RU97109260A - STRAIN AMYCOLATOPSIS ORIENTALIS SUBSP. EREMOMYCINI VKPM-S 892-PRODUCER EREMOMYCIN AND METHOD FOR PRODUCING ANTIBIOTICS - Google Patents

STRAIN AMYCOLATOPSIS ORIENTALIS SUBSP. EREMOMYCINI VKPM-S 892-PRODUCER EREMOMYCIN AND METHOD FOR PRODUCING ANTIBIOTICS

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Publication number
RU97109260A
RU97109260A RU97109260/13A RU97109260A RU97109260A RU 97109260 A RU97109260 A RU 97109260A RU 97109260/13 A RU97109260/13 A RU 97109260/13A RU 97109260 A RU97109260 A RU 97109260A RU 97109260 A RU97109260 A RU 97109260A
Authority
RU
Russia
Prior art keywords
eremomycin
antibiotic
eremomycini
vkpm
producer
Prior art date
Application number
RU97109260/13A
Other languages
Russian (ru)
Other versions
RU2110578C1 (en
Inventor
М.Г. Бражникова
А.В. Лайко
Г.Б. Федорова
Т.П. Преображенская
М.А. Свешникова
О.А. Лапчинская
Т.П. Сабурова
В.В. Погожева
Н.Н. Ломакина
Т.Ф. Бердникова
Г.С. Катруха
И.В. Толстых
Т.П. Голова
Н.М. Архангельская
Е.Г. Гладких
И.О. Макарова
С.П. Шаповалова
Н.Г. Шепелевцева
С.Т. Филиппосьянц
Original Assignee
Научно-исследовательский институт по изысканию новых антибиотиков РАМН
Filing date
Publication date
Application filed by Научно-исследовательский институт по изысканию новых антибиотиков РАМН filed Critical Научно-исследовательский институт по изысканию новых антибиотиков РАМН
Priority to RU97109260/13A priority Critical patent/RU2110578C1/en
Priority claimed from RU97109260/13A external-priority patent/RU2110578C1/en
Application granted granted Critical
Publication of RU2110578C1 publication Critical patent/RU2110578C1/en
Publication of RU97109260A publication Critical patent/RU97109260A/en

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Claims (2)

1. Штамм Amycolatopsis orientalis eremomycini ВКПМ-S892 - продуцент антибиотика эремомицина.1. The strain Amycolatopsis orientalis eremomycini VKPM-S892 is a producer of the antibiotic eremomycin. 2. Способ получения антибиотика эремомицина, включающий фильтрацию культуральной жидкости, сорбцию, элюцию с последующим получением целевого продукта, отличающийся тем, что для сорбции используют отечественный сорбент карбоксильный катионит КБ-2 в солевой форме, антибиотик с сорбента элюируют раствором аммиака, элюат нейтрализуют и обеззоливают и фильтруют через сорбент ПТФЭ, антибиотик с сорбента ПТФЭ вытесняют водой, фильтруют и промывные воды объединяют, концентрируют в вакууме до содержания антибиотика 140-120 мг/мл и кристаллизуют из 20,0-25,0% раствора этилового спирта в форме сульфата. 2. A method of obtaining an antibiotic eremomycin, including filtering the culture fluid, sorption, elution, followed by obtaining the target product, characterized in that for sorption using domestic sorbent carboxylic cation exchange resin KB-2 in salt form, the antibiotic from the sorbent is eluted with ammonia solution, the eluate is neutralized and anesthetized and filtered through a PTFE sorbent, the antibiotic is displaced from the PTFE sorbent with water, filtered and the washings are combined, concentrated in vacuo to an antibiotic content of 140-120 mg / ml and crystallized from 20.0-25.0% solution of ethyl alcohol in the form of sulfate.
RU97109260/13A 1997-06-18 1997-06-18 Strain amycolatopsis orientalis subspecies eremomycini vkpm-s892 - a producer of antibiotic eremomycin and a method of antibiotic eremomycin producing RU2110578C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU97109260/13A RU2110578C1 (en) 1997-06-18 1997-06-18 Strain amycolatopsis orientalis subspecies eremomycini vkpm-s892 - a producer of antibiotic eremomycin and a method of antibiotic eremomycin producing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU97109260/13A RU2110578C1 (en) 1997-06-18 1997-06-18 Strain amycolatopsis orientalis subspecies eremomycini vkpm-s892 - a producer of antibiotic eremomycin and a method of antibiotic eremomycin producing

Publications (2)

Publication Number Publication Date
RU2110578C1 RU2110578C1 (en) 1998-05-10
RU97109260A true RU97109260A (en) 1998-09-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU97109260/13A RU2110578C1 (en) 1997-06-18 1997-06-18 Strain amycolatopsis orientalis subspecies eremomycini vkpm-s892 - a producer of antibiotic eremomycin and a method of antibiotic eremomycin producing

Country Status (1)

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RU (1) RU2110578C1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533551B (en) * 2010-12-15 2013-10-09 上海天伟生物制药有限公司 High-yield strain of peptide antibiotic, preparation method and use thereof
RU2661613C1 (en) * 2017-11-01 2018-07-17 Дафот Энтерпрайзес Лимитед Method for treatment of human diseases caused by gram-positive bacteria
RU2689699C1 (en) * 2018-06-05 2019-05-28 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе" Amycolatopsis umgeniensis strain - producer of uremycin antibiotic

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