RU98113650A - Новое медицинское применение ингибитора ангиотензин-конвертирующего фермента (акф) для лечения диспептических симптомов - Google Patents
Новое медицинское применение ингибитора ангиотензин-конвертирующего фермента (акф) для лечения диспептических симптомовInfo
- Publication number
- RU98113650A RU98113650A RU98113650/14A RU98113650A RU98113650A RU 98113650 A RU98113650 A RU 98113650A RU 98113650/14 A RU98113650/14 A RU 98113650/14A RU 98113650 A RU98113650 A RU 98113650A RU 98113650 A RU98113650 A RU 98113650A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- acf
- hydrochloride
- dyspeptic symptoms
- fosinopril
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 2
- 230000002401 inhibitory effect Effects 0.000 title claims 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- BIDNLKIUORFRQP-XYGFDPSESA-N (2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims 4
- 229960002490 fosinopril Drugs 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 150000001875 compounds Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- FIQOFIRCTOWDOW-BJLQDIEVSA-N 2-[(2S,6R)-6-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]azaniumyl]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetate Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 claims 2
- XRKXJJYSKUIIEN-LLVKDONJSA-N 2-[cyclopentyl-[(2S)-3-(2,2-dimethylpropanoylsulfanyl)-2-methylpropanoyl]amino]acetic acid Chemical compound CC(C)(C)C(=O)SC[C@@H](C)C(=O)N(CC(O)=O)C1CCCC1 XRKXJJYSKUIIEN-LLVKDONJSA-N 0.000 claims 2
- IPOLXDNCMOVXCP-YZVVJARPSA-N Lyciumin A Natural products O=C(N[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C(=O)O)Cc2c3c(n1c2)cccc3)[C@H](NC(=O)[C@H]1N(C(=O)[C@@H]2NC(=O)CC2)CCC1)Cc1ccc(O)cc1 IPOLXDNCMOVXCP-YZVVJARPSA-N 0.000 claims 2
- HRWCVUIFMSZDJS-SZMVWBNQSA-N Spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 claims 2
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 229960002909 spirapril Drugs 0.000 claims 2
- 229960004084 temocapril Drugs 0.000 claims 2
- QKIVRALZQSUWHH-SFYZADRCSA-N (1S,2R)-2-[[2-(hydroxyamino)-2-oxoethyl]-methylcarbamoyl]cyclohexane-1-carboxylic acid Chemical compound ONC(=O)CN(C)C(=O)[C@@H]1CCCC[C@@H]1C(O)=O QKIVRALZQSUWHH-SFYZADRCSA-N 0.000 claims 1
- NVXFXLSOGLFXKQ-JMSVASOKSA-N (2S)-1-[(2R,4R)-5-ethoxy-2,4-dimethyl-5-oxopentanoyl]-2,3-dihydroindole-2-carboxylic acid Chemical compound C1=CC=C2N(C(=O)[C@H](C)C[C@@H](C)C(=O)OCC)[C@H](C(O)=O)CC2=C1 NVXFXLSOGLFXKQ-JMSVASOKSA-N 0.000 claims 1
- QIJLJZOGPPQCOG-NFAWXSAZSA-N (2S)-1-[(2S)-3-[(2R)-2-(cyclohexanecarbonylamino)propanoyl]sulfanyl-2-methylpropanoyl]pyrrolidine-2-carboxylic acid Chemical compound N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)C1CCCCC1 QIJLJZOGPPQCOG-NFAWXSAZSA-N 0.000 claims 1
- QHRDRNITQKNXNS-JGYLIOAXSA-N (2S)-10-[[(2R)-1-[[(2S)-2-[2-[(2S,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoyl]-[(1R)-1-carboxyethyl]amino]-1-oxopropan-2-yl]amino]-2,9-diamino-6-(1,2-diamino-2-oxoethyl)-5,10-dioxodecanoic acid Chemical compound OC(=O)[C@@H](N)CCC(=O)C(C(N)C(N)=O)CCC(N)C(=O)N[C@H](C)C(=O)N([C@H](C)C(O)=O)C(=O)[C@H](C)NC(=O)C(C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O QHRDRNITQKNXNS-JGYLIOAXSA-N 0.000 claims 1
