RU98105169A - DERIVATIVES 8-AZABICYCLO [3.2.1] OCT-2-ENA, THEIR RECEIVING AND APPLICATION - Google Patents

DERIVATIVES 8-AZABICYCLO [3.2.1] OCT-2-ENA, THEIR RECEIVING AND APPLICATION

Info

Publication number
RU98105169A
RU98105169A RU98105169/04A RU98105169A RU98105169A RU 98105169 A RU98105169 A RU 98105169A RU 98105169/04 A RU98105169/04 A RU 98105169/04A RU 98105169 A RU98105169 A RU 98105169A RU 98105169 A RU98105169 A RU 98105169A
Authority
RU
Russia
Prior art keywords
disorder
disease
azabicyclo
oct
disorders
Prior art date
Application number
RU98105169/04A
Other languages
Russian (ru)
Other versions
RU2157372C2 (en
Inventor
Петер Мольдт
Йорген Шеел-Крюгер
Гуннар М. Ольсен
Эльсебет Эстергорд Нильсен
Original Assignee
Нюросерч А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нюросерч А/С filed Critical Нюросерч А/С
Publication of RU98105169A publication Critical patent/RU98105169A/en
Application granted granted Critical
Publication of RU2157372C2 publication Critical patent/RU2157372C2/en

Links

Claims (11)

1. Соединение, имеющее формулу
Figure 00000001

или любой из его энантиомеров либо любая их смесь, или его фармацевтически приемлемая соль,
где R представляет собой водород, алкил, алкенил, алкинил, циклоалкил, циклоалкилалкил или 2-гидроксиэтил;
R4 представляет собой фенил, который может быть замещен одним или более чем одним заместителем, выбранным из группы, состоящей из галогена, CF3, CN, алкоксила, циклоалкоксила, алкила, циклоалкила, алкенила, алкинила, аминогруппы, нитрогруппы, гетероарила и арила; 3,4-метилендиоксифенил; бензил, который может быть замещен одним или более чем одним заместителем, выбранным из группы, состоящей из галогена, CF3, CN, алкоксила, циклоалкоксила, алкила, циклоалкила, алкенила, алкинила, аминогруппы, нитрогруппы, гетероарила и арила; гетероарил, который может быть замещен одним или более чем одним заместителем, выбранным из группы, состоящей из галогена, СF3, CN, алкоксила, циклоалкоксила, алкила, циклоалкила, алкенила, алкинила, аминогруппы, нитрогруппы, гетероарила и арила; или нафтил, который может быть замещен одним или более чем одним заместителем, выбранным из группы, состоящей из галогена, CF3, CN, алкоксила, циклоалкоксила, алкила, циклоалкила, алкенила, алкинила, аминогруппы, нитрогруппы, гетероарила и арила.1. The compound having the formula
Figure 00000001

