RU97114608A - METHOD FOR TREATING CEREBRAL ISCHEMIA AND CEREBRAL DAMAGE TO NEUROPROTECTIVE MEANS - Google Patents
METHOD FOR TREATING CEREBRAL ISCHEMIA AND CEREBRAL DAMAGE TO NEUROPROTECTIVE MEANSInfo
- Publication number
- RU97114608A RU97114608A RU97114608/14A RU97114608A RU97114608A RU 97114608 A RU97114608 A RU 97114608A RU 97114608/14 A RU97114608/14 A RU 97114608/14A RU 97114608 A RU97114608 A RU 97114608A RU 97114608 A RU97114608 A RU 97114608A
- Authority
- RU
- Russia
- Prior art keywords
- neuroprotective agent
- metabolites
- variants
- salts
- functional derivatives
- Prior art date
Links
- 208000001183 Brain Injury Diseases 0.000 title 1
- 206010008120 Cerebral ischaemia Diseases 0.000 title 1
- 201000006474 brain ischemia Diseases 0.000 title 1
- 230000000324 neuroprotective Effects 0.000 title 1
- 239000004090 neuroprotective agent Substances 0.000 claims 10
- 108010036941 Cyclosporins Proteins 0.000 claims 8
- 239000002207 metabolite Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 210000001218 Blood-Brain Barrier Anatomy 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000001519 tissues Anatomy 0.000 claims 2
- 210000004556 Brain Anatomy 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims 1
- FBPFZTCFMRRESA-KAZBKCHUSA-N D-Mannitol Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KAZBKCHUSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229950008679 Protamine sulfate Drugs 0.000 claims 1
- 210000000278 Spinal Cord Anatomy 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000001808 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500209A SE520730C2 (en) | 1995-01-20 | 1995-01-20 | Treatment of brain ischemia and brain damage with a neuroprotective drug |
SE9500209-3 | 1995-01-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU97114608A true RU97114608A (en) | 1999-06-20 |
RU2194527C2 RU2194527C2 (en) | 2002-12-20 |
Family
ID=20396911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU97114608/14A RU2194527C2 (en) | 1995-01-20 | 1996-01-18 | Method for treating ischemia and cerebral lesion with a neuroprotector preparation |
Country Status (18)
Country | Link |
---|---|
US (1) | US5972924A (en) |
EP (1) | EP0813420B1 (en) |
JP (1) | JP3643380B2 (en) |
CN (1) | CN1123359C (en) |
AP (1) | AP734A (en) |
AT (1) | ATE218360T1 (en) |
AU (1) | AU712974B2 (en) |
CA (1) | CA2210241C (en) |
CZ (1) | CZ291233B6 (en) |
DE (1) | DE69621603T2 (en) |
DK (1) | DK0813420T3 (en) |
ES (1) | ES2176432T3 (en) |
MX (1) | MX9706362A (en) |
NZ (1) | NZ300699A (en) |
PT (1) | PT813420E (en) |
RU (1) | RU2194527C2 (en) |
SE (1) | SE520730C2 (en) |
WO (1) | WO1996022104A1 (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19711795C2 (en) * | 1997-03-21 | 2001-03-08 | Apogepha Arzneimittel Gmbh | Use of cyclosporin for the treatment of myocardial infarctions and their consequences |
US6921751B1 (en) * | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
US20050227925A1 (en) * | 2004-04-08 | 2005-10-13 | Robbert Benner | Compositions capable of reducing elevated blood urea concentration |
EP1138692A1 (en) | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragments of human chorionic gonadotropin (hcg) as immunoregulator |
US20040202645A1 (en) * | 2003-04-08 | 2004-10-14 | Khan Nisar Ahmed | Administration of gene-regulatory peptides |
US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
US8680059B2 (en) * | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
US20030220258A1 (en) | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
AP1040A (en) * | 1998-09-17 | 2002-01-30 | Panacea Biotec Ltd | A novel composition containing cyclosporin. |
CN1322136A (en) * | 1998-09-23 | 2001-11-14 | 马库斯·基普 | Neuroimmunophilins for selective neuronal radioprotection |
DE19857609A1 (en) | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Use of erythropoietin for the treatment of human cerebral ischemia |
AU766910B2 (en) * | 1999-04-13 | 2003-10-23 | North Shore-Long Island Jewish Research Institute | Prevention of brain damage in stroke |
EP1214293A1 (en) | 1999-09-08 | 2002-06-19 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
DE19961733A1 (en) * | 1999-12-21 | 2001-06-28 | Ciclomulsion Ag | Oil-in-water emulsion comprising cyclosporin, is useful for treating neurological disease and as a neuroprotectant, comprises triglyceride, natural emulsifier and a hypertonicity agent |
KR20010069066A (en) * | 2000-01-12 | 2001-07-23 | 이종원 | Culturing Method Which Allows Growth of Animal Cells Under Hypoxic Condition |
US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
WO2001076517A2 (en) * | 2000-04-07 | 2001-10-18 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Methods and apparatus for thermally affecting tissue |
WO2002028331A1 (en) | 2000-10-05 | 2002-04-11 | Seacoast Technologies, Inc. | Expandable device for thermal therapy including spiral element |
