001105536A/en
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Publication of RU2225389C2 publication Critical patent/RU2225389C2/en

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Claims (10)

1. Производное аминометилкарбоновой кислоты, имеющее общую формулу I
Figure 00000001

где Z представляет (СН2)n, О, S, SO, SO2 или N-R5;
n представляет 0, 1 или 2;
X представляет 1-3 заместителя, независимо выбранных из водорода, галогена, (C1-6) алкилокси, (С3-6) циклоалкилокси, (С6-12) арилокси, (C6-12) арила, тиенила, SR6, SOR6, SO2R6, NR6R6, NHR6, NH2, NHCOR6, NHSO2R6, CN, COOR6 и (C1-4) алкила, необязательно замещенного галогеном, (С6-12) арилом, (C1-6) алкилокси или (C6-12) арилокси, или 2 заместителя в смежных положениях вместе представляют конденсированную (С5-6)арильную группу, конденсированное (C5-6) циклоалкильное кольцо или O-(СН2)m-0, где m представляет 1 или 2;
Y представляет 1-3 заместителя, независимо выбранных из водорода, галогена, (C1-4) алкилокси, SR6, NR6R6, и (C1-4) алкила, необязательно замещенного галогеном;
R1 представляет COOR7 или CONR8R9;
R2 и R6 представляют (С1-4)алкил;
R3, R4 и R5 независимо представляют водород или (C1-4) алкил;
R7, R8 и R9 независимо представляют водород, (C1-4) алкил, (С6-12) арил или арилалкил;
или его фармацевтически приемлемая соль.1. Derived aminomethylcarboxylic acid having the General formula I
Figure 00000001

where Z represents (CH 2 ) n , O, S, SO, SO 2 or NR 5 ;
n represents 0, 1 or 2;
X represents 1-3 substituents independently selected from hydrogen, halogen, (C 1-6 ) alkyloxy, (C 3-6 ) cycloalkyloxy, (C 6-12 ) aryloxy, (C 6-12 ) aryl, thienyl, SR 6 , SOR 6 , SO 2 R 6 , NR 6 R 6 , NHR 6 , NH 2 , NHCOR 6 , NHSO 2 R 6 , CN, COOR 6 and (C 1-4 ) alkyl optionally substituted with halogen, (C 6-12 ) aryl, (C 1-6 ) alkyloxy or (C 6-12 ) aryloxy, or 2 substituents in adjacent positions together represent a fused (C 5-6 ) aryl group, a fused (C 5-6 ) cycloalkyl ring, or O- ( CH 2 ) m -0, where m is 1 or 2;
Y represents 1-3 substituents independently selected from hydrogen, halogen, (C 1-4 ) alkyloxy, SR 6 , NR 6 R 6 , and (C 1-4 ) alkyl optionally substituted with halogen;
R 1 represents COOR 7 or CONR 8 R 9 ;
R 2 and R 6 are (C 1-4 ) alkyl;
R 3 , R 4 and R 5 independently represent hydrogen or (C 1-4 ) alkyl;
R 7 , R 8 and R 9 independently represent hydrogen, (C 1-4 ) alkyl, (C 6-12 ) aryl or arylalkyl;
or a pharmaceutically acceptable salt thereof. 2. Производное аминометилкарбоновой кислоты по п. 1, в котором Z представляет (СН2)n и n= 1.2. The aminomethylcarboxylic acid derivative of claim 1, wherein Z is (CH 2 ) n and n = 1. 3. Производное аминометилкарбоновой кислоты по п. 2, в котором R2 представляет метил и R3 и R4 представляют каждый водород.3. The aminomethylcarboxylic acid derivative of claim 2, wherein R 2 is methyl and R 3 and R 4 are each hydrogen. 4. Производное аминометилкарбоновой кислоты по п. 3, в котором R1 представляет COOR7.4. The aminomethylcarboxylic acid derivative of claim 3, wherein R 1 is COOR 7 . 5. Производное аминометилкарбоновой кислоты по любому из пп. 1-4, имеющее цис-конфигурацию. 5. Derived aminomethylcarboxylic acid according to any one of paragraphs. 1-4 having a cis configuration. 6. Производное аминометилкарбоновой кислоты по п. 1, выбранное из следующих левовращающих энантиомеров: (-)-Лития цис-N-метил-N-(6-метокси-1-фенил-1,2,3,4-тетрагидронафталин-2-илметил)аминометилкарбоксилат; (-)-Натрия цис-N-метил-N-(6-метил-1-фенил-1,2,3,4-тетрагидронафталин-2-илметил)аминометилкарбоксилат; (-)-Натрия цис-N-метил-N-(6-фенокси-1-фенил-1,2,3,4-тетрагидронафталин-2-илметил)аминометилкарбоксилат; (-)-Лития N-метил-N-[1-(4-фторфенил)-6-трифторметил-1,2,3,4-тетрагидронафталин-2-илметил] аминометилкарбоксилат; (-)-Лития цис-N-метил-N-[1-фенил-6-(2,2-диметилпропилокси)-1,2,3,4-тетрагидронафталин-2-илметил] аминометилкарбоксилат. 6. The aminomethylcarboxylic acid derivative according to claim 1, selected from the following levorotatory enantiomers: (-) - Lithium cis-N-methyl-N- (6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalene-2- ilmethyl) aminomethyl carboxylate; (-) - Sodium cis-N-methyl-N- (6-methyl-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl) aminomethyl carboxylate; (-) - Sodium cis-N-methyl-N- (6-phenoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl) aminomethyl carboxylate; (-) - Lithium N-methyl-N- [1- (4-fluorophenyl) -6-trifluoromethyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl] aminomethyl carboxylate; (-) - Lithium cis-N-methyl-N- [1-phenyl-6- (2,2-dimethylpropyloxy) -1,2,3,4-tetrahydronaphthalen-2-ylmethyl] aminomethylcarboxylate. 7. Производные аминометилкарбоновой кислоты по любому из пп. 1-6 для применения в терапии. 7. Derivatives of aminomethylcarboxylic acid according to any one of paragraphs. 1-6 for use in therapy. 8. Производные аминометилкарбоновой кислоты формулы I или их фармацевтически приемлемые соли по любому из пп. 1-6 в качестве активного компонента лекарственного средства, обладающего действием на ЦНС. 8. Derivatives of aminomethylcarboxylic acid of the formula I or their pharmaceutically acceptable salts according to any one of paragraphs. 1-6 as an active component of a drug having an effect on the central nervous system. 9. Производные аминометилкарбоновой кислоты формулы I или их фармацевтически приемлемые соли по любому из пп. 1-6 в качестве активного компонента лекарственного средства для лечения или профилактики шизофрении, депрессии, деменции и других форм нарушенной познавательной способности, нейродегенеративных заболеваний, таких, как болезнь Альцгеймера, болезнь Паркинсона и болезнь Хантингтона, или мышечной гиперактивности, связанной с мышечной спастичностью, миоклонусом и эпилепсией. 9. Derivatives of aminomethylcarboxylic acid of the formula I or their pharmaceutically acceptable salts according to any one of paragraphs. 1-6 as an active component of a medicament for the treatment or prevention of schizophrenia, depression, dementia and other forms of impaired cognitive ability, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, or muscle hyperactivity associated with muscle spasticity, myoclonus and epilepsy. 10. Фармацевтическая композиция, содержащая производное аминометилкарбоновой кислоты, имеющее формулу I, или его фармацевтически приемлемую соль в смеси с фармацевтически приемлемыми вспомогательными веществами. 10. A pharmaceutical composition comprising an aminomethyl carboxylic acid derivative having the formula I, or a pharmaceutically acceptable salt thereof, in admixture with pharmaceutically acceptable excipients.
RU2001105536/04A 1998-07-31 1999-07-26 Derivatives of aminomethylcarboxylic acid and pharmaceutical composition based on thereof RU2225389C2 (en)