or any of its enantiomers, or any mixture thereof, or a pharmaceutically acceptable salt thereof,
where R represents hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl;
R 4 is phenyl, which may be substituted by one or more substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; 3,4-methylenedioxyphenyl; benzyl, which may be substituted by one or more substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; heteroaryl, which may be substituted by one or more substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl; or naphthyl, which may be substituted by one or more substituents selected from the group consisting of halogen, CF 3 , CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino, nitro, heteroaryl and aryl. 2. Соединение по п. 1, которое представляет собой
(+)-3-(3,4-дихлорфенил)-8-метил-8-азабицикло[3.2.1]окт-2-ен,
(+)-3-(4-хлорфенил)-8-метил-8-азабицикло[3.2.1]окт-2-ен или
(+)-3-(3,4-дихлорфенил)-8-азабицикло[3.2.1]окт-2-ен
либо их фармацевтически приемлемая соль присоединения.2. The compound according to claim 1, which is
(+) - 3- (3,4-dichlorophenyl) -8-methyl-8-azabicyclo [3.2.1] oct-2-ene,
(+) - 3- (4-chlorophenyl) -8-methyl-8-azabicyclo [3.2.1] oct-2-ene or
(+) - 3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] oct-2-ene
or a pharmaceutically acceptable addition salt thereof. 3. Фармацевтическая композиция, содержащая терапевтически эффективное количество соединения по п.1 вместе с по меньшей мере одним фармацевтически приемлемым носителем или разбавителем. 3. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, together with at least one pharmaceutically acceptable carrier or diluent. 4. Способ изготовления лекарственного средства для лечения расстройства или заболевания живого организма, включая человека, причем это расстройство или заболевание является чувствительным к ингибированию обратного захвата моноаминного нейромедиатора в центральной нервной системе, отличающийся тем, что для изготовления используют соединение по п.1. 4. A method of manufacturing a drug for treating a disorder or disease of a living organism, including a human, this disorder or disease is sensitive to inhibiting the reuptake of a monoamine neurotransmitter in the central nervous system, characterized in that the compound according to claim 1 is used for manufacturing. 5. Способ изготовления лекарственного средства для лечения расстройства или заболевания живого организма, включая человека, причем это расстройство или заболевание является чувствительным к ингибированию обратного захвата серотонина в центральной нервной системе, отличающийся тем, что для изготовления используют соединение по п.1. 5. A method of manufacturing a drug for treating a disorder or disease of a living organism, including a human, and this disorder or disease is sensitive to inhibition of serotonin reuptake in the central nervous system, characterized in that the compound according to claim 1 is used for manufacturing. 6. Способ изготовления лекарственного средства для лечения депрессии и родственных расстройств, таких как псевдодеменции или синдром Ганзера, обсессивно-компульсивные расстройства, состояния паники, нарушения памяти, состояние гиперактивности дефицита внимания, ожирение, состояния тревоги и расстройства при приеме пищи, отличающийся тем, что для изготовления используют соединение по п.1. 6. A method of manufacturing a drug for treating depression and related disorders such as pseudodementia or Ganser syndrome, obsessive-compulsive disorders, panic conditions, memory disorders, attention deficit hyperactivity disorder, obesity, anxiety and eating disorders, characterized in for manufacturing use the compound according to claim 1. 7. Способ по пп. 4-6, отличающийся тем, что используемое соединение представляет собой
(+)-3-(3,4-дихлорфенил)-8-метил-8-азабицикло[3.2.1]окт-2-ен,
(+)-3-(4-хлорфенил)-8-метил-8-азабицикло[3.2.1]окт-2-ен или
(+)-3-(3,4-дихлорфенил)-8-азабицикло[3.2.1]окт-2-ен
либо их фармацевтически приемлемую соль присоединения.7. The method according to paragraphs. 4-6, characterized in that the compound used is
(+) - 3- (3,4-dichlorophenyl) -8-methyl-8-azabicyclo [3.2.1] oct-2-ene,
(+) - 3- (4-chlorophenyl) -8-methyl-8-azabicyclo [3.2.1] oct-2-ene or
(+) - 3- (3,4-dichlorophenyl) -8-azabicyclo [3.2.1] oct-2-ene
or their pharmaceutically acceptable salt accession. 8. Способ лечения расстройства или заболевания живого организма, включая человека, причем это расстройство или заболевание является чувствительным к ингибированию обратного захвата моноаминного нейромедиатора, при котором нуждающемуся в таком лечении живому организму, включая человека, вводят терапевтически эффективное количество соединения по п.1. 8. A method of treating a disorder or disease of a living organism, including a human, and this disorder or disease is sensitive to inhibition of the reuptake of a monoamine neurotransmitter, in which a therapeutic effective amount of a compound according to claim 1 is administered to a living organism in need of such treatment. 9. Способ лечения расстройства или заболевания живого организма, включая человека, причем это расстройство или заболевание является чувствительным к ингибированию обратного захвата серотонина, при котором нуждающемуся в таком лечении живому организму, включая человека, вводят терапевтически эффективное количество соединения по п.1. 9. A method of treating a disorder or disease of a living organism, including a human, and this disorder or disease is sensitive to inhibition of serotonin reuptake, in which a living therapeutically effective amount, including a human, is administered a therapeutically effective amount of a compound according to claim 1. 10. Способ по пп. 8 и 9, отличающийся тем, что лечат депрессию и родственные расстройства, такие как псевдодеменции или синдром Ганзера, обсессивно-компульсивные расстройства, состояния паники, нарушения памяти, состояние гиперактивности дефицита внимания, ожирение, состояния тревоги и расстройства при приеме пищи. 10. The method according to paragraphs. 8 and 9, characterized in that they treat depression and related disorders such as pseudodementia or Ganser syndrome, obsessive-compulsive disorders, panic conditions, memory disorders, attention deficit hyperactivity disorder, obesity, anxiety disorders and eating disorders. 11. Способ получения соединений по п.1, при котором дегидратируют соединение, имеющее формулу
Figure 00000002

где R и R4 такие, как определено в п.1, после чего возможно образуют его фармацевтически приемлемую соль присоединения.11. The method of producing compounds according to claim 1, wherein the compound having the formula
Figure 00000002

where R and R 4 are as defined in claim 1, after which it is possible to form its pharmaceutically acceptable addition salt.
RU98105169/04A 1995-10-13 1996-10-11 Derivatives of 8-azabicyclo[3,2,1]oct-2-ene, method of their synthesis, pharmaceutical composition, method of drug preparing, methods of inhibition of reuptake of monoamine neuromediating agent, especially, serotonin RU2157372C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK1156/95 1995-10-13
DK115695 1995-10-13

