RU96123232A - 1- METHYL ETHER OF N- [N- (3,3-DIMETHYLBUTYL) -L-α-ASPARTYL] -L- HEXAHYDROPHENYLALANANINE AS A SUGGESTING AGENT AND METHOD FOR ITS PREPARATION - Google Patents

1- METHYL ETHER OF N- [N- (3,3-DIMETHYLBUTYL) -L-α-ASPARTYL] -L- HEXAHYDROPHENYLALANANINE AS A SUGGESTING AGENT AND METHOD FOR ITS PREPARATION

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Publication number
RU96123232A
RU96123232A RU96123232/04A RU96123232A RU96123232A RU 96123232 A RU96123232 A RU 96123232A RU 96123232/04 A RU96123232/04 A RU 96123232/04A RU 96123232 A RU96123232 A RU 96123232A RU 96123232 A RU96123232 A RU 96123232A
Authority
RU
Russia
Prior art keywords
aspartyl
dimethylbutyl
solution
hexahydrophenylalananine
suggesting
Prior art date
Application number
RU96123232/04A
Other languages
Russian (ru)
Other versions
RU2138511C1 (en
Inventor
Нофр Клод
Тинти Жан-Мари
Original Assignee
Нофр Клод
Тинти Жан-Мари
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9405675A external-priority patent/FR2719591B1/en
Application filed by Нофр Клод, Тинти Жан-Мари filed Critical Нофр Клод
Publication of RU96123232A publication Critical patent/RU96123232A/en
Application granted granted Critical
Publication of RU2138511C1 publication Critical patent/RU2138511C1/en

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Claims (6)

1. 1-Метиловый эфир N-[N-(3,3-диметилбутил)-L-α-аспартил] -α-гексагидрофенилаланина формулы
Figure 00000001

в качестве подслащивающего агента.1.1-N- [N- (3,3-dimethylbutyl) -L-α-aspartyl] -α-hexahydrophenylalanine 1-methyl ester of the formula
Figure 00000001

as a sweetening agent. 2. Способ получения 1-метилового эфира N-[N-(3,3-диметилбутил)-L-α-аспартил]-L-гексагидрофенилаланина формулы
Figure 00000002

отличающийся тем, что раствор аспартама и 3,3-диметилбутиральдегида при комнатной температуре обрабатывают водородом при относительном давлении 3 бар в присутствии платинового катализатора.2. The method of obtaining 1-methyl ester of N- [N- (3,3-dimethylbutyl) -L-α-aspartyl] -L-hexahydrophenylalanine of the formula
Figure 00000002

characterized in that a solution of aspartame and 3,3-dimethylbutyraldehyde at room temperature is treated with hydrogen at a relative pressure of 3 bar in the presence of a platinum catalyst. 3. Способ по п.2, отличающийся тем, что катализатор представляет собой платиновую чернь или оксид платины. 3. The method according to claim 2, characterized in that the catalyst is platinum black or platinum oxide. 4. Способ по пп.2 и 3, отличающийся тем, что раствор аспартама и 3,3-диметилбутиральдегида представляет собой водно-спиртовый раствор с pH 4,5-5, полученный смешением 0,1 М раствора уксусной кислоты и метанола. 4. The method according to PP.2 and 3, characterized in that the solution of aspartame and 3,3-dimethylbutyraldehyde is a water-alcohol solution with a pH of 4.5-5, obtained by mixing a 0.1 M solution of acetic acid and methanol. 5. Способ по пп.2 - 4, отличающийся тем, что концентрация аспартама в водно-спиртовом растворе находится в интервале между 50 и 60 г/л, а концентрация 3,3-диметилбутиральдегида в интервале между 20 и 30 г/л. 5. The method according to claims 2 to 4, characterized in that the concentration of aspartame in the aqueous-alcoholic solution is in the range between 50 and 60 g / l, and the concentration of 3,3-dimethylbutyraldehyde is in the range between 20 and 30 g / l. 6. Способ по пп.2 - 5, отличающийся тем, что полученный продукт очищают осаждением и фильтрацией после упаривания в вакууме спиртовой части растворителя. 6. The method according to PP.2 to 5, characterized in that the resulting product is purified by precipitation and filtration after evaporation in vacuum of the alcoholic part of the solvent.
RU96123232A 1994-05-09 1995-05-05 N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-HEXAHYDROPHENYLALANINE METHYL ESTER AS SWEETENER AND METHOD OF PREPARATION THEREOF RU2138511C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9405675A FR2719591B1 (en) 1994-05-09 1994-05-09 New compound useful as a sweetening agent, its preparation process.
FR9405675 1994-05-09
PCT/FR1995/000588 WO1995030688A1 (en) 1994-05-09 1995-05-05 N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-HEXAHYDROPHENYLALANINE 1-METHYL ESTER USEFUL AS A SWEETENING AGENT AND METHOD OF PREPARATION

Publications (2)

Publication Number Publication Date
RU96123232A true RU96123232A (en) 1999-02-20
RU2138511C1 RU2138511C1 (en) 1999-09-27

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RU96123232A RU2138511C1 (en) 1994-05-09 1995-05-05 N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-HEXAHYDROPHENYLALANINE METHYL ESTER AS SWEETENER AND METHOD OF PREPARATION THEREOF

Country Status (15)

Country Link
US (1) US5773640A (en)
EP (1) EP0759030B1 (en)
JP (1) JP3627062B2 (en)
CN (1) CN1147818A (en)
AT (1) ATE170872T1 (en)
AU (1) AU2528495A (en)
BR (1) BR9507628A (en)
CA (1) CA2189558A1 (en)
DE (1) DE69504651T2 (en)
DK (1) DK0759030T3 (en)
ES (1) ES2123984T3 (en)
FR (1) FR2719591B1 (en)
HK (1) HK1012407A1 (en)
RU (1) RU2138511C1 (en)
WO (1) WO1995030688A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11169132A (en) * 1997-12-15 1999-06-29 Ajinomoto Co Inc Mixed crystal of aspartame and its derivative, and production of the mixed crystal
US6692778B2 (en) * 1998-06-05 2004-02-17 Wm. Wrigley Jr. Company Method of controlling release of N-substituted derivatives of aspartame in chewing gum
KR100631306B1 (en) * 1998-06-26 2006-10-09 아지노모토 가부시키가이샤 Aspartyl dipeptide ester derivatives and sweeteners containing the same
US6844465B2 (en) 1998-10-30 2005-01-18 Ajinomoto Co., Inc. Method for preparing highly stable crystals of aspartame derivative
WO2000026235A1 (en) * 1998-10-30 2000-05-11 Ajinomoto Co., Inc. Method for preparing crystal of aspartame derivative excellent in stability
CN1317012A (en) 1998-10-30 2001-10-10 味之素株式会社 Crystallization process for formation of stable crystal of aspartame derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1258248A (en) * 1968-07-17 1971-12-22
FR2719590B1 (en) * 1994-05-09 1996-07-26 Claude Nofre Improved process for the preparation of a compound derived from aspartame useful as a sweetening agent.

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