- GKYIONYOYVKKQI-MPGHIAIKSA-N (2S)-2-[[(2S,3R)-2-(benzoylsulfanylmethyl)-3-phenylbutanoyl]amino]propanoic acid Chemical compound C([C@H](C(=O)N[C@@H](C)C(O)=O)[C@@H](C)C=1C=CC=CC=1)SC(=O)C1=CC=CC=C1 GKYIONYOYVKKQI-MPGHIAIKSA-N 0.000 claims 1
- HBZJVGFXZTUXNI-XMQLQKOFSA-N (2S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-3-azabicyclo[2.2.2]octane-2-carboxylic acid Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C2CCC1CC2)C(O)=O)C(O)=O)CC1=CC=CC=C1 HBZJVGFXZTUXNI-XMQLQKOFSA-N 0.000 claims 1
- FTYVYAGWBXTWTN-ZVZYQTTQSA-N (2S)-5-tert-butyl-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2H-1,3,4-thiadiazole-2-carboxylic acid Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](SC(=N1)C(C)(C)C)C(O)=O)CC1=CC=CC=C1 FTYVYAGWBXTWTN-ZVZYQTTQSA-N 0.000 claims 1
- AXTCRUUITQKBAV-KBPBESRZSA-N (2S)-6-amino-2-[[(3S)-1-(carboxymethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]amino]hexanoic acid Chemical compound OC(=O)CN1C(=O)[C@@H](N[C@@H](CCCCN)C(O)=O)CCC2=CC=CC=C21 AXTCRUUITQKBAV-KBPBESRZSA-N 0.000 claims 1
- AHYHTSYNOHNUSH-GBBGEASQSA-N (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 AHYHTSYNOHNUSH-GBBGEASQSA-N 0.000 claims 1
- NZFXQRHFBLVEQA-GXOSTJLWSA-N (6R)-2-[[(4S)-4-[[(2S)-2-[2-[(2S,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoyl]amino]-4-carboxybutanoyl]amino]-6,7-diamino-7-oxoheptanoic acid Chemical compound NC(=O)[C@H](N)CCCC(C(O)=O)NC(=O)CC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)C(C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O NZFXQRHFBLVEQA-GXOSTJLWSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- FHHHOYXPRDYHEZ-COXVUDFISA-N Alacepril Chemical compound CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 FHHHOYXPRDYHEZ-COXVUDFISA-N 0.000 claims 1
- 229950007884 Alacepril Drugs 0.000 claims 1
- 101700008793 BNP Proteins 0.000 claims 1
- 101700018247 BPP Proteins 0.000 claims 1
- 101700071361 BPP4 Proteins 0.000 claims 1
- 101700034740 BPP8 Proteins 0.000 claims 1
- 229960001880 Fosinopril Sodium Drugs 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- WEGGKZQIJMQCGR-RECQUVTISA-N Hemorphin-4 Chemical compound C([C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H]([C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 WEGGKZQIJMQCGR-RECQUVTISA-N 0.000 claims 1
- 229950010375 Idrapril Drugs 0.000 claims 1
- KLZWOWYOHUKJIG-BPUTZDHNSA-N Imidapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1C(N(C)C[C@H]1C(O)=O)=O)CC1=CC=CC=C1 KLZWOWYOHUKJIG-BPUTZDHNSA-N 0.000 claims 1
- 229950009810 Indolapril Drugs 0.000 claims 1
- 229950001218 Libenzapril Drugs 0.000 claims 1
- 229960002394 Lisinopril Drugs 0.000 claims 1
- 108010007859 Lisinopril Proteins 0.000 claims 1
- BWRVBFMWWHWLBW-UHFFFAOYSA-N Lyciumin B Chemical compound C12=CC=CC=C2N2C=C1CC(C(O)=O)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C2NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCCN1C(=O)C1CCC(=O)N1 BWRVBFMWWHWLBW-UHFFFAOYSA-N 0.000 claims 1