JP2004532187A (en) | 2001-01-25 | 2004-10-21 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | Trisubstituted carbocyclic cyclophilin binding compounds and their uses |
US6936589B2 (en) * | 2001-09-28 | 2005-08-30 | Albert T. Naito | Parenteral delivery systems |
PL210795B1 (en) | 2001-10-19 | 2012-03-30 | Isotechnika Inc | The method of producing the ISATX247 enriched isomer (E), the method of producing the ISATX247 enriched mixture of the (Z) isomer, the method of stereoselective synthesis of the (E) ISATX247 isomer, the method of stereoselective synthesis of the (Z) isomer ISATX247 and the method of producing the mixture of ISATX247 isomers |
US20030224995A1 (en) * | 2001-12-21 | 2003-12-04 | Khan Nisar Ahmed | Treatment of burns |
US20030220257A1 (en) * | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of trauma |
US7501391B2 (en) * | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
US20030220261A1 (en) * | 2001-12-21 | 2003-11-27 | Khan Nisar Ahmed | Treatment of iatrogenic disease |
US20040013661A1 (en) * | 2001-12-21 | 2004-01-22 | Gert Wensvoort | Stratification |
US7786084B2 (en) * | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
US20030220260A1 (en) * | 2001-12-21 | 2003-11-27 | Khan Nisar Ahmed | Peptide compositions |
US20080242837A1 (en) * | 2001-12-21 | 2008-10-02 | Khan Nisar A | Peptide compositions |
US20080318871A1 (en) * | 2001-12-21 | 2008-12-25 | Khan Nisar A | Treatment of neurological disorders |
US20090227505A1 (en) * | 2004-01-07 | 2009-09-10 | Biotempt B.V. | Methods and uses for protein breakdown products |
US7074775B2 (en) * | 2004-09-14 | 2006-07-11 | Miller Landon C G | Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders |
US8420602B2 (en) * | 2004-09-14 | 2013-04-16 | Landon C. G. Miller | Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders |
KR20080033331A (en) * | 2005-07-05 | 2008-04-16 | 바이오템프트, 비.브이. | Treatment of tumors |
EP1864692A1 (en) * | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Use of peptides for the control of radiation injury |
MX2009001966A (en) * | 2006-08-23 | 2009-06-19 | Univ Montana | Method of reducing neuronal cell damage. |
CA2677948C (en) * | 2007-02-12 | 2014-12-09 | Biotempt B.V. | Treatment of trauma-hemorrhage with short oligopeptides |
JP2013522311A (en) * | 2010-03-15 | 2013-06-13 | ステルス ペプチドズ インターナショナル インコーポレイテッド | Combination therapy with cyclosporine and aromatic-cationic peptide |
RU2475233C2 (en) * | 2010-12-01 | 2013-02-20 | Учреждение Российской академии наук Институт кристаллографии им. А.В. Шубникова РАН | Pharmacological composition for intranasal introduction for cerebral delivery of pharmacologically active component, and method for preparing it |
TR201900128T4 (en) | 2010-12-15 | 2019-02-21 | Contravir Pharmaceuticals Inc | Cyclosporine analog molecules modified at amino acid 1 and 3. |
CN102784102A (en) * | 2012-08-28 | 2012-11-21 | 赵继红 | Tetraodotoxin oral liquid state preparation and preparation method thereof |
US10123969B2 (en) | 2015-10-15 | 2018-11-13 | Wisconsin Alumni Research Foundation | Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid |
EP3801217A4 (en) * | 2018-05-30 | 2022-07-20 | Zap Surgical Systems, Inc. | Radiosurgical neuromodlation close to critical structures |
US20220296540A1 (en) | 2019-09-15 | 2022-09-22 | Celagenex Research (India) Pvt. Ltd. | Synergistic bioactive compositions for treating neurological disorders |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
-
1995
- 1995-01-20 SE SE9500209A patent/SE520730C2/en not_active IP Right Cessation
-
1996
- 1996-01-18 AT AT96901587T patent/ATE218360T1/en active
- 1996-01-18 DK DK96901587T patent/DK0813420T3/en active
- 1996-01-18 US US08/860,898 patent/US5972924A/en not_active Expired - Lifetime
- 1996-01-18 AU AU45924/96A patent/AU712974B2/en not_active Expired
- 1996-01-18 CZ CZ19972336A patent/CZ291233B6/en not_active IP Right Cessation
- 1996-01-18 CA CA002210241A patent/CA2210241C/en not_active Expired - Lifetime
- 1996-01-18 CN CN96192572A patent/CN1123359C/en not_active Expired - Lifetime
- 1996-01-18 JP JP52220296A patent/JP3643380B2/en not_active Expired - Lifetime
- 1996-01-18 RU RU97114608/14A patent/RU2194527C2/en active
- 1996-01-18 ES ES96901587T patent/ES2176432T3/en not_active Expired - Lifetime
- 1996-01-18 EP EP96901587A patent/EP0813420B1/en not_active Expired - Lifetime
- 1996-01-18 NZ NZ300699A patent/NZ300699A/en not_active IP Right Cessation
- 1996-01-18 PT PT96901587T patent/PT813420E/en unknown
- 1996-01-18 AP APAP/P/1997/001049A patent/AP734A/en active
- 1996-01-18 DE DE69621603T patent/DE69621603T2/en not_active Expired - Lifetime
- 1996-01-18 WO PCT/SE1996/000036 patent/WO1996022104A1/en active IP Right Grant
-
1997
- 1997-08-20 MX MX9706362A patent/MX9706362A/en unknown
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