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Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
DE102004030099A1 (en) * 2004-06-22 2006-01-12 Grünenthal GmbH Saturated and unsaturated 3-pyridylbenzocycloalkylmethylamines as serotonin and / or norepinephrine reuptake inhibitors and / or μ-opioid receptor modulators
AU2006205796B2 (en) * 2005-01-14 2010-09-02 Merck Sharp & Dohme B.V. Glycine reuptake inhibitors for treating drug and alcohol dependence
JP5438975B2 (en) * 2006-01-06 2014-03-12 サノビオン ファーマシューティカルズ インク Tetralone monoamine reuptake inhibitor
CA2703497A1 (en) * 2007-11-06 2009-05-14 N.V. Organon A method of hormone suppression in humans
AR075442A1 (en) * 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES IN THERAPY
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
US8883839B2 (en) * 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) * 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP2739614B1 (en) * 2011-08-05 2017-02-22 AbbVie Deutschland GmbH & Co KG AMINOCHROMANEs, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
KR102021162B1 (en) 2011-11-01 2019-09-11 메르크 파텐트 게엠베하 Organic electroluminescent device
KR20210124523A (en) 2011-11-17 2021-10-14 메르크 파텐트 게엠베하 Spirodihydroacridine derivatives and the use thereof as materials for organic electroluminescent devices
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6105040B2 (en) 2012-03-23 2017-03-29 メルク パテント ゲーエムベーハー 9,9'-spirobixanthene derivatives for electroluminescent devices
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055771A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
AU2014336153A1 (en) 2013-10-17 2016-04-28 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CN104844471B (en) * 2015-04-21 2017-05-03 苏州远智医药科技有限公司 Compound used as DOR receptor antagonist
US10226442B2 (en) * 2017-07-10 2019-03-12 Syneurx International (Taiwan) Corp. Lithium salts of N-substituted glycine compounds and uses thereof
AU2018336171B2 (en) 2017-09-22 2023-01-05 Jubilant Epipad LLC Heterocyclic compounds as PAD inhibitors
IL272667B (en) 2017-10-18 2022-09-01 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
KR20200085836A (en) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pyrimidine derivatives as PD1/PD-L1 activation inhibitors
US11459338B2 (en) 2017-11-24 2022-10-04 Jubilant Episcribe Llc Heterocyclic compounds as PRMT5 inhibitors
KR20200131845A (en) 2018-03-13 2020-11-24 주빌런트 프로델 엘엘씨 Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation
CN110003160B (en) * 2019-05-14 2022-10-11 贵州中医药大学 Osthole hydrazone/acylhydrazone/sulfonylhydrazone derivatives, and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5657157A (en) * 1995-06-23 1997-08-12 Sdl, Inc. Semiconductor optical amplifying media with reduced self-focusing
CN1130346C (en) * 1995-09-29 2003-12-10 意大利葛兰素惠尔康股份公司 Tetrahydroquinolines as NMDA antagonists
WO1997045423A1 (en) * 1996-05-31 1997-12-04 Trophix Neuroscience Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
SK285854B6 (en) 1996-05-31 2007-09-06 Allelix Neuroscience Inc. Substituted amine and pharmaceutical composition, their use and method for preparing the amine

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