- 229960005170 MOEXIPRIL Drugs 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- UWWDHYUMIORJTA-HSQYWUDLSA-N Moexipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 UWWDHYUMIORJTA-HSQYWUDLSA-N 0.000 claims 1
- 229950006549 Moveltipril Drugs 0.000 claims 1
- QWRYRQKHCGBRGW-NJJVJDFKSA-N N-[(3R,4R,5S,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-(1-oxopropan-2-yloxy)oxan-3-yl]acetamide Chemical compound O=CC(C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O QWRYRQKHCGBRGW-NJJVJDFKSA-N 0.000 claims 1
- 229950008492 PENTOPRIL Drugs 0.000 claims 1
- 229960002582 Perindopril Drugs 0.000 claims 1
- IPVQLZZIHOAWMC-QXKUPLGCSA-N Perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 claims 1
- ODAIHABQVKJNIY-PEDHHIEDSA-N Perindoprilat Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(O)=O)[C@H]21 ODAIHABQVKJNIY-PEDHHIEDSA-N 0.000 claims 1
- 229960005226 Perindoprilat Drugs 0.000 claims 1
- 229950008688 Pivopril Drugs 0.000 claims 1
- JSDRRTOADPPCHY-HSQYWUDLSA-N Quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 claims 1
- 229960003042 Quinapril hydrochloride Drugs 0.000 claims 1
- 229960003401 Ramipril Drugs 0.000 claims 1
- HDACQVRGBOVJII-JBDAPHQKSA-N Ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims 1
- 229960002231 Ramiprilat Drugs 0.000 claims 1
- FMMDBLMCSDRUPA-BPUTZDHNSA-N Spiraprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)C(O)=O)CC1=CC=CC=C1 FMMDBLMCSDRUPA-BPUTZDHNSA-N 0.000 claims 1
- 229950006297 Spiraprilat Drugs 0.000 claims 1
- UUUHXMGGBIUAPW-CSCXCSGISA-N Teprotide Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(O)=O)C(=O)[C@@H]1CCC(=O)N1 UUUHXMGGBIUAPW-CSCXCSGISA-N 0.000 claims 1
- 108010045759 Teprotide Proteins 0.000 claims 1
- 229950010186 Teprotide Drugs 0.000 claims 1
- AHYHTSYNOHNUSH-HXFGRODQSA-N Trandolaprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 AHYHTSYNOHNUSH-HXFGRODQSA-N 0.000 claims 1
- 229950005696 Utibapril Drugs 0.000 claims 1
- 101710004889 Vejaci Proteins 0.000 claims 1
- 229950005973 Zabiciprilat Drugs 0.000 claims 1
- IAIDUHCBNLFXEF-MNEFBYGVSA-N Zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 claims 1
- UQWLOWFDKAFKAP-WXHSDQCUSA-N Zofenoprilat Chemical compound C1[C@@H](C(O)=O)N(C(=O)[C@@H](CS)C)C[C@H]1SC1=CC=CC=C1 UQWLOWFDKAFKAP-WXHSDQCUSA-N 0.000 claims 1
- 229950001300 Zofenoprilat Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- XPCFTKFZXHTYIP-PMACEKPBSA-N benzazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims 1
- IVBOFTGCTWVBLF-GOSISDBHSA-N benzyl 2-[[(2S)-2-(acetylsulfanylmethyl)-3-(1,3-benzodioxol-5-yl)propanoyl]amino]acetate Chemical compound O=C([C@H](CC=1C=C2OCOC2=CC=1)CSC(=O)C)NCC(=O)OCC1=CC=CC=C1 IVBOFTGCTWVBLF-GOSISDBHSA-N 0.000 claims 1
