RU98101470A - NEW STABLE MEDICINAL COMPOSITION FOR PRODUCING AEROSOLS OF WORKING GAS - Google Patents

NEW STABLE MEDICINAL COMPOSITION FOR PRODUCING AEROSOLS OF WORKING GAS

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Publication number
RU98101470A
RU98101470A RU98101470/14A RU98101470A RU98101470A RU 98101470 A RU98101470 A RU 98101470A RU 98101470/14 A RU98101470/14 A RU 98101470/14A RU 98101470 A RU98101470 A RU 98101470A RU 98101470 A RU98101470 A RU 98101470A
Authority
RU
Russia
Prior art keywords
composition according
medicinal composition
paragraphs
drug composition
working gas
Prior art date
Application number
RU98101470/14A
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Russian (ru)
Other versions
RU2223750C2 (en
Inventor
Фройнд Бернхард
Крюгер Михаэль
Циренберг Бернд
Original Assignee
Берингер Ингельхайм КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Берингер Ингельхайм КГ filed Critical Берингер Ингельхайм КГ
Publication of RU98101470A publication Critical patent/RU98101470A/en
Application granted granted Critical
Publication of RU2223750C2 publication Critical patent/RU2223750C2/en

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Claims (11)

1. Лекарственная композиция для получения аэрозолей без содержания рабочего газа, например, для ингаляции, содержащая фармакологически активное вещество и растворитель, отличающаяся тем, что в качестве растворителя она содержит по меньшей мере 70%-ный (об.%) этанол.1. A medicinal composition for producing aerosols without a working gas, for example, for inhalation, containing a pharmacologically active substance and a solvent, characterized in that it contains at least 70% (vol.%) Ethanol as a solvent. 2. Лекарственная композиция по п. 1, отличающаяся тем, что она содержит в качестве растворителя 85 - 96%-ный (об.%) этанол. 2. The drug composition according to p. 1, characterized in that it contains as a solvent 85 - 96% (vol.%) Ethanol. 3. Лекарственная композиция по п. 1 или 2, отличающаяся тем, что она дополнительно содержит фармакологически приемлемые вспомогательные и/или вкусовые вещества. 3. The drug composition according to p. 1 or 2, characterized in that it further comprises pharmacologically acceptable auxiliary and / or flavoring substances. 4. Лекарственная композиция по одному из пунктов 1-3, отличающаяся тем, что она дополнительно содержит комплексообразователь. 4. The medicinal composition according to one of paragraphs 1-3, characterized in that it further comprises a complexing agent. 5. Лекарственная композиция по п. 4, отличающаяся тем, что комплексообразователем является этилендиаминтетрауксусная кислота или ее соль. 5. The drug composition according to p. 4, characterized in that the complexing agent is ethylenediaminetetraacetic acid or its salt. 6. Лекарственная композиция по п. 4 или 5, отличающаяся тем, что количество комплексообразователя составляет от 0,1 до 5 мг на 100 мл композиции. 6. The drug composition according to p. 4 or 5, characterized in that the amount of complexing agent is from 0.1 to 5 mg per 100 ml of composition. 7. Лекарственная композиция по одному из пп. 1-6, отличающаяся тем, что величина рН композиции установлена равной 3,2-4,5. 7. The drug composition according to one of paragraphs. 1-6, characterized in that the pH of the composition is set equal to 3.2-4.5. 8. Лекарственная композиция по одному из пп. 1-7, отличающаяся тем, что она содержит в качестве активного вещества по меньшей мере одно соединение из группы бетамиметических, антихолинергических, противоаллергических средств и/или антагонистов ФАТ. 8. The medicinal composition according to one of paragraphs. 1-7, characterized in that it contains as an active substance at least one compound from the group of betamimetic, anticholinergic, antiallergic agents and / or FAT antagonists. 9. Лекарственная композиция по одному из пп. 1-8, отличающаяся тем, что доля растворенного активного вещества в лекарственной композиции составляет от 0,001 до 5,0 вес.%. 9. The medicinal composition according to one of paragraphs. 1-8, characterized in that the proportion of dissolved active substance in the medicinal composition is from 0.001 to 5.0 wt.%. 10. Лекарственная композиция по п. 7 или 8, отличающаяся тем, что активным веществом является флунизолид, будезонид, тиотропий или его соль присоединения кислоты. 10. The drug composition according to p. 7 or 8, characterized in that the active substance is flunisolide, budesonide, tiotropium or its acid addition salt. 11. Лекарственная композиция по одному из пп. 1-9, отличающаяся тем, что для получения дозируемых аэрозолей без содержания рабочего газа она содержит на 100 мл 90-96%-ного (об.%) этанола 1,333 г будезонида или 1,667 г полугидрата флунизолида и 1 мг динатриевой соли этилендиаминтетрауксусной кислоты, причем величина рН готовой лекарственной композиции установлена равной 4,0. 11. The medicinal composition according to one of paragraphs. 1-9, characterized in that to obtain metered aerosols without a working gas content it contains per 100 ml of 90-96% (vol.%) Ethanol 1,333 g of budesonide or 1,667 g of flunisolid hemihydrate and 1 mg of disodium salt of ethylenediaminetetraacetic acid, and the pH of the finished drug composition is set to 4.0.
RU98101470/15A 1995-06-27 1996-06-21 Medicinal composition as solution designated for preparing aerosol for inhalation RU2223750C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19523207.0 1995-06-27
DE19523207 1995-06-27

Publications (2)

Publication Number Publication Date
RU98101470A true RU98101470A (en) 1999-12-10
RU2223750C2 RU2223750C2 (en) 2004-02-20

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Application Number Title Priority Date Filing Date
RU98101470/15A RU2223750C2 (en) 1995-06-27 1996-06-21 Medicinal composition as solution designated for preparing aerosol for inhalation

Country Status (35)

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US (5) US6491897B1 (en)
EP (1) EP0835098B1 (en)
JP (1) JP3875993B2 (en)
KR (1) KR100392280B1 (en)
CN (1) CN1086575C (en)
AR (1) AR002614A1 (en)
AT (1) ATE223203T1 (en)
AU (1) AU721566B2 (en)
BG (1) BG64112B1 (en)
BR (1) BR9609307B1 (en)
CA (1) CA2225601C (en)
CZ (1) CZ288337B6 (en)
DE (2) DE19625027A1 (en)
DK (1) DK0835098T3 (en)
EE (1) EE03509B2 (en)
EG (1) EG23912A (en)
ES (1) ES2183001T3 (en)
HU (1) HU223072B1 (en)
IL (1) IL122752A (en)
MX (1) MX9800125A (en)
MY (1) MY116535A (en)
NO (1) NO315452B1 (en)
NZ (1) NZ312662A (en)
PE (1) PE11098A1 (en)
PL (1) PL186196B1 (en)
PT (1) PT835098E (en)
RU (1) RU2223750C2 (en)
SA (1) SA96170213B1 (en)
SI (1) SI0835098T1 (en)
SK (1) SK282468B6 (en)
TR (1) TR199701711T1 (en)
TW (1) TW537903B (en)
UA (1) UA62917C2 (en)
WO (1) WO1997001329A1 (en)
ZA (1) ZA965411B (en)

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