RU97114883A - METHODS FOR INHIBITING IL-6 ACTION - Google Patents
METHODS FOR INHIBITING IL-6 ACTIONInfo
- Publication number
- RU97114883A RU97114883A SU97114883/14A SU97114883A RU97114883A RU 97114883 A RU97114883 A RU 97114883A SU 97114883/14 A SU97114883/14 A SU 97114883/14A SU 97114883 A SU97114883 A SU 97114883A RU 97114883 A RU97114883 A RU 97114883A
- Authority
- RU
- Russia
- Prior art keywords
- inhibiting
- action
- compound
- hexamethyleneimino
- piperidino
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title claims 4
- 108090001005 Interleukin-6 Proteins 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 4
- -1 hexamethyleneimino Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 102000027575 transmembrane receptors Human genes 0.000 claims 1
- 108091007901 transmembrane receptors Proteins 0.000 claims 1
Claims (1)
где R1 и R3 независимо представляют водород, -СН3,
R2 выбирают из группы, включающей пирролидин, гексаметиленимино и пиперидино; или его фармацевтически приемлемой соли или сольвата.1. A method of inhibiting the action of IL-6, comprising administering to a person in need thereof an effective amount of a compound having the formula
where R 1 and R 3 independently represent hydrogen, -CH 3 ,
R 2 is selected from the group consisting of pyrrolidine, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
4. Способ ингибирования действия ФИЛ, включающий введение человеку, нуждающемуся в этом, эффективного количества соединения, имеющего формулу 1
где R1 и R3 независимо представляют водород, -СН3-,
R2 выбирают из группы, включающей пирропидин, гексаметиленимино и пиперидино; или его фармацевтически приемлемой соли или сольвата.3. The method of claim 1, where the compound is
4. A method of inhibiting the action of PHIL, comprising administering to a person in need thereof an effective amount of a compound having the formula 1
where R 1 and R 3 independently represent hydrogen, -CH 3 -,
R 2 is selected from the group consisting of pyrropidine, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof.
где R1 и R3 независимо представляют водород, -СН3,
R2 выбирают из группы, включающей пирролидин, гексаметиленимино и пиперидино; или его фармацевтически приемлемой соли или сольвата на указанную систему поверхностных рецепторов.5. A method of inhibiting a surface receptor system using the gp130 transmembrane receptor, comprising the action of a compound of formula 1
where R 1 and R 3 independently represent hydrogen, -CH 3 ,
R 2 is selected from the group consisting of pyrrolidine, hexamethyleneimino and piperidino; or a pharmaceutically acceptable salt or solvate thereof to said surface receptor system.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08.384.730 | 1995-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU97114883A true RU97114883A (en) | 1999-07-20 |
Family
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