- CUZMQPZYCDIHQL-VCTVXEGHSA-L calcium;(2S)-1-[(2S)-3-[(2R)-2-(cyclohexanecarbonylamino)propanoyl]sulfanyl-2-methylpropanoyl]pyrrolidine-2-carboxylate Chemical compound [Ca+2].N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C([O-])=O)C(=O)C1CCCCC1.N([C@H](C)C(=O)SC[C@@H](C)C(=O)N1[C@@H](CCC1)C([O-])=O)C(=O)C1CCCCC1 CUZMQPZYCDIHQL-VCTVXEGHSA-L 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- WOIWWYDXDVSWAZ-RTWAWAEBSA-N fosinoprilat Chemical compound C([C@@H](C[C@H]1C(=O)O)C2CCCCC2)N1C(=O)CP(O)(=O)CCCCC1=CC=CC=C1 WOIWWYDXDVSWAZ-RTWAWAEBSA-N 0.000 claims 1
- 108010047748 hemorphin 4 Proteins 0.000 claims 1
- 229960001195 imidapril Drugs 0.000 claims 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
- 229960001455 quinapril Drugs 0.000 claims 1
- IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 claims 1
- KEDYTOTWMPBSLG-HILJTLORSA-N ramiprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 KEDYTOTWMPBSLG-HILJTLORSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- TVTJZMHAIQQZTL-LVCDZQEYSA-M sodium;(2S,4S)-4-cyclohexyl-1-[2-[[(1S)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate Chemical compound [Na+].C([P@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C([O-])=O)CCCC1=CC=CC=C1 TVTJZMHAIQQZTL-LVCDZQEYSA-M 0.000 claims 1
- 229960002051 trandolapril Drugs 0.000 claims 1
- 229960002651 trandolaprilat Drugs 0.000 claims 1
- 229960002769 zofenopril Drugs 0.000 claims 1
Claims (8)
1. Применение ингибитора ангиотензин-конвертирующего фермента (АКФ) или его физиологически приемлемой соли в изготовлении лекарственного средства для профилактики и/или лечения диспептических симптомов неизвестного происхождения.
2. Применение по п.1 АКФ-ингибитора, выбранного из группы, состоящей из алацеприла алатриоприла алтиоприл-кальция анковенина беназеприла беназеприла гидрохлорида беназеприлата бензазеприла бензоилкаптоприла каптоприла каптоприл-цистеина каптоприл-глютатиона церанаприла цераноприла церонаприла цилазаприла цилазаприлата конверстатина делаприла делаприл-диацида эналаприла эналаприлата эналкирена энаприла эпикаптоприла фороксимптина фосфеноприла фозеноприла фозеноприл-натрия фозиноприла фозиноприл-натрия фозиноприлата фозиноприловой кислоты гликоприла геморфина-4 идраприла имидаприла индолаприла индолаприлата либензаприла лизиноприла лициумина А лициумина В миксанприла моэксиприла моэксиприлата мовелтиприла мурацеина А мурацеина В мурацеина С пентоприла периндоприла периндоприлата пивалоприла пивоприла хинаприла хинаприла гидрохлорида хинаприлата рамиприла рамиприлата спираприла спираприла гидрохлорида спираприлата спироприла спироприла гидрохлорида темокаприла темокаприла гидрохлорида тепротида трандолаприла трандолаприлата утибаприла забициприла забициприлата зофеноприла зофеноприлата.
3. Фармацевтический препарат, пригодный для использования в профилактике и/или лечении диспептических симптомов неизвестного происхождения, отличающийся тем, что активный ингредиент представляет собой соединение по п. 1 или 2.
4. Лекарственное средство по п. 1 или 2, или фармацевтический препарат по п. 3 в стандартной лекарственной форме.
5. Лекарственное средство по п. 1 или 2, или фармацевтический препарат по пп. 3 и 4, содержащий активный ингредиент в сочетании с фармацевтически приемлемым носителем.