Publications (2)

Publication Number Publication Date
RU98105169A true RU98105169A (en) 1999-12-20
RU2157372C2 RU2157372C2 (en) 2000-10-10

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98105169/04A RU2157372C2 (en) 1995-10-13 1996-10-11 Derivatives of 8-azabicyclo[3,2,1]oct-2-ene, method of their synthesis, pharmaceutical composition, method of drug preparing, methods of inhibition of reuptake of monoamine neuromediating agent, especially, serotonin

Country Status (24)

Country Link
US (1) US6100275A (en)
EP (1) EP0859777B1 (en)
JP (1) JP3462505B2 (en)
KR (1) KR100274829B1 (en)
CN (1) CN1083840C (en)
AT (1) ATE362931T1 (en)
AU (1) AU709327B2 (en)
BR (1) BR9610960A (en)
CA (1) CA2233541C (en)
CZ (1) CZ285093B6 (en)
DE (1) DE69637097T2 (en)
DK (1) DK0859777T3 (en)
EE (1) EE03446B1 (en)
HU (1) HUP9802433A3 (en)
IL (1) IL123583A (en)
IS (1) IS4681A (en)
NO (1) NO980919L (en)
NZ (1) NZ320216A (en)
PL (1) PL185357B1 (en)
RU (1) RU2157372C2 (en)
SK (1) SK283425B6 (en)
TR (1) TR199800628T2 (en)
UA (1) UA63894C2 (en)
WO (1) WO1997013770A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
JP2000510144A (en) * 1996-05-13 2000-08-08 ゼネカ リミテッド Bicyclic amines as insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
TW370451B (en) 1996-11-26 1999-09-21 Zeneca Ltd Bicyclic amine derivatives
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
BR9809697A (en) 1997-05-30 2000-07-11 Neurosearch As Compound, use, and process for the preparation thereof, pharmaceutical composition, and, process for treating a disease of a live animal body, including a human
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
AU2609999A (en) * 1998-01-28 1999-08-16 Neurosearch A/S 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form
US6403605B1 (en) * 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
CA2335336A1 (en) * 1998-06-19 1999-12-23 James Edmund Audia Inhibition of serotonin reuptake
EP1133494B1 (en) 1998-11-27 2004-02-18 Neurosearch A/S 8-azabicyclo 3.2.1]oct-2-ene and -octane derivatives
EP1149095B1 (en) * 1999-01-28 2004-01-21 Neurosearch A/S Novel azabicyclo derivatives and their use
JP2002538134A (en) * 1999-03-01 2002-11-12 ファイザー・インク 1,2,3,4-tetrahydro-1-naphthalenamine compounds useful for therapy
EA004101B1 (en) 1999-09-03 2003-12-25 Эли Лилли Энд Компани Using rapid-onset selective serotonin reuptake inhibitors for treating sexual dysfunction
US6835733B2 (en) 1999-12-20 2004-12-28 Eli Lilly And Company Tropane linked benzofuran derivatives
CA2409644A1 (en) 2000-05-25 2001-11-29 Targacept, Inc. Heteroaryldiazabicycloalkanes as nicotinic cholinergic receptor ligands
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
EP1757600A2 (en) * 2000-10-13 2007-02-28 NeuroSearch A/S Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
DE60231386D1 (en) 2001-04-09 2009-04-16 Neurosearch As ADENOSINE A2A RECEPTOR ANTAGONISTS IN COMBINATION WITH COMPOUNDS WITH NEUROTROPHIC ACTIVITY IN THE TREATMENT OF MORBUS PARKINSON
AR035898A1 (en) 2001-05-25 2004-07-21 Wyeth Corp ARIL-8-AZABICICLO [3.2.1] OCTANS, A PROCESS FOR THEIR PREPARATION, A FORMULATION AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION
MXPA04010965A (en) * 2002-05-07 2005-01-25 Neurosearch As Novel azacyclic ethynyl derivatives.
WO2006108789A1 (en) * 2005-04-08 2006-10-19 Neurosearch A/S Novel enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (en) * 2006-10-16 2008-03-11 이도훈 Anticonvulsant
TWI415850B (en) * 2007-07-20 2013-11-21 Theravance Inc Process for preparing an intermediate to mu opioid receptor antagonists
JP2011513354A (en) * 2008-03-05 2011-04-28 ノイロサーチ アクティーゼルスカブ Novel 4-benzhydryl-tetrahydro-pyridine derivatives and their use as monoamine neurotransmitter reuptake inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB247886A (en) * 1925-11-02 1926-02-25 Thomas Stewart Hamilton Improvements in attachments for leaf springs
US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
US3657257A (en) * 1970-08-31 1972-04-18 Robins Co Inc A H 3-aryl-8-carbamoyl nortropanes
US4180669A (en) * 1976-12-13 1979-12-25 Abbott Laboratories 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol
US4132710A (en) * 1976-12-20 1979-01-02 Ayerst, Mckenna And Harrison, Ltd. [2]Benzopyrano[3,4-c]pyridines and process therefor
DK75680A (en) * 1979-02-22 1980-08-23 Wellcome Found PROCEDURE FOR THE PREPARATION OF 1-SUBSTITUTED IMIDAZOLS
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198590D0 (en) * 1990-08-21 1990-08-21 Novo Nordisk As HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE
GB9019973D0 (en) * 1990-09-12 1990-10-24 Wyeth John & Brother Ltd Azabicyclic derivatives
FI111367B (en) * 1991-02-04 2003-07-15 Aventis Pharma Inc Process for the preparation of therapeutically useful N- (aryloxyalkyl) heteroaryl-8-azabicyclo [3.2.1] octane derivatives and intermediates used in the process
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DE4200145A1 (en) * 1992-01-07 1993-07-08 Kali Chemie Pharma Gmbh 7,10-EPOXY-OXACYCLODODANE DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
DK154192D0 (en) * 1992-12-23 1992-12-23 Neurosearch As HETEROCYCLIC COMPOUNDS
CA2163095A1 (en) * 1993-05-18 1994-11-24 Huw M. L. Davies Treatment process with biologically active tropane derivatives
EE03877B1 (en) * 1994-04-19 2002-10-15 Neurosearch A/S Tropane-2-aldoxime derivatives as neurotransmitter reuptake inhibitors
US5731317A (en) * 1995-03-10 1998-03-24 Merck & Co., Inc. Bridged piperidines promote release of growth hormone

