RU97121841A - PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS PREPARATION - Google Patents
PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS PREPARATIONInfo
- Publication number
- RU97121841A RU97121841A RU97121841/14A RU97121841A RU97121841A RU 97121841 A RU97121841 A RU 97121841A RU 97121841/14 A RU97121841/14 A RU 97121841/14A RU 97121841 A RU97121841 A RU 97121841A RU 97121841 A RU97121841 A RU 97121841A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- mixture
- silicon dioxide
- microcrystalline cellulose
- colloidal silicon
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 235000021355 Stearic acid Nutrition 0.000 claims 3
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 239000008117 stearic acid Substances 0.000 claims 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- PFUVRDFDKPNGAV-UHFFFAOYSA-N Sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
Claims (1)
Ацетилсалициловая кислота - 89,28
Целлюлоза микрокристаллическая - 7,24 - 7,94
Кроскармелоза натрия - 2,24
Диоксид кремния коллоидный - 0,24
Стеариновая кислота - 0,30 - 1,00
2. Способ получения фармацевтической композиции в форме таблеток путем смешивания активного ингредиента с наполнителями, измельчения просеивания и прессования, отличающийся тем, что перед прямым прессованием перемешиваются ацетилсалициловая кислота с целлюлозой микрокристаллической, образуя смесь 1, измельчаются и просеиваются при скорости крыльчатки 1000 об./мин. предварительно смешанные кроскармелоза натрия и диоксид кремния коллоидный до достижения размера частиц 0,6 мм с образованием смеси 2, полученные смесь 1 и смесь 2 перемешиваются со стеариновой кислотой.1. Pharmaceutical composition in the form of tablets, including acetylsalicylic acid, microcrystalline cellulose, croscarmelose sodium, colloidal silicon dioxide, stearic acid, characterized in that these components are contained in the following ratio of ingredients, wt.%:
Acetylsalicylic acid - 89,28
Microcrystalline cellulose - 7.24 - 7.94
Croscarmelose sodium - 2.24
Colloidal silicon dioxide - 0.24
Stearic acid - 0.30 - 1.00
2. A method of obtaining a pharmaceutical composition in the form of tablets by mixing the active ingredient with excipients, grinding sifting and pressing, characterized in that acetylsalicylic acid and microcrystalline cellulose are mixed before being directly compressed, forming a mixture 1, crushed and sieved at a speed of impeller 1000 rpm . pre-mixed croscarmelose sodium and colloidal silicon dioxide to achieve a particle size of 0.6 mm with the formation of a mixture of 2, the resulting mixture 1 and a mixture of 2 mixed with stearic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU97121841A RU2153875C2 (en) | 1997-06-19 | 1997-12-30 | Pharmaceutical composition and method of its preparing |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UA9706898 | 1997-06-19 | ||
| RU97121841A RU2153875C2 (en) | 1997-06-19 | 1997-12-30 | Pharmaceutical composition and method of its preparing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97121841A true RU97121841A (en) | 1999-09-27 |
| RU2153875C2 RU2153875C2 (en) | 2000-08-10 |
Family
ID=20200646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97121841A RU2153875C2 (en) | 1997-06-19 | 1997-12-30 | Pharmaceutical composition and method of its preparing |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2153875C2 (en) |
-
1997
- 1997-12-30 RU RU97121841A patent/RU2153875C2/en active
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