6. Фармацевтический препарат по пп. 3-5, содержащий в качестве активного ингредиента соединение, указанное в списке в п. 2.
7. Способ профилактики или лечения диспептических симптомов неизвестного происхождения у млекопитающих, включая человека, при котором реципиенту, нуждающемуся в такой профилактике или лечении, вводят эффективное количество соединения, как определено в п. 1.
8. Способ по п. 7, отличающийся тем, что вводят соединение, указанное в списке в п. 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600120-1 | 1996-01-15 | ||
| SE9600120A SE9600120D0 (sv) | 1996-01-15 | 1996-01-15 | Novel medical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98113650A true RU98113650A (ru) | 2000-06-20 |
| RU2203092C2 RU2203092C2 (ru) | 2003-04-27 |
Family
ID=20401013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98113650/14A RU2203092C2 (ru) | 1996-01-15 | 1996-12-20 | Новое медицинское применение ингибитора ангиотензин-конвертирующего фермента (акф) для лечения диспептических симптомов |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5977159A (ru) |
| EP (1) | EP0876158B1 (ru) |
| JP (1) | JP2001501908A (ru) |
| KR (1) | KR19990076973A (ru) |
| CN (1) | CN1090031C (ru) |
| AT (1) | ATE218885T1 (ru) |
| AU (1) | AU710846B2 (ru) |
| BR (1) | BR9612483A (ru) |
| CA (1) | CA2240199A1 (ru) |
| CZ (1) | CZ222398A3 (ru) |
| DE (1) | DE69621834T2 (ru) |
| DK (1) | DK0876158T3 (ru) |
| EE (1) | EE03517B1 (ru) |
| ES (1) | ES2175182T3 (ru) |
| HK (1) | HK1014870A1 (ru) |
| HU (1) | HUP9901353A3 (ru) |
| ID (1) | ID16186A (ru) |
| IL (1) | IL125195A (ru) |
| IS (1) | IS4778A (ru) |
| MX (1) | MX9805506A (ru) |
| MY (1) | MY129782A (ru) |
| NO (1) | NO983234L (ru) |
| NZ (1) | NZ325973A (ru) |
| PL (1) | PL327818A1 (ru) |
| PT (1) | PT876158E (ru) |
| RU (1) | RU2203092C2 (ru) |
| SE (1) | SE9600120D0 (ru) |
| SI (1) | SI0876158T1 (ru) |
| SK (1) | SK282781B6 (ru) |
| TR (1) | TR199801298T2 (ru) |
| UA (1) | UA49861C2 (ru) |
| WO (1) | WO1997026014A1 (ru) |
| ZA (1) | ZA9783B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012110A2 (en) * | 1998-08-26 | 2000-03-09 | Queen's University At Kingston | Use of anti(w)pressor agents for vascular remodeling in genital dysfunction |
| US6730775B1 (en) | 1999-03-23 | 2004-05-04 | University Of Southern California | Methods for limiting scar and adhesion formation |
| US6747008B1 (en) | 2000-06-19 | 2004-06-08 | University Of Southern California | Methods for treating and preventing alopecia |
| AU2002308522A1 (en) * | 2001-05-01 | 2002-11-11 | University Of Southern California | Methods for inhibiting tumor cell proliferation |
| US20030215526A1 (en) * | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
| WO2003075842A2 (en) * | 2002-03-08 | 2003-09-18 | Teva Pharmeceuticals Usa, Inc. | Stable formulations of angiotensin converting enzyme (ace) inhibitors |
| US6869963B2 (en) * | 2003-07-11 | 2005-03-22 | Sandoz Ag | Stable pharmaceutical compositions containing an ACE inhibitor |
| US20050271657A1 (en) * | 2004-06-08 | 2005-12-08 | Australian Stem Cell Centre Ltd. | Intermittent treatment regime for organ failure |