Similar Documents

Publication Publication Date Title
RU98105169A (en) DERIVATIVES 8-AZABICYCLO [3.2.1] OCT-2-ENA, THEIR RECEIVING AND APPLICATION
RU98117314A (en) TROPANIC DERIVATIVES, THEIR PRODUCTION AND APPLICATION
KR100236666B1 (en) Compositions comprising a tramadol and any of codeine, oxycodone or hydrocodone, and their use
RU93058534A (en) APPLICATION OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5-NT * 001 RECEPTOR ANTAGONISTS, TETRAHYDROCARBAZOLE DERIVATIVES, METHOD FOR PRODUCING THERAPY, METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITION
KR940013555A (en) Alkyl Substituted Heterocyclic Compounds
JP2020528431A5 (en)
RU98110007A (en) CONDENSED TROPANE DERIVATIVES AS NEURAL MEDIATOR REVERSE INHIBITORS
RU2018130727A (en) ORGANIC COMPOUNDS
RU2006131132A (en) 1,3,5, -TRISubstituted derivatives of 4,5-dihydro-1H-pyrazole possessing CB1-antagonistic activity
US20070249681A1 (en) Bupivacaines
UA41254C2 (en) TETRAHYDROCARBAZOLE DERIVATIVE OR ITS SALT, SOLVATE OR HYDRATE AS AN AGONIST OF 5-HT <sub> 1 </sub> -SILE RECEPTOR, METHOD OF THEIR DETERMINATION
EP1928451B1 (en) Methods for treating substance-related disorders
US20070105884A1 (en) Opiate analogs selective for the delta-opioid receptor
JP2003530345A (en) Pharmaceutical composition for the treatment of acute, chronic pain and / or neuropathic pain and migraine
BR0312216A (en) Compound, process for producing a compound, pharmaceutical composition, use of the compound, method for treating a subject suffering from a disease or condition and product combination
JP2003514818A (en) New uses and new N-azabicyclo-amide derivatives
CN101300006B (en) MAO-B inhibitors useful for treating obesity
CH616668A5 (en)
IS4681A (en) 8-azabicyclo (3.2.1) oct-2-ene derivatives, their preparation and use
RU96121937A (en) DERIVATIVES OF TROPAN-2-ALDOXIM AS REQUIRED INHIBITORS OF REVERSE CAPTURE OF NEUROTREMITTERS
JP2005508872A5 (en)
JPH10316567A (en) Nk-1 receptor antagonist for treatment of symptom of hypersensitive intestinal syndrome
ATE403426T1 (en) OPIOID RECEPTOR ACTIVE 4-(3-HYDROXYPHENYL) OR 4-(3-ALKOXYPHENYL)-1,2,4-TRIAZOLE COMPOUNDS
CN101262867A (en) MAO-B inhibitors useful for treating obesity
CN105209445B (en) The method for treating dyskinesia and associated conditions