RU98116597A - N- (S) -1-Phenyl-1-alkanamide N- (3,3-dimethylbutyl) -l-aspartyl-d-α-aminoalkanoic acid as a sweetener - Google Patents
N- (S) -1-Phenyl-1-alkanamide N- (3,3-dimethylbutyl) -l-aspartyl-d-α-aminoalkanoic acid as a sweetenerInfo
- Publication number
- RU98116597A RU98116597A RU98116597/04A RU98116597A RU98116597A RU 98116597 A RU98116597 A RU 98116597A RU 98116597/04 A RU98116597/04 A RU 98116597/04A RU 98116597 A RU98116597 A RU 98116597A RU 98116597 A RU98116597 A RU 98116597A
- Authority
- RU
- Russia
- Prior art keywords
- aspartyl
- dimethylbutyl
- phenyl
- formula
- alkanamide
- Prior art date
Links
- -1 3,3-dimethylbutyl Chemical group 0.000 title claims 5
- 235000003599 food sweetener Nutrition 0.000 title claims 2
- 239000003765 sweetening agent Substances 0.000 title claims 2
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000003638 reducing agent Substances 0.000 claims 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- LTNUSYNQZJZUSY-UHFFFAOYSA-N 3,3-dimethylbutanal Chemical compound CC(C)(C)CC=O LTNUSYNQZJZUSY-UHFFFAOYSA-N 0.000 claims 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N Sodium cyanoborohydride Chemical group [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
Claims (1)
в которой Y является C2H5 или CH(CH3)2 или (R)CH(OH)CH3; и R'' является (S)CH(CH2H5)C6H5, (S)CH(CH3)C6H5 или (R)CH(CH2OCH3)C6H5. 2. Соединение по п.1, отличающееся тем, что оно представляет собой N-(S)-1-фенил-1-пропанамид N-(3,3-диметилбутил)-L-аспартил-D-α-аминомасляной кислоты, имеющей формулу:
3. Соединение по п.1, отличающееся тем, что оно представляет собой N-(S)-1-фенил-1-пропанамид N-(3,3-диметилбутил)-L-аспартил-D-валина, имеющей формулу:
4. Соединение, по п.1, отличающееся тем, что оно представляет собой N-(S)-1-фенил-2-метокси-1-этанамид N-(3,3-диметилбутил)-L-аспартил-D-α-аминомасляной кислоты, имеющей формулу:
5. Соединение по п.1, отличающееся тем, что оно представляет собой N-(S)-1-фенил-2-метокси-1-этинамид N-(3,3-диметилбутил)-L-аспартил-D-валина, имеющей формулу:
6. Применение соединений по любому из пп.1 - 5 в качестве подсластитетелей.1. The compound of the formula:
in which Y is C 2 H 5 or CH (CH 3 ) 2 or (R) CH (OH) CH 3 ; and R ″ is (S) CH (CH 2 H 5 ) C 6 H 5 , (S) CH (CH 3 ) C 6 H 5 or (R) CH (CH 2 OCH 3 ) C 6 H 5 . 2. The compound according to claim 1, characterized in that it is N- (3,3-dimethylbutyl) -L-aspartyl-D-α-aminobutyric acid N- (S) -1-phenyl-1-propanamide having the formula:
3. The compound according to claim 1, characterized in that it is N- (3,3-dimethylbutyl) -L-aspartyl-D-valine N- (S) -1-phenyl-1-propanamide having the formula:
4. The compound according to claim 1, characterized in that it is N- (S) -1-phenyl-2-methoxy-1-ethanamide N- (3,3-dimethylbutyl) -L-aspartyl-D-α -aminobutyric acid having the formula:
5. The compound according to claim 1, characterized in that it is N- (3,3-dimethylbutyl) -L-aspartyl-D-valine N- (S) -1-phenyl-2-methoxy-1-ethinamide, having the formula:
6. The use of compounds according to any one of claims 1 to 5 as sweeteners.
в которой Y и R'' - те же, что и определенные в п.1.7. The method of producing compounds according to any one of claims 1 to 5, characterized in that it consists in treating with a reducing agent a mixture of 3,3-dimethylbutyraldehyde and a compound having the formula:
in which Y and R '' are the same as defined in claim 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9601491A FR2744454B1 (en) | 1996-02-07 | 1996-02-07 | N- (3,3-DIMETHYLBUTYL) -L-ASPARTYL-D-ALPHA- AMINOALKANOIC ACID N- (S) -1-PHENYL-1-ALCANAMIDE USEFUL AS A SWEETENING AGENT |
FR9601491 | 1996-02-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98116597A true RU98116597A (en) | 2000-10-10 |
RU2174983C2 RU2174983C2 (en) | 2001-10-20 |
Family
ID=9488941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98116597/04A RU2174983C2 (en) | 1996-02-07 | 1997-02-07 | N-(s)-1-phenyl-1-alkaneamide as sweetening agent |
Country Status (16)
Country | Link |
---|---|
US (2) | US5777159A (en) |
EP (1) | EP0879243B1 (en) |
JP (1) | JP2000505799A (en) |
KR (1) | KR19990082328A (en) |
CN (1) | CN1210542A (en) |
AR (1) | AR005563A1 (en) |
AT (1) | ATE201695T1 (en) |
AU (1) | AU708899B2 (en) |
BR (1) | BR9707377A (en) |
DE (1) | DE69705024T2 (en) |
FR (1) | FR2744454B1 (en) |
IL (1) | IL125256A (en) |
NO (1) | NO983609L (en) |
RU (1) | RU2174983C2 (en) |
WO (1) | WO1997029122A1 (en) |
ZA (1) | ZA971022B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6692778B2 (en) * | 1998-06-05 | 2004-02-17 | Wm. Wrigley Jr. Company | Method of controlling release of N-substituted derivatives of aspartame in chewing gum |
JPWO2002062746A1 (en) * | 2001-02-08 | 2004-06-03 | 味の素株式会社 | Novel N-alkyl aspartylamide derivative and sweetener |
KR100965662B1 (en) * | 2003-01-11 | 2010-06-24 | 삼성전자주식회사 | Navigation system using paging channel and method for providing traffic information |
AR055329A1 (en) * | 2005-06-15 | 2007-08-15 | Senomyx Inc | BIS-AROMATIC AMIDAS AND ITS USES AS SWEET FLAVORS, FLAVORS, AND FLAVOR ENHANCERS |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5286509A (en) * | 1992-06-22 | 1994-02-15 | The Coca-Cola Company | L-aspartyl-D-α-aminoalkanoyl-(S)-N-alpha-alkylbenzyl amides useful as artificial sweeteners |
FR2697844B1 (en) * | 1992-11-12 | 1995-01-27 | Claude Nofre | New compounds derived from dipeptides or dipeptide analogues useful as sweetening agents, process for their preparation. |
FR2719592B1 (en) * | 1994-05-09 | 1996-07-26 | Claude Nofre | New dipeptide derivatives useful as sweetening agents. |
FR2719590B1 (en) * | 1994-05-09 | 1996-07-26 | Claude Nofre | Improved process for the preparation of a compound derived from aspartame useful as a sweetening agent. |
-
1996
- 1996-02-07 FR FR9601491A patent/FR2744454B1/en not_active Expired - Fee Related
-
1997
- 1997-01-27 AR ARP970100317A patent/AR005563A1/en unknown
- 1997-02-05 US US08/796,034 patent/US5777159A/en not_active Expired - Fee Related
- 1997-02-07 CN CN97192136A patent/CN1210542A/en active Pending
- 1997-02-07 JP JP9528231A patent/JP2000505799A/en active Pending
- 1997-02-07 BR BR9707377A patent/BR9707377A/en unknown
- 1997-02-07 KR KR1019980706058A patent/KR19990082328A/en not_active Application Discontinuation
- 1997-02-07 EP EP97903422A patent/EP0879243B1/en not_active Expired - Lifetime
- 1997-02-07 AT AT97903422T patent/ATE201695T1/en not_active IP Right Cessation
- 1997-02-07 DE DE69705024T patent/DE69705024T2/en not_active Expired - Fee Related
- 1997-02-07 RU RU98116597/04A patent/RU2174983C2/en active
- 1997-02-07 ZA ZA9701022A patent/ZA971022B/en unknown
- 1997-02-07 WO PCT/FR1997/000245 patent/WO1997029122A1/en not_active Application Discontinuation
- 1997-02-07 IL IL12525697A patent/IL125256A/en not_active IP Right Cessation
- 1997-02-07 AU AU18003/97A patent/AU708899B2/en not_active Ceased
- 1997-11-28 US US08/980,306 patent/US5997933A/en not_active Expired - Fee Related
-
1998
- 1998-08-06 NO NO983609A patent/NO983609L/en not_active Application Discontinuation
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