| US7776831B2 (en) | 2006-02-01 | 2010-08-17 | Weg Stuart L | Use of antifungal compositions to treat upper gastrointestinal conditions |
| US20090227507A1 (en) * | 2008-03-10 | 2009-09-10 | University Of Southern California | Angiotensin (1-7) Dosage Forms and Uses Thereof |
| EP2350031A2 (en) | 2008-08-20 | 2011-08-03 | Ensemble Therapeutics Corporation | Macrocyclic compounds for inhibition of tumor necrosis factor alpha |
| WO2010110439A1 (ja) * | 2009-03-27 | 2010-09-30 | カルピス株式会社 | 自律神経活動調節用組成物および自律神経を調節する方法 |
| UA108742C2 (uk) | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK9200258U4 (da) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Farmaceutisk præparat indeholdende enalapril til brug mod hypertension |
-
1996
- 1996-01-15 SE SE9600120A patent/SE9600120D0/xx unknown
- 1996-12-20 CA CA002240199A patent/CA2240199A1/en not_active Abandoned
- 1996-12-20 HU HU9901353A patent/HUP9901353A3/hu unknown
- 1996-12-20 UA UA98063020A patent/UA49861C2/ru unknown
- 1996-12-20 DK DK96944722T patent/DK0876158T3/da active
- 1996-12-20 CN CN96199635A patent/CN1090031C/zh not_active Expired - Fee Related
- 1996-12-20 CZ CZ982223A patent/CZ222398A3/cs unknown
- 1996-12-20 DE DE69621834T patent/DE69621834T2/de not_active Expired - Fee Related
- 1996-12-20 AU AU13237/97A patent/AU710846B2/en not_active Ceased
- 1996-12-20 BR BR9612483A patent/BR9612483A/pt unknown
- 1996-12-20 SI SI9630497T patent/SI0876158T1/xx unknown
- 1996-12-20 PT PT96944722T patent/PT876158E/pt unknown
- 1996-12-20 US US08/793,059 patent/US5977159A/en not_active Expired - Fee Related
- 1996-12-20 RU RU98113650/14A patent/RU2203092C2/ru not_active IP Right Cessation
- 1996-12-20 NZ NZ325973A patent/NZ325973A/en unknown
- 1996-12-20 ES ES96944722T patent/ES2175182T3/es not_active Expired - Lifetime
- 1996-12-20 JP JP09525898A patent/JP2001501908A/ja not_active Abandoned
- 1996-12-20 TR TR1998/01298T patent/TR199801298T2/xx unknown
- 1996-12-20 KR KR1019980705101A patent/KR19990076973A/ko not_active Application Discontinuation
- 1996-12-20 AT AT96944722T patent/ATE218885T1/de not_active IP Right Cessation
- 1996-12-20 PL PL96327818A patent/PL327818A1/xx unknown
- 1996-12-20 SK SK879-98A patent/SK282781B6/sk unknown
- 1996-12-20 EP EP96944722A patent/EP0876158B1/en not_active Expired - Lifetime
- 1996-12-20 IL IL12519596A patent/IL125195A/en not_active IP Right Cessation
- 1996-12-20 WO PCT/SE1996/001733 patent/WO1997026014A1/en not_active Application Discontinuation
- 1996-12-20 EE EE9800203A patent/EE03517B1/xx not_active IP Right Cessation
-
1997
- 1997-01-06 ZA ZA9783A patent/ZA9783B/xx unknown
- 1997-01-14 MY MYPI97000128A patent/MY129782A/en unknown
- 1997-01-15 ID IDP970100A patent/ID16186A/id unknown
-
1998
- 1998-06-19 IS IS4778A patent/IS4778A/is unknown
- 1998-07-07 MX MX9805506A patent/MX9805506A/es not_active IP Right Cessation
- 1998-07-14 NO NO983234A patent/NO983234L/no not_active Application Discontinuation
-
1999
- 1999-01-04 HK HK99100001A patent/HK1014870A1/xx not_active IP Right